MA31432B1 - Metabolites de derives de (thio) carbamoyl-cyclohexane - Google Patents

Metabolites de derives de (thio) carbamoyl-cyclohexane

Info

Publication number
MA31432B1
MA31432B1 MA32403A MA32403A MA31432B1 MA 31432 B1 MA31432 B1 MA 31432B1 MA 32403 A MA32403 A MA 32403A MA 32403 A MA32403 A MA 32403A MA 31432 B1 MA31432 B1 MA 31432B1
Authority
MA
Morocco
Prior art keywords
metabolites
derivatives
theo
carbamoyl
cyclohexane
Prior art date
Application number
MA32403A
Other languages
Arabic (ar)
English (en)
French (fr)
Inventor
Csongor Éva Ágainé
Norbert Antal Kirschner
Éva Schmidt
István Gyertyán
Béla Kiss
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of MA31432B1 publication Critical patent/MA31432B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/24Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MA32403A 2007-05-18 2009-12-07 Metabolites de derives de (thio) carbamoyl-cyclohexane MA31432B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0700353A HUP0700353A2 (en) 2007-05-18 2007-05-18 Metabolites of (thio)carbamoyl-cyclohexane derivatives
PCT/HU2008/000046 WO2008142461A1 (en) 2007-05-18 2008-05-15 Metabolites of (thio)carbamoyl-cyclohexane derivatives

Publications (1)

Publication Number Publication Date
MA31432B1 true MA31432B1 (fr) 2010-06-01

Family

ID=89987527

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32403A MA31432B1 (fr) 2007-05-18 2009-12-07 Metabolites de derives de (thio) carbamoyl-cyclohexane

Country Status (24)

Country Link
US (1) US8765765B2 (cg-RX-API-DMAC7.html)
EP (1) EP2155707B1 (cg-RX-API-DMAC7.html)
JP (1) JP5406827B2 (cg-RX-API-DMAC7.html)
CN (1) CN101679330A (cg-RX-API-DMAC7.html)
AP (1) AP2009005011A0 (cg-RX-API-DMAC7.html)
AU (1) AU2008252619A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0811744A2 (cg-RX-API-DMAC7.html)
CA (1) CA2684149C (cg-RX-API-DMAC7.html)
CO (1) CO6251252A2 (cg-RX-API-DMAC7.html)
CU (1) CU23852B1 (cg-RX-API-DMAC7.html)
EA (1) EA200971069A1 (cg-RX-API-DMAC7.html)
EC (1) ECSP099819A (cg-RX-API-DMAC7.html)
GE (1) GEP20125523B (cg-RX-API-DMAC7.html)
HU (1) HUP0700353A2 (cg-RX-API-DMAC7.html)
IL (1) IL201534A0 (cg-RX-API-DMAC7.html)
MA (1) MA31432B1 (cg-RX-API-DMAC7.html)
MX (1) MX2009012371A (cg-RX-API-DMAC7.html)
MY (1) MY150784A (cg-RX-API-DMAC7.html)
NI (1) NI200900202A (cg-RX-API-DMAC7.html)
NZ (1) NZ580646A (cg-RX-API-DMAC7.html)
TN (1) TN2009000459A1 (cg-RX-API-DMAC7.html)
TW (1) TW201002324A (cg-RX-API-DMAC7.html)
WO (1) WO2008142461A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200907425B (cg-RX-API-DMAC7.html)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0700353A2 (en) 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US7875610B2 (en) 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
CA2715760C (en) * 2008-02-21 2017-06-13 Mitsubishi Tanabe Pharma Corporation Solid preparation for oral administration of cariprazine hydrochloride
KR101612146B1 (ko) 2008-07-16 2016-04-12 리히터 게데온 닐트. 도파민 수용체 리간드를 함유하는 약학적 제형
HU230067B1 (hu) 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800765A2 (en) * 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
JP5836280B2 (ja) * 2009-11-06 2015-12-24 エスケー バイオファーマスティカルズ カンパニー リミテッド 注意欠陥/多動性障害(adhd)の治療方法
US20110117214A1 (en) * 2009-11-16 2011-05-19 Auspex Pharmaceuticals, Inc. Cyclohexyl urea modulators of d2 receptors and/or d3 receptors
HUP0900790A2 (en) * 2009-12-17 2011-09-28 Richter Gedeon Nyrt A new process for the preparation of piperazine and their hydrochloric salts
WO2014031162A1 (en) * 2012-08-20 2014-02-27 Forest Laboratories Holdings Limited Crystalline form of carbamoyl-cyclohexane derivatives
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
EP3587398A4 (en) * 2017-02-24 2020-01-01 Shenzhen Linglan Bio-pharmaceutical Technology Co., Ltd INNOVATIVE SELECTIVE LIGAND FOR DOPAMINE D3 RECEPTOR, MANUFACTURING METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF
CN108586389B (zh) * 2018-06-29 2020-06-12 成都福柯斯医药技术有限公司 一种合成卡利拉嗪的方法
HU231500B1 (hu) 2019-04-10 2024-04-28 Richter Gedeon Nyrt Karbamoil-ciklohexán származékok autizmus spektrum betegség kezelésére
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder
CN112239433B (zh) * 2019-07-17 2024-05-14 北京盈科瑞创新药物研究有限公司 一种环己烷衍生物、制备方法及其应用
EP4056568A4 (en) * 2019-11-05 2024-02-28 Shanghai Hansoh Biomedical Co., Ltd. BENZOTHIOPHENE DERIVATIVE REGULATOR, PRODUCTION METHOD THEREOF AND USE THEREOF
CA3268476A1 (en) * 2022-09-30 2024-04-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Partial dopamine D3/D2 receptor agonists for the treatment of neuropsychiatric disorders

