LU91433I2 - "Tenofovir disoproxil et les sels, en particulier le fumarate, hydrates, tautomers et solvates en combination avec l'emtricitabine et l'efavirenz (ATRIPLA) - Google Patents
"Tenofovir disoproxil et les sels, en particulier le fumarate, hydrates, tautomers et solvates en combination avec l'emtricitabine et l'efavirenz (ATRIPLA)Info
- Publication number
- LU91433I2 LU91433I2 LU91433C LU91433C LU91433I2 LU 91433 I2 LU91433 I2 LU 91433I2 LU 91433 C LU91433 C LU 91433C LU 91433 C LU91433 C LU 91433C LU 91433 I2 LU91433 I2 LU 91433I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- tautomers
- solvates
- atripla
- emtricitabine
- efavirenz
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- 239000012453 solvate Substances 0.000 title abstract 2
- XPOQHMRABVBWPR-UHFFFAOYSA-N Efavirenz Natural products O1C(=O)NC2=CC=C(Cl)C=C2C1(C(F)(F)F)C#CC1CC1 XPOQHMRABVBWPR-UHFFFAOYSA-N 0.000 title 1
- XQSPYNMVSIKCOC-NTSWFWBYSA-N Emtricitabine Chemical compound C1=C(F)C(N)=NC(=O)N1[C@H]1O[C@@H](CO)SC1 XQSPYNMVSIKCOC-NTSWFWBYSA-N 0.000 title 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 title 1
- 229940068561 atripla Drugs 0.000 title 1
- XPOQHMRABVBWPR-ZDUSSCGKSA-N efavirenz Chemical compound C([C@]1(C2=CC(Cl)=CC=C2NC(=O)O1)C(F)(F)F)#CC1CC1 XPOQHMRABVBWPR-ZDUSSCGKSA-N 0.000 title 1
- 229960003804 efavirenz Drugs 0.000 title 1
- 229960000366 emtricitabine Drugs 0.000 title 1
- 150000004677 hydrates Chemical class 0.000 title 1
- SGOIRFVFHAKUTI-ZCFIWIBFSA-N tenofovir (anhydrous) Chemical compound N1=CN=C2N(C[C@@H](C)OCP(O)(O)=O)C=NC2=C1N SGOIRFVFHAKUTI-ZCFIWIBFSA-N 0.000 title 1
- 229960001355 tenofovir disoproxil Drugs 0.000 title 1
- JFVZFKDSXNQEJW-CQSZACIVSA-N tenofovir disoproxil Chemical compound N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N JFVZFKDSXNQEJW-CQSZACIVSA-N 0.000 title 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Oscillators With Electromechanical Resonators (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68683896A | 1996-07-26 | 1996-07-26 | |
| PCT/US1997/013244 WO1998004569A1 (fr) | 1996-07-26 | 1997-07-25 | Analogues de nucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU91433I2 true LU91433I2 (fr) | 2008-06-30 |
Family
ID=24757965
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU91178C LU91178I2 (fr) | 1996-07-26 | 2005-06-22 | Emtricitabine / Tenofovir Disoproxil et ses dérivés pharmaceutiquement acceptables (TRUVADA). |
| LU91433C LU91433I2 (fr) | 1996-07-26 | 2008-04-30 | "Tenofovir disoproxil et les sels, en particulier le fumarate, hydrates, tautomers et solvates en combination avec l'emtricitabine et l'efavirenz (ATRIPLA) |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU91178C LU91178I2 (fr) | 1996-07-26 | 2005-06-22 | Emtricitabine / Tenofovir Disoproxil et ses dérivés pharmaceutiquement acceptables (TRUVADA). |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0915894B1 (fr) |
