KR20210016330A - 생산성이 향상된 바이러스 및 비-바이러스 나노 플라스미드 벡터 - Google Patents

생산성이 향상된 바이러스 및 비-바이러스 나노 플라스미드 벡터 Download PDF

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KR20210016330A
KR20210016330A KR1020207030139A KR20207030139A KR20210016330A KR 20210016330 A KR20210016330 A KR 20210016330A KR 1020207030139 A KR1020207030139 A KR 1020207030139A KR 20207030139 A KR20207030139 A KR 20207030139A KR 20210016330 A KR20210016330 A KR 20210016330A
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replication
origin
seq
rna
vector
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제임스 에이. 윌리엄스
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네이쳐 테크놀로지 코포레이션
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KR1020207030139A 2018-03-21 2019-03-20 생산성이 향상된 바이러스 및 비-바이러스 나노 플라스미드 벡터 Ceased KR20210016330A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862645892P 2018-03-21 2018-03-21
US62/645,892 2018-03-21
PCT/US2019/023209 WO2019183248A1 (en) 2018-03-21 2019-03-20 Viral and non-viral nanoplasmid vectors with improved production

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KR20210016330A true KR20210016330A (ko) 2021-02-15

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KR1020207030139A Ceased KR20210016330A (ko) 2018-03-21 2019-03-20 생산성이 향상된 바이러스 및 비-바이러스 나노 플라스미드 벡터

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US (1) US12600984B2 (https=)
EP (2) EP3768846B1 (https=)
JP (2) JP7520719B2 (https=)
KR (1) KR20210016330A (https=)
CN (2) CN112154208B (https=)
AU (2) AU2019240068B2 (https=)
CA (1) CA3093346A1 (https=)
DK (1) DK3768846T5 (https=)
ES (1) ES2950736T3 (https=)
FI (1) FI3768846T3 (https=)
LT (1) LT3768846T (https=)
SG (1) SG11202009009UA (https=)
WO (1) WO2019183248A1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019183248A1 (en) * 2018-03-21 2019-09-26 Nature Technology Corporation Viral and non-viral nanoplasmid vectors with improved production
US20220042038A1 (en) * 2018-12-20 2022-02-10 Poseida Therapeutics, Inc. Nanotransposon compositions and methods of use
GB2700048B (en) 2019-09-18 2026-03-04 Aldevron Llc synthetic dna vectors and method of use
JP7833134B2 (ja) * 2020-03-11 2026-03-19 アルデブロン，エル．エル．シー． 細菌宿主株
CA3201499A1 (en) 2020-11-13 2022-05-19 Catamaran Bio, Inc. Genetically modified natural killer cells and methods of use thereof
CA3223292A1 (en) 2021-06-25 2022-12-29 Laura Van Lieshout Adeno-associated virus packaging systems
US20250114452A1 (en) 2021-08-04 2025-04-10 The Regents Of The University Of Colorado, A Body Corporate Lat activating chimeric antigen receptor t cells and methods of use thereof
CN114045305B (zh) * 2021-10-15 2023-03-24 深圳市深研生物科技有限公司 多转座子系统
WO2023114901A2 (en) 2021-12-15 2023-06-22 Oxford Biomedica Solutions Llc Methods and compositions for the production of adeno-associated virus
WO2023172514A1 (en) 2022-03-07 2023-09-14 Catamaran Bio, Inc. Engineered immune cell therapeutics targeted to her2 and methods of use thereof
US20250354159A1 (en) * 2022-06-13 2025-11-20 Nanjing GenScript Biotech Co., Ltd. Wild-type-mutant pi protein switching expression system capable of increasing efficiency of preparing screening-tag-free plasmid
JP2025525583A (ja) 2022-07-19 2025-08-05 ランパート バイオサイエンス インコーポレイテッド 非免疫原性環状非ウイルス性ｄｎａベクター
CN117305339B (zh) * 2023-11-30 2024-02-06 苏州左旋星生物科技有限公司 优化大肠杆菌基因编辑的载体及其应用
WO2025160245A1 (en) 2024-01-25 2025-07-31 Aldevron, L.L.C. Viral and non-viral nanoplasmid vectors with improved production
WO2025231315A2 (en) 2024-05-03 2025-11-06 Aldevron, L.L.C. Bacterial host strains
WO2026076187A1 (en) * 2024-10-03 2026-04-09 Aldevron, L.L.C. Compositions and methods for microbial production of antibiotic-free closed-ended linear dna

