LT3675B - Indenoindole copounds ii, process for preraring them and pharmaceutical composition containing them - Google Patents

Indenoindole copounds ii, process for preraring them and pharmaceutical composition containing them Download PDF

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Publication number
LT3675B
LT3675B LTIP912A LTIP912A LT3675B LT 3675 B LT3675 B LT 3675B LT IP912 A LTIP912 A LT IP912A LT IP912 A LTIP912 A LT IP912A LT 3675 B LT3675 B LT 3675B
Authority
LT
Lithuania
Prior art keywords
tetrahydro
indole
cis
formula
thii
Prior art date
Application number
LTIP912A
Other languages
English (en)
Lithuanian (lt)
Inventor
Malcolm Sainsbury
Howard G Shertzer
Original Assignee
Univ Bath
Univ Cincinnati
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bath, Univ Cincinnati filed Critical Univ Bath
Publication of LTIP912A publication Critical patent/LTIP912A/xx
Publication of LT3675B publication Critical patent/LT3675B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
LTIP912A 1989-06-22 1993-08-30 Indenoindole copounds ii, process for preraring them and pharmaceutical composition containing them LT3675B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8902274A SE8902274D0 (sv) 1989-06-22 1989-06-22 Indenoidole compounds ii

Publications (2)

Publication Number Publication Date
LTIP912A LTIP912A (en) 1995-03-27
LT3675B true LT3675B (en) 1996-01-25

Family

ID=20376370

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP912A LT3675B (en) 1989-06-22 1993-08-30 Indenoindole copounds ii, process for preraring them and pharmaceutical composition containing them

Country Status (34)

Country Link
EP (1) EP0409410B1 (fr)
JP (1) JP3064411B2 (fr)
KR (1) KR920702679A (fr)
CN (1) CN1033029C (fr)
AT (1) ATE135688T1 (fr)
BG (1) BG60317B2 (fr)
CA (1) CA2060897A1 (fr)
DD (1) DD297960A5 (fr)
DE (1) DE69025998T2 (fr)
DK (1) DK0409410T3 (fr)
DZ (1) DZ1428A1 (fr)
ES (1) ES2084660T3 (fr)
FI (1) FI100800B (fr)
GR (1) GR3019779T3 (fr)
HR (1) HRP920903B1 (fr)
HU (1) HUT59097A (fr)
IE (1) IE74682B1 (fr)
IL (1) IL94830A (fr)
IS (1) IS3590A7 (fr)
LT (1) LT3675B (fr)
LV (1) LV10253B (fr)
MX (1) MX21244A (fr)
MY (1) MY107311A (fr)
NO (1) NO177932C (fr)
NZ (1) NZ234175A (fr)
PL (1) PL167761B1 (fr)
PT (1) PT94468B (fr)
RO (1) RO111573B1 (fr)
RU (1) RU2104270C1 (fr)
SE (1) SE8902274D0 (fr)
SI (1) SI9011223B (fr)
WO (1) WO1990015799A1 (fr)
YU (1) YU122390A (fr)
ZA (1) ZA904827B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT67274A (en) * 1990-10-16 1995-03-28 Univ Bath Process for producing of tetrahydroindenoindoles and farmaceutical composition comprising them
JPH0656669A (ja) * 1992-06-11 1994-03-01 Asahi Breweries Ltd 活性酸素消去作用を持つプテリン誘導体製剤
SE9302431D0 (sv) * 1993-07-16 1993-07-16 Ab Astra Use of indenoindole compounds
CA2128283A1 (fr) * 1993-07-20 1995-01-21 Paul Caubere (thia)cycloalkyl¬b|indoles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2350590A1 (fr) * 1998-12-04 2000-06-15 John A. Butera Indenoindoles et benzofuranoindoles substitues utilises comme nouveaux elements d'ouverture de canaux potassiques
US6288099B1 (en) 1998-12-04 2001-09-11 American Home Products Corporation Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers
FR2826009B1 (fr) * 2001-06-13 2003-08-15 Servier Lab Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP5132554B2 (ja) 2005-07-14 2013-01-30 アイアールエム・リミテッド・ライアビリティ・カンパニー Ｔｐｏ模倣剤としてのヘテロ四環化合物
DE102006047231B4 (de) * 2006-10-04 2009-02-12 Hemmerling, Hans-Jörg, Dr. Substituierte Indeno[1,2-b]indolderivate als neue Hemmstoffe der Protein Kinase CK2 und ihre Verwendung als Tumor Therapeutika, Cytostatika und Diagnostika
CA2984974C (fr) * 2011-06-16 2021-08-24 Korea Research Institute Of Chemical Technology Derives d'indenoindole, sels pharmaceutiquement acceptables ou isomeres optiques de ceux-ci, leur procede de preparation et compositions pharmaceutiques les contenant en tant que principe actif pour la prevention ou le traitement de maladies virales
JP6293168B2 (ja) 2012-12-14 2018-03-14 コーリア リサーチ インスティテュート オブ ケミカル テクノロジー 新規の化合物、その薬学的に許容可能な塩又は光学異性体、それを作製する方法、及びそれを有効成分として含有するウイルス疾患の予防又は治療用の医薬組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A.G. ANASTASSIOU ET AL.: "Generation and thermal reorganization of a linearly-fused N-methyldibenzoazocinyl anion", J. CHEM. SOC., CHEM. COMMUN., 1981, pages 647 - 648

