MA31183B1 - Inhibiteurs de mek - Google Patents
Inhibiteurs de mekInfo
- Publication number
- MA31183B1 MA31183B1 MA32166A MA32166A MA31183B1 MA 31183 B1 MA31183 B1 MA 31183B1 MA 32166 A MA32166 A MA 32166A MA 32166 A MA32166 A MA 32166A MA 31183 B1 MA31183 B1 MA 31183B1
- Authority
- MA
- Morocco
- Prior art keywords
- mek inhibitors
- compounds
- mek
- inhibitors
- arylamino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
La présente invention concerne des n-(2-arylamino) aryle sulfonamides, qui sont des inhibiteurs de mek, des procédés d'utilisation de tels composés dans le traitement de maladies hyperprolifératives, et des compositions pharmaceutiques contenant de tels composés.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88584907P | 2007-01-19 | 2007-01-19 | |
PCT/US2008/051518 WO2008089459A1 (fr) | 2007-01-19 | 2008-01-18 | Inhibiteurs de mek |
Publications (1)
Publication Number | Publication Date |
---|---|
MA31183B1 true MA31183B1 (fr) | 2010-02-01 |
Family
ID=39333043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA32166A MA31183B1 (fr) | 2007-01-19 | 2009-08-12 | Inhibiteurs de mek |
Country Status (19)
Country | Link |
---|---|
US (2) | US7820664B2 (fr) |
EP (1) | EP2121620B1 (fr) |
JP (1) | JP5491199B2 (fr) |
KR (1) | KR20090111847A (fr) |
CN (1) | CN101663279A (fr) |
AU (1) | AU2008206045A1 (fr) |
BR (1) | BRPI0806898A2 (fr) |
CA (1) | CA2675358C (fr) |
CO (1) | CO6210813A2 (fr) |
CR (1) | CR10939A (fr) |
DO (1) | DOP2009000181A (fr) |
EA (1) | EA200900959A1 (fr) |
EC (1) | ECSP099525A (fr) |
ES (1) | ES2547303T3 (fr) |
IL (1) | IL199727A0 (fr) |
MA (1) | MA31183B1 (fr) |
MX (1) | MX2009007661A (fr) |
TN (1) | TN2009000291A1 (fr) |
WO (1) | WO2008089459A1 (fr) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
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US8969379B2 (en) | 2004-09-17 | 2015-03-03 | Eisai R&D Management Co., Ltd. | Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide |
US7429667B2 (en) | 2005-01-20 | 2008-09-30 | Ardea Biosciences, Inc. | Phenylamino isothiazole carboxamidines as MEK inhibitors |
US8648116B2 (en) * | 2005-07-21 | 2014-02-11 | Ardea Biosciences, Inc. | Derivatives of N-(arylamino) sulfonamides including polymorphs as inhibitors of MEK as well as compositions, methods of use and methods for preparing the same |
US9095581B2 (en) | 2005-07-21 | 2015-08-04 | Ardea Biosciences, Inc. | Combinations of MEK inhibitors and Raf kinase inhibitors and uses thereof |
WO2007015578A1 (fr) | 2005-08-02 | 2007-02-08 | Eisai R & D Management Co., Ltd. | Procédé d’analyse de l’effet d’un inhibiteur de vascularisation |
CA2652442C (fr) | 2006-05-18 | 2014-12-09 | Eisai R & D Management Co., Ltd. | Agent antitumoral destine au cancer de la thyroide |
US8227603B2 (en) | 2006-08-01 | 2012-07-24 | Cytokinetics, Inc. | Modulating skeletal muscle |
US8299248B2 (en) | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
PT2583970E (pt) | 2006-08-02 | 2016-02-08 | Cytokinetics Inc | Certas entidades químicas, composições e métodos compreendendo imidazopirimidinas |
WO2008121333A1 (fr) * | 2007-03-30 | 2008-10-09 | Cytokinetics, Incorporated | Entités chimiques, compositions et procédés |
US8044240B2 (en) | 2008-03-06 | 2011-10-25 | Ardea Biosciences Inc. | Polymorphic form of N-(S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and uses thereof |
