LV12443B - 7-(2-aminoetil)-benzotiazoloni - Google Patents

7-(2-aminoetil)-benzotiazoloni Download PDF

Info

Publication number
LV12443B
LV12443B LVP-99-152A LV990152A LV12443B LV 12443 B LV12443 B LV 12443B LV 990152 A LV990152 A LV 990152A LV 12443 B LV12443 B LV 12443B
Authority
LV
Latvia
Prior art keywords
formula
compound
benzothiazol
hydroxy
ethyl
Prior art date
Application number
LVP-99-152A
Other languages
English (en)
Other versions
LV12443A (en
Inventor
Roger Victor Bonnert
Roger Charles Brown
David Ranulf Cheshire
Francis Ince
Original Assignee
Astra Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharmaceuticals Limited filed Critical Astra Pharmaceuticals Limited
Publication of LV12443A publication Critical patent/LV12443A/xx
Publication of LV12443B publication Critical patent/LV12443B/lv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Cosmetics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Claims (7)

  1. LV 12443 IZGUDROJUMA FORMULA 1. Savienojumi ar formulu I
  2. 2.
  3. 3.
  4. 4.
  5. 5.
  6. 6.
  7. 7. (I) kur X un Y neatkarīgi attēlo -S(0)n- vai -O-, n attēlo 0,1 vai 2, p, q un r neatkarīgi attēlo 2 vai 3, Z attēlo fenilgrupu, kas neobligāti aizvietota ar halogēnu, hidroksilgrupu, metoksigrupu, nitrogrupu vai aminogrupu, vai attēlo piridilgrupu vai tienilgrupu, un to farmaceitiski sadehgi sāļi. Savienojums ar formulu I saskaņā ar 1. punktu, kur Z attēlo fenilgrupu. Savienojums ar formulu I saskaņā ar 1. punktu vai 2. punktu, kur r attēlo 2. Savienojums ar formulu I saskaņā ar jebkuru no iepriekšējiem punktiem, kur p+q attēlo 5. Savienojums ar formulu I saskaņā ar jebkuru no iepriekšējiem punktiem, kur Y attēlo O. Savienojums ar formulu I saskaņā ar jebkuru no iepriekšējiem punktiem, kur X attēlo -S- vai -S02-. Savienojums ar formulu I, kurš ir 2 4-hidroksi-7-[2-[3-[2-[2-feniletoksi]etilsulfonil]propilamino]etil]-1,3-benzoti- azol-2(3H)-ons, 4-hidroksi-7-[2-[2-[3-[2-feniletoksi]propoksi]etilamino]etil]-1,3-benzotiazol- 2(3H)-ons, 4-hidroksi-7-[2-[3-[2-[2-feniletoksi]etoksi]propilamino]etil]-1,3-benzotiazol- 2(3H)-ons, 4-hidroksi-7-[2-[2-[2-[2-feniletoksi]etoksi]etilamino]etil]-1,3-benzotiazol- 2(3H)-ons, 4-hidroksi-7-[2-[2-[3-[2-feniletoksi]propiltio]etilamino]etil]-1,3-benzotiazof-2(3H)-ons, 