MA26703A1 - Macrolides antibiotiques nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

Macrolides antibiotiques nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
MA26703A1
MA26703A1 MA25832A MA25832A MA26703A1 MA 26703 A1 MA26703 A1 MA 26703A1 MA 25832 A MA25832 A MA 25832A MA 25832 A MA25832 A MA 25832A MA 26703 A1 MA26703 A1 MA 26703A1
Authority
MA
Morocco
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
novel antibiotic
macrolides
Prior art date
Application number
MA25832A
Other languages
English (en)
Inventor
Kaneko Takushi
Original Assignee
Pfizer Products Inc Etat De Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc Etat De Co filed Critical Pfizer Products Inc Etat De Co
Publication of MA26703A1 publication Critical patent/MA26703A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08Hetero rings containing eight or more ring members, e.g. erythromycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

DEPOSANT Société dite : PFIZER PRODUCTS INC REVENDICATION DE PRIORITES US 03/11/1998 60/106,836 Voir en annexe le titre de l'invention et le texte de l'abrégé Macrolides antibiotiques nouveaux, procédé pour leur préparation et compositions pharmaceutiqueS les contenant La présente invention concerne des composés répondant à la formule : dans laquelle a est égal à 0 ou 1, et R1, R2, R3, R4, R5, R6 et X représentent divers radicaux. Elle concerne également un procédé pour leur préparation et des compositions pharmaceutiques les contenant. Application : utilisation de ces composés et compositions pour le traitement d'infections par des bactéries et des protozoaires.
MA25832A 1998-11-03 1999-11-02 Macrolides antibiotiques nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant MA26703A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10683698P 1998-11-03 1998-11-03

Publications (1)

Publication Number Publication Date
MA26703A1 true MA26703A1 (fr) 2004-12-20

Family

ID=22313524

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25832A MA26703A1 (fr) 1998-11-03 1999-11-02 Macrolides antibiotiques nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant

Country Status (34)

Country Link
US (3) US20020040007A1 (fr)
EP (1) EP1124837A2 (fr)
JP (1) JP4043191B2 (fr)
KR (1) KR20010083944A (fr)
CN (1) CN1376160A (fr)
AP (1) AP2001002131A0 (fr)
AU (1) AU5995299A (fr)
BG (1) BG105543A (fr)
BR (1) BR9914998A (fr)
CA (1) CA2349338C (fr)
CO (1) CO5140110A1 (fr)
CZ (1) CZ20011512A3 (fr)
EA (1) EA200100396A1 (fr)
EE (1) EE200100245A (fr)
GT (1) GT199900192A (fr)
HK (1) HK1049010A1 (fr)
HR (1) HRP20010306A2 (fr)
HU (1) HUP0104192A3 (fr)
ID (1) ID28286A (fr)
IL (1) IL142628A0 (fr)
IS (1) IS5919A (fr)
MA (1) MA26703A1 (fr)
NO (1) NO20012155L (fr)
OA (1) OA11670A (fr)
PA (1) PA8485101A1 (fr)
PE (1) PE20001289A1 (fr)
PL (1) PL348114A1 (fr)
SK (1) SK5812001A3 (fr)
SV (1) SV1999000188A (fr)
TN (1) TNSN99205A1 (fr)
TR (4) TR200200436T2 (fr)
UY (1) UY25780A1 (fr)
WO (1) WO2000026224A2 (fr)
ZA (1) ZA200103289B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
IL142628A0 (en) 1998-11-03 2002-03-10 Pfizer Prod Inc Novel macrolide antibiotics
EA200100623A1 (ru) 1999-01-27 2002-02-28 Пфайзер Продактс Инк. Кетолидные антибиотики
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
CA2369816A1 (fr) 1999-04-16 2000-10-26 Kosan Biosciences, Inc. Agents anti-infectieux macrolides
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
IL145976A0 (en) 1999-04-16 2002-07-25 Ortho Mcneil Pharm Inc Ketolide antibacterials
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
BR0010938A (pt) 1999-05-24 2002-03-19 Pfizer Prod Inc Derivados da 13-metil eritromicina
EP1114826A3 (fr) * 1999-12-29 2001-10-31 Pfizer Products Inc. Macrolides antibactériennes et prokinétiques
EP1146051A3 (fr) * 2000-04-10 2001-10-31 Pfizer Products Inc. Dérivées de l' érythromycine A
ES2222966T3 (es) * 2000-06-30 2005-02-16 Pfizer Products Inc. Macrolidos antibioticos.
EP1794171A2 (fr) * 2004-07-28 2007-06-13 Ranbaxy Laboratories, Ltd. Derives de cetolides agents antibacteriens
WO2006046112A2 (fr) * 2004-10-25 2006-05-04 Ranbaxy Laboratories Limited Derives de cetolides utiles comme agents antibacteriens
DE602005019786D1 (de) 2004-12-21 2010-04-15 Pfizer Prod Inc Makrolide
EP1960413A2 (fr) * 2005-11-23 2008-08-27 Ranbaxy Laboratories Limited Derives macrolides en tant qu agents antibacteriens
US20090005325A1 (en) * 2005-11-23 2009-01-01 Biswajit Bas Ketolide Derivatives as Antibacterial Agents
US7801502B2 (en) * 2006-12-18 2010-09-21 Aai Corporation Method for implementing continuous radio frequency (RF) alignment in advanced electronic warfare (EW) signal stimulation systems
US8409628B2 (en) 2010-02-04 2013-04-02 Penguin IP Holdings, Inc. Methods and compositions for oxygenation of skin to treat skin disorders
US8900601B2 (en) 2010-03-31 2014-12-02 Jennifer Bartels Permeable mixtures, methods and compositions for the skin
EP2991638B1 (fr) * 2013-05-01 2019-06-26 Neoculi Pty Ltd Méthodes de traitement des infections bactériennes
RU2537143C1 (ru) * 2013-11-08 2014-12-27 Государственное научное учреждение Ставропольский научно-исследовательский институт животноводства и кормопроизводства РАСХН Препарат для лечения и профилактики мастита у коров
WO2018080072A2 (fr) * 2016-10-27 2018-05-03 한국생명공학연구원 Nouveau composé à base de macrolide, son procédé de production, et composition pharmaceutique destinée à prévenir ou à traiter le paludisme et le contenant à titre de principe actif

