MA32248B1 - مشتقات من 6 هيتيرواريل-إيميدازو - [1،2-a] بيريدينات، وإعدادها وتطبيقها في العلاج - Google Patents

مشتقات من 6 هيتيرواريل-إيميدازو - [1،2-a] بيريدينات، وإعدادها وتطبيقها في العلاج

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Publication number
MA32248B1
MA32248B1 MA33274A MA33274A MA32248B1 MA 32248 B1 MA32248 B1 MA 32248B1 MA 33274 A MA33274 A MA 33274A MA 33274 A MA33274 A MA 33274A MA 32248 B1 MA32248 B1 MA 32248B1
Authority
MA
Morocco
Prior art keywords
group
optionally substituted
alkyl
alkoxy
halogen
Prior art date
Application number
MA33274A
Other languages
English (en)
French (fr)
Inventor
Peretti Danielle De
Yannick Evanno
David Machnik
Nathalie Rakotoarisoa
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Sanofi Aventis
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39764971&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32248(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MA32248B1 publication Critical patent/MA32248B1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

مركبات الصيغة(i) : حيث تمثل r1 مجموعة فينيل أو مجموعة نفثيل،مجموعة أريل غير متجانس، أو مجموعة حلقية غير متجانسة،مستبدلة اختياريا مستبدلة بذرة أو مجموعة واحدة أو العديد من الذرات أو المجموعات ؛ تمثل het مجموعة أريل غير متجانسة أحادية الحلقة مع 5 إلى 6 منها 1 إلى 3 ذرات غير متجانسة مختارة من بين n، o و s ؛ تمثل x 1 إلى 3 مستبدلات متشابهة أو مختلفة بعضها عن بعض مختارة من بين الهيدروجين، الهالوجين، (c1-c10) ألكيل يمكن استبداله اختياريا بمجموعة أو مجموعات عديدة مختارة من بين الهالوجين، (c1-c10) ألكوكسي، (c1-c10)هالوألكوكسي ، nrarb أو هيدروكسيل؛ r تمثل في موضعها 3، 5، 7، 8 من الإيميدازو [1.2 -a] بيريدين من 1 إلى 4 مستبدلات أو مختلفة عن بعضها البعض مختارة من بين الهيدروجين،الهالوجين، (c1-c10) ألكيل، (c1-c10)هالو (c1-c10) ألكيل ،(c1-c10)ألكوكسي؛ تمثل 2r و 3r ،بصورة مستقلة عن بعضها البعض، ذرة الهيدروجين، مجموعة (c1-c10) ألكيل، مستبدلة اختياريا بمجموعة rf ،أو مجموعة أريل مستبدلة اختياريا ؛ تمثل r4 ذرة الهيدروجين، مجموعة (c1-c10) ألكيل، مستبدلة اختياريا بمجموعة rf ؛ مجموعة أريل مستبدلة اختياريا ، في حالة قاعدة أو ملح إضافة إلى حمض. الاستخدام العلاجي وطريقة التحضير.
MA33274A 2008-03-21 2010-10-19 مشتقات من 6 هيتيرواريل-إيميدازو - [1،2-a] بيريدينات، وإعدادها وتطبيقها في العلاج MA32248B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0801585A FR2928924B1 (fr) 2008-03-21 2008-03-21 Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique
PCT/FR2009/000298 WO2009144392A1 (fr) 2008-03-21 2009-03-20 DÉRIVÉS POLYSUBSTITUES DE 6-HETEROARYLE-IMIDAZO[1,2-α]PYRIDINES, LEUR PRÉPARATION ET LEUR APPLICATION EN THÉRAPEUTIQUE

Publications (1)

Publication Number Publication Date
MA32248B1 true MA32248B1 (ar) 2011-04-01

Family

ID=39764971

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33274A MA32248B1 (ar) 2008-03-21 2010-10-19 مشتقات من 6 هيتيرواريل-إيميدازو - [1،2-a] بيريدينات، وإعدادها وتطبيقها في العلاج

Country Status (23)