4-hidroksi-7-[2-[2-[3-[2-feniietoksi]propilsulfonil]etilamino]etil]-1,3-benzo- tiazol-2(3H)-ons, 4-hidroksi-7-[2-[3-[2-[2-feniletoksi]etiltio]propilamino]etil]-1,3-benzotiazol- 2(3H)-ons, 4-hidroksi-7-[2-[3-[2-[2-[2-aminofenil]etoksi]etilsulfonil]propilamino]etil]-1,3-benzotiazol-2(3H)-ons, 4-hidroksi-7-[2-[3-[2-[2-[4-nitrofenil]etoksi]etilsulfonil]propilamino]etil]-1,3- benzotiazol-2(3H)-ons, 7-[2-[2-[3-[2-[4-fluorfenil]etoksi]propilsulfonil]etilamino]etil]-4-hidroksi-1,3- benzotiazol-2(3H)-ons, 4-hidroksi-7-[2-[2-[3-[2-[2-tienil]etoksi]propiltio]etilamino]etil]-1,3-benzotia-zol-2(3H)-ons, vai 4-hidroksi-7-[2-[3-[2-[2-[2-piridil]etoksi]etiltio]propilamino]etil]-1,3-benzoti- azol-2(3H)-ons vai jebkura no tiem farmaceitiski saderīgs sēlis. Farmaceitiska kompozīcija, kas satur savienojumu ar formulu I saskaņā ar jebkuru no iepriekšējiem punktiem vai tā farmaceitiski saderīgu sāli apvienojumā ar farmaceitiski saderīgu atšķaidītāju vai nesēju. Metode savienojuma ar formulu I saskaņā ar jebkuru no 1. līdz 7. punktiem vai tā farmaceitiski saderīga sāļa iegūšanai, kas ietver a) savienojuma ar formulu II 3 LV 12443
    aikiiēšanu ar alkilēšanas aģentu ar formulu III L-(CH2)p-X-(CH2)q-Y-(CH2)r-Z (III), kurā p, q, r, X, Y un Z ir kā noteikts 1. punktā un L attēlo atmetamu grupu, b) savienojuma ar formulu II, kā noteikts iepriekš, aikiiēšanu ar savienojumu ar formulu IV 0=CH-(CH2)(p.1)-X-(CH2)q-Y-(CH2)r-Z (IV), kurā p, q, r, X, Y un Z ir kā noteikts 1. punkta, reducēšanas aģenta klātbūtnē, c) savienojuma ar formulu V CH2C(=0)-NH-(CH2)p-X-(CH2)q-Y-(CH2)r-Z
    S )=°
    N H OH (V) kur p, q, r, X, Y un Z ir kā noteikts 1. punktā, selektīvu reducēšanu, d) savienojuma ar formulu Va 4 4
    (Va) kur p, q, r, X, Y un Z ir kā noteikts 1. punkta, selektīvu reducēšanu, e) aizsarggrupas atšķelšanu attiecīgi aizsargātajam savienojumam ar formulu I, kurā ir aizsargātas viena vai vairākas funkcionālās grupas, un, kur vēlams vai nepieciešams, savienojuma ar formulu I pārvēršanu par tā farmaceitiski saderīgu sāli, vai otrādi. Savienojumi ar formulu Va
    (Va) kur p, q, r, X, Y un Z ir ka noteikts 1. punktā.
LVP-99-152A 1992-05-27 1999-10-28 7-(2-aminoetil)-benzotiazoloni LV12443B (lv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929211172A GB9211172D0 (en) 1992-05-27 1992-05-27 Compounds

