LT5353B - Rekombinantiniai antikūniai ir jų fragmentai, atpažįstantys n-glikolil-gm3 gangliozidus, ir jų panaudojimas auglių diagnozei ir gydymui - Google Patents

Rekombinantiniai antikūniai ir jų fragmentai, atpažįstantys n-glikolil-gm3 gangliozidus, ir jų panaudojimas auglių diagnozei ir gydymui Download PDF

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Publication number
LT5353B
LT5353B LT2005101A LT2005101A LT5353B LT 5353 B LT5353 B LT 5353B LT 2005101 A LT2005101 A LT 2005101A LT 2005101 A LT2005101 A LT 2005101A LT 5353 B LT5353 B LT 5353B
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LT
Lithuania
Prior art keywords
changed
light chain
antibody
heavy
variable region
Prior art date
Application number
LT2005101A
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English (en)
Lithuanian (lt)
Other versions
LT2005101A (en
Inventor
Loudes Tatiana Roque Navarro
Cristina Maria Mateo De Acosta Del Rio
Mabel Rodriguez Gonzalez
Gertrudis Rojas Dorantes
Ariel Talavera Perez
Ernesto Moreno Frais
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Centro De Immunologia Molecular
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Publication date
Application filed by Centro De Immunologia Molecular filed Critical Centro De Immunologia Molecular
Publication of LT2005101A publication Critical patent/LT2005101A/xx
Publication of LT5353B publication Critical patent/LT5353B/lt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
LT2005101A 2003-04-23 2005-11-21 Rekombinantiniai antikūniai ir jų fragmentai, atpažįstantys n-glikolil-gm3 gangliozidus, ir jų panaudojimas auglių diagnozei ir gydymui LT5353B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20030092A CU23403A1 (es) 2003-04-23 2003-04-23 Anticuerpos recombinantes y fragmentos que reconocen el gangliósido n-glicolil gm3 y su uso para diagnóstico y tratamiento de tumores

Publications (2)

Publication Number Publication Date
LT2005101A LT2005101A (en) 2006-03-27
LT5353B true LT5353B (lt) 2006-07-25

Family

ID=40261249

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2005101A LT5353B (lt) 2003-04-23 2005-11-21 Rekombinantiniai antikūniai ir jų fragmentai, atpažįstantys n-glikolil-gm3 gangliozidus, ir jų panaudojimas auglių diagnozei ir gydymui

Country Status (32)