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666911A (en) 1981-07-14 1987-05-19 Taiho Pharmaceutical Company Limited Allophanoylpiperazine compound and analgesic composition containing same as active ingredient
US4880797A (en) 1986-03-20 1989-11-14 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives and antibacterial agents
JPH01199977A (ja) 1987-11-16 1989-08-11 Mochida Pharmaceut Co Ltd セファロスポリン誘導体の結晶、その製造法およびそれらを有効成分とする医薬組成物
GB8802622D0 (en) 1988-02-05 1988-03-02 Glaxo Group Ltd Chemical compound
US5047406A (en) 1989-12-06 1991-09-10 Warner-Lambert Co. Substituted cyclohexanols as central nervous system agents
US4957921A (en) 1989-12-06 1990-09-18 Warner-Lambert Company Substituted cyclohexanols as central nervous system agents
JPH04275280A (ja) 1991-03-04 1992-09-30 Nippon Chem Ind Co Ltd 4h−2,3−ジヒドロ−2−イミノ−1,3−ベンゾチアジン−4−オン類の製造方法
JPH0532586A (ja) 1991-07-26 1993-02-09 Mitsubishi Petrochem Co Ltd 2,6−ナフタレンジカルボン酸の製造方法
JPH05310745A (ja) 1992-05-13 1993-11-22 Takeda Chem Ind Ltd ジエラジラクトンおよび抗炎症剤
BR9507200A (pt) 1994-03-25 1997-09-16 Isotechnika Inc Melhora da eficácia de drogas por deuteração
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
AU6859096A (en) 1995-09-22 1997-04-09 Warner-Lambert Company Substituted cyclohexylamines as central nervous system agents
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
JP2002509918A (ja) 1998-03-31 2002-04-02 アケイディア ファーマスーティカルズ インコーポレイテッド ムスカリン性レセプタに活性を有する化合物
SE9802208D0 (sv) 1998-06-22 1998-06-22 Astra Pharma Inc Novel compounds
KR20010053010A (ko) 1998-06-30 2001-06-25 이베 사치아키 엔-페닐-엔'-페닐프로필피페라진 유도체 및 그의제조방법
US6489341B1 (en) 1999-06-02 2002-12-03 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using sertindole derivatives
ES2295320T3 (es) 2001-02-27 2008-04-16 Ortho-Mcneil Pharmaceutical, Inc. Compuestos de carbamato utiles para prevenir o tratar el trastorno bipolar.
US6566550B2 (en) 2001-06-21 2003-05-20 Pfizer Inc Substituted aromatic ethers as inhibitors of glycine transport
HU227543B1 (en) 2001-09-28 2011-08-29 Richter Gedeon Nyrt N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
SE0200301D0 (sv) * 2002-02-01 2002-02-01 Axon Biochemicals Bv Thio-carbostyril derivative
US6919342B2 (en) 2003-06-05 2005-07-19 Abbott Gmbh & Co. Kg Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
HU227534B1 (en) * 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
DE102004047517A1 (de) 2004-09-28 2006-03-30 Merck Patent Gmbh Neuartige Kristallform von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, Hydrochlorid
HUP0500170A3 (en) 2005-02-03 2007-11-28 Richter Gedeon Nyrt Piperazine derivatives, process for producing them and pharmaceutical compositions containing them
GT200600414A (es) 2005-09-12 2007-09-20 Sal de glucuranato de compuesto de piperazine
DK2155200T3 (en) 2007-05-11 2017-03-13 Richter Gedeon Nyrt CRYSTALLIC FORM OF A CARBAMOYL-CYCLOHEXAN DERIVATE
HU230748B1 (hu) 2007-05-11 2018-02-28 Richter Gedeon Nyrt Új piperazin só és előállítási eljárása
HUP0700353A2 (en) 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
HUP0700369A2 (en) 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment in the manufacture of a medicament for the treatment of schizophrenia
HUP0700370A2 (en) 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania
CA2694887A1 (en) 2007-08-01 2009-02-05 Henriette Husum Bak-Jensen Use of kncq potassium channel openers for reducing symptoms of or treating disorders or conditions wherein the dopaminergic system is disrupted
US7875610B2 (en) 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
CA2715760C (en) 2008-02-21 2017-06-13 Mitsubishi Tanabe Pharma Corporation Solid preparation for oral administration of cariprazine hydrochloride
KR101612146B1 (ko) 2008-07-16 2016-04-12 리히터 게데온 닐트. 도파민 수용체 리간드를 함유하는 약학적 제형
HU230067B1 (hu) 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800765A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives

