MA26772A1 - Derives de phenylalaninol - Google Patents

Derives de phenylalaninol

Info

Publication number
MA26772A1
MA26772A1 MA26298A MA26298A MA26772A1 MA 26772 A1 MA26772 A1 MA 26772A1 MA 26298 A MA26298 A MA 26298A MA 26298 A MA26298 A MA 26298A MA 26772 A1 MA26772 A1 MA 26772A1
Authority
MA
Morocco
Prior art keywords
alkyl
lower alkyl
alkanoyl
aryl
halo
Prior art date
Application number
MA26298A
Other languages
English (en)
Inventor
Achytharao Sidduri
Jefferson Wright Tilley
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA26772A1 publication Critical patent/MA26772A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
MA26298A 1999-02-18 2001-08-17 Derives de phenylalaninol MA26772A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12049899P 1999-02-18 1999-02-18

Publications (1)

Publication Number Publication Date
MA26772A1 true MA26772A1 (fr) 2004-12-20

Family

ID=22390691

Family Applications (1)

Application Number Title Priority Date Filing Date
MA26298A MA26772A1 (fr) 1999-02-18 2001-08-17 Derives de phenylalaninol

Country Status (29)

Country Link
US (1) US6420600B1 (fr)
EP (1) EP1154987B1 (fr)
JP (1) JP2002537283A (fr)
KR (1) KR100636458B1 (fr)
CN (1) CN1213020C (fr)
AT (1) ATE264835T1 (fr)
AU (1) AU771938B2 (fr)
BR (1) BR0008368A (fr)
CA (1) CA2362833C (fr)
CZ (1) CZ20012984A3 (fr)
DE (1) DE60010049T2 (fr)
DK (1) DK1154987T3 (fr)
ES (1) ES2218116T3 (fr)
HK (1) HK1043589A1 (fr)
HR (1) HRP20010594B1 (fr)
HU (1) HUP0200343A3 (fr)
ID (1) ID30057A (fr)
IL (2) IL144641A0 (fr)
MA (1) MA26772A1 (fr)
MX (1) MXPA01008178A (fr)
NO (1) NO20013946L (fr)
PL (1) PL349463A1 (fr)
PT (1) PT1154987E (fr)
RU (1) RU2238265C2 (fr)
SI (1) SI1154987T1 (fr)
TR (1) TR200102395T2 (fr)
WO (1) WO2000048988A1 (fr)
YU (1) YU58601A (fr)
ZA (1) ZA200106075B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939855B2 (en) * 1997-07-31 2005-09-06 Elan Pharmaceuticals, Inc. Anti-inflammatory compositions and method
EP1741428A3 (fr) * 1999-08-13 2007-05-09 Biogen Idec MA, Inc. inhibiteurs d'adhésion cellulaire
US6388084B1 (en) 1999-12-06 2002-05-14 Hoffmann-La Roche Inc. 4-pyridinyl-n-acyl-l-phenylalanines
US6380387B1 (en) 1999-12-06 2002-04-30 Hoffmann-La Roche Inc. 4-Pyrimidinyl-n-acyl-l phenylalanines
CA2525934A1 (fr) 2003-05-20 2004-12-02 Genentech, Inc. Inhibiteurs de type thiocarbamates d'integrines alpha-4
WO2006081986A1 (fr) * 2005-02-07 2006-08-10 F.Hoffmann-La Roche Ag Combinaison de bambuterol et d'inhibiteur d'integrine
WO2006094640A2 (fr) * 2005-03-04 2006-09-14 F.Hoffmann-La Roche Ag Association de roflumilast et d'un inhibiteur de l'integrine, et procede de traitement
IL172896A0 (en) * 2005-12-29 2006-06-11 Yeda Res & Dev Cxcr4 inhibition
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE584914A (fr) 1958-11-24
US3527793A (en) 1967-08-18 1970-09-08 Bristol Myers Co Phenylglycine derivatives
IT1190378B (it) 1985-06-21 1988-02-16 Isf Spa Derivati pirrolidonici
US5039805A (en) 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
US5463116A (en) 1991-07-30 1995-10-31 Ajinomoto Co., Inc. Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them
CN1046725C (zh) 1994-06-20 1999-11-24 武田药品工业株式会社 稠合的咪唑化合物,它们的制备和应用
US6306840B1 (en) 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
US5804595A (en) 1995-12-05 1998-09-08 Regents Of The University Of Minnesota Kappa opioid receptor agonists
ATE212978T1 (de) * 1996-03-29 2002-02-15 Searle & Co Para-substituierte phenylpropansäure derivate als integrin-antagonisten
PT889877E (pt) 1996-03-29 2002-02-28 Searle & Co Derivados fenileno meta substituidos e sua utilizacao como antagonitas ou inibidores integrina alfa v beta3
ID19155A (id) * 1996-12-13 1998-06-18 Tanabe Seiyaku Co Turunan-turunan piridin, pembuatannya dan intermediet untuk pembuatannya
CA2291778A1 (fr) * 1997-05-29 1998-12-03 Merck & Co., Inc. Composes d'amide heterocycliques utilises en tant qu'inhibiteurs de l'adhesion cellulaire
CA2301377C (fr) * 1997-08-22 2009-10-06 F. Hoffmann-La Roche Ag Derives de n-alcanoylphenilalanine
BR9811988A (pt) * 1997-08-22 2000-09-05 Hoffmann La Roche Derivados de n-alcanoilfenilalanina
ATE273273T1 (de) 1998-02-26 2004-08-15 Celltech Therapeutics Ltd Phenylalaninderivate als inhibitoren von alpha4 integrinen
US6521626B1 (en) 1998-03-24 2003-02-18 Celltech R&D Limited Thiocarboxamide derivatives
GB9811159D0 (en) 1998-05-22 1998-07-22 Celltech Therapeutics Ltd Chemical compounds