Country Link
EP (1) EP1623997B1 (de)
JP (1) JP2006524194A (de)
KR (1) KR20060006937A (de)
CN (2) CN103012586B (de)
AR (1) AR044076A1 (de)
AU (1) AU2004232391B2 (de)
BR (1) BRPI0409664A (de)
CA (1) CA2523449C (de)
CL (1) CL2004000843A1 (de)
CR (1) CR8105A (de)
CU (1) CU23403A1 (de)
EA (1) EA008353B1 (de)
ES (1) ES2535813T3 (de)
GE (1) GEP20084476B (de)
HK (1) HK1183492A1 (de)
HR (1) HRP20050922A2 (de)
HU (1) HUE025266T2 (de)
IL (1) IL171541A (de)
LT (1) LT5353B (de)
LV (1) LV13427B (de)
MX (1) MXPA05011368A (de)
MY (1) MY144620A (de)
NZ (1) NZ543345A (de)
PE (1) PE20050422A1 (de)
PL (1) PL1623997T3 (de)
RS (2) RS51853B (de)
SI (1) SI1623997T1 (de)
TN (1) TNSN05274A1 (de)
TW (1) TWI343923B (de)
UY (1) UY28289A1 (de)
WO (1) WO2004094477A1 (de)
ZA (1) ZA200509457B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ552959A (en) 1998-11-27 2008-06-30 Darwin Discovery Ltd Compositions and methods for increasing bone mineralization
ES2586401T3 (es) 2003-06-16 2016-10-14 Ucb Pharma S.A. Anticuerpos específicos para la esclerostina y métodos para aumentar la mineralización ósea
US8003108B2 (en) 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
US7592429B2 (en) 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
CL2008002775A1 (es) 2007-09-17 2008-11-07 Amgen Inc Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
EA037392B1 (ru) 2010-05-14 2021-03-23 Эмджен Инк. Композиции с высокой концентрацией антител
MX2013010011A (es) 2011-03-01 2014-10-24 Amgen Inc Agentes de unión biespecífica.
AU2012236962B2 (en) 2011-03-25 2017-05-11 Amgen Inc. Anti-sclerostin antibody crystals and formulations thereof
PT2739311T (pt) 2011-08-04 2018-03-26 Amgen Inc Método para tratamento de defeitos de lacunas ósseas
CU24070B1 (es) * 2011-12-27 2015-01-29 Ct De Inmunología Molecular Composiciones farmacéuticas para el tratamiento de tumores que expresan regf y gangliósidos n-glicolilados gm3 (neugcgm3)
SG10201509629QA (en) 2011-12-28 2015-12-30 Amgen Inc Method Of Treating Alveolar Bone Loss Through The Use Of Anti-Sclerostin Antibodies
CU24120B1 (es) * 2012-03-01 2015-08-27 Ct De Inmunología Molecular Anticuerpos recombinantes con especificidad dual por los gangliósidos n-acetil gm3 y n-glicolil gm3
EP3626267A1 (de) 2012-07-05 2020-03-25 UCB Pharma, S.A. Behandlung von knochenerkrankungen
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
ES2939760T3 (es) 2014-03-15 2023-04-26 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico para antígenos
MA41142A (fr) 2014-12-12 2017-10-17 Amgen Inc Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement
CN104651314B (zh) * 2015-02-14 2018-06-19 百泰生物药业有限公司 获得高产稳定表达细胞克隆的方法及由此获得的抗体分子
WO2016172583A1 (en) 2015-04-23 2016-10-27 Novartis Ag Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
WO2017027392A1 (en) 2015-08-07 2017-02-16 Novartis Ag Treatment of cancer using chimeric cd3 receptor proteins
SG11201805451TA (en) 2015-12-30 2018-07-30 Novartis Ag Immune effector cell therapies with enhanced efficacy
GB201604124D0 (en) 2016-03-10 2016-04-27 Ucb Biopharma Sprl Pharmaceutical formulation
WO2018140725A1 (en) 2017-01-26 2018-08-02 Novartis Ag Cd28 compositions and methods for chimeric antigen receptor therapy
WO2018144535A1 (en) 2017-01-31 2018-08-09 Novartis Ag Treatment of cancer using chimeric t cell receptor proteins having multiple specificities
US20210040205A1 (en) 2017-10-25 2021-02-11 Novartis Ag Antibodies targeting cd32b and methods of use thereof
BR112020007710A2 (pt) 2017-10-25 2020-10-20 Novartis Ag métodos para produzir células que expressam receptor de antígeno quimérico
CU20170173A7 (es) * 2017-12-27 2019-11-04 Ct Inmunologia Molecular Nano-partículas que contienen el gangliósido gm3 como inmunomoduladoras
EP3774879A1 (de) 2018-03-30 2021-02-17 Amgen Inc. C-terminale antikörpervarianten
EP3784351A1 (de) 2018-04-27 2021-03-03 Novartis AG Car-t-zelltherapien mit erhöhter wirksamkeit
EP3801769A1 (de) 2018-05-25 2021-04-14 Novartis AG Kombinationstherapie mit therapien mit chimärem antigen-rezeptor (car)
WO2019237035A1 (en) 2018-06-08 2019-12-12 Intellia Therapeutics, Inc. Compositions and methods for immunooncology
KR102344948B1 (ko) * 2018-09-03 2021-12-28 세종대학교산학협력단 인간 순수만능줄기세포에 특이적인 단일클론항체 n1-a4
CA3123511A1 (en) 2018-12-20 2020-06-25 Novartis Ag Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
US20220144807A1 (en) 2019-02-15 2022-05-12 Novartis Ag 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
CN110208409A (zh) * 2019-06-05 2019-09-06 中国海洋大学 一种乳腺癌的生物标志物及其应用
WO2021123908A1 (en) 2019-12-20 2021-06-24 Ludwig Institute For Cancer Research Ltd Car-t cell therapy targeting ngcgm3
CN115175937A (zh) 2019-12-20 2022-10-11 诺华股份有限公司 用于治疗骨髓纤维化和骨髓增生异常综合征的抗TIM-3抗体MBG453和抗TGF-β抗体NIS793与或不与地西他滨或抗PD-1抗体斯巴达珠单抗的组合
WO2024089639A1 (en) 2022-10-26 2024-05-02 Novartis Ag Lentiviral formulations