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
FR2697524B1 (fr) 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
US5332807A (en) 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
HRP931480B1 (en) 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
HRP950145A2 (en) 1995-03-27 1997-08-31 Sour Pliva New compounds of the secomacrolide and secoazalide class and a process for the preparation thereof
HN1996000101A (es) 1996-02-28 1997-06-26 Inc Pfizer Terapia combinada para la osteoporosis
WO1997042204A1 (fr) 1996-05-07 1997-11-13 Abbott Laboratories Erythromycines 6-o substituees et leur procede de preparation
IL127916A0 (en) 1996-07-05 1999-11-30 Biotica Technology Ltd And Pfi Erythromycins and process for their preparation
CN100441591C (zh) 1996-09-04 2008-12-10 艾博特公司 酮基内酯类化合物,其用途和制备方法以及药用组合物
UA51730C2 (uk) 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
HRP960497B1 (en) 1996-10-28 2003-08-31 Pliva Pharm & Chem Works 9-n-ethenyl derivatives of 9(s)-erythromycylamine
HN1998000074A (es) 1997-06-11 1999-01-08 Pfizer Prod Inc Derivados de macrolidos c-4 sustituidos
US6407074B1 (en) 1997-06-11 2002-06-18 Pfizer Inc C-4″-substituted macrolide derivatives
EP0895999A1 (fr) 1997-08-06 1999-02-10 Pfizer Products Inc. Macrolides antibiotiques substitués C"-4
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
DE69824201T2 (de) 1997-10-16 2005-09-22 Pliva - Istrazivacki Institut D.O.O. Neue 9a-azalide
EP0941998B1 (fr) 1998-03-03 2004-09-01 Pfizer Products Inc. Antibiotiques macrolides de type 3,6-cétal
IL142628A0 (en) 1998-11-03 2002-03-10 Pfizer Prod Inc Novel macrolide antibiotics
BR0010938A (pt) 1999-05-24 2002-03-19 Pfizer Prod Inc Derivados da 13-metil eritromicina
EP1114826A3 (fr) 1999-12-29 2001-10-31 Pfizer Products Inc. Macrolides antibactériennes et prokinétiques
EP1122261A3 (fr) 2000-01-31 2001-09-26 Pfizer Products Inc. Macrolides antibactériennes à 13 ou 14 chainons
ES2222966T3 (es) 2000-06-30 2005-02-16 Pfizer Products Inc. Macrolidos antibioticos.
EP1404693A2 (fr) 2001-07-03 2004-04-07 Chiron Corporation Macrolides et cetolides d'erythromycine modifiee c12 a activite antibacterienne

