LU88049A1 - Bis(acyloxy-o)borate de l'(acide-o3,o4-6,7-substitue-8-alcoxy-l-cyclopropyl-1,4-dihydro-4-oxo-3-quinoleinecarboxylique et le sel de ce dernier,ainsi que leur procede de preparation - Google Patents
Bis(acyloxy-o)borate de l'(acide-o3,o4-6,7-substitue-8-alcoxy-l-cyclopropyl-1,4-dihydro-4-oxo-3-quinoleinecarboxylique et le sel de ce dernier,ainsi que leur procede de preparation Download PDFInfo
- Publication number
- LU88049A1 LU88049A1 LU88049A LU88049A LU88049A1 LU 88049 A1 LU88049 A1 LU 88049A1 LU 88049 A LU88049 A LU 88049A LU 88049 A LU88049 A LU 88049A LU 88049 A1 LU88049 A1 LU 88049A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- group
- denotes
- lower alkyl
- halogen atom
- alkyl group
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 11
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 title claims description 10
- 150000003839 salts Chemical class 0.000 title claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 36
- 125000005843 halogen group Chemical group 0.000 claims description 30
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 26
- 150000001875 compounds Chemical class 0.000 claims description 22
- 125000004432 carbon atom Chemical group C* 0.000 claims description 12
- 125000004423 acyloxy group Chemical group 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- -1 3-hydroxypyrrolidino group Chemical group 0.000 claims description 10
- 125000002252 acyl group Chemical group 0.000 claims description 8
- 125000001931 aliphatic group Chemical group 0.000 claims description 8
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 8
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims description 6
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 5
- 125000003277 amino group Chemical group 0.000 claims description 4
- 239000004327 boric acid Substances 0.000 claims description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 4
- 150000007524 organic acids Chemical class 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 4
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 4
- 125000005505 thiomorpholino group Chemical group 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 12
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 10
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 9
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 6
- IBDSQYFVWPZWTH-UHFFFAOYSA-N B1(OOO1)O.C(C)(=O)O Chemical compound B1(OOO1)O.C(C)(=O)O IBDSQYFVWPZWTH-UHFFFAOYSA-N 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 4
- 229960000583 acetic acid Drugs 0.000 description 4
- 125000003545 alkoxy group Chemical group 0.000 description 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 4
- 239000013067 intermediate product Substances 0.000 description 4
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 4
- 0 *c(c(N)c1C2*O)c(*)c(O)c1N(C1CC1)C=C2C(O)=O Chemical compound *c(c(N)c1C2*O)c(*)c(O)c1N(C1CC1)C=C2C(O)=O 0.000 description 3
- XOQQVKDBGLYPGH-UHFFFAOYSA-N 2-oxo-1h-quinoline-3-carboxylic acid Chemical compound C1=CC=C2NC(=O)C(C(=O)O)=CC2=C1 XOQQVKDBGLYPGH-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000012362 glacial acetic acid Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 2
- 125000004193 piperazinyl group Chemical group 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 235000019260 propionic acid Nutrition 0.000 description 2
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- QAEDZJGFFMLHHQ-UHFFFAOYSA-N trifluoroacetic anhydride Chemical compound FC(F)(F)C(=O)OC(=O)C(F)(F)F QAEDZJGFFMLHHQ-UHFFFAOYSA-N 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 239000011592 zinc chloride Substances 0.000 description 2
- 235000005074 zinc chloride Nutrition 0.000 description 2
- PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 description 1
- BSKHPKMHTQYZBB-UHFFFAOYSA-N 2-methylpyridine Chemical compound CC1=CC=CC=N1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 description 1