Publications (2)

Publication Number Publication Date
LV12443A LV12443A (en) 2000-03-20
LV12443B true LV12443B (lv) 2000-06-20

Family

ID=10716059

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-99-152A LV12443B (lv) 1992-05-27 1999-10-28 7-(2-aminoetil)-benzotiazoloni

Country Status (31)

Country Link
EP (1) EP0649418B1 (lv)
JP (1) JP3094452B2 (lv)
KR (1) KR100279132B1 (lv)
CN (1) CN1036393C (lv)
AT (1) ATE172726T1 (lv)
AU (1) AU675649B2 (lv)
CA (1) CA2136553C (lv)
CZ (1) CZ286905B6 (lv)
DE (1) DE69321835T2 (lv)
DK (1) DK0649418T3 (lv)
DZ (1) DZ1694A1 (lv)
ES (1) ES2123652T3 (lv)
FI (1) FI945538A0 (lv)
GB (1) GB9211172D0 (lv)
HU (2) HUT71124A (lv)
IL (1) IL105801A (lv)
LV (1) LV12443B (lv)
MA (1) MA22895A1 (lv)
MX (1) MX9303145A (lv)
MY (1) MY131193A (lv)
NO (1) NO304739B1 (lv)
NZ (1) NZ253190A (lv)
PH (1) PH31453A (lv)
PL (2) PL172904B1 (lv)
RU (1) RU2114108C1 (lv)
SG (1) SG48068A1 (lv)
SK (1) SK281282B6 (lv)
TW (1) TW368501B (lv)
UA (1) UA27901C2 (lv)
WO (1) WO1993024473A1 (lv)
ZA (1) ZA933648B (lv)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW356468B (en) * 1995-09-15 1999-04-21 Astra Pharma Prod Benzothiazolone compounds useful as beta2-adrenoreceptor and dopamine DA2 receptor agonists process for preparing same and pharmaceutical compositions containing same
GB9526511D0 (en) * 1995-12-23 1996-02-28 Astra Pharma Prod Pharmaceutically active compounds
SE9900693D0 (sv) * 1999-02-26 1999-02-26 Astra Pharma Prod Novel process
SE9902938D0 (sv) * 1999-08-18 1999-08-18 Astra Pharma Prod Pharmaceutical compositions
SE9902936D0 (sv) * 1999-08-18 1999-08-18 Astra Pharma Prod Pharmaceutical compositions
SE9902937D0 (sv) * 1999-08-18 1999-08-18 Astra Pharma Prod Pharmaceutical compositions
SE9902935D0 (sv) * 1999-08-18 1999-08-18 Astra Pharma Prod Pharmaceutical compositions
DE10063957A1 (de) * 2000-12-20 2002-06-27 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Dopamin-Agonisten
PE20050130A1 (es) * 2002-08-09 2005-03-29 Novartis Ag Compuestos organicos
GB0218629D0 (en) * 2002-08-09 2002-09-18 Novartis Ag Organic compounds
JP4851937B2 (ja) 2003-11-21 2012-01-11 セラヴァンス， インコーポレーテッド β２アドレナリン作動性受容体作動薬活性およびムスカリン受容体拮抗薬活性を有する化合物
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
TW200738658A (en) 2005-08-09 2007-10-16 Astrazeneca Ab Novel compounds
TW200738659A (en) * 2005-08-29 2007-10-16 Astrazeneca Ab Novel compounds
TW200745067A (en) 2006-03-14 2007-12-16 Astrazeneca Ab Novel compounds
RU2455295C2 (ru) * 2006-12-20 2012-07-10 АстраЗенека AБ 4-ГИДРОКСИ-2-ОКСО-2,3-ДИГИДРО-1,3-БЕНЗОТИАЗОЛ-7-ИЛЬНЫЕ СОЕДИНЕНИЯ ДЛЯ МОДУЛЯЦИИ β2-АДРЕНОРЕЦЕПТОРНОЙ АКТИВНОСТИ
TW200833670A (en) 2006-12-20 2008-08-16 Astrazeneca Ab Novel compounds 569
GB0702458D0 (en) 2007-02-08 2007-03-21 Astrazeneca Ab Salts 668
GB0704000D0 (en) * 2007-03-01 2007-04-11 Astrazeneca Ab Salts 670
CN102124003A (zh) 2008-06-18 2011-07-13 阿斯利康(瑞典)有限公司 作为治疗呼吸系统疾病的β2肾上腺素受体拮抗剂的苯并噁嗪酮衍生物
CN102977050B (zh) * 2012-11-20 2015-04-22 浙江工业大学 一种2-苯并噻唑二甲缩醛和2-苯并噻唑甲醛的合成方法
CN106748930B (zh) * 2016-12-05 2019-03-15 三门峡奥科化工有限公司 3-巯基-1-丙醇的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554284A (en) * 1984-09-12 1985-11-19 Smithkline Beckman Corporation 7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones
IE914003A1 (en) * 1990-11-20 1992-05-20 Astra Pharma Prod Biologically Active Amines

