MA30522B1 - Composes ayant une activite au niveau du transporteur glyt1 - Google Patents
Composes ayant une activite au niveau du transporteur glyt1Info
- Publication number
- MA30522B1 MA30522B1 MA31488A MA31488A MA30522B1 MA 30522 B1 MA30522 B1 MA 30522B1 MA 31488 A MA31488 A MA 31488A MA 31488 A MA31488 A MA 31488A MA 30522 B1 MA30522 B1 MA 30522B1
- Authority
- MA
- Morocco
- Prior art keywords
- activity
- compounds
- transporter glyt1
- benzamide
- trifluoromethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Dérivés de pyrrolidine ayant une activité au niveau du transporteur GlyTl Les sels consistant en succinate et napadisylate et produits de solvatation de napadisylate de 2 - (méthyloxy ) -N- [2-méthyl-l-phényl-2- (1-pyrrolidinyl) -propyl]-4,6-bis(trifluorométhyl)benzamide,6-bis(trifluoro-méthyl)benzamide, et leurs utilisations dans le traitement de troubles en rapport avec le transporteur GlyTl, tels que la schizophrénie, sont décrits.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0612420.0A GB0612420D0 (en) | 2006-06-22 | 2006-06-22 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MA30522B1 true MA30522B1 (fr) | 2009-06-01 |
Family
ID=36803732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA31488A MA30522B1 (fr) | 2006-06-22 | 2008-12-19 | Composes ayant une activite au niveau du transporteur glyt1 |
Country Status (23)
Country | Link |
---|---|
US (1) | US20080070973A1 (fr) |
EP (1) | EP2041082B1 (fr) |
JP (1) | JP2009541261A (fr) |
KR (1) | KR20090019847A (fr) |
CN (1) | CN101506156A (fr) |
AR (1) | AR061554A1 (fr) |
AT (1) | ATE444288T1 (fr) |
AU (1) | AU2007263058A1 (fr) |
BR (1) | BRPI0713311A2 (fr) |
CA (1) | CA2655399A1 (fr) |
CL (1) | CL2007001808A1 (fr) |
CR (1) | CR10498A (fr) |
DE (1) | DE602007002642D1 (fr) |
EA (1) | EA200970044A1 (fr) |
ES (1) | ES2333918T3 (fr) |
GB (1) | GB0612420D0 (fr) |
IL (1) | IL195633A0 (fr) |
MA (1) | MA30522B1 (fr) |
NO (1) | NO20085412L (fr) |
PE (1) | PE20080380A1 (fr) |
TW (1) | TW200817322A (fr) |
WO (1) | WO2007147831A1 (fr) |
ZA (1) | ZA200810009B (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20061156A1 (es) | 2004-12-23 | 2006-12-16 | Glaxo Group Ltd | Derivados de benzamida como agentes inhibidores del transportador de glicina |
JP2010530397A (ja) * | 2007-06-20 | 2010-09-09 | グラクソ グループ リミテッド | アミド形成の改善方法 |
AU2011261375B2 (en) | 2010-06-04 | 2016-09-22 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
US20120035156A1 (en) * | 2010-08-09 | 2012-02-09 | Daniela Alberati | Combination of glyt1 compound with antipsychotics |
ES2928785T3 (es) | 2017-10-13 | 2022-11-22 | Treeway Tw001 B V | Sal de edaravona |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2746959A (en) * | 1953-06-02 | 1956-05-22 | American Home Prod | Diphenylethylenediamine-penicillin salt |
US3145209A (en) * | 1961-07-31 | 1964-08-18 | Olin Mathieson | Substituted aminophenyl-ethylamine derivatives |
NZ237443A (en) * | 1990-04-10 | 1993-11-25 | Asta Medica Ag | Phenalkylethylenediamine and aminomethyltetra hydroisoquinoline derivatives, platinum (ii) and (iv) complexes, methods of preparation and pharmaceutical compositions |
GB0130696D0 (en) * | 2001-12-21 | 2002-02-06 | Smithkline Beecham Plc | Chemical Compounds |
FR2861070B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-[phenyl(pyrrolidin-2-yl)methyl]benzamide et n-[(azepan-2-yl)phenylmethyl]benzamide, leur preparation et leur application en therapeutique |
PE20061156A1 (es) * | 2004-12-23 | 2006-12-16 | Glaxo Group Ltd | Derivados de benzamida como agentes inhibidores del transportador de glicina |
-
2006
- 2006-06-22 GB GBGB0612420.0A patent/GB0612420D0/en not_active Ceased
-
2007
- 2007-06-20 EP EP07786764A patent/EP2041082B1/fr active Active
- 2007-06-20 AU AU2007263058A patent/AU2007263058A1/en not_active Abandoned
- 2007-06-20 TW TW096121972A patent/TW200817322A/zh unknown
- 2007-06-20 CL CL2007001808A patent/CL2007001808A1/es unknown
- 2007-06-20 CA CA002655399A patent/CA2655399A1/fr not_active Abandoned
- 2007-06-20 PE PE2007000782A patent/PE20080380A1/es not_active Application Discontinuation
- 2007-06-20 AR ARP070102723A patent/AR061554A1/es unknown
- 2007-06-20 JP JP2009515863A patent/JP2009541261A/ja not_active Withdrawn
- 2007-06-20 CN CNA2007800312340A patent/CN101506156A/zh active Pending