PE20100747A1 (es) * | 2008-04-21 | 2010-11-03 | Novartis Ag | Compuestos heterociclicos como inhibidores de mek |
DK2440545T3 (da) * | 2009-06-12 | 2019-07-22 | Abivax | Forbindelser, der er anvendelige til behandling af cancer |
US10253020B2 (en) | 2009-06-12 | 2019-04-09 | Abivax | Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging |
KR20120094165A (ko) | 2009-10-13 | 2012-08-23 | 알로스팀 테라퓨틱스 엘엘씨 | 질병의 치료에 유용한 신규 mek 억제제 |
KR20120087923A (ko) | 2009-10-21 | 2012-08-07 | 베링거 인겔하임 인터내셔날 게엠베하 | Ccr1 수용체 길항제로서의 인다졸 및 피라졸로피리딘 화합물 |
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BR112012010519A2 (pt) * | 2009-11-04 | 2017-12-05 | Novartis Ag | derivados de sulfonamida heterocíclicos |
EA201200823A1 (ru) * | 2009-12-08 | 2013-02-28 | Новартис Аг | Гетероциклические производные сульфонамидов |
US8871786B2 (en) | 2010-04-30 | 2014-10-28 | Boehringer Ingelheim International Gmbh | Azaindazole amide compounds as CCR1 receptor antagonists |
CA2828946C (fr) | 2011-04-18 | 2016-06-21 | Eisai R&D Management Co., Ltd. | Agent therapeutique pour les tumeurs |
ES2705950T3 (es) | 2011-06-03 | 2019-03-27 | Eisai R&D Man Co Ltd | Biomarcadores para predecir y valorar la capacidad de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib |
CN103748085A (zh) * | 2011-06-09 | 2014-04-23 | 诺华股份有限公司 | 杂环磺酰胺衍生物 |
CA2838029A1 (fr) * | 2011-06-09 | 2012-12-13 | Novartis Ag | Derives de sulfonamide heterocyclique |
CN109316480A (zh) | 2011-07-13 | 2019-02-12 | 赛特凯恩蒂克公司 | 组合als疗法 |
CN103204822B (zh) | 2012-01-17 | 2014-12-03 | 上海科州药物研发有限公司 | 作为蛋白激酶抑制剂的苯并噁唑化合物及其制备方法和用途 |
WO2014071183A1 (fr) | 2012-11-02 | 2014-05-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Méthode de réduction des effets secondaires chez un patient souffrant de cancer traité par un inhibiteur de la mek |
CN104755463A (zh) | 2012-12-21 | 2015-07-01 | 卫材R&D管理有限公司 | 非晶态形式的喹啉衍生物及其生产方法 |
EP2757161A1 (fr) | 2013-01-17 | 2014-07-23 | Splicos | miRNA-124 comme biomarqueur de l'infection virale |
MX368099B (es) | 2013-05-14 | 2019-09-19 | Eisai R&D Man Co Ltd | Biomarcadores para predecir y evaluar el grado de respuesta de sujetos con cancer de endometrio a compuestos de tipo lenvatinib. |
CA2916623C (fr) | 2013-07-05 | 2021-09-14 | Abivax | Composes bicycliques utiles pour le traitement de maladies causees par des retrovirus |
CN103739550B (zh) * | 2014-01-02 | 2016-06-01 | 中国药科大学 | 2,3-二甲基-6-脲-2h-吲唑类化合物及其制备方法与应用 |
EP2974729A1 (fr) | 2014-07-17 | 2016-01-20 | Abivax | Dérivés de quinoléine utilisés dans le traitement de maladies inflammatoires |
JO3783B1 (ar) | 2014-08-28 | 2021-01-31 | Eisai R&D Man Co Ltd | مشتق كوينولين عالي النقاء وطريقة لإنتاجه |
CN105384754B (zh) * | 2014-09-02 | 2018-04-20 | 上海科州药物研发有限公司 | 作为蛋白激酶抑制剂的杂环类化合物及其制备方法和用途 |
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CA2978226A1 (fr) | 2015-03-04 | 2016-09-09 | Merck Sharpe & Dohme Corp. | Association d'un antagoniste de pd-1 et d'un inhibiteur des tyrosines kinases vegfr/fgfr/ret pour traiter le cancer |
MA41866A (fr) | 2015-03-31 | 2018-02-06 | Massachusetts Gen Hospital | Molécules à auto-assemblage pour l'administration ciblée de médicaments |
CN107801379B (zh) | 2015-06-16 | 2021-05-25 | 卫材R&D管理有限公司 | 抗癌剂 |
US20190008859A1 (en) | 2015-08-21 | 2019-01-10 | Acerta Pharma B.V. | Therapeutic Combinations of a MEK Inhibitor and a BTK Inhibitor |
