LT3768846T - Virusiniai ir nevirusiniai nanoplazmidiniai vektoriai su patobulinta gamyba - Google Patents
Virusiniai ir nevirusiniai nanoplazmidiniai vektoriai su patobulinta gamybaInfo
- Publication number
- LT3768846T LT3768846T LTEPPCT/US2019/023209T LTUS2019023209T LT3768846T LT 3768846 T LT3768846 T LT 3768846T LT US2019023209 T LTUS2019023209 T LT US2019023209T LT 3768846 T LT3768846 T LT 3768846T
- Authority
- LT
- Lithuania
- Prior art keywords
- viral
- improved production
- nanoplasmid vectors
- nanoplasmid
- vectors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15051—Methods of production or purification of viral material
- C12N2740/15052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
- C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/101—Plasmid DNA for bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/24—Vectors characterised by the absence of particular element, e.g. selectable marker, viral origin of replication
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/90—Vectors containing a transposable element
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2820/00—Vectors comprising a special origin of replication system
- C12N2820/55—Vectors comprising a special origin of replication system from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Carbon And Carbon Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862645892P | 2018-03-21 | 2018-03-21 | |
| PCT/US2019/023209 WO2019183248A1 (en) | 2018-03-21 | 2019-03-20 | Viral and non-viral nanoplasmid vectors with improved production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3768846T true LT3768846T (lt) | 2023-08-10 |
Family
ID=66001381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEPPCT/US2019/023209T LT3768846T (lt) | 2018-03-21 | 2019-03-20 | Virusiniai ir nevirusiniai nanoplazmidiniai vektoriai su patobulinta gamyba |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12600984B2 (https=) |
| EP (2) | EP3768846B1 (https=) |
| JP (2) | JP7520719B2 (https=) |
| KR (1) | KR20210016330A (https=) |
| CN (2) | CN112154208B (https=) |
| AU (2) | AU2019240068B2 (https=) |
| CA (1) | CA3093346A1 (https=) |
| DK (1) | DK3768846T5 (https=) |
| ES (1) | ES2950736T3 (https=) |
| FI (1) | FI3768846T3 (https=) |
| LT (1) | LT3768846T (https=) |
| SG (1) | SG11202009009UA (https=) |
| WO (1) | WO2019183248A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019183248A1 (en) * | 2018-03-21 | 2019-09-26 | Nature Technology Corporation | Viral and non-viral nanoplasmid vectors with improved production |
| US20220042038A1 (en) * | 2018-12-20 | 2022-02-10 | Poseida Therapeutics, Inc. | Nanotransposon compositions and methods of use |
| GB2700048B (en) | 2019-09-18 | 2026-03-04 | Aldevron Llc | synthetic dna vectors and method of use |
| JP7833134B2 (ja) * | 2020-03-11 | 2026-03-19 | アルデブロン，エル．エル．シー． | 細菌宿主株 |
| CA3201499A1 (en) | 2020-11-13 | 2022-05-19 | Catamaran Bio, Inc. | Genetically modified natural killer cells and methods of use thereof |
| CA3223292A1 (en) | 2021-06-25 | 2022-12-29 | Laura Van Lieshout | Adeno-associated virus packaging systems |
| US20250114452A1 (en) | 2021-08-04 | 2025-04-10 | The Regents Of The University Of Colorado, A Body Corporate | Lat activating chimeric antigen receptor t cells and methods of use thereof |
| CN114045305B (zh) * | 2021-10-15 | 2023-03-24 | 深圳市深研生物科技有限公司 | 多转座子系统 |
| WO2023114901A2 (en) | 2021-12-15 | 2023-06-22 | Oxford Biomedica Solutions Llc | Methods and compositions for the production of adeno-associated virus |
