DE69532580D1 - Neue antagonistische verbindungen - Google Patents

Neue antagonistische verbindungen

Info

Publication number
DE69532580D1
DE69532580D1 DE69532580T DE69532580T DE69532580D1 DE 69532580 D1 DE69532580 D1 DE 69532580D1 DE 69532580 T DE69532580 T DE 69532580T DE 69532580 T DE69532580 T DE 69532580T DE 69532580 D1 DE69532580 D1 DE 69532580D1
Authority
DE
Germany
Prior art keywords
pct
connections
sec
date
new antagonistic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69532580T
Other languages
English (en)
Other versions
DE69532580T2 (de
Inventor
Helmut Schmidhammer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcasynn Pharmaceuticals GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of DE69532580D1 publication Critical patent/DE69532580D1/de
Application granted granted Critical
Publication of DE69532580T2 publication Critical patent/DE69532580T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69532580T 1994-05-18 1995-05-09 Neue antagonistische verbindungen Expired - Lifetime DE69532580T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9401728A SE9401728D0 (sv) 1994-05-18 1994-05-18 New compounds II
SE9401728 1994-05-18
PCT/SE1995/000503 WO1995031463A1 (en) 1994-05-18 1995-05-09 New antagonist compounds

Publications (2)

Publication Number Publication Date
DE69532580D1 true DE69532580D1 (de) 2004-03-25
DE69532580T2 DE69532580T2 (de) 2004-07-29

Family

ID=20394059

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69532580T Expired - Lifetime DE69532580T2 (de) 1994-05-18 1995-05-09 Neue antagonistische verbindungen

Country Status (11)

Country Link
US (1) US6136817A (de)
EP (1) EP0759922B1 (de)
JP (1) JP4117801B2 (de)
AT (1) ATE259815T1 (de)
AU (1) AU690996B2 (de)
DE (1) DE69532580T2 (de)
ES (1) ES2214501T3 (de)
IL (1) IL113631A0 (de)
SE (1) SE9401728D0 (de)
WO (1) WO1995031463A1 (de)
ZA (1) ZA953701B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1093862C (zh) * 1995-09-26 2002-11-06 东丽株式会社 吲哚衍生物及其制备方法和用途
US5994327A (en) * 1995-11-17 1999-11-30 Astra Ab Process for the preparation of morphinans
EP0946564A1 (de) * 1996-11-19 1999-10-06 Astra Aktiebolag Neues verfahren zur herstellung von morphinanen
WO1998031684A1 (fr) * 1997-01-16 1998-07-23 Toray Industries, Inc. Derives d'indolomorphinane et medicaments/remedes preventifs contre les troubles cerebraux
DE19939044A1 (de) * 1999-08-18 2001-03-15 Gruenenthal Gmbh Verwendung von Morphinanderivaten als Arzneimittel
AU2003217436A1 (en) * 2002-02-15 2003-09-09 Howard Brooks-Korn Use of opioid compound to treat a neurologic or neurogenic disorder
DE10229842A1 (de) * 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
US7285665B2 (en) 2002-11-08 2007-10-23 Mallinckrodt Inc. Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
EP1595541A1 (de) * 2004-05-12 2005-11-16 Alcasynn Pharmaceuticals Gmbh Verwendung von Opioid-Rezeptor Antagonisten zur Vorbeugung und/oder Behandlung von Krankheiten die im zusammenhang mit den Angrifftspunkt Calcineurin stehen
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
JPWO2006064779A1 (ja) * 2004-12-14 2008-06-12 塩野義製薬株式会社 ６’位にカルボキシを有するインドロモルヒナン誘導体
WO2007123920A2 (en) * 2006-04-18 2007-11-01 Joseph Nicholas Logan Spinal rod system
CA2663909A1 (en) * 2006-09-20 2008-03-27 Mallinckrodt Inc. Preparation of substituted morphinan-6-ones and salts and intermediates thereof
US9040726B2 (en) * 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
CA2707757C (en) * 2007-03-06 2017-01-03 Peter X. Wang Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
US8748448B2 (en) 2007-10-18 2014-06-10 Aiko Biotechnology Combination analgesic employing opioid agonist and neutral antagonist
JP2011500686A (ja) * 2007-10-18 2011-01-06 アイコ バイオテクノロジー オピオイドと中性アンタゴニストを用いる組合せ鎮痛剤
CA2709886C (en) 2007-12-17 2016-10-25 Mallinckrodt Inc. Processes for the production of (+)-"nal" morphinan compounds
WO2009132313A2 (en) * 2008-04-25 2009-10-29 Progenics Pharmaceuticals, Inc. Morphinan derivatives of organic and inorganic acids
WO2009146288A1 (en) * 2008-05-27 2009-12-03 Mallinckrodt Inc. Processes and compounds for the preparation of normorphinans
US9458109B2 (en) * 2008-09-03 2016-10-04 Mallinckrodt Llc Substituted berbines and processes for their synthesis
EP2340832A1 (de) 2009-12-23 2011-07-06 Universität Innsbruck Morphinan-6-one-Verbindungen zur Behandlung oder Prävention von neurodegenerativen Erkrankungen
JP6173431B2 (ja) * 2013-03-08 2017-08-02 学校法人北里研究所 モルヒナン誘導体
US9969746B2 (en) 2013-12-05 2018-05-15 The University Of Bath Opioid compounds and their uses
US10807995B2 (en) 2018-07-13 2020-10-20 Alkermes Pharma Ireland Limited Thienothiophene compounds for long-acting injectable compositions and related methods
WO2020012248A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Novel naphthylenyl compounds for long-acting injectable compositions and related methods
WO2020094634A1 (en) 2018-11-05 2020-05-14 Alkermes Pharma Ireland Limited Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816586A (en) * 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists
JP2906654B2 (ja) * 1989-11-28 1999-06-21 東レ株式会社 免疫抑制剤及びその製造方法
JPH04342529A (ja) * 1991-05-21 1992-11-30 Toray Ind Inc 抗アレルギー剤
US5225417A (en) * 1992-01-21 1993-07-06 G. D. Searle & Co. Opioid agonist compounds
US5223507A (en) * 1992-01-21 1993-06-29 G. D. Searle & Co. Method of using opioid compounds as delta opioid selective agonist analgesics
JP3605825B2 (ja) * 1992-09-29 2004-12-22 東レ株式会社 インドール誘導体，その製造方法およびその医薬用途

Also Published As

Publication number Publication date
WO1995031463A1 (en) 1995-11-23
JPH10500131A (ja) 1998-01-06
EP0759922A1 (de) 1997-03-05
EP0759922B1 (de) 2004-02-18
SE9401728D0 (sv) 1994-05-18
AU690996B2 (en) 1998-05-07
ATE259815T1 (de) 2004-03-15
ZA953701B (en) 1995-11-20
JP4117801B2 (ja) 2008-07-16
AU2581795A (en) 1995-12-05
IL113631A0 (en) 1995-08-31
DE69532580T2 (de) 2004-07-29
US6136817A (en) 2000-10-24
ES2214501T3 (es) 2004-09-16

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: ALCASYNN PHARMACEUTICALS GMBH, INNSBRUCK, AT

8364 No opposition during term of opposition