Country Link
US (2) US8088765B2 (ar)
EP (1) EP2262804B1 (ar)
JP (1) JP5508384B2 (ar)
KR (1) KR20100124830A (ar)
CN (2) CN103145747B (ar)
AR (1) AR070995A1 (ar)
AU (1) AU2009253232B2 (ar)
BR (1) BRPI0910309A2 (ar)
CA (1) CA2719118C (ar)
CL (1) CL2009000699A1 (ar)
CO (1) CO6300864A2 (ar)
EA (1) EA201071111A1 (ar)
FR (1) FR2928924B1 (ar)
IL (1) IL208247A0 (ar)
MA (1) MA32248B1 (ar)
ME (1) ME01112B (ar)
MX (1) MX2010010268A (ar)
NZ (1) NZ588083A (ar)
PE (1) PE20091694A1 (ar)
TW (1) TW200942541A (ar)
UY (1) UY31730A (ar)
WO (1) WO2009144392A1 (ar)
ZA (1) ZA201006725B (ar)

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FR2928922B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique
EP2297133B1 (en) 2008-06-25 2017-09-13 Forum Pharmaceuticals Inc. 1, 2 disubstituted heterocyclic compounds
TWI453207B (zh) * 2008-09-08 2014-09-21 Signal Pharm Llc 胺基三唑并吡啶，其組合物及使用其之治療方法
WO2010128995A1 (en) 2009-05-07 2010-11-11 Envivo Pharmaceuticals, Inc. Phenoxymethyl heterocyclic compounds
FR2953520B1 (fr) * 2009-12-04 2011-11-25 Sanofi Aventis Derives de diphenyl-pyrazolopyridines, leur preparation et leur application en therapeutique
TWI429628B (zh) 2010-03-29 2014-03-11 Univ Taipei Medical 吲哚基或吲哚啉基羥肟酸化合物
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MX2020010321A (es) 2018-03-30 2021-01-08 Incyte Corp Compuestos heterociclicos como inmunomoduladores.
MX2020012045A (es) 2018-05-11 2021-03-29 Incyte Corp Derivados de tetrahidro-imidazo[4,5-c]piridina como inmunomoduladores de ligando 1 de muerte programada (pd-l1).
MX2022001671A (es) 2019-08-09 2022-05-13 Incyte Corp Sales de un inhibidor de pd-1/pd-l1.
AR120109A1 (es) 2019-09-30 2022-02-02 Incyte Corp Compuestos de pirido[3,2-d]pirimidina como inmunomoduladores
CN114829366A (zh) 2019-11-11 2022-07-29 因赛特公司 Pd-1/pd-l1抑制剂的盐及结晶形式
WO2021216973A1 (en) * 2020-04-24 2021-10-28 The Regents Of The University Of California Nurr1 receptor modulators and uses thereof
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WO2022099071A1 (en) 2020-11-06 2022-05-12 Incyte Corporation Process for making a pd-1/pd-l1 inhibitor and salts and crystalline forms thereof
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Also Published As

Publication number Publication date
JP2011515381A (ja) 2011-05-19
KR20100124830A (ko) 2010-11-29
BRPI0910309A2 (pt) 2015-09-29
PE20091694A1 (es) 2009-11-20
US8088765B2 (en) 2012-01-03
FR2928924B1 (fr) 2010-04-23
FR2928924A1 (fr) 2009-09-25
CN102036989A (zh) 2011-04-27
UY31730A (es) 2009-11-10
MX2010010268A (es) 2011-04-05
US20110065700A1 (en) 2011-03-17
NZ588083A (en) 2012-07-27
CN103145747A (zh) 2013-06-12
EP2262804B1 (fr) 2014-12-03
US8598166B2 (en) 2013-12-03
WO2009144392A1 (fr) 2009-12-03
CL2009000699A1 (es) 2010-04-09
JP5508384B2 (ja) 2014-05-28
EA201071111A1 (ru) 2011-08-30
IL208247A0 (en) 2010-12-30
AR070995A1 (es) 2010-05-19
CA2719118A1 (fr) 2009-12-03
CN102036989B (zh) 2014-05-07
ME01112B (me) 2012-12-20
US20120053202A1 (en) 2012-03-01
TW200942541A (en) 2009-10-16
CO6300864A2 (es) 2011-07-21
AU2009253232B2 (en) 2013-07-11
ZA201006725B (en) 2011-11-30
CA2719118C (fr) 2016-07-26
CN103145747B (zh) 2015-06-17
AU2009253232A1 (en) 2009-12-03
EP2262804A1 (fr) 2010-12-22

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