MA29433B1 - COMPOSES IMIDAZO[1,2-a]PYRIDINYLE INHIBITEURS DU VEGF-R2. - Google Patents

COMPOSES IMIDAZO[1,2-a]PYRIDINYLE INHIBITEURS DU VEGF-R2.

Info

Publication number
MA29433B1
MA29433B1 MA30233A MA30233A MA29433B1 MA 29433 B1 MA29433 B1 MA 29433B1 MA 30233 A MA30233 A MA 30233A MA 30233 A MA30233 A MA 30233A MA 29433 B1 MA29433 B1 MA 29433B1
Authority
MA
Morocco
Prior art keywords
vegf
imidazo
inhibitors
pyridinyl compounds
compounds
Prior art date
Application number
MA30233A
Other languages
English (en)
French (fr)
Inventor
David Anthony Barda
Timothy Paul Burkholder
Joshua Ryan Clayton
Yan Hao
Perry Clark Heath
James Robert Henry
John Monte Knobeloch
David Mendel
Johnathan Alexander Mclean
David Michael Remick
Mark Edward Rempala
Zhao-Qing Wang
Yvonne Yee Mai Yip
Boyu Zhong
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MA29433B1 publication Critical patent/MA29433B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MA30233A 2005-02-24 2007-09-24 COMPOSES IMIDAZO[1,2-a]PYRIDINYLE INHIBITEURS DU VEGF-R2. MA29433B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65598105P 2005-02-24 2005-02-24

Publications (1)

Publication Number Publication Date
MA29433B1 true MA29433B1 (fr) 2008-05-02

Family

ID=36587138

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30233A MA29433B1 (fr) 2005-02-24 2007-09-24 COMPOSES IMIDAZO[1,2-a]PYRIDINYLE INHIBITEURS DU VEGF-R2.

Country Status (33)

Country Link
US (1) US7666879B2 (enExample)
EP (1) EP1904494B1 (enExample)
JP (1) JP5055136B2 (enExample)
KR (1) KR100904938B1 (enExample)
CN (1) CN101128461B (enExample)
AR (1) AR056186A1 (enExample)
AT (1) ATE490254T1 (enExample)
AU (1) AU2006216710B2 (enExample)
BR (1) BRPI0609047A2 (enExample)
CA (1) CA2599124C (enExample)
CR (1) CR9331A (enExample)
CY (1) CY1111154T1 (enExample)
DE (1) DE602006018615D1 (enExample)
DK (1) DK1904494T3 (enExample)
DO (1) DOP2006000051A (enExample)
EA (1) EA011691B1 (enExample)
ES (1) ES2354716T3 (enExample)
HR (1) HRP20100677T1 (enExample)
IL (1) IL184717A (enExample)
MA (1) MA29433B1 (enExample)
MX (1) MX2007010326A (enExample)
NO (1) NO20074666L (enExample)
NZ (2) NZ560402A (enExample)
PE (1) PE20061098A1 (enExample)
PL (1) PL1904494T3 (enExample)
PT (1) PT1904494E (enExample)
RS (1) RS51590B (enExample)
SI (1) SI1904494T1 (enExample)
TN (1) TNSN07323A1 (enExample)
TW (1) TW200640924A (enExample)
UA (1) UA91535C2 (enExample)
WO (1) WO2006091671A1 (enExample)
ZA (1) ZA200707136B (enExample)

