PE20021152A1 - Derivados de oxazol como agonistas de receptores activados por proliferacion de peroxisoma - Google Patents

Derivados de oxazol como agonistas de receptores activados por proliferacion de peroxisoma

Info

Publication number
PE20021152A1
PE20021152A1 PE2002000399A PE2002000399A PE20021152A1 PE 20021152 A1 PE20021152 A1 PE 20021152A1 PE 2002000399 A PE2002000399 A PE 2002000399A PE 2002000399 A PE2002000399 A PE 2002000399A PE 20021152 A1 PE20021152 A1 PE 20021152A1
Authority
PE
Peru
Prior art keywords
agonists
proliferation
oxazole derivatives
activated receptors
peroxisome
Prior art date
Application number
PE2002000399A
Other languages
English (en)
Spanish (es)
Inventor
Alfred Binggeli
Markus Boehringer
Uwe Grether
Fabienne Ricklin
Hans-Peter Maerki
Markus Meyer
Peter Mohr
Hans Hilpert
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20021152A1 publication Critical patent/PE20021152A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PE2002000399A 2001-05-15 2002-05-14 Derivados de oxazol como agonistas de receptores activados por proliferacion de peroxisoma PE20021152A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01111745 2001-05-15

Publications (1)

Publication Number Publication Date
PE20021152A1 true PE20021152A1 (es) 2003-02-07

Family

ID=8177436

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000399A PE20021152A1 (es) 2001-05-15 2002-05-14 Derivados de oxazol como agonistas de receptores activados por proliferacion de peroxisoma

Country Status (38)

Country Link
US (1) US6642389B2 (OSRAM)
EP (1) EP1392295B1 (OSRAM)
JP (2) JP4330883B2 (OSRAM)
KR (1) KR100654516B1 (OSRAM)
CN (1) CN100356917C (OSRAM)
AR (1) AR035892A1 (OSRAM)
AT (1) ATE327753T1 (OSRAM)
AU (1) AU2002342244B2 (OSRAM)
BG (1) BG66316B1 (OSRAM)
BR (1) BRPI0209821B1 (OSRAM)
CA (1) CA2445145C (OSRAM)
CY (1) CY1105160T1 (OSRAM)
CZ (1) CZ20033037A3 (OSRAM)
DE (1) DE60211891T2 (OSRAM)
DK (1) DK1392295T3 (OSRAM)
EC (1) ECSP034848A (OSRAM)
EG (1) EG25755A (OSRAM)
ES (1) ES2264482T3 (OSRAM)
GT (1) GT200200085A (OSRAM)
HR (1) HRP20030889B1 (OSRAM)
HU (1) HU230224B1 (OSRAM)
IL (2) IL158589A0 (OSRAM)
JO (1) JO2282B1 (OSRAM)
MA (1) MA27025A1 (OSRAM)
ME (1) ME01310B (OSRAM)
MX (1) MXPA03010435A (OSRAM)
MY (1) MY136761A (OSRAM)
NO (1) NO333833B1 (OSRAM)
NZ (1) NZ529033A (OSRAM)
PA (1) PA8544901A1 (OSRAM)
PE (1) PE20021152A1 (OSRAM)
PL (1) PL208074B1 (OSRAM)
PT (1) PT1392295E (OSRAM)
RU (1) RU2278859C2 (OSRAM)
SI (1) SI1392295T1 (OSRAM)
SK (1) SK287842B6 (OSRAM)
WO (1) WO2002092084A1 (OSRAM)
ZA (1) ZA200308538B (OSRAM)

