LT4972B - Benzenamine derivatives as anti-coagulants - Google Patents

Benzenamine derivatives as anti-coagulants Download PDF

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Publication number
LT4972B
LT4972B LT2002009A LT2002009A LT4972B LT 4972 B LT4972 B LT 4972B LT 2002009 A LT2002009 A LT 2002009A LT 2002009 A LT2002009 A LT 2002009A LT 4972 B LT4972 B LT 4972B
Authority
LT
Lithuania
Prior art keywords
oxy
piperidin
benzenamine
prop
amidinophenyl
Prior art date
Application number
LT2002009A
Other languages
English (en)
Lithuanian (lt)
Other versions
LT2002009A (en
Inventor
William J. Guilford
Steven T. Sakata
Kenneth J. Shaw
Shung Wu
Wei Xu
Zuchun Zhao
Original Assignee
Berlex Laboratories,Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlex Laboratories,Inc. filed Critical Berlex Laboratories,Inc.
Publication of LT2002009A publication Critical patent/LT2002009A/xx
Publication of LT4972B publication Critical patent/LT4972B/lt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
LT2002009A 1999-07-30 2002-01-24 Benzenamine derivatives as anti-coagulants LT4972B (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14657299P 1999-07-30 1999-07-30
US09/624,519 US6350761B1 (en) 1999-07-30 2000-07-24 Benzenamine derivatives as anti-coagulants

Publications (2)

Publication Number Publication Date
LT2002009A LT2002009A (en) 2002-07-25
LT4972B true LT4972B (lt) 2002-11-25

Family

ID=26844067

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2002009A LT4972B (lt) 1999-07-30 2002-01-24 Benzenamine derivatives as anti-coagulants

Country Status (23)

Country Link
US (1) US6350761B1 (ja)
EP (1) EP1200405A1 (ja)
JP (1) JP2003506353A (ja)
KR (1) KR20020068494A (ja)
CN (1) CN1367777A (ja)
AU (1) AU766820B2 (ja)
BR (1) BR0013292A (ja)
CA (1) CA2380029A1 (ja)
CZ (1) CZ2002346A3 (ja)
EE (1) EE200200050A (ja)
HK (1) HK1049482A1 (ja)
HR (1) HRP20020185A2 (ja)
HU (1) HUP0202234A3 (ja)
IL (2) IL147746A0 (ja)
LT (1) LT4972B (ja)
LV (1) LV12844B (ja)
MX (1) MXPA02001065A (ja)
NO (1) NO20020457L (ja)
NZ (1) NZ516804A (ja)
PL (1) PL357871A1 (ja)
SI (1) SI20815A (ja)
SK (1) SK1252002A3 (ja)
WO (1) WO2001009093A1 (ja)

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Publication number Priority date Publication date Assignee Title
CA2214685C (en) 1995-03-10 2008-05-20 Berlex Laboratories, Inc. Benzamidine derivatives their preparation and their use as anti-coagulants
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
DE60027204T2 (de) * 1999-10-28 2006-11-23 Sankyo Co., Ltd. Benzamidinderivate
AU2004203154B2 (en) * 1999-10-28 2006-06-01 Sankyo Company, Limited Benzamidine derivatives
US20020065303A1 (en) * 2000-02-01 2002-05-30 Bing-Yan Zhu Bivalent phenylene inhibitors of factor Xa
DE10110325A1 (de) * 2001-03-03 2002-09-05 Merck Patent Gmbh Phenylderivate 2
AU2002246336B2 (en) * 2001-04-05 2005-05-19 Sankyo Company, Limited Benzamidine derivative
EP2982668A3 (en) 2002-12-03 2016-04-13 Pharmacyclics LLC 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors for the treatment of thromboembolic disorders
JP5468900B2 (ja) * 2006-07-24 2014-04-09 ユセベ ファルマ ソシエテ アノニム 置換されたアニリン誘導体
AU2008335788B2 (en) * 2007-12-12 2012-11-29 Amgen Inc. Glycine transporter-1 inhibitors
EP2602248A1 (en) * 2011-12-05 2013-06-12 University Of Leicester Novel pyrrole compounds
US11596612B1 (en) 2022-03-08 2023-03-07 PTC Innovations, LLC Topical anesthetics

Citations (8)

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US5451700A (en) 1991-06-11 1995-09-19 Ciba-Geigy Corporation Amidino compounds, their manufacture and methods of treatment
WO1996028427A1 (en) 1995-03-10 1996-09-19 Berlex Laboratories, Inc. Benzamidine derivatives their preparation and their use as anti-coagulants
US5612363A (en) 1995-06-02 1997-03-18 Berlex Laboratories, Inc. N,N-di(aryl) cyclic urea derivatives as anti-coagulants
US5633381A (en) 1994-07-05 1997-05-27 Berlex Laboratories, Inc. (Z,Z), (Z,E) and (E,Z) isomers of substituted bis(phenylmethylene)cycloketones
WO1997021437A1 (en) 1995-12-08 1997-06-19 Berlex Laboratories, Inc. Naphthyl-substituted benzimidazole derivatives as anticoagulants
WO1997029067A1 (en) 1996-02-12 1997-08-14 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
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EP0540051A1 (en) 1991-10-31 1993-05-05 Daiichi Pharmaceutical Co., Ltd. Aromatic amidine derivatives and salts thereof
US5633381A (en) 1994-07-05 1997-05-27 Berlex Laboratories, Inc. (Z,Z), (Z,E) and (E,Z) isomers of substituted bis(phenylmethylene)cycloketones
US5869501A (en) 1994-12-02 1999-02-09 Yamanouchi Pharmaceutical Co. Ltd Amidinonaphthyl derivative or salt thereof
WO1996028427A1 (en) 1995-03-10 1996-09-19 Berlex Laboratories, Inc. Benzamidine derivatives their preparation and their use as anti-coagulants
US5612363A (en) 1995-06-02 1997-03-18 Berlex Laboratories, Inc. N,N-di(aryl) cyclic urea derivatives as anti-coagulants
WO1997021437A1 (en) 1995-12-08 1997-06-19 Berlex Laboratories, Inc. Naphthyl-substituted benzimidazole derivatives as anticoagulants
WO1997029067A1 (en) 1996-02-12 1997-08-14 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants

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Also Published As

Publication number Publication date
KR20020068494A (ko) 2002-08-27
WO2001009093A8 (en) 2005-11-10
NZ516804A (en) 2003-08-29
WO2001009093A1 (en) 2001-02-08
LV12844B (en) 2002-11-20
HK1049482A1 (zh) 2003-05-16
LT2002009A (en) 2002-07-25
BR0013292A (pt) 2002-04-02
SK1252002A3 (en) 2002-08-06
CZ2002346A3 (cs) 2002-06-12
CN1367777A (zh) 2002-09-04
HRP20020185A2 (en) 2004-02-29
EP1200405A1 (en) 2002-05-02
AU6380500A (en) 2001-02-19
US6350761B1 (en) 2002-02-26
PL357871A1 (en) 2004-07-26
NO20020457D0 (no) 2002-01-29
IL147746A (en) 2007-02-11
IL147746A0 (en) 2002-08-14
AU766820B2 (en) 2003-10-23
MXPA02001065A (es) 2002-10-31
EE200200050A (et) 2003-04-15
HUP0202234A2 (en) 2002-10-28
HUP0202234A3 (en) 2005-02-28
JP2003506353A (ja) 2003-02-18
CA2380029A1 (en) 2001-02-08
NO20020457L (no) 2002-03-27
SI20815A (sl) 2002-08-31

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LT4972B (lt) Benzenamine derivatives as anti-coagulants
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