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0796334A1 (de) 1994-10-28 1997-09-24 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Tumorspezifische antikörperfragmente, fusionsproteine, und deren verwendungen
US5712120A (en) 1994-06-30 1998-01-27 Centro De Immunologia Molecular Method for obtaining modified immunoglobulins with reduced immunogenicity of murine antibody variable domains, compositions containing them

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2078539C (en) * 1991-09-18 2005-08-02 Kenya Shitara Process for producing humanized chimera antibody
CA2182013C (en) * 1994-01-25 2007-07-17 Mary M. Bendig Humanized antibodies against leukocyte adhesion molecule vla-4
AU724856B2 (en) * 1995-06-30 2000-10-05 Mochida Pharmaceutical Co., Ltd. Anti-Fas ligand antibody and assay method using the anti-Fas ligand antibody
US5834597A (en) * 1996-05-20 1998-11-10 Protein Design Labs, Inc. Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
CU22731A1 (es) * 1998-02-05 2002-02-28 Centro Inmunologia Molecular Anticuerpo monoclonal que reconoce el oligosacárido ácido siálico n´glicolilado-galactosa-glucosa (ngcneu-gal-glu) en tumores malignos y composiciones farmacéuticas que los contienen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712120A (en) 1994-06-30 1998-01-27 Centro De Immunologia Molecular Method for obtaining modified immunoglobulins with reduced immunogenicity of murine antibody variable domains, compositions containing them
EP0796334A1 (de) 1994-10-28 1997-09-24 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Tumorspezifische antikörperfragmente, fusionsproteine, und deren verwendungen

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A KLIMKA ET AL.: "Human anti-CD30 recombinant antibodies by guided phage antibody selection using cell panning", BR J CANCER., 2000, pages 252 - 260, XP001021661, DOI: doi:10.1054/bjoc.2000.1226
A N HOUGHTON ET AL.: "Mouse monoclonal IgG3 antibody detecting GD3 ganglioside: a phase I trial in patients with malignant melanoma", PNAS, 1986, pages 1242 - 1246
HAKOMORI S.: "Possible functions of tumor-associated carbohydrate antigens", CURR OPIN IMMUNOL., 1991, pages 646 - 653, XP024355520, DOI: doi:10.1016/0952-7915(91)90091-E
STULTS CL ET AL.: "Glycosphingolipids: structure, biological source, and properties", METHODS ENZYMOL., 1989, pages 167 - 214

Also Published As

Publication number Publication date
HK1183492A1 (en) 2013-12-27
TNSN05274A1 (en) 2007-07-10
RS51853B (en) 2012-02-29
JP2006524194A (ja) 2006-10-26
RS20110319A3 (en) 2012-10-31
RS20050795A (en) 2007-12-31
BRPI0409664A (pt) 2006-04-18
AR044076A1 (es) 2005-08-24
EA008353B1 (ru) 2007-04-27
MXPA05011368A (es) 2006-03-08
SI1623997T1 (sl) 2015-07-31
WO2004094477A1 (es) 2004-11-04
TW200504090A (en) 2005-02-01
KR20060006937A (ko) 2006-01-20
CU23403A1 (es) 2009-08-04
GEP20084476B (en) 2008-09-10
LV13427B (en) 2006-09-20
TWI343923B (en) 2011-06-21
UY28289A1 (es) 2004-11-30
MY144620A (en) 2011-10-14
HRP20050922A2 (en) 2007-03-31
EP1623997B1 (de) 2015-04-22
HUE025266T2 (en) 2016-02-29
RS20110319A2 (en) 2012-02-29
CL2004000843A1 (es) 2005-04-15
CA2523449C (en) 2012-09-18
PL1623997T3 (pl) 2015-08-31
CR8105A (es) 2006-05-31
CN1809592A (zh) 2006-07-26
LT2005101A (en) 2006-03-27
EP1623997A1 (de) 2006-02-08
PE20050422A1 (es) 2005-06-29
CA2523449A1 (en) 2004-11-04
AU2004232391B2 (en) 2008-10-30
CN103012586B (zh) 2014-08-06
IL171541A (en) 2013-11-28
CN103012586A (zh) 2013-04-03
NZ543345A (en) 2009-09-25
ZA200509457B (en) 2006-07-26
ES2535813T3 (es) 2015-05-18
EA200501653A1 (ru) 2006-06-30
AU2004232391A1 (en) 2004-11-04

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