MA27025A1 - Derives d'oxazole substitues par de l'acide carboxylique utiles en tant qu'activateurs ppar-alpha et gamma dans le traitement du diabete - Google Patents

Derives d'oxazole substitues par de l'acide carboxylique utiles en tant qu'activateurs ppar-alpha et gamma dans le traitement du diabete

Info

Publication number
MA27025A1
MA27025A1 MA27399A MA27399A MA27025A1 MA 27025 A1 MA27025 A1 MA 27025A1 MA 27399 A MA27399 A MA 27399A MA 27399 A MA27399 A MA 27399A MA 27025 A1 MA27025 A1 MA 27025A1
Authority
MA
Morocco
Prior art keywords
ppar
diabetes
alpha
treatment
carboxylic acid
Prior art date
Application number
MA27399A
Other languages
English (en)
French (fr)
Inventor
Alfred Binggeli
Markus Boehringer
Uwe Grether
Hans Hilpert
Hans-Peter Maerki
Markus Meyer
Peter Mohr
Fabienne Ricklin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA27025A1 publication Critical patent/MA27025A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MA27399A 2001-05-15 2003-11-14 Derives d'oxazole substitues par de l'acide carboxylique utiles en tant qu'activateurs ppar-alpha et gamma dans le traitement du diabete MA27025A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01111745 2001-05-15

Publications (1)

Publication Number Publication Date
MA27025A1 true MA27025A1 (fr) 2004-12-20

Family

ID=8177436

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27399A MA27025A1 (fr) 2001-05-15 2003-11-14 Derives d'oxazole substitues par de l'acide carboxylique utiles en tant qu'activateurs ppar-alpha et gamma dans le traitement du diabete

Country Status (38)

Country Link
US (1) US6642389B2 (OSRAM)
EP (1) EP1392295B1 (OSRAM)
JP (2) JP4330883B2 (OSRAM)
KR (1) KR100654516B1 (OSRAM)
CN (1) CN100356917C (OSRAM)
AR (1) AR035892A1 (OSRAM)
AT (1) ATE327753T1 (OSRAM)
AU (1) AU2002342244B2 (OSRAM)
BG (1) BG66316B1 (OSRAM)
BR (1) BRPI0209821B1 (OSRAM)
CA (1) CA2445145C (OSRAM)
CY (1) CY1105160T1 (OSRAM)
CZ (1) CZ20033037A3 (OSRAM)
DE (1) DE60211891T2 (OSRAM)
DK (1) DK1392295T3 (OSRAM)
EC (1) ECSP034848A (OSRAM)
EG (1) EG25755A (OSRAM)
ES (1) ES2264482T3 (OSRAM)
GT (1) GT200200085A (OSRAM)
HR (1) HRP20030889B1 (OSRAM)
HU (1) HU230224B1 (OSRAM)
IL (2) IL158589A0 (OSRAM)
JO (1) JO2282B1 (OSRAM)
MA (1) MA27025A1 (OSRAM)
ME (1) ME01310B (OSRAM)
MX (1) MXPA03010435A (OSRAM)
MY (1) MY136761A (OSRAM)
NO (1) NO333833B1 (OSRAM)
NZ (1) NZ529033A (OSRAM)
PA (1) PA8544901A1 (OSRAM)
PE (1) PE20021152A1 (OSRAM)
PL (1) PL208074B1 (OSRAM)
PT (1) PT1392295E (OSRAM)
RU (1) RU2278859C2 (OSRAM)
SI (1) SI1392295T1 (OSRAM)
SK (1) SK287842B6 (OSRAM)
WO (1) WO2002092084A1 (OSRAM)
ZA (1) ZA200308538B (OSRAM)