- JDWLROHWYAZRBW-LKFCYVNXSA-N 7-[(3s,4s)-3-amino-4-methylpyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2C3CC3)=O)=C2C(OC)=C1N1C[C@H](C)[C@H](N)C1 JDWLROHWYAZRBW-LKFCYVNXSA-N 0.000 description 1
- CDGYPATWKVOBIY-UHFFFAOYSA-N 8-methoxy-4-oxo-1h-quinoline-3-carboxylic acid Chemical compound N1C=C(C(O)=O)C(=O)C2=C1C(OC)=CC=C2 CDGYPATWKVOBIY-UHFFFAOYSA-N 0.000 description 1
- 229910015900 BF3 Inorganic materials 0.000 description 1
- ZGSGKSHGFAIVSV-GQCTYLIASA-N CCN/C(/C)=C/C Chemical compound CCN/C(/C)=C/C ZGSGKSHGFAIVSV-GQCTYLIASA-N 0.000 description 1
- 101150041968 CDC13 gene Proteins 0.000 description 1
- SPLNGOFULBNITO-UHFFFAOYSA-N O=C1C(C(O)=O)C=NC2=C1C=CC=C2OC Chemical compound O=C1C(C(O)=O)C=NC2=C1C=CC=C2OC SPLNGOFULBNITO-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000008065 acid anhydrides Chemical class 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 description 1
- 239000007810 chemical reaction solvent Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 230000020335 dealkylation Effects 0.000 description 1
- 238000006900 dealkylation reaction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- XUBOMFCQGDBHNK-UHFFFAOYSA-N gatifloxacin Chemical compound FC1=CC(C(C(C(O)=O)=CN2C3CC3)=O)=C2C(OC)=C1N1CCNC(C)C1 XUBOMFCQGDBHNK-UHFFFAOYSA-N 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- WYVAMUWZEOHJOQ-UHFFFAOYSA-N propionic anhydride Chemical compound CCC(=O)OC(=O)CC WYVAMUWZEOHJOQ-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- BKITXDSDJGOXPN-JGVFFNPUSA-N tert-butyl n-[(3s,4s)-4-methylpyrrolidin-3-yl]carbamate Chemical compound C[C@H]1CNC[C@H]1NC(=O)OC(C)(C)C BKITXDSDJGOXPN-JGVFFNPUSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2178765A JPH0778065B2 (ja) | 1990-07-06 | 1990-07-06 | （６，７―置換―８―アルコキシ―１―シクロプロピル―１，４―ジヒドロ―４―オキソ―３―キノリンカルボン酸―ｏ▲上３▼，ｏ▲上４▼）ビス（アシルオキシ―ｏ）ホウ素化合物及びその塩並びにその製造方法 |
| AT0000992A AT397656B (de) | 1990-07-06 | 1992-01-07 | (6,7-substituierte-8-alkoxy-1-cyclopropyl-1,4- |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU88049A1 true LU88049A1 (fr) | 1992-08-25 |
Family
ID=25591090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU88049A LU88049A1 (fr) | 1990-07-06 | 1992-01-03 | Bis(acyloxy-o)borate de l'(acide-o3,o4-6,7-substitue-8-alcoxy-l-cyclopropyl-1,4-dihydro-4-oxo-3-quinoleinecarboxylique et le sel de ce dernier,ainsi que leur procede de preparation |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5157117A (de) |
| EP (1) | EP0464823B1 (de) |
| JP (1) | JPH0778065B2 (de) |
| KR (1) | KR960002273B1 (de) |
| CN (1) | CN1031795C (de) |
| AT (1) | AT397656B (de) |
| AU (1) | AU646055B2 (de) |
| CA (1) | CA2046361C (de) |
| DE (1) | DE69131636T2 (de) |
| ES (1) | ES2137154T3 (de) |
| HU (1) | HU215429B (de) |
| LU (1) | LU88049A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR910100517A (el) * | 1991-12-30 | 1993-08-31 | Kyorin Seiyaku Kk | Δις(ακυλοξυ-ο) βορικος εστερας του (6,7-υποκατεστημενου-8-αλκοξυ-1- κυκλοπροπυλ-1,4,-διυδρο-4-οξο-3-κινολινοκαρβοξυλικου οξεως-ο3,ο4)και αλας αυτου, και μεθοδος παρασκευης αυτου. |
| WO1994014794A1 (fr) * | 1992-12-28 | 1994-07-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Derive d'acide 8-methoxyquinolonecarboxylique |
| CA2152828A1 (en) * | 1993-03-16 | 1994-07-07 | Shin-Ichi Uesato | 8-methoxy-quinolonecarboxylic acid derivatives |
| ES2092963B1 (es) * | 1995-04-12 | 1997-12-16 | Sint Quimica Sa | Procedimiento para la preparacion del acido 1-ciclopropil-6-fluoro-1, 4-dihidro-7-(1s,4s)-5-metil-2,5-diazabiciclo(2.2.1) hept-2-il)-4-oxo-3-quinolincarboxilico y sus sales. |
| WO2004069825A1 (en) * | 2002-08-14 | 2004-08-19 | Teva Pharmaceutical Industries Ltd. | Synthesis of gatifloxacin |
| WO2005009970A1 (en) * | 2003-07-28 | 2005-02-03 | Matrix Laboratories Ltd | An improved process for the preparation of gatifloxacin |
| EP1651630A1 (de) * | 2003-08-05 | 2006-05-03 | Matrix Laboratories Ltd | Verbessertes verfahren zur herstellung von moxifloxacin-hydrochlorid |
| ES2232309B1 (es) * | 2003-11-13 | 2006-08-01 | Quimica Sintetica, S.A. | Procedimiento simplificado para la obtencion de gatifloxacino. |