- 2007-06-20 KR KR1020087030915A patent/KR20090019847A/ko not_active Application Discontinuation
- 2007-06-20 WO PCT/EP2007/056106 patent/WO2007147831A1/fr active Application Filing
- 2007-06-20 BR BRPI0713311-1A patent/BRPI0713311A2/pt not_active IP Right Cessation
- 2007-06-20 AT AT07786764T patent/ATE444288T1/de not_active IP Right Cessation
- 2007-06-20 DE DE602007002642T patent/DE602007002642D1/de active Active
- 2007-06-20 EA EA200970044A patent/EA200970044A1/ru unknown
- 2007-06-20 ES ES07786764T patent/ES2333918T3/es active Active
- 2007-06-20 US US11/765,478 patent/US20080070973A1/en not_active Abandoned
-
2008
- 2008-11-25 ZA ZA200810009A patent/ZA200810009B/xx unknown
- 2008-12-01 IL IL195633A patent/IL195633A0/en unknown
- 2008-12-11 CR CR10498A patent/CR10498A/es not_active Application Discontinuation
- 2008-12-19 MA MA31488A patent/MA30522B1/fr unknown
- 2008-12-30 NO NO20085412A patent/NO20085412L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CL2007001808A1 (es) | 2008-01-18 |
DE602007002642D1 (de) | 2009-11-12 |
IL195633A0 (en) | 2009-09-01 |
ES2333918T3 (es) | 2010-03-02 |
PE20080380A1 (es) | 2008-05-31 |
AR061554A1 (es) | 2008-09-03 |
BRPI0713311A2 (pt) | 2012-03-06 |
NO20085412L (no) | 2009-01-22 |
CA2655399A1 (fr) | 2007-12-27 |
WO2007147831A1 (fr) | 2007-12-27 |
EA200970044A1 (ru) | 2009-04-28 |
EP2041082A1 (fr) | 2009-04-01 |
EP2041082B1 (fr) | 2009-09-30 |
AU2007263058A1 (en) | 2007-12-27 |
TW200817322A (en) | 2008-04-16 |
GB0612420D0 (en) | 2006-08-02 |
ATE444288T1 (de) | 2009-10-15 |
JP2009541261A (ja) | 2009-11-26 |
CN101506156A (zh) | 2009-08-12 |
KR20090019847A (ko) | 2009-02-25 |
CR10498A (es) | 2009-03-20 |
US20080070973A1 (en) | 2008-03-20 |
ZA200810009B (en) | 2009-11-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA30522B1 (fr) | Composes ayant une activite au niveau du transporteur glyt1 | |
CY1111086T1 (el) | Παραγωγα 2-αμινο-κιναζολινης χρησιμα ως αναστολεις της βητα-σεκρετασης (bace) | |
MA29354B1 (fr) | Derives de cyclopentapyridine et tetrahydroquinoleine. | |
MA31906B1 (fr) | Inhibiteurs de la replication du virus de limmunodeficience humaine | |
MA35364B1 (fr) | Dérivés hétérocycliques bicycliques pour le traitement d'une hypertension artérielle pulmonaire | |
ATE482936T1 (de) | Als b-sekretase (bace)-hemmer nützliche 2-amino- chinazolinderivate | |
MA33209B1 (fr) | Inhibiteurs de la replication du virus de l'hepatite c | |
MA31683B1 (fr) | Composes et procedes pour moduler fxr | |
DE602005024279D1 (de) | 5-substituierte-2-phenylaminobenzamide als mek-inhibitoren | |
MA31158B1 (fr) | Composes tricycliques et leur utilisation comme modulateurs du recepteur de glucocorticoïdes | |
MA32711B1 (fr) | Pyrrolidine-2-carboxamides substitues | |
MA33636B1 (fr) | Dérivés aminopropioniques substitués comme inhibiteurs de néprilysine | |
MA32468B1 (fr) | Derives de thiophene ou de thiazole et leur utilisation comme inhibiteurs de pi3k | |
MA33334B1 (fr) | Derives de l-(piperidine-4-yl)-pyrazole servant de modulateurs de gpr 119 | |
MA31580B1 (fr) | Derives de bicyclolactames substitués | |
TN2012000192A1 (fr) | N1-pyrazolospirocetones inhibitrices d'acetyl-coa-carboxylase | |
DK1723144T3 (da) | Yderligere heteropolycykliske forbindelser og anvendelse deraf som metabotropiske glutamareceptor-antagonister | |
MA33451B1 (fr) | Dérivés d'imidazolidin-2-one 1,3-disubstitués en tant qu'inhibiteurs de cyp 17 | |
FR2903618B1 (fr) | Agent de dispersion et/ou d'aide au broyage pour dispersion et suspension aqueuse de matieres minerales, dispersion et suspension obtenues et leurs utilisations. | |
GT200500309A (es) | Derivados de sulfonilbencilimidazol | |
ATE484505T1 (de) | 5-sulfanylmethylä1,2,4ütriazolä1,5-aüpyrimidin- - olderivate als cxcr2-antagonisten | |
MA30324B1 (fr) | Benzimidazoles presentant une activite au niveau du recepteur m1 et leurs utilisations en medecine. | |
Nowak et al. | Discovery and initial optimization of 5, 5′-disubstituted aminohydantoins as potent β-secretase (BACE1) inhibitors | |
NO20076479L (no) | Nye oksadiazolderivater og anvendelse derav som positive allosteriske metabotropiske modulatorer av glutamatreseptorer | |
UY30274A1 (es) | Derivados sustituidos de la n-(4-metil-1,3-tiazol-2-il)guanidina, formulaciones farmacéuticas conteniéndolo y aplicaciones |