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US7456184B2 (en) * 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
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DK1537091T3 (da) * 2002-08-30 2010-11-08 Hoffmann La Roche Hidtil ukendte 2-arylthiazolforbindelser som PPAR alpha- og PPAR gamma-agonister
TWI343915B (en) 2002-10-07 2011-06-21 Hoffmann La Roche Chirale ppar agonists
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US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
CA2564563C (en) 2004-05-03 2011-07-05 F. Hoffmann-La Roche Ag Indolyl derivatives as liver-x-receptor modulators
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CN100436430C (zh) * 2004-05-24 2008-11-26 北京摩力克科技有限公司 作为hPPARα和hPPARγ激动剂的烷酰基取代的酪氨酸衍生物
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GB2460784A (en) * 2007-03-07 2009-12-16 Dong A Pharmtech Co Ltd Novel phenylpropionic acid derivatives as peroxisome proliferator-activated gamma receptor modulators,method of the same,and pharmaceutical composition
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CN104619689B (zh) * 2012-09-12 2017-08-08 霍夫曼-拉罗奇有限公司 (S)‑2‑甲氧基‑3‑{4‑[2‑(5‑甲基‑2‑苯基‑噁唑‑4‑基)‑乙氧基]‑苯并[b]噻吩‑7‑基}‑丙酸的固体形式及其盐的固体形式
CN109588042A (zh) 2015-11-18 2019-04-05 豪夫迈·罗氏有限公司 用于治疗糖尿病肾病的阿格列扎
WO2018002215A1 (en) 2016-06-30 2018-01-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of cardiomyopathies
WO2020156683A1 (en) 2019-02-01 2020-08-06 F. Hoffmann-La Roche Ag Aleglitazar for use in the treatment or prevention of major adverse cardiac events
WO2020201263A1 (en) 2019-04-01 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment and prevention of cardiac remodeling
JP2024532807A (ja) * 2021-08-13 2024-09-10 アレバンド ファーマシューティカルズ(ホンコン)リミテッド 重水素化化合物
JP2025538159A (ja) 2022-11-08 2025-11-26 ジェンフィット 肝不全の治療において使用するためのppar-アルファ/ガンマアゴニスト
CN118480034B (zh) * 2023-02-13 2025-02-11 礼邦医药(香港)有限公司 氘代化合物的晶型或盐

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Also Published As

Publication number Publication date
CA2445145C (en) 2008-10-14
ES2264482T3 (es) 2007-01-01
DE60211891T2 (de) 2007-05-24
PE20021152A1 (es) 2003-02-07
MXPA03010435A (es) 2004-03-09
KR20030096397A (ko) 2003-12-24
CY1105160T1 (el) 2009-11-04
PL208074B1 (pl) 2011-03-31
DE60211891D1 (de) 2006-07-06
AU2002342244B2 (en) 2005-06-16
NO20035086D0 (no) 2003-11-14
IL158589A (en) 2010-11-30
BRPI0209821B1 (pt) 2016-09-27
HRP20030889A2 (en) 2005-08-31
GT200200085A (es) 2003-01-16
ZA200308538B (en) 2005-04-26
ME01310B (me) 2011-10-10
BG66316B1 (bg) 2013-04-30
CZ20033037A3 (cs) 2004-06-16
CN100356917C (zh) 2007-12-26
ECSP034848A (es) 2003-12-24
PT1392295E (pt) 2006-09-29
BG108362A (bg) 2005-03-31
AR035892A1 (es) 2004-07-21
WO2002092084A1 (en) 2002-11-21
US6642389B2 (en) 2003-11-04
HU230224B1 (hu) 2015-10-28
HRP20030889B1 (hr) 2011-10-31
JP2004529174A (ja) 2004-09-24
NZ529033A (en) 2005-06-24
ATE327753T1 (de) 2006-06-15
SK287842B6 (sk) 2011-12-05
US20030055265A1 (en) 2003-03-20
JP2009138011A (ja) 2009-06-25
SI1392295T1 (sl) 2006-10-31
HUP0400992A2 (hu) 2004-08-30
BR0209821A (pt) 2004-06-01
IL158589A0 (en) 2004-05-12
MY136761A (en) 2008-11-28
NO20035086L (no) 2003-11-14
HK1067534A1 (en) 2005-04-15
HUP0400992A3 (en) 2007-11-28
EP1392295A1 (en) 2004-03-03
CN1509173A (zh) 2004-06-30
KR100654516B1 (ko) 2006-12-05
RU2003134150A (ru) 2005-06-10
EP1392295B1 (en) 2006-05-31
EG25755A (en) 2012-06-26
PL367087A1 (en) 2005-02-21
RU2278859C2 (ru) 2006-06-27
NO333833B1 (no) 2013-09-30
JO2282B1 (en) 2005-09-12
PA8544901A1 (es) 2003-01-24
DK1392295T3 (da) 2006-10-02
CA2445145A1 (en) 2002-11-21
JP4330883B2 (ja) 2009-09-16
SK13852003A3 (en) 2004-10-05

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