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PL208074B1 (pl) * 2001-05-15 2011-03-31 Hoffmann La Roche Pochodne oksazolu, sposób ich wytwarzania, środek farmaceutyczny i zastosowanie pochodnych oksazolu
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US7655658B2 (en) * 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
JP2005504043A (ja) * 2001-08-10 2005-02-10 パラチン テクノロジーズ インク． 生物学的に活性な金属ペプチド類のペプチド模倣体類
US7456184B2 (en) * 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
US7732451B2 (en) * 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
JP2005528346A (ja) 2002-02-25 2005-09-22 イーライ・リリー・アンド・カンパニー ペルオキシソーム増殖因子活性化受容体調節物質
DK1537091T3 (da) * 2002-08-30 2010-11-08 Hoffmann La Roche Hidtil ukendte 2-arylthiazolforbindelser som PPAR alpha- og PPAR gamma-agonister
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US7968548B2 (en) * 2003-05-01 2011-06-28 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine compounds with diamine groups
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US7262303B2 (en) 2003-09-29 2007-08-28 Hoffman-La Roche Inc. Process for the production of chiral propionic acid derivatives
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US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
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CN100344618C (zh) * 2004-05-24 2007-10-24 北京摩力克科技有限公司 作为hPPARα和hPPARγ激动剂的N－芳丙烯酰基取代的酪氨酸衍生物
CN100436430C (zh) * 2004-05-24 2008-11-26 北京摩力克科技有限公司 作为hPPARα和hPPARγ激动剂的烷酰基取代的酪氨酸衍生物
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CN104619689B (zh) * 2012-09-12 2017-08-08 霍夫曼-拉罗奇有限公司 (S)‑2‑甲氧基‑3‑{4‑[2‑(5‑甲基‑2‑苯基‑噁唑‑4‑基)‑乙氧基]‑苯并[b]噻吩‑7‑基}‑丙酸的固体形式及其盐的固体形式
CN109588042A (zh) 2015-11-18 2019-04-05 豪夫迈·罗氏有限公司 用于治疗糖尿病肾病的阿格列扎
WO2018002215A1 (en) 2016-06-30 2018-01-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of cardiomyopathies
WO2020156683A1 (en) 2019-02-01 2020-08-06 F. Hoffmann-La Roche Ag Aleglitazar for use in the treatment or prevention of major adverse cardiac events
WO2020201263A1 (en) 2019-04-01 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment and prevention of cardiac remodeling
JP2024532807A (ja) * 2021-08-13 2024-09-10 アレバンド ファーマシューティカルズ（ホンコン）リミテッド 重水素化化合物
JP2025538159A (ja) 2022-11-08 2025-11-26 ジェンフィット 肝不全の治療において使用するためのｐｐａｒ－アルファ／ガンマアゴニスト
CN118480034B (zh) * 2023-02-13 2025-02-11 礼邦医药(香港)有限公司 氘代化合物的晶型或盐

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Also Published As

Publication number Publication date
CA2445145C (en) 2008-10-14
ES2264482T3 (es) 2007-01-01
DE60211891T2 (de) 2007-05-24
MXPA03010435A (es) 2004-03-09
KR20030096397A (ko) 2003-12-24
CY1105160T1 (el) 2009-11-04
PL208074B1 (pl) 2011-03-31
DE60211891D1 (de) 2006-07-06
AU2002342244B2 (en) 2005-06-16
NO20035086D0 (no) 2003-11-14
IL158589A (en) 2010-11-30
BRPI0209821B1 (pt) 2016-09-27
HRP20030889A2 (en) 2005-08-31
GT200200085A (es) 2003-01-16
ZA200308538B (en) 2005-04-26
ME01310B (me) 2011-10-10
BG66316B1 (bg) 2013-04-30
CZ20033037A3 (cs) 2004-06-16
CN100356917C (zh) 2007-12-26
ECSP034848A (es) 2003-12-24
PT1392295E (pt) 2006-09-29
BG108362A (bg) 2005-03-31
AR035892A1 (es) 2004-07-21
WO2002092084A1 (en) 2002-11-21
MA27025A1 (fr) 2004-12-20
US6642389B2 (en) 2003-11-04
HU230224B1 (hu) 2015-10-28
HRP20030889B1 (hr) 2011-10-31
JP2004529174A (ja) 2004-09-24
NZ529033A (en) 2005-06-24
ATE327753T1 (de) 2006-06-15
SK287842B6 (sk) 2011-12-05
US20030055265A1 (en) 2003-03-20
JP2009138011A (ja) 2009-06-25
SI1392295T1 (sl) 2006-10-31
HUP0400992A2 (hu) 2004-08-30
BR0209821A (pt) 2004-06-01
IL158589A0 (en) 2004-05-12
MY136761A (en) 2008-11-28
NO20035086L (no) 2003-11-14
HK1067534A1 (en) 2005-04-15
HUP0400992A3 (en) 2007-11-28
EP1392295A1 (en) 2004-03-03
CN1509173A (zh) 2004-06-30
KR100654516B1 (ko) 2006-12-05
RU2003134150A (ru) 2005-06-10
EP1392295B1 (en) 2006-05-31
EG25755A (en) 2012-06-26
PL367087A1 (en) 2005-02-21
RU2278859C2 (ru) 2006-06-27
NO333833B1 (no) 2013-09-30
JO2282B1 (en) 2005-09-12
PA8544901A1 (es) 2003-01-24
DK1392295T3 (da) 2006-10-02
CA2445145A1 (en) 2002-11-21
JP4330883B2 (ja) 2009-09-16
SK13852003A3 (en) 2004-10-05

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