LT4800B - Aii antagonisto sulėtinto atpalaidavimo preparatas, jo gavimas ir panaudojimas - Google Patents

Aii antagonisto sulėtinto atpalaidavimo preparatas, jo gavimas ir panaudojimas Download PDF

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Publication number
LT4800B
LT4800B LT2000082A LT2000082A LT4800B LT 4800 B LT4800 B LT 4800B LT 2000082 A LT2000082 A LT 2000082A LT 2000082 A LT2000082 A LT 2000082A LT 4800 B LT4800 B LT 4800B
Authority
LT
Lithuania
Prior art keywords
compound
group
sustained release
angiotensin
acid
Prior art date
Application number
LT2000082A
Other languages
English (en)
Lithuanian (lt)
Other versions
LT2000082A (en
Inventor
Yasutaka Igari
Akira Saikawa
Yoshiyuki Inada
Shigeru Kamei
Original Assignee
Takeda Chemical Industries,Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries,Ltd filed Critical Takeda Chemical Industries,Ltd
Publication of LT2000082A publication Critical patent/LT2000082A/xx
Publication of LT4800B publication Critical patent/LT4800B/lt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1611Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
LT2000082A 1998-03-04 2000-08-31 Aii antagonisto sulėtinto atpalaidavimo preparatas, jo gavimas ir panaudojimas LT4800B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5236698 1998-03-04

Publications (2)

Publication Number Publication Date
LT2000082A LT2000082A (en) 2001-03-26
LT4800B true LT4800B (lt) 2001-06-25

Family

ID=12912818

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2000082A LT4800B (lt) 1998-03-04 2000-08-31 Aii antagonisto sulėtinto atpalaidavimo preparatas, jo gavimas ir panaudojimas

Country Status (21)

Country Link
US (2) US6589547B1 (et)
EP (1) EP1058541B1 (et)
KR (1) KR20010086245A (et)
CN (1) CN1291888A (et)
AT (1) ATE258430T1 (et)
AU (1) AU2745199A (et)
BR (1) BR9908474A (et)
CA (1) CA2318446C (et)
DE (1) DE69914460T2 (et)
EE (1) EE200000499A (et)
ES (1) ES2214013T3 (et)
HU (1) HUP0101439A3 (et)
ID (1) ID25640A (et)
IL (1) IL137979A0 (et)
LT (1) LT4800B (et)
LV (1) LV12585B (et)
NO (1) NO20004350L (et)
PL (1) PL342684A1 (et)
SK (1) SK11902000A3 (et)
WO (1) WO1999044590A1 (et)
ZA (1) ZA991706B (et)