Also Published As

Publication number Publication date
JP5406827B2 (ja) 2014-02-05
ECSP099819A (es) 2010-03-31
BRPI0811744A2 (pt) 2014-11-11
EP2155707A1 (en) 2010-02-24
NZ580646A (en) 2012-03-30
NI200900202A (es) 2010-03-11
CA2684149C (en) 2012-12-04
HU0700353D0 (en) 2007-07-30
US20100137335A1 (en) 2010-06-03
TN2009000459A1 (en) 2011-03-31
CO6251252A2 (es) 2011-02-21
HUP0700353A2 (en) 2008-12-29
AU2008252619A1 (en) 2008-11-27
ZA200907425B (en) 2010-07-28
CU20090196A7 (es) 2011-07-11
GEP20125523B (en) 2012-05-25
US8765765B2 (en) 2014-07-01
CA2684149A1 (en) 2008-11-27
AP2009005011A0 (en) 2009-10-31
TW201002324A (en) 2010-01-16
JP2010527983A (ja) 2010-08-19
EA200971069A1 (ru) 2010-04-30
IL201534A0 (en) 2010-05-31
MY150784A (en) 2014-02-28
EP2155707B1 (en) 2013-03-13
MX2009012371A (es) 2009-12-03
CN101679330A (zh) 2010-03-24
WO2008142461A1 (en) 2008-11-27
CU23852B1 (es) 2012-10-15

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