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04197185A (ja) * 1990-11-28 1992-07-16 Mitsui Toatsu Chem Inc 酵母発現ベクター及びこれを用いた誘導的発現
GB9506051D0 (en) * 1995-03-24 1995-05-10 Univ Singapore Gene expression
FR2738842B1 (fr) 1995-09-15 1997-10-31 Rhone Poulenc Rorer Sa Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique
US7279313B2 (en) 1995-09-15 2007-10-09 Centelion Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy
US5922583A (en) 1995-10-17 1999-07-13 Biostar Inc. Methods for production of recombinant plasmids
US6709844B1 (en) * 2000-11-16 2004-03-23 Mannkind Corporation Avoidance of undesirable replication intermediates in plasmid propagation
JP2004267001A (ja) * 2000-08-16 2004-09-30 Kansai Tlo Kk トランスジェニック哺乳動物及びその作製方法並びにこれを用いた遺伝子機能の解明方法
UY26317A1 (es) * 2000-08-30 2000-10-31 Alfonso Cayota Carlos Pritsch Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo
FR2821855B1 (fr) 2001-03-09 2004-04-02 Cayla Genes synthetiques et plasmides bacteriens depourvus de cpg
CA2794446C (en) * 2001-04-04 2015-09-08 Genencor International, Inc. Uncoupled productive and catabolic host cell pathways
US20060088837A1 (en) * 2002-04-26 2006-04-27 Kazunari Taira Expression system for stem-loop rna molecule having rnai effect
WO2005003359A1 (ja) * 2003-07-08 2005-01-13 Japan Science And Technology Corporation トランスジェニック生物を作製する方法およびシステム
GB0327056D0 (en) 2003-11-20 2003-12-24 Cobra Biolog Ltd Plasmid maintenance
MX2007001889A (es) 2004-08-19 2007-05-09 Nature Technology Corp Proceso para la fermentacion de adn de plasmido.
CA2577519A1 (en) * 2004-08-23 2006-03-30 Nucleonics, Inc. Multiple rna polymerase iii promoter expression constructs
TWI311152B (en) 2004-09-17 2009-06-21 Boehringer Ingelheim Rcv Gmbh & Co K Host-vector system for antibiotic-free cole1 plasmid propagation
US9018012B2 (en) 2005-01-20 2015-04-28 Nature Technology Corporation Vectors and methods for genetic immunization
EP1921140B1 (en) 2005-07-05 2011-12-14 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Mutant transposon vector and use thereof
US9017966B2 (en) 2007-05-23 2015-04-28 Nature Technology Corporation E. coli plasmid DNA production
EP2152889B1 (en) * 2007-05-29 2017-03-15 Nature Technology Corporation Vectors and methods for genetic immunization
ES2651911T3 (es) * 2007-08-14 2018-01-30 Commonwealth Scientific And Industrial Research Organisation Métodos mejorados de silenciamiento génico
US9045759B2 (en) 2009-01-21 2015-06-02 James Arthur Williams DNA plasmids with improved copy number
US9012226B2 (en) 2009-03-13 2015-04-21 Nature Technology Corporation Bacterial strains with improved plasmid stability
US9506082B2 (en) 2010-04-12 2016-11-29 Nature Technology Corporation Eukaryotic expression vectors resistant to transgene silencing
EP2788483B1 (en) * 2011-12-07 2018-06-27 Glenmark Pharmaceuticals S.A. Expression cassette
US9550998B2 (en) * 2012-08-29 2017-01-24 Nature Technology Corporation DNA plasmids with improved expression
US20150322439A1 (en) * 2012-11-19 2015-11-12 Nature Technology Corporation Replicative minicircle vectors with improved expression
CA2914604A1 (en) * 2013-06-06 2014-12-11 Novartis Ag Influenza virus reassortment
WO2017025447A1 (en) 2015-08-10 2017-02-16 Curevac Ag Method of increasing the replication of a circular dna molecule
US11230720B2 (en) 2015-10-14 2022-01-25 Audentes Therapeutics, Inc. Nucleic acid molecules containing spacers and methods of use thereof
WO2019183248A1 (en) 2018-03-21 2019-09-26 Nature Technology Corporation Viral and non-viral nanoplasmid vectors with improved production
US20220042038A1 (en) * 2018-12-20 2022-02-10 Poseida Therapeutics, Inc. Nanotransposon compositions and methods of use

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Publication number Publication date
DK3768846T5 (da) 2024-08-19
JP7520719B2 (ja) 2024-07-23
JP2021518150A (ja) 2021-08-02
US12600984B2 (en) 2026-04-14
EP4151735A1 (en) 2023-03-22
EP3768846B1 (en) 2023-06-21
DK3768846T3 (da) 2023-07-24
LT3768846T (lt) 2023-08-10
FI3768846T3 (fi) 2023-06-30
CA3093346A1 (en) 2019-09-29
JP2024138410A (ja) 2024-10-08
ES2950736T3 (es) 2023-10-13
AU2019240068B2 (en) 2025-03-13
SG11202009009UA (en) 2020-10-29
CN112154208B (zh) 2025-04-15
CN112154208A (zh) 2020-12-29
AU2019240068A1 (en) 2020-10-01
US20210010021A1 (en) 2021-01-14
AU2025203312A1 (en) 2025-05-29
WO2019183248A1 (en) 2019-09-26
CN120249340A (zh) 2025-07-04
EP3768846A1 (en) 2021-01-27

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