| KR (1) | KR100619298B1 (fr) |
| CN (2) | CN100384859C (fr) |
| AT (1) | ATE240339T1 (fr) |
| AU (1) | AU713374B2 (fr) |
| DE (3) | DE69722004T2 (fr) |
| DK (1) | DK0915894T3 (fr) |
| ES (1) | ES2198003T3 (fr) |
| FR (1) | FR05C0032I2 (fr) |
| HK (1) | HK1020964A1 (fr) |
| LU (2) | LU91178I2 (fr) |
| NL (2) | NL300202I1 (fr) |
| NZ (1) | NZ333687A (fr) |
| PT (1) | PT915894E (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100396689C (zh) * | 2006-03-07 | 2008-06-25 | 中国医学科学院医药生物技术研究所 | 一组具有抑制hiv-1/hbv病毒复制活性的替诺福韦单酯化合物 |
| CN102453055B (zh) * | 2010-10-29 | 2015-04-01 | 上海迪赛诺医药发展有限公司 | 制备(r)-9-(2-膦酰甲氧基丙基)腺嘌呤双(异丙氧羰基氧甲基)酯的方法 |
| CN102887901B (zh) * | 2011-07-01 | 2015-01-07 | 四川好医生攀西药业有限责任公司 | 无环核苷酸类似物及其制备方法和应用 |
| ES2608871T5 (es) | 2011-08-16 | 2024-04-04 | Gilead Sciences Inc | Alafenamide hemifumarate de tenofovir |
| CN103232490B (zh) * | 2013-01-31 | 2015-06-10 | 洛阳聚慧投资股份有限公司 | 具有抑制hiv-1/hbv病毒复制活性的核苷类化合物、制备方法及抗病毒方面的应用 |
| CN103242366B (zh) * | 2012-08-13 | 2014-08-20 | 洛阳聚慧投资股份有限公司 | 一组替诺福韦酯化合物、制备方法及其在抗病毒方面的应用 |
| CN104230934B (zh) * | 2013-06-08 | 2016-12-28 | 上海医药工业研究院 | 一种化合物及其制备方法和用途 |
| EP2860184B1 (fr) | 2013-10-09 | 2018-08-29 | Zentiva, k.s. | Sel dihydrogénophosphate du Ténofovir disoproxil |
| CN104844459B (zh) * | 2014-02-18 | 2016-08-24 | 扬州三友合成化工有限公司 | 一种氯甲基异丙基碳酸酯的制备方法 |
| CN103880884A (zh) * | 2014-03-21 | 2014-06-25 | 浙江苏泊尔制药有限公司 | 一种高纯度富马酸泰诺福韦酯的制备方法 |
| CN104098605B (zh) * | 2014-07-30 | 2015-09-30 | 福建广生堂药业股份有限公司 | 一种适合于工业化生产的替诺福韦制备方法 |
| KR101703257B1 (ko) | 2014-09-30 | 2017-02-06 | 한미정밀화학주식회사 | 고순도의 (r)-9-[2-(포스포노메톡시)프로필]아데닌의 제조방법 |
| KR101703258B1 (ko) | 2014-12-30 | 2017-02-06 | 한미정밀화학주식회사 | 고순도의 (r)-9-[2-(포스포노메톡시)프로필]아데닌의 제조방법 |
| CN105985381B (zh) * | 2014-12-30 | 2018-10-30 | 安徽贝克联合制药有限公司 | 一种替诺福韦的制备方法 |
| KR101761466B1 (ko) * | 2015-01-20 | 2017-07-26 | 씨제이헬스케어 주식회사 | 신규한 테노포비어 디소프록실 캠실레이트, 이의 결정형 및 이의 제조방법 |
| CN106349289A (zh) * | 2016-08-03 | 2017-01-25 | 上海延安药业有限公司 | 替诺福韦酯原料药及片剂 |
| KR101909570B1 (ko) * | 2016-12-05 | 2018-10-19 | (주) 성운파마코피아 | 고순도 테노포비어 디소프록실 제조방법 |
| CN108358968B (zh) * | 2018-04-03 | 2020-09-15 | 科兴生物制药股份有限公司 | 一种替诺福韦的制备方法 |
| KR20220141457A (ko) | 2021-04-13 | 2022-10-20 | 경동제약 주식회사 | 신규 결정형의 테노포비어 알라펜아미드 말레산염 및 이를 포함하는 약제학적 조성물 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2111043B (en) * | 1980-12-12 | 1985-02-06 | Ciba Geigy Ag | Novel cephalosporin esters |
| CS263951B1 (en) * | 1985-04-25 | 1989-05-12 | Antonin Holy | 9-(phosponylmethoxyalkyl)adenines and method of their preparation |
| EP0481214B1 (fr) * | 1990-09-14 | 1998-06-24 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Pro-médicaments dérivés de phosphonates |