CN105085427B (zh) * | 2015-08-21 | 2018-06-05 | 中国科学院广州生物医药与健康研究院 | 一类苯并[d]异恶唑类化合物及其应用 |
BR112019020163A2 (pt) | 2017-03-30 | 2020-04-22 | Bristol-Myers Squibb Company | forma cristalina de 6-(ciclopropanocarboxamido)-4-((2-metóxi-3-(1-metil-1h-1,2,4-triazol-3-il)fenil)amino)-n-(metil-d3) piridazina-3-carboxamida |
EP3860998B1 (fr) | 2018-10-05 | 2023-12-27 | Annapurna Bio Inc. | Composés et compositions destinés au traitement d'états pathologiques associés à une activité du récepteur de l'apj |
AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
CN110229173A (zh) * | 2019-07-17 | 2019-09-13 | 泰州职业技术学院 | 一种5-6-5氮杂三环化合物及其制备方法 |
US20220401436A1 (en) | 2019-11-08 | 2022-12-22 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (fr) | 2020-01-22 | 2021-07-29 | Onxeo | Nouvelle molécule dbait et son utilisation |
CN112759552A (zh) * | 2020-12-31 | 2021-05-07 | 武汉九州钰民医药科技有限公司 | 司美替尼的合成方法 |
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-
2008
- 2008-01-18 AU AU2008206045A patent/AU2008206045A1/en not_active Abandoned
- 2008-01-18 EA EA200900959A patent/EA200900959A1/ru unknown
- 2008-01-18 EP EP08727965.9A patent/EP2121620B1/fr active Active
- 2008-01-18 US US12/016,897 patent/US7820664B2/en not_active Expired - Fee Related
- 2008-01-18 CA CA2675358A patent/CA2675358C/fr not_active Expired - Fee Related
- 2008-01-18 WO PCT/US2008/051518 patent/WO2008089459A1/fr active Application Filing
- 2008-01-18 JP JP2009546558A patent/JP5491199B2/ja not_active Expired - Fee Related
- 2008-01-18 CN CN200880007510A patent/CN101663279A/zh active Pending
- 2008-01-18 BR BRPI0806898-4A patent/BRPI0806898A2/pt not_active IP Right Cessation
- 2008-01-18 ES ES08727965.9T patent/ES2547303T3/es active Active
- 2008-01-18 KR KR1020097017247A patent/KR20090111847A/ko not_active Application Discontinuation
- 2008-01-18 MX MX2009007661A patent/MX2009007661A/es not_active Application Discontinuation
-
2009
- 2009-07-07 IL IL199727A patent/IL199727A0/en unknown
- 2009-07-07 TN TNP2009000291A patent/TN2009000291A1/fr unknown
- 2009-07-17 CR CR10939A patent/CR10939A/es unknown
- 2009-07-17 EC EC2009009525A patent/ECSP099525A/es unknown
- 2009-07-17 CO CO09074929A patent/CO6210813A2/es not_active Application Discontinuation
- 2009-07-22 DO DO2009000181A patent/DOP2009000181A/es unknown
- 2009-08-12 MA MA32166A patent/MA31183B1/fr unknown
-
2010
- 2010-09-10 US US12/879,314 patent/US8063049B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP2121620A1 (fr) | 2009-11-25 |
EP2121620B1 (fr) | 2015-06-17 |
MX2009007661A (es) | 2009-12-14 |
DOP2009000181A (es) | 2010-04-30 |
US7820664B2 (en) | 2010-10-26 |
WO2008089459A1 (fr) | 2008-07-24 |
JP5491199B2 (ja) | 2014-05-14 |
US20080255133A1 (en) | 2008-10-16 |
KR20090111847A (ko) | 2009-10-27 |
US8063049B2 (en) | 2011-11-22 |
CA2675358A1 (fr) | 2008-07-24 |
IL199727A0 (en) | 2010-04-15 |
CA2675358C (fr) | 2016-01-05 |
BRPI0806898A2 (pt) | 2015-07-14 |
CN101663279A (zh) | 2010-03-03 |
US20100331334A1 (en) | 2010-12-30 |
CO6210813A2 (es) | 2010-10-20 |
AU2008206045A1 (en) | 2008-07-24 |
CR10939A (es) | 2009-11-13 |
ECSP099525A (es) | 2009-11-30 |
JP2010516698A (ja) | 2010-05-20 |
EA200900959A1 (ru) | 2010-02-26 |
ES2547303T3 (es) | 2015-10-05 |
TN2009000291A1 (en) | 2010-12-31 |
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