Also Published As

Publication number Publication date
DE69321835D1 (de) 1998-12-03
FI945538A (fi) 1994-11-25
DK0649418T3 (da) 1999-07-12
WO1993024473A1 (en) 1993-12-09
MA22895A1 (fr) 1993-12-31
RU94046093A (ru) 1996-09-27
CZ291694A3 (en) 1995-03-15
HU211947A9 (en) 1996-01-29
NZ253190A (en) 1995-12-21
GB9211172D0 (en) 1992-07-08
IL105801A (en) 1997-01-10
ZA933648B (en) 1993-11-25
PL172904B1 (pl) 1997-12-31
FI945538A0 (fi) 1994-11-25
DE69321835T2 (de) 1999-05-12
JP3094452B2 (ja) 2000-10-03
JPH08503923A (ja) 1996-04-30
UA27901C2 (uk) 2000-10-16
ATE172726T1 (de) 1998-11-15
SG48068A1 (en) 1998-04-17
SK143394A3 (en) 1995-06-07
AU675649B2 (en) 1997-02-13
PH31453A (en) 1998-11-03
LV12443A (en) 2000-03-20
IL105801A0 (en) 1993-09-22
NO304739B1 (no) 1999-02-08
HU9403387D0 (en) 1995-02-28
PL172807B1 (pl) 1997-11-28
TW368501B (en) 1999-09-01
ES2123652T3 (es) 1999-01-16
RU2114108C1 (ru) 1998-06-27
EP0649418A1 (en) 1995-04-26
CA2136553C (en) 2000-08-15
MX9303145A (es) 1994-06-30
CZ286905B6 (en) 2000-08-16
NO944509L (no) 1994-11-24
EP0649418B1 (en) 1998-10-28
KR100279132B1 (ko) 2001-01-15
MY131193A (en) 2007-07-31
DZ1694A1 (fr) 2002-02-17
CA2136553A1 (en) 1993-12-09
CN1036393C (zh) 1997-11-12
HUT71124A (en) 1995-11-28
NO944509D0 (no) 1994-11-24
CN1085899A (zh) 1994-04-27
SK281282B6 (sk) 2001-02-12
AU4334393A (en) 1993-12-30

Similar Documents

Publication Publication Date Title
LV12443B (lv) 7-(2-aminoetil)-benzotiazoloni
US5648370A (en) 7-(2-aminoethyl) benzothiazolones
EP0558677B1 (en) Biologically active amines
WO1993023385A1 (en) Biologically active amines
CA2018307A1 (en) Halogen substituted diphenylsulfides
JPH0383979A (ja) 新規ベンゾピランおよびベンゾチオピラン誘導体
US5747513A (en) Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene active on the cardiovascular system
KR19990076688A (ko) 생물학적으로 활성인 벤조티아졸론 에탄아민
NL8701372A (nl) Indoolderivaten, werkwijze ter bereiding daarvan alsmede farmaceutische preparaten die deze derivaten als actieve component bevatten.
US5523475A (en) New compounds
US4988701A (en) Cyclic amino-thioacetal amides, a process for the preparation thereof and pharmaceutical compositions
US7683075B2 (en) Isoquinoline-3-carboxylic acid amides and pharmaceutical uses thereof
JP2772650B2 (ja) 新規化合物およびその医薬的用途
JPH06510058A (ja) 新規な化合物
EP1829870A1 (en) 2-(pyrazol-1-yl)pyridine derivative
CZ299029B6 (cs) Smesi piperidinylaminomethyltrifluormethyl-cyklických etherových sloucenin, zpusoby a meziprodukty pro jejich výrobu
CZ352996A3 (en) Quinoline derivatives, process of their preparation and pharmaceutical compositions based thereon
PL162009B1 (pl) Sposób wytwarzania nowych pochodnych etanoloaminy