| WO2023172514A1 (en) | 2022-03-07 | 2023-09-14 | Catamaran Bio, Inc. | Engineered immune cell therapeutics targeted to her2 and methods of use thereof |
| US20250354159A1 (en) * | 2022-06-13 | 2025-11-20 | Nanjing GenScript Biotech Co., Ltd. | Wild-type-mutant pi protein switching expression system capable of increasing efficiency of preparing screening-tag-free plasmid |
| JP2025525583A (ja) | 2022-07-19 | 2025-08-05 | ランパート バイオサイエンス インコーポレイテッド | 非免疫原性環状非ウイルス性ｄｎａベクター |
| CN117305339B (zh) * | 2023-11-30 | 2024-02-06 | 苏州左旋星生物科技有限公司 | 优化大肠杆菌基因编辑的载体及其应用 |
| WO2025160245A1 (en) | 2024-01-25 | 2025-07-31 | Aldevron, L.L.C. | Viral and non-viral nanoplasmid vectors with improved production |
| WO2025231315A2 (en) | 2024-05-03 | 2025-11-06 | Aldevron, L.L.C. | Bacterial host strains |
| WO2026076187A1 (en) * | 2024-10-03 | 2026-04-09 | Aldevron, L.L.C. | Compositions and methods for microbial production of antibiotic-free closed-ended linear dna |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04197185A (ja) * | 1990-11-28 | 1992-07-16 | Mitsui Toatsu Chem Inc | 酵母発現ベクター及びこれを用いた誘導的発現 |
| GB9506051D0 (en) * | 1995-03-24 | 1995-05-10 | Univ Singapore | Gene expression |
| FR2738842B1 (fr) | 1995-09-15 | 1997-10-31 | Rhone Poulenc Rorer Sa | Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique |
| US7279313B2 (en) | 1995-09-15 | 2007-10-09 | Centelion | Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy |
| US5922583A (en) | 1995-10-17 | 1999-07-13 | Biostar Inc. | Methods for production of recombinant plasmids |
| US6709844B1 (en) * | 2000-11-16 | 2004-03-23 | Mannkind Corporation | Avoidance of undesirable replication intermediates in plasmid propagation |
| JP2004267001A (ja) * | 2000-08-16 | 2004-09-30 | Kansai Tlo Kk | トランスジェニック哺乳動物及びその作製方法並びにこれを用いた遺伝子機能の解明方法 |
| UY26317A1 (es) * | 2000-08-30 | 2000-10-31 | Alfonso Cayota Carlos Pritsch | Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo |
| FR2821855B1 (fr) | 2001-03-09 | 2004-04-02 | Cayla | Genes synthetiques et plasmides bacteriens depourvus de cpg |
| CA2794446C (en) * | 2001-04-04 | 2015-09-08 | Genencor International, Inc. | Uncoupled productive and catabolic host cell pathways |
| US20060088837A1 (en) * | 2002-04-26 | 2006-04-27 | Kazunari Taira | Expression system for stem-loop rna molecule having rnai effect |
| WO2005003359A1 (ja) * | 2003-07-08 | 2005-01-13 | Japan Science And Technology Corporation | トランスジェニック生物を作製する方法およびシステム |
| GB0327056D0 (en) | 2003-11-20 | 2003-12-24 | Cobra Biolog Ltd | Plasmid maintenance |
| MX2007001889A (es) | 2004-08-19 | 2007-05-09 | Nature Technology Corp | Proceso para la fermentacion de adn de plasmido. |
| CA2577519A1 (en) * | 2004-08-23 | 2006-03-30 | Nucleonics, Inc. | Multiple rna polymerase iii promoter expression constructs |
| TWI311152B (en) | 2004-09-17 | 2009-06-21 | Boehringer Ingelheim Rcv Gmbh & Co K | Host-vector system for antibiotic-free cole1 plasmid propagation |
| US9018012B2 (en) | 2005-01-20 | 2015-04-28 | Nature Technology Corporation | Vectors and methods for genetic immunization |
| EP1921140B1 (en) | 2005-07-05 | 2011-12-14 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Mutant transposon vector and use thereof |
| US9017966B2 (en) | 2007-05-23 | 2015-04-28 | Nature Technology Corporation | E. coli plasmid DNA production |
| EP2152889B1 (en) * | 2007-05-29 | 2017-03-15 | Nature Technology Corporation | Vectors and methods for genetic immunization |