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ID25640A (id) * 1998-03-04 2000-10-19 Takeda Chemical Industries Ltd Preparat pelepasan terus menerus untuk antagonistik aii, produksi dan penggunaannya
CZ301913B6 (cs) 1999-04-28 2010-07-28 Takeda Pharmaceutical Company Limited Farmaceutický prípravek pro predcházení, lécení nebo inhibování vývoje jednoduché retinopatie nebo predproliferacní retinopatie
SE9903028D0 (sv) * 1999-08-27 1999-08-27 Astra Ab New use
AU2001234088B2 (en) * 2000-02-18 2005-12-01 Takeda Pharmaceutical Company Limited Tnf-alpha inhibitors
AU2001232348A1 (en) * 2000-02-21 2001-08-27 Takeda Chemical Industries Ltd. Sustained release preparations of physiologically active compound hardly solublein water and production process and use of the same
CA2420055C (en) * 2000-08-25 2010-06-01 Takeda Chemical Industries, Ltd. Fibrinogen-lowering agent
US20040102502A1 (en) * 2000-10-25 2004-05-27 Toshifumi Watanabe Preventing/remedies for portal hypertension
WO2002074340A1 (fr) * 2001-03-16 2002-09-26 Takeda Chemical Industries, Ltd. Procede de fabrication d'une preparation a liberation continue
WO2003013609A1 (en) * 2001-08-03 2003-02-20 Takeda Chemical Industries, Ltd. Sustained-release medicines
BRPI0105509B8 (pt) * 2001-11-05 2021-05-25 Univ Minas Gerais formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga
US7812044B2 (en) 2001-11-13 2010-10-12 Takeda Pharmaceutical Company Limited Anticancer agents
AU2002349673A1 (en) * 2001-12-03 2003-06-17 Takeda Chemical Industries, Ltd. Insulin resistance improving agents
US7407778B2 (en) * 2002-02-07 2008-08-05 Pettegrew Jay W Compounds, compositions and methods for treating neuropsychiatric disorders
US7700074B2 (en) * 2002-02-07 2010-04-20 Pettegrew Jay W Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism
CN100438911C (zh) * 2002-12-27 2008-12-03 武田药品工业株式会社 体重增加抑制剂
US20050038093A1 (en) * 2003-05-02 2005-02-17 Boehringer Ingelheim International Gmbh Treating diabetic retinopathy with angiotensin II receptor blockers
US20060257842A1 (en) * 2003-05-29 2006-11-16 Pettegrew Jay W Cryopreservation media and molecules
EP1641806B1 (en) * 2003-05-29 2009-07-29 Jay W. Pettegrew Glycerophosphocholine and its derivatives for medical imaging of neuropsychiatric disorders
WO2005097109A1 (en) * 2004-04-01 2005-10-20 Daniel Batlle Methods for achieving a protective ace2 expression level
EP1750862B1 (en) 2004-06-04 2011-01-05 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing irbesartan
CA2583768A1 (en) * 2004-10-07 2006-04-13 Takeda Pharmaceutical Company Limited Agent for prophylaxis or treatment of metabolic syndrome
WO2006046528A1 (ja) * 2004-10-29 2006-05-04 Kowa Co., Ltd. 糸球体疾患治療剤
CA2598410A1 (fr) * 2005-02-21 2006-08-24 Flamel Technologies Forme pharmaceutique orale de losartan
BRPI0608944A2 (pt) * 2005-03-30 2010-11-16 Takeda Pharmaceutical composto, cristal, método para produzir um composto, agente farmacêutico, sensor de insulina, melhorador de uma atividade hipoglicêmica de um sensor de insulina, e, uso composto
KR20080039510A (ko) * 2005-08-22 2008-05-07 알렘빅 리미티드 발사르탄 제조 방법
MX2009001429A (es) * 2006-08-10 2009-02-17 Takeda Pharmaceutical Composicion farmaceutica.
EP1897537A1 (en) * 2006-09-04 2008-03-12 Novartis AG Composition comprising an angiotensin II receptor antagonist
PE20081364A1 (es) * 2006-09-04 2008-12-04 Novartis Ag Composicion farmaceutica que comprende valsartan
EP1908469A1 (en) 2006-10-06 2008-04-09 Boehringer Ingelheim Vetmedica Gmbh Angiotensin II receptor antagonist for the treatment of systemic diseases in cats
MY148370A (en) 2006-12-18 2013-04-15 Takeda Pharmaceutical Sustained-release composition and method for producing the same
CN101011393B (zh) * 2007-02-16 2010-10-06 广州柏赛罗药业有限公司 厄贝沙坦胃内滞留型缓释药物组合物
AU2008235790B2 (en) * 2007-03-28 2013-06-06 Takeda Pharmaceutical Company Limited Solid pharmaceutical composition comprising a benzimidazole-7-carboxylate derivative and a pH control agent
KR101209319B1 (ko) * 2008-04-29 2012-12-06 한올바이오파마주식회사 안지오텐신-ⅱ-수용체 차단제를 포함하는 약제학적 제제
EP2432452B1 (de) 2009-05-20 2016-07-27 Boehringer Ingelheim Vetmedica GmbH Pharmazeutische telmisartan-trinklösung
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists

Citations (23)

