ATE259815T1 - Neue antagonistische verbindungen - Google Patents

Neue antagonistische verbindungen

Info

Publication number
ATE259815T1
ATE259815T1 AT95920328T AT95920328T ATE259815T1 AT E259815 T1 ATE259815 T1 AT E259815T1 AT 95920328 T AT95920328 T AT 95920328T AT 95920328 T AT95920328 T AT 95920328T AT E259815 T1 ATE259815 T1 AT E259815T1
Authority
AT
Austria
Prior art keywords
pct
antagonistic compounds
sec
date
new antagonistic
Prior art date
Application number
AT95920328T
Other languages
English (en)
Inventor
Helmut Schmidhammer
Original Assignee
Schmidhammer Helmut Prof Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schmidhammer Helmut Prof Dr filed Critical Schmidhammer Helmut Prof Dr
Application granted granted Critical
Publication of ATE259815T1 publication Critical patent/ATE259815T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT95920328T 1994-05-18 1995-05-09 Neue antagonistische verbindungen ATE259815T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9401728A SE9401728D0 (sv) 1994-05-18 1994-05-18 New compounds II
PCT/SE1995/000503 WO1995031463A1 (en) 1994-05-18 1995-05-09 New antagonist compounds

Publications (1)

Publication Number Publication Date
ATE259815T1 true ATE259815T1 (de) 2004-03-15

Family

ID=20394059

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95920328T ATE259815T1 (de) 1994-05-18 1995-05-09 Neue antagonistische verbindungen

Country Status (11)

Country Link
US (1) US6136817A (de)
EP (1) EP0759922B1 (de)
JP (1) JP4117801B2 (de)
AT (1) ATE259815T1 (de)
AU (1) AU690996B2 (de)
DE (1) DE69532580T2 (de)
ES (1) ES2214501T3 (de)
IL (1) IL113631A0 (de)
SE (1) SE9401728D0 (de)
WO (1) WO1995031463A1 (de)
ZA (1) ZA953701B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1093862C (zh) * 1995-09-26 2002-11-06 东丽株式会社 吲哚衍生物及其制备方法和用途
US5994327A (en) * 1995-11-17 1999-11-30 Astra Ab Process for the preparation of morphinans
JP2001504829A (ja) * 1996-11-19 2001-04-10 アストラ・アクチエボラーグ モルフィナン類の新規な製造方法
NZ331769A (en) * 1997-01-16 2000-05-26 Toray Industries Indolomorphinan derivative and agent for curing and preventing cerebral disorder
DE19939044A1 (de) * 1999-08-18 2001-03-15 Gruenenthal Gmbh Verwendung von Morphinanderivaten als Arzneimittel
US8410129B2 (en) * 2002-02-15 2013-04-02 Howard Brooks-Korn Treatment for paresis/paralysis
DE10229842A1 (de) * 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
US7285665B2 (en) 2002-11-08 2007-10-23 Mallinckrodt Inc. Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
EP1595541A1 (de) * 2004-05-12 2005-11-16 Alcasynn Pharmaceuticals Gmbh Verwendung von Opioid-Rezeptor Antagonisten zur Vorbeugung und/oder Behandlung von Krankheiten die im zusammenhang mit den Angrifftspunkt Calcineurin stehen
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
US20080227803A1 (en) * 2004-12-14 2008-09-18 Shioonogi & Co., Ltd., A Legal Entity Of Japan Indolomorphinan Derivative Having Carboxy in 6'-Position
EP2012686B1 (de) * 2006-04-18 2013-10-02 Joseph Nicholas Logan Spinales stangensystem
JP2010504325A (ja) * 2006-09-20 2010-02-12 マリンクロット インコーポレイテッド 置換モルフィナン−６−オン、並びにその塩および中間体の調製
PL2137189T3 (pl) * 2007-03-06 2015-12-31 SpecGx LLC Sposób wytwarzania czwartorzędowych N-alkilowych soli alkaloidu morfinanowego
US9040726B2 (en) 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
WO2009051824A2 (en) * 2007-10-18 2009-04-23 Aiko Biotechnology Combination analgesic employing opioid and neutral antagonist
US8748448B2 (en) 2007-10-18 2014-06-10 Aiko Biotechnology Combination analgesic employing opioid agonist and neutral antagonist
AU2008338906B2 (en) 2007-12-17 2013-06-27 SpecGx LLC Processes for the production of (+)-'nal' morphinan compounds
WO2009132313A2 (en) * 2008-04-25 2009-10-29 Progenics Pharmaceuticals, Inc. Morphinan derivatives of organic and inorganic acids
ES2641887T3 (es) * 2008-05-27 2017-11-14 Mallinckrodt Llc Procesos y compuestos para la preparación de normorfinanos
WO2010028004A2 (en) 2008-09-03 2010-03-11 Mallinckrodt Inc. Substituted berbines and processes for their synthesis
EP2340832A1 (de) 2009-12-23 2011-07-06 Universität Innsbruck Morphinan-6-one-Verbindungen zur Behandlung oder Prävention von neurodegenerativen Erkrankungen
US9624223B2 (en) 2013-03-08 2017-04-18 The Kitasato Institute Morphinan derivative
US9969746B2 (en) 2013-12-05 2018-05-15 The University Of Bath Opioid compounds and their uses
WO2020012245A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Thienothiophene-naltrexone prodrugs for long-acting injectable compositions
WO2020012248A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Novel naphthylenyl compounds for long-acting injectable compositions and related methods
WO2020094634A1 (en) 2018-11-05 2020-05-14 Alkermes Pharma Ireland Limited Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816586A (en) * 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists
JP2906654B2 (ja) * 1989-11-28 1999-06-21 東レ株式会社 免疫抑制剤及びその製造方法
JPH04342529A (ja) * 1991-05-21 1992-11-30 Toray Ind Inc 抗アレルギー剤
US5223507A (en) * 1992-01-21 1993-06-29 G. D. Searle & Co. Method of using opioid compounds as delta opioid selective agonist analgesics
US5225417A (en) * 1992-01-21 1993-07-06 G. D. Searle & Co. Opioid agonist compounds
WO1994007896A1 (fr) * 1992-09-29 1994-04-14 Toray Industries, Inc. Derive indole, procede pour sa fabrication, et son usage medicinal

Also Published As

Publication number Publication date
ES2214501T3 (es) 2004-09-16
DE69532580D1 (de) 2004-03-25
JP4117801B2 (ja) 2008-07-16
ZA953701B (en) 1995-11-20
AU690996B2 (en) 1998-05-07
SE9401728D0 (sv) 1994-05-18
IL113631A0 (en) 1995-08-31
EP0759922B1 (de) 2004-02-18
US6136817A (en) 2000-10-24
AU2581795A (en) 1995-12-05
WO1995031463A1 (en) 1995-11-23
JPH10500131A (ja) 1998-01-06
EP0759922A1 (de) 1997-03-05
DE69532580T2 (de) 2004-07-29

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