| ES2651911T3 (es) * | 2007-08-14 | 2018-01-30 | Commonwealth Scientific And Industrial Research Organisation | Métodos mejorados de silenciamiento génico |
| US9045759B2 (en) | 2009-01-21 | 2015-06-02 | James Arthur Williams | DNA plasmids with improved copy number |
| US9012226B2 (en) | 2009-03-13 | 2015-04-21 | Nature Technology Corporation | Bacterial strains with improved plasmid stability |
| US9506082B2 (en) | 2010-04-12 | 2016-11-29 | Nature Technology Corporation | Eukaryotic expression vectors resistant to transgene silencing |
| EP2788483B1 (en) * | 2011-12-07 | 2018-06-27 | Glenmark Pharmaceuticals S.A. | Expression cassette |
| US9550998B2 (en) * | 2012-08-29 | 2017-01-24 | Nature Technology Corporation | DNA plasmids with improved expression |
| US20150322439A1 (en) * | 2012-11-19 | 2015-11-12 | Nature Technology Corporation | Replicative minicircle vectors with improved expression |
| CA2914604A1 (en) * | 2013-06-06 | 2014-12-11 | Novartis Ag | Influenza virus reassortment |
| WO2017025447A1 (en) | 2015-08-10 | 2017-02-16 | Curevac Ag | Method of increasing the replication of a circular dna molecule |
| US11230720B2 (en) | 2015-10-14 | 2022-01-25 | Audentes Therapeutics, Inc. | Nucleic acid molecules containing spacers and methods of use thereof |
| WO2019183248A1 (en) | 2018-03-21 | 2019-09-26 | Nature Technology Corporation | Viral and non-viral nanoplasmid vectors with improved production |
| US20220042038A1 (en) * | 2018-12-20 | 2022-02-10 | Poseida Therapeutics, Inc. | Nanotransposon compositions and methods of use |
-
2019
- 2019-03-20 WO PCT/US2019/023209 patent/WO2019183248A1/en not_active Ceased
- 2019-03-20 EP EP19715345.5A patent/EP3768846B1/en active Active
- 2019-03-20 AU AU2019240068A patent/AU2019240068B2/en active Active
- 2019-03-20 SG SG11202009009UA patent/SG11202009009UA/en unknown
- 2019-03-20 DK DK19715345.5T patent/DK3768846T5/da active
- 2019-03-20 KR KR1020207030139A patent/KR20210016330A/ko not_active Ceased
- 2019-03-20 JP JP2020551263A patent/JP7520719B2/ja active Active
- 2019-03-20 FI FIEP19715345.5T patent/FI3768846T3/fi active
- 2019-03-20 LT LTEPPCT/US2019/023209T patent/LT3768846T/lt unknown
- 2019-03-20 CN CN201980034026.9A patent/CN112154208B/zh active Active
- 2019-03-20 EP EP22194460.6A patent/EP4151735A1/en active Pending
- 2019-03-20 CA CA3093346A patent/CA3093346A1/en active Pending
- 2019-03-20 CN CN202510450562.4A patent/CN120249340A/zh active Pending
- 2019-03-20 ES ES19715345T patent/ES2950736T3/es active Active
-
2020
- 2020-09-18 US US17/026,101 patent/US12600984B2/en active Active
-
2024
- 2024-07-10 JP JP2024110895A patent/JP2024138410A/ja active Pending
-
2025
- 2025-05-08 AU AU2025203312A patent/AU2025203312A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK3768846T5 (da) | 2024-08-19 |
| JP7520719B2 (ja) | 2024-07-23 |
| JP2021518150A (ja) | 2021-08-02 |
| US12600984B2 (en) | 2026-04-14 |
| EP4151735A1 (en) | 2023-03-22 |
| EP3768846B1 (en) | 2023-06-21 |
| DK3768846T3 (da) | 2023-07-24 |
| FI3768846T3 (fi) | 2023-06-30 |
| CA3093346A1 (en) | 2019-09-29 |
| JP2024138410A (ja) | 2024-10-08 |
| ES2950736T3 (es) | 2023-10-13 |
| AU2019240068B2 (en) | 2025-03-13 |
| SG11202009009UA (en) | 2020-10-29 |
| CN112154208B (zh) | 2025-04-15 |
| CN112154208A (zh) | 2020-12-29 |
| AU2019240068A1 (en) | 2020-10-01 |
| US20210010021A1 (en) | 2021-01-14 |
| AU2025203312A1 (en) | 2025-05-29 |
| WO2019183248A1 (en) | 2019-09-26 |
| KR20210016330A (ko) | 2021-02-15 |
| CN120249340A (zh) | 2025-07-04 |
| EP3768846A1 (en) | 2021-01-27 |
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