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Publication number Priority date Publication date Assignee Title
JPS5671073A (en) 1979-11-12 1981-06-13 Takeda Chem Ind Ltd Imidazole derivative
JPS5671074A (en) 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
JPS5798270A (en) 1980-10-21 1982-06-18 Takeda Chem Ind Ltd 1,2-disubstituted-4-chloroimidazole-5-acetic acid derivative
JPS58157768A (ja) 1982-03-16 1983-09-19 Takeda Chem Ind Ltd 4−クロロ−2−フエニルイミダゾ−ル−5−酢酸誘導体
EP0253310A2 (en) 1986-07-11 1988-01-20 E.I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
EP0291969A2 (en) 1987-05-22 1988-11-23 E.I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
EP0323841A2 (en) 1988-01-07 1989-07-12 E.I. Du Pont De Nemours And Company Substituted pyrrole, pyrazole and triazole angiotensin II antagonists
EP0324377A2 (en) 1988-01-07 1989-07-19 E.I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles and combinations thereof with diuretics and NSaids
US4880804A (en) 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
EP0392317A2 (de) 1989-04-08 1990-10-17 Dr. Karl Thomae GmbH Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
EP0399731A1 (en) 1989-05-23 1990-11-28 Zeneca Limited Azaindenes
EP0403158A2 (en) 1989-06-14 1990-12-19 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
EP0407342A2 (de) 1989-07-06 1991-01-09 Ciba-Geigy Ag Neue Pyrimidin Derivate
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EP0409332A2 (en) 1989-07-19 1991-01-23 Merck & Co. Inc. Substituted triazoles as angiotensin II antagonists
EP0411766A1 (en) 1989-07-03 1991-02-06 Merck & Co. Inc. Substituted quinazolinones as angiotensin II antagonists
EP0434038A1 (en) 1989-12-22 1991-06-26 Takeda Chemical Industries, Ltd. Fused imidazole derivatives, their production and use
EP0442473A1 (en) 1990-02-15 1991-08-21 Takeda Chemical Industries, Ltd. Pyrimidinedione derivatives, their production and use
EP0443568A1 (en) 1990-02-22 1991-08-28 Takeda Chemical Industries, Ltd. Fused thiophene derivatives, their production and use
EP0518033A1 (en) 1991-04-16 1992-12-16 Takeda Chemical Industries, Ltd. Fused heterocyclic compounds, their production and use
US5183899A (en) 1989-08-02 1993-02-02 Takeda Chemical Industries, Ltd. Pyrazole derivative
EP0603712A2 (en) 1992-12-22 1994-06-29 Takeda Chemical Industries, Ltd. Heterocyclic compounds having angiotensin II antagonistic activity and use thereof
JPH10504017A (ja) 1994-05-03 1998-04-14 アルカームズ コントロールド セラピューティックス,インコーポレイテッド 生体適合性ポリマーからの薬物放出調節方法