Also Published As

Publication number Publication date
PT1154987E (pt) 2004-08-31
HK1043589A1 (en) 2002-09-20
SI1154987T1 (en) 2004-08-31
KR20010102260A (ko) 2001-11-15
HUP0200343A2 (en) 2002-06-29
US6420600B1 (en) 2002-07-16
DK1154987T3 (da) 2004-08-09
TR200102395T2 (tr) 2001-12-21
CA2362833A1 (fr) 2000-08-24
CZ20012984A3 (cs) 2002-02-13
ATE264835T1 (de) 2004-05-15
NO20013946D0 (no) 2001-08-14
MXPA01008178A (es) 2002-03-13
BR0008368A (pt) 2001-11-06
ES2218116T3 (es) 2004-11-16
CN1213020C (zh) 2005-08-03
HUP0200343A3 (en) 2005-04-28
ID30057A (id) 2001-11-01
KR100636458B1 (ko) 2006-10-18
RU2238265C2 (ru) 2004-10-20
DE60010049T2 (de) 2005-03-31
DE60010049D1 (de) 2004-05-27
EP1154987A1 (fr) 2001-11-21
AU2548600A (en) 2000-09-04
HRP20010594B1 (en) 2006-02-28
PL349463A1 (en) 2002-07-29
JP2002537283A (ja) 2002-11-05
IL144641A0 (en) 2002-05-23
CA2362833C (fr) 2009-04-07
EP1154987B1 (fr) 2004-04-21
HRP20010594A2 (en) 2002-08-31
YU58601A (sh) 2004-05-12
IL144641A (en) 2006-09-05
WO2000048988A1 (fr) 2000-08-24
NO20013946L (no) 2001-08-14
ZA200106075B (en) 2002-10-24
AU771938B2 (en) 2004-04-08
CN1340043A (zh) 2002-03-13

Similar Documents

Publication Publication Date Title
MA26772A1 (fr) Derives de phenylalaninol
US20020133015A1 (en) 4-pyridinyl-N-acyl-L-phenylalanines
MY144184A (en) Disposable wearing article
IL160139A0 (en) Spiro compounds
AU2349697A (en) Monoclonal antibodies against the interferon receptor with neutralizing activity against type I interferon
GB2285409B (en) Method of bonding an elastic material to a substrate and article manufactured by said method
NZ505089A (en) PPAR-gamma receptor activators, useful for the treatment of skin disorders
ATE309249T1 (de) Chemokin rezeptor antagonisten und verwndung
ATE204471T1 (de) Pyrimidin- oder triazincarbonsäurederivate zur verwendung als arzneimittel
ATE264298T1 (de) Alpha-aminoessigsäure derivate als alpha 4 beta 7-rezeptor antagonisten
PL321593A1 (en) Method of actiwating biological tissue gluing adhesives, bonding agents and haemorrhage arresting agents by use colour-changing chromophores
HU9303009D0 (en) New 2-saccharinyl-methyl-aryl-carboxylat derivatives and pharmaceutical preparations containing said compounds
ATE99531T1 (de) Windel mit dichtungsklappen.
DE602004011805D1 (de) Medizinische verwendung von zwitterion-verbindungen als modulatoren des cftr -kanals
NZ335318A (en) (o-acyl-p-N-acylamino-phenyl)-O-phosphoethanolamines with anti-inflammatory activity
HUP0302440A2 (hu) Amino-kinolin származékok, eljárás előállításukra és ezeket hatóanyagként tartalmazó gyógyszerkészítmények
HUP0401467A2 (en) Aminoquinoline derivatives, process for producing them and their use as adenosine a3 ligands
TR200202476U (tr) Sıvı geçirmeyen özelliği bulunan hasta ve hemşire kontrol panelli hasta karyolası