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EP2126574B1 (en) 2007-03-08 2015-12-23 The Board of Trustees of the Leland Stanford Junior University Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
GB0720041D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New Compounds
PL2212323T3 (pl) 2007-10-17 2013-01-31 Novartis Ag Pochodne imidazo[1,2-a]pirydyny użyteczne jako inhibitory ALK
GB0810902D0 (en) * 2008-06-13 2008-07-23 Astex Therapeutics Ltd New compounds
ES2477552T3 (es) 2008-09-08 2014-07-17 The Board Of Trustees Of The Leland Stanford Junior University Moduladores de la actividad de la aldehidodeshidrogenasa y métodos de uso de los mismos
KR20110082180A (ko) 2008-10-28 2011-07-18 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 알데히드 탈수소효소의 조절자 및 그것의 사용방법
JO3265B1 (ar) 2008-12-09 2018-09-16 Novartis Ag مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض
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CN104768548B (zh) 2012-09-28 2018-08-10 范德比尔特大学 作为选择性bmp抑制剂的稠合杂环化合物
KR101735975B1 (ko) * 2012-11-29 2017-05-15 에프. 호프만-라 로슈 아게 이미다조피리딘 유도체
KR20150135332A (ko) 2013-03-14 2015-12-02 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법
US9944637B2 (en) 2013-12-16 2018-04-17 Asana Biosciences, Llc P2X3 and/or P2X2/3 compounds and methods
CN103772308B (zh) * 2013-12-31 2015-11-18 北京颖泰嘉和生物科技股份有限公司 5-氨基-3-(1-乙基-1-甲基丙基)异噁唑中间体的制备方法和异噁草胺的制备方法
EP3152194B8 (en) * 2014-06-03 2019-10-09 Arizona Board of Regents on Behalf of the University of Arizona Benzimidazole derivatives
JP6665154B2 (ja) 2014-07-17 2020-03-13 ノース・アンド・サウス・ブラザー・ファーマシー・インベストメント・カンパニー・リミテッド 置換尿素誘導体及びその薬学的使用
CN104163790B (zh) * 2014-08-19 2016-02-10 贵州威顿晶磷电子材料股份有限公司 一种2-氨基-4-甲基-5溴吡啶的制备工艺
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US10745400B2 (en) 2018-03-14 2020-08-18 Vanderbuilt University Inhibition of BMP signaling, compounds, compositions and uses thereof
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Also Published As

Publication number Publication date
PT1904494E (pt) 2010-12-23
CY1111154T1 (el) 2015-06-11
KR20070099029A (ko) 2007-10-08
AU2006216710A1 (en) 2006-08-31
CN101128461B (zh) 2010-12-22
ATE490254T1 (de) 2010-12-15
CA2599124C (en) 2013-08-06
TNSN07323A1 (en) 2008-12-31
CN101128461A (zh) 2008-02-20
EA200701802A1 (ru) 2008-02-28
DOP2006000051A (es) 2006-08-31
MX2007010326A (es) 2007-10-16
US20090227622A1 (en) 2009-09-10
US7666879B2 (en) 2010-02-23
EA011691B1 (ru) 2009-04-28
NZ584753A (en) 2011-06-30
EP1904494B1 (en) 2010-12-01
PE20061098A1 (es) 2006-10-20
KR100904938B1 (ko) 2009-06-29
JP5055136B2 (ja) 2012-10-24
CR9331A (es) 2008-03-31
PL1904494T3 (pl) 2011-04-29
CA2599124A1 (en) 2006-08-31
WO2006091671A1 (en) 2006-08-31
BRPI0609047A2 (pt) 2010-11-16
HRP20100677T1 (hr) 2011-01-31
JP2008531574A (ja) 2008-08-14
SI1904494T1 (sl) 2011-02-28
RS51590B (sr) 2011-08-31
TW200640924A (en) 2006-12-01
NZ560402A (en) 2010-06-25
EP1904494A1 (en) 2008-04-02
AU2006216710B2 (en) 2011-08-11
IL184717A0 (en) 2007-12-03
UA91535C2 (en) 2010-08-10
NO20074666L (no) 2007-11-09
HK1118284A1 (en) 2009-02-06
ZA200707136B (en) 2008-11-26
DE602006018615D1 (de) 2011-01-13
IL184717A (en) 2011-11-30
ES2354716T3 (es) 2011-03-17
AR056186A1 (es) 2007-09-26
DK1904494T3 (da) 2011-02-21

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