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Patent Citations (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5671073A (en) 1979-11-12 1981-06-13 Takeda Chem Ind Ltd Imidazole derivative
JPS5671074A (en) 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
US4340598A (en) 1979-11-12 1982-07-20 Takeda Chemical Industries, Ltd. Hypotensive imidazole derivatives
US4355040A (en) 1979-11-12 1982-10-19 Takeda Chemical Industries, Ltd. Hypotensive imidazole-5-acetic acid derivatives
JPS5798270A (en) 1980-10-21 1982-06-18 Takeda Chem Ind Ltd 1,2-disubstituted-4-chloroimidazole-5-acetic acid derivative
JPS58157768A (ja) 1982-03-16 1983-09-19 Takeda Chem Ind Ltd 4−クロロ−2−フエニルイミダゾ−ル−5−酢酸誘導体
EP0253310A2 (en) 1986-07-11 1988-01-20 E.I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
EP0291969A2 (en) 1987-05-22 1988-11-23 E.I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
EP0323841A2 (en) 1988-01-07 1989-07-12 E.I. Du Pont De Nemours And Company Substituted pyrrole, pyrazole and triazole angiotensin II antagonists
EP0324377A2 (en) 1988-01-07 1989-07-19 E.I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles and combinations thereof with diuretics and NSaids
US4880804A (en) 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
EP0392317A2 (de) 1989-04-08 1990-10-17 Dr. Karl Thomae GmbH Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
EP0399731A1 (en) 1989-05-23 1990-11-28 Zeneca Limited Azaindenes
EP0403158A2 (en) 1989-06-14 1990-12-19 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
WO1991000277A1 (en) 1989-06-30 1991-01-10 E.I. Du Pont De Nemours And Company Substituted imidazoles
EP0411766A1 (en) 1989-07-03 1991-02-06 Merck & Co. Inc. Substituted quinazolinones as angiotensin II antagonists
EP0407342A2 (de) 1989-07-06 1991-01-09 Ciba-Geigy Ag Neue Pyrimidin Derivate
EP0409332A2 (en) 1989-07-19 1991-01-23 Merck & Co. Inc. Substituted triazoles as angiotensin II antagonists
US5183899A (en) 1989-08-02 1993-02-02 Takeda Chemical Industries, Ltd. Pyrazole derivative
EP0434038A1 (en) 1989-12-22 1991-06-26 Takeda Chemical Industries, Ltd. Fused imidazole derivatives, their production and use
EP0442473A1 (en) 1990-02-15 1991-08-21 Takeda Chemical Industries, Ltd. Pyrimidinedione derivatives, their production and use
EP0443568A1 (en) 1990-02-22 1991-08-28 Takeda Chemical Industries, Ltd. Fused thiophene derivatives, their production and use
EP0518033A1 (en) 1991-04-16 1992-12-16 Takeda Chemical Industries, Ltd. Fused heterocyclic compounds, their production and use
EP0603712A2 (en) 1992-12-22 1994-06-29 Takeda Chemical Industries, Ltd. Heterocyclic compounds having angiotensin II antagonistic activity and use thereof
JPH10504017A (ja) 1994-05-03 1998-04-14 アルカームズ コントロールド セラピューティックス,インコーポレイテッド 生体適合性ポリマーからの薬物放出調節方法

Non-Patent Citations (1)

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Title
PATRICE HILDGEN ET AL.: "Improved Activity of a New Angiotensin Receptor Antagonist by an Injectable Spray-Dried Polymer Microsphere Preparation", PHARMACEUTICAL RESEARCH, 1997, pages 887 - 891, XP002109157, DOI: doi:10.1023/A:1012147700014

Also Published As

Publication number Publication date
AU2745199A (en) 1999-09-20
ES2214013T3 (es) 2004-09-01
HUP0101439A2 (hu) 2001-10-28
SK11902000A3 (sk) 2001-02-12
LV12585B (en) 2001-03-20
LT2000082A (en) 2001-03-26
US20030198676A1 (en) 2003-10-23
ATE258430T1 (de) 2004-02-15
DE69914460D1 (de) 2004-03-04
LV12585A (en) 2000-12-20
NO20004350L (no) 2000-10-03
US7294344B2 (en) 2007-11-13
WO1999044590A1 (en) 1999-09-10
HUP0101439A3 (en) 2002-09-30
KR20010086245A (ko) 2001-09-10
EP1058541B1 (en) 2004-01-28
EP1058541A1 (en) 2000-12-13
CA2318446A1 (en) 1999-09-10
US6589547B1 (en) 2003-07-08
DE69914460T2 (de) 2004-10-28
CA2318446C (en) 2008-09-23
CN1291888A (zh) 2001-04-18
IL137979A0 (en) 2001-10-31
NO20004350D0 (no) 2000-09-01
EE200000499A (et) 2002-02-15
BR9908474A (pt) 2000-12-05
ZA991706B (en) 2000-10-03
ID25640A (id) 2000-10-19
PL342684A1 (en) 2001-07-02

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