| WO2005118546A1 (en) | 2004-06-04 | 2005-12-15 | Matrix Laboratories Ltd | Novel crystalline forms of gatifloxacin |
| EP1891037A1 (de) * | 2005-06-15 | 2008-02-27 | Hetero Drugs Limited | Gemifloxacin-verfahren und - polymorphe |
| CN101045724B (zh) * | 2006-03-28 | 2011-08-17 | 宝洁公司 | 用于制备喹诺酮中间体的偶联方法 |
| BRPI0709220A2 (pt) * | 2006-03-28 | 2011-07-12 | Procter & Gamble | processo de acoplamento para preparo de intermediários de quinolona |
| SI2001862T1 (sl) * | 2006-03-28 | 2011-10-28 | Warner Chilcott Co Llc | Soli malatov in polimorfi (3S, 5S)-7-(3-amino-5-metil-piperidinil)-1-ciklopropil-1,4-dihidro-8-metoksi- 4-okso-3-kinolinkarboksline kisline |
| WO2008059223A2 (en) * | 2006-11-13 | 2008-05-22 | Cipla Limited | Process for the synthesis of moxifloxacin hydrochloride |
| CN102617622B (zh) * | 2011-01-31 | 2016-06-15 | 深圳信立泰药业股份有限公司 | 一种制备莫西沙星或其可药用盐及其中间体的方法 |
| CN102351858B (zh) * | 2011-09-21 | 2013-03-27 | 浙江新东港药业股份有限公司 | 一种高选择性合成莫西沙星的方法 |
| CA2893534A1 (en) | 2012-12-04 | 2014-06-12 | Mankind Research Centre | An improved process for the preparation of moxifloxacin hydrochloride |
| CN103739547B (zh) * | 2014-01-03 | 2015-09-02 | 沈阳药科大学 | 2-[6-甲氧基-3-(2,3-二氯苯基)甲基-4-氧代-1,4-二氢-1(4h)-喹啉基]乙酸的合成方法 |
| CN104031078A (zh) * | 2014-05-28 | 2014-09-10 | 成都克莱蒙医药科技有限公司 | 一种盐酸莫西沙星中间体的合成方法 |
| KR102184814B1 (ko) * | 2019-05-23 | 2020-11-30 | 재단법인 한국탄소융합기술원 | 접착력이 향상된 에폭시 수지 조성물 및 이를 이용한 섬유-고무복합 연결재 |
| CN111233858B (zh) * | 2020-03-23 | 2022-05-24 | 常州方圆制药有限公司 | 一种盐酸莫西沙星的制备方法 |
| CN111777632A (zh) * | 2020-07-20 | 2020-10-16 | 浙江国邦药业有限公司 | 一种盐酸莫西沙星螯合物的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3705621C2 (de) * | 1986-02-25 | 1997-01-09 | Otsuka Pharma Co Ltd | Heterocyclisch substituierte Chinoloncarbonsäurederivate |
| JPS63198664A (ja) * | 1986-03-31 | 1988-08-17 | Sankyo Co Ltd | キノロンカルボン酸誘導体 |
| EP0241206A3 (de) * | 1986-03-31 | 1989-05-10 | Sankyo Company Limited | Chinolin-3-carbonsäurederivate, ihre Herstellung und Verwendung |
| HU198709B (en) * | 1987-04-08 | 1989-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing quinoline-carboxylic acid derivatives |
| SI8810667A8 (en) * | 1987-04-08 | 1996-04-30 | Chinoin Gyogyszer Es Vegyeszet | Anhydride of quinoline carboxylic acid of boron acid and process for their production. |
-
1990
- 1990-07-06 JP JP2178765A patent/JPH0778065B2/ja not_active Expired - Lifetime
-
1991
- 1991-07-01 US US07/724,164 patent/US5157117A/en not_active Expired - Lifetime
- 1991-07-03 KR KR1019910011229A patent/KR960002273B1/ko not_active Expired - Lifetime
- 1991-07-04 ES ES91111139T patent/ES2137154T3/es not_active Expired - Lifetime
- 1991-07-04 EP EP91111139A patent/EP0464823B1/de not_active Expired - Lifetime
- 1991-07-04 DE DE69131636T patent/DE69131636T2/de not_active Expired - Lifetime
- 1991-07-05 CA CA002046361A patent/CA2046361C/en not_active Expired - Lifetime
- 1991-07-05 HU HU2279/91A patent/HU215429B/hu unknown
- 1991-07-05 AU AU80263/91A patent/AU646055B2/en not_active Expired
- 1991-07-06 CN CN91104666A patent/CN1031795C/zh not_active Expired - Lifetime
-
1992
- 1992-01-03 LU LU88049A patent/LU88049A1/fr unknown
- 1992-01-07 AT AT0000992A patent/AT397656B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69131636T2 (de) | 2000-05-04 |
| CA2046361C (en) | 1999-07-20 |
| CN1031795C (zh) | 1996-05-15 |
| KR960002273B1 (ko) | 1996-02-14 |
| HUT58747A (en) | 1992-03-30 |
| EP0464823B1 (de) | 1999-09-22 |
| JPH0778065B2 (ja) | 1995-08-23 |
| AU8026391A (en) | 1993-01-28 |
| AT397656B (de) | 1994-06-27 |
| KR920002615A (ko) | 1992-02-28 |
| CN1059527A (zh) | 1992-03-18 |
| US5157117A (en) | 1992-10-20 |
| HU215429B (hu) | 1999-04-28 |
| ES2137154T3 (es) | 1999-12-16 |
| EP0464823A1 (de) | 1992-01-08 |
| CA2046361A1 (en) | 1992-01-07 |
| ATA992A (de) | 1993-10-15 |
| DE69131636D1 (de) | 1999-10-28 |
| JPH0469388A (ja) | 1992-03-04 |
| HU912279D0 (en) | 1991-12-30 |
| AU646055B2 (en) | 1994-02-03 |
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