| CA2054126A1 (fr) * | 1990-10-26 | 1992-04-27 | Michiyuki Sendai | Production et utilisation de composes de type cephem |
| US6057305A (en) * | 1992-08-05 | 2000-05-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Antiretroviral enantiomeric nucleotide analogs |
| WO1995032957A1 (fr) * | 1994-05-27 | 1995-12-07 | Astra Aktiebolag | Nouveaux derives ethoxycarbonyloxymethyles de benzinidazoles substituees |
-
1997
- 1997-07-25 ES ES97936257T patent/ES2198003T3/es not_active Expired - Lifetime
- 1997-07-25 KR KR1019997000806A patent/KR100619298B1/ko not_active IP Right Cessation
- 1997-07-25 CN CNB971974608A patent/CN100384859C/zh not_active Expired - Lifetime
- 1997-07-25 DE DE69722004T patent/DE69722004T2/de not_active Expired - Lifetime
- 1997-07-25 AT AT97936257T patent/ATE240339T1/de active
- 1997-07-25 PT PT97936257T patent/PT915894E/pt unknown
- 1997-07-25 DE DE200512000041 patent/DE122005000041I2/de active Active
- 1997-07-25 DE DE122008000033C patent/DE122008000033I1/de active Pending
- 1997-07-25 AU AU38970/97A patent/AU713374B2/en not_active Expired
- 1997-07-25 DK DK97936257T patent/DK0915894T3/da active
- 1997-07-25 CN CN2008100832337A patent/CN101239989B/zh not_active Expired - Lifetime
- 1997-07-25 EP EP97936257A patent/EP0915894B1/fr not_active Expired - Lifetime
- 1997-07-25 NZ NZ333687A patent/NZ333687A/xx not_active IP Right Cessation
-
1999
- 1999-11-19 HK HK99105370A patent/HK1020964A1/xx not_active IP Right Cessation
-
2005
- 2005-06-22 LU LU91178C patent/LU91178I2/fr unknown
- 2005-07-13 NL NL300202C patent/NL300202I1/nl unknown
- 2005-07-19 FR FR05C0032C patent/FR05C0032I2/fr active Active
-
2008
- 2008-04-30 LU LU91433C patent/LU91433I2/fr unknown
- 2008-05-13 NL NL300344C patent/NL300344I1/nl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE240339T1 (de) | 2003-05-15 |
| EP0915894A1 (fr) | 1999-05-19 |
| CN101239989B (zh) | 2012-12-12 |
| DE122008000033I1 (de) | 2008-10-02 |
| ES2198003T3 (es) | 2004-01-16 |
| NZ333687A (en) | 2000-08-25 |
| CN100384859C (zh) | 2008-04-30 |
| AU3897097A (en) | 1998-02-20 |
| CN101239989A (zh) | 2008-08-13 |
| CN1244200A (zh) | 2000-02-09 |
| PT915894E (pt) | 2003-10-31 |
| EP0915894B1 (fr) | 2003-05-14 |
| DE69722004T2 (de) | 2004-04-01 |
| DE122005000041I1 (de) | 2005-10-20 |
| HK1020964A1 (en) | 2000-05-26 |
| NL300202I1 (nl) | 2005-09-01 |
| LU91178I9 (fr) | 2018-12-28 |
| LU91178I2 (fr) | 2005-08-22 |
| AU713374B2 (en) | 1999-12-02 |
| FR05C0032I1 (fr) | 2005-08-26 |
| FR05C0032I2 (fr) | 2006-12-29 |
| KR100619298B1 (ko) | 2006-09-08 |
| DK0915894T3 (da) | 2003-09-15 |
| DE122005000041I2 (de) | 2012-05-24 |
| DE69722004D1 (de) | 2003-06-18 |
| KR20000029705A (ko) | 2000-05-25 |
| NL300344I1 (nl) | 2008-07-01 |
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