Also Published As

Publication number Publication date
WO1990015799A1 (fr) 1990-12-27
EP0409410A1 (fr) 1991-01-23
PT94468B (pt) 1997-12-31
IE902247A1 (en) 1991-01-16
FI915999A0 (fi) 1991-12-19
RO111573B1 (ro) 1996-11-29
ATE135688T1 (de) 1996-04-15
IL94830A (en) 1996-07-23
DD297960A5 (de) 1992-01-30
IE74682B1 (en) 1997-07-30
HRP920903A2 (hr) 1994-04-30
SE8902274D0 (sv) 1989-06-22
KR920702679A (ko) 1992-10-06
SI9011223B (sl) 1998-08-31
BG60317B2 (bg) 1994-07-25
IS3590A7 (is) 1990-12-23
LV10253A (lv) 1994-10-20
MX21244A (es) 1994-03-31
RU2104270C1 (ru) 1998-02-10
YU122390A (sh) 1992-09-07
ES2084660T3 (es) 1996-05-16
NO177932B (no) 1995-09-11
DK0409410T3 (da) 1996-04-29
LTIP912A (en) 1995-03-27
SI9011223A (en) 1997-10-31
FI100800B (fi) 1998-02-27
HRP920903B1 (en) 1998-06-30
DE69025998D1 (de) 1996-04-25
NO177932C (no) 1995-12-20
IE902247L (en) 1990-12-22
PT94468A (pt) 1991-02-08
JPH04505923A (ja) 1992-10-15
EP0409410B1 (fr) 1996-03-20
NZ234175A (en) 1992-12-23
DZ1428A1 (fr) 2004-09-13
IL94830A0 (en) 1991-04-15
HUT59097A (en) 1992-04-28
ZA904827B (en) 1991-04-24
PL167761B1 (pl) 1995-10-31
AU644084B2 (en) 1993-12-02
AU5836990A (en) 1991-01-08
PL285752A1 (en) 1991-03-11
LV10253B (en) 1995-04-20
CA2060897A1 (fr) 1990-12-23
NO915049L (no) 1992-02-21
CN1051554A (zh) 1991-05-22
GR3019779T3 (en) 1996-07-31
JP3064411B2 (ja) 2000-07-12
DE69025998T2 (de) 1996-08-08
MY107311A (en) 1995-11-30
HU904825D0 (en) 1992-03-30
NO915049D0 (no) 1991-12-20
CN1033029C (zh) 1996-10-16

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Effective date: 19980830