BRPI0713311A2 - derivados de pirrolidina tendo atividade no transportador de glyt1 - Google Patents

derivados de pirrolidina tendo atividade no transportador de glyt1 Download PDF

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Publication number
BRPI0713311A2
BRPI0713311A2 BRPI0713311-1A BRPI0713311A BRPI0713311A2 BR PI0713311 A2 BRPI0713311 A2 BR PI0713311A2 BR PI0713311 A BRPI0713311 A BR PI0713311A BR PI0713311 A2 BRPI0713311 A2 BR PI0713311A2
Authority
BR
Brazil
Prior art keywords
transporter activity
pyrrolidine derivatives
glyt1 transporter
glyt1
trifluoromethyl
Prior art date
Application number
BRPI0713311-1A
Other languages
English (en)
Inventor
Louise Anderton Claire
Clapham David
Raymond Keel Trevor
Jane Kindon Leanda
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of BRPI0713311A2 publication Critical patent/BRPI0713311A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

DERIVADOS DE PIRROLIDINA TENDO ATIVIDADE NO TRANSPORTADOR DE GLYT1 São descritos sais de succinato e napadisilatos e solvatos de napadisilato de 2- (Metilóxi)-/V-[2-metiI-I-fenil-2-(1-pirrolidinil)propil]-4,6-bis(trifluormetil)b enzamida,6-bis(trifluormetil)benzamida, e é revelado o uso destes no tratamento de transtornos relacionados ao transportadores de GIyT1,tal como esquizofrenia.
BRPI0713311-1A 2006-06-22 2007-06-20 derivados de pirrolidina tendo atividade no transportador de glyt1 BRPI0713311A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0612420.0 2006-06-22
GBGB0612420.0A GB0612420D0 (en) 2006-06-22 2006-06-22 Compounds
PCT/EP2007/056106 WO2007147831A1 (en) 2006-06-22 2007-06-20 Pyrrolidine derivatives having activity at the glyt1 transporter

Publications (1)

Publication Number Publication Date
BRPI0713311A2 true BRPI0713311A2 (pt) 2012-03-06

Family

ID=36803732

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0713311-1A BRPI0713311A2 (pt) 2006-06-22 2007-06-20 derivados de pirrolidina tendo atividade no transportador de glyt1

Country Status (23)

Country Link
US (1) US20080070973A1 (pt)
EP (1) EP2041082B1 (pt)
JP (1) JP2009541261A (pt)
KR (1) KR20090019847A (pt)
CN (1) CN101506156A (pt)
AR (1) AR061554A1 (pt)
AT (1) ATE444288T1 (pt)
AU (1) AU2007263058A1 (pt)
BR (1) BRPI0713311A2 (pt)
CA (1) CA2655399A1 (pt)
CL (1) CL2007001808A1 (pt)
CR (1) CR10498A (pt)
DE (1) DE602007002642D1 (pt)
EA (1) EA200970044A1 (pt)
ES (1) ES2333918T3 (pt)
GB (1) GB0612420D0 (pt)
IL (1) IL195633A0 (pt)
MA (1) MA30522B1 (pt)
NO (1) NO20085412L (pt)
PE (1) PE20080380A1 (pt)
TW (1) TW200817322A (pt)
WO (1) WO2007147831A1 (pt)
ZA (1) ZA200810009B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20061156A1 (es) 2004-12-23 2006-12-16 Glaxo Group Ltd Derivados de benzamida como agentes inhibidores del transportador de glicina
JP2010530397A (ja) * 2007-06-20 2010-09-09 グラクソ グループ リミテッド アミド形成の改善方法
AU2011261375B2 (en) 2010-06-04 2016-09-22 Albany Molecular Research, Inc. Glycine transporter-1 inhibitors, methods of making them, and uses thereof
US20120035156A1 (en) * 2010-08-09 2012-02-09 Daniela Alberati Combination of glyt1 compound with antipsychotics
ES2928785T3 (es) 2017-10-13 2022-11-22 Treeway Tw001 B V Sal de edaravona

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2746959A (en) * 1953-06-02 1956-05-22 American Home Prod Diphenylethylenediamine-penicillin salt
US3145209A (en) * 1961-07-31 1964-08-18 Olin Mathieson Substituted aminophenyl-ethylamine derivatives
NZ237443A (en) * 1990-04-10 1993-11-25 Asta Medica Ag Phenalkylethylenediamine and aminomethyltetra hydroisoquinoline derivatives, platinum (ii) and (iv) complexes, methods of preparation and pharmaceutical compositions
GB0130696D0 (en) * 2001-12-21 2002-02-06 Smithkline Beecham Plc Chemical Compounds
FR2861070B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(pyrrolidin-2-yl)methyl]benzamide et n-[(azepan-2-yl)phenylmethyl]benzamide, leur preparation et leur application en therapeutique
PE20061156A1 (es) * 2004-12-23 2006-12-16 Glaxo Group Ltd Derivados de benzamida como agentes inhibidores del transportador de glicina

Also Published As

Publication number Publication date
CL2007001808A1 (es) 2008-01-18
DE602007002642D1 (de) 2009-11-12
IL195633A0 (en) 2009-09-01
ES2333918T3 (es) 2010-03-02
PE20080380A1 (es) 2008-05-31
AR061554A1 (es) 2008-09-03
NO20085412L (no) 2009-01-22
CA2655399A1 (en) 2007-12-27
WO2007147831A1 (en) 2007-12-27
EA200970044A1 (ru) 2009-04-28
EP2041082A1 (en) 2009-04-01
EP2041082B1 (en) 2009-09-30
AU2007263058A1 (en) 2007-12-27
TW200817322A (en) 2008-04-16
GB0612420D0 (en) 2006-08-02
ATE444288T1 (de) 2009-10-15
JP2009541261A (ja) 2009-11-26
CN101506156A (zh) 2009-08-12
KR20090019847A (ko) 2009-02-25
CR10498A (es) 2009-03-20
US20080070973A1 (en) 2008-03-20
ZA200810009B (en) 2009-11-25
MA30522B1 (fr) 2009-06-01

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE A 5A ANUIDADE.