Also Published As

Publication number Publication date
CZ20011512A3 (cs) 2001-09-12
WO2000026224A3 (fr) 2000-11-16
BR9914998A (pt) 2001-07-10
PA8485101A1 (es) 2002-08-26
JP2002528553A (ja) 2002-09-03
US7071170B2 (en) 2006-07-04
HRP20010306A2 (en) 2002-06-30
NO20012155D0 (no) 2001-05-02
PL348114A1 (en) 2002-05-06
US20050004047A1 (en) 2005-01-06
US6835716B2 (en) 2004-12-28
PE20001289A1 (es) 2000-11-22
EE200100245A (et) 2002-10-15
CO5140110A1 (es) 2002-03-22
WO2000026224A2 (fr) 2000-05-11
SK5812001A3 (en) 2001-12-03
UY25780A1 (es) 2001-08-27
IS5919A (is) 2001-04-17
BG105543A (en) 2001-12-29
TR200200436T2 (tr) 2002-06-21
KR20010083944A (ko) 2001-09-03
JP4043191B2 (ja) 2008-02-06
SV1999000188A (es) 2000-10-16
AP2001002131A0 (en) 2001-06-30
US20030013665A1 (en) 2003-01-16
US20020040007A1 (en) 2002-04-04
CA2349338A1 (fr) 2000-05-11
HK1049010A1 (zh) 2003-04-25
TR200101241T2 (tr) 2001-09-21
IL142628A0 (en) 2002-03-10
TNSN99205A1 (fr) 2005-11-10
HUP0104192A3 (en) 2003-12-29
TR200200435T2 (tr) 2002-07-22
TR200200434T2 (tr) 2002-09-23
AU5995299A (en) 2000-05-22
HUP0104192A2 (hu) 2002-02-28
NO20012155L (no) 2001-07-02
ID28286A (id) 2001-05-10
EA200100396A1 (ru) 2001-10-22
EP1124837A2 (fr) 2001-08-22
GT199900192A (es) 2001-04-26
CN1376160A (zh) 2002-10-23
OA11670A (en) 2005-01-12
ZA200103289B (en) 2002-08-28
CA2349338C (fr) 2005-12-06

Similar Documents

Publication Publication Date Title
MA26703A1 (fr) Macrolides antibiotiques nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
MA24729A1 (fr) Macrolides nouveaux.
MA26689A1 (fr) Derives de tetrahydroquinoleine substitues nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26688A1 (fr) 4-carboxamino-2-substitue-1,2,3,4-tetrahydroquinoleines, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26733A1 (fr) Derives d'isothiazole nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
TNSN98194A1 (fr) Derives nouveaux de 6-o-methylerythromycine a, procede pour leur preparation et compositions pharmaceutiques les contenant
MA25035A1 (fr) Derives de 3-azabicyclo [3,1,0] hexane nouveaux, procede pour leur preparation et compositions les contenant
MA26717A1 (fr) Macrolides nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
TNSN05073A1 (fr) Quinazolinones spirocondensees nouvelles et leur utilisation comme inhibiteurs de phosphodiesterase
MA26723A1 (fr) Acides oxamiques nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
DZ1889A1 (fr) Dérivés de quinoléine nouveaux, procédé pour leur préparation et compositions pharmaceutiques les contenant.
TNSN99236A1 (fr) Derives bicycliques substitues nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant.
MA24936A1 (fr) Procede d'emulsification
MA26701A1 (fr) PYRAZOLOPYRIMIDINONES NOUVELLES INHIBITRICES DE PDE-5 GMPc, PROCEDE POUR LEUR PREPARATION ET COMPOSTIONS PHARMACEUTIQUES LES CONTENANT.
TNSN01121A1 (fr) Antibiotiques nouveaux faisant partie des macrolides, et compositions les contenant
MA27676A1 (fr) 2-amino-6-(2-substitue-4-phenoxy)-substitue-pyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26690A1 (fr) COMPOSITIONS PHARMACEUTIQUES CONTENANT DES DERIVES DE PYRIDO [1,2-a ] PYRAZINE ET PROCEDE POUR LEUR PREPARATION
CA2285037A1 (fr) Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
MX9803650A (es) Agentes antimicrobianos de benzoxazina.
TNSN99227A1 (fr) Macrolides nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
TNSN99214A1 (fr) Azalides nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant.
MA24685A1 (fr) Derives d'erythromycine tricycliques nouveaux, procede pour leur preparation et composition les contenant
FR2716883B1 (fr) Nouveaux dérivés tétrasubstitués de l'imidazole, leur préparation, nouveaux intermédiaires obtenus, leur application à titre de médicaments, compositions pharmaceutiques les renfermant.
MA26735A1 (fr) Formes cristallines nouvelles d'un antibiotique macrolide, procede pour leur preparation et compositions pharmaceutiques les contenant
HUP0004793A2 (hu) Eljárás alatrofloxacin-mezilát tisztítására és alkalmazására, a vegyületet tartalmazó parenterális készítmények