LT3118B - Novel, biologically active eburnamenine derivatives and a process for preparing the same - Google Patents

Novel, biologically active eburnamenine derivatives and a process for preparing the same Download PDF

Info

Publication number
LT3118B
LT3118B LTIP599A LTIP599A LT3118B LT 3118 B LT3118 B LT 3118B LT IP599 A LTIP599 A LT IP599A LT IP599 A LTIP599 A LT IP599A LT 3118 B LT3118 B LT 3118B
Authority
LT
Lithuania
Prior art keywords
formula
piperazine
meanings
amino
eburnamenine
Prior art date
Application number
LTIP599A
Other languages
English (en)
Lithuanian (lt)
Inventor
Zoltan Tuba
Sandor Maho
Aniko Gere
Pal Vittay
Bela Kiss
Eva Palosi
Lazlo Szporny
Csaba Szantay
Ferenc Soti
Zsuzsa Balogh
Maria Incze
Gabor Balogh
Maria Gazdag
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of LTIP599A publication Critical patent/LTIP599A/xx
Publication of LT3118B publication Critical patent/LT3118B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
LTIP599A 1992-06-09 1993-06-02 Novel, biologically active eburnamenine derivatives and a process for preparing the same LT3118B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9201911A HU209678B (en) 1992-06-09 1992-06-09 Process for producing biologically active eburnamenin-14-carbonyl-amino derivatives and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
LTIP599A LTIP599A (en) 1994-07-15
LT3118B true LT3118B (en) 1994-12-27

Family

ID=10982021

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP599A LT3118B (en) 1992-06-09 1993-06-02 Novel, biologically active eburnamenine derivatives and a process for preparing the same

Country Status (18)

Country Link
US (1) US5510345A (ko)
EP (1) EP0644885A1 (ko)
JP (1) JPH07507793A (ko)
KR (1) KR950701924A (ko)
AU (1) AU4352493A (ko)
CA (1) CA2136547A1 (ko)
CZ (1) CZ307994A3 (ko)
EE (1) EE9400070A (ko)
FI (1) FI945780A0 (ko)
GR (1) GR1001597B (ko)
HR (1) HRP930957A2 (ko)
HU (1) HU209678B (ko)
IL (1) IL105942A0 (ko)
LT (1) LT3118B (ko)
NZ (1) NZ253308A (ko)
SI (1) SI9300309A (ko)
WO (1) WO1993025550A1 (ko)
ZA (1) ZA934037B (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1799664A1 (en) 2004-09-20 2007-06-27 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
BRPI0515505A (pt) 2004-09-20 2008-07-29 Xenon Pharmaceuticals Inc derivados heterocìclicos e sua utilização como inibidores da estearoil-coa desaturase
EP1799668A1 (en) 2004-09-20 2007-06-27 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase
TW200626138A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
CA2580845A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
CA2580787A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
CA2580857A1 (en) 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
US7820654B2 (en) * 2004-09-23 2010-10-26 Dr. Reddy's Laboratories Ltd. Pyrimidine compounds, process for their preparation and compositions containing them
US8541457B2 (en) 2005-06-03 2013-09-24 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors
EP2276750A2 (en) * 2008-03-27 2011-01-26 Auckland Uniservices Limited Substituted pyrimidines and triazines and their use in cancer therapy
CN101928286A (zh) * 2009-06-18 2010-12-29 谢开智 长春胺衍生物及制备方法
ES2753386T3 (es) 2013-03-13 2020-04-08 Forma Therapeutics Inc Derivados de 2-hidroxi-1-{4-[(4-fenil)fenil]carbonil}piperazin-1-il}etano-1-ona y compuestos relacionados como inhibidores de sintasa de ácido graso (FASN) para el tratamiento del cáncer
WO2017210545A1 (en) 2016-06-02 2017-12-07 Cadent Therapeutics, Inc. Potassium channel modulators
SG11201905893WA (en) 2017-01-23 2019-08-27 Cadent Therapeutics Inc Potassium channel modulators
MX2021004647A (es) 2018-10-22 2021-08-16 Novartis Ag Formas cristalinas de moduladores de los canales de potasio.
CN113382633A (zh) 2018-10-29 2021-09-10 福马治疗股份有限公司 (4-(2-氟-4-(1-甲基-1H-苯并[d]咪唑-5-基)苯甲酰基)哌嗪-1-基)(1-羟基环丙基)甲酮的固体形式

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001706A2 (en) 1985-09-12 1987-03-26 The Upjohn Company C20 through c26 amino steroids
WO1987007895A1 (en) 1986-06-23 1987-12-30 The Upjohn Company Androstane-type and cortical aminoesters
WO1988007527A1 (en) 1987-04-03 1988-10-06 The Upjohn Company Amino-9,10-secosteroids
WO1988008424A1 (en) 1987-04-27 1988-11-03 The Upjohn Company Pharmaceutically active amines
WO1991011453A2 (en) 1990-01-26 1991-08-08 The Upjohn Company 5-oxygenated-2,4,6-triaminopyrimidines
EP0389370B1 (fr) 1989-03-22 1994-04-27 Roussel-Uclaf Nouveaux stéroides 19-Nor 3-céto comportant une chaîne en 17 aminosubstituée, leur procédé de préparation et les intermédiaires de ce procédé,leur application comme médicaments et les compositions pharmaceutiques les contenant
EP0389369B1 (fr) 1989-03-22 1994-11-09 Roussel-Uclaf Nouveaux stéroides 3-céto comportant une chaîne en 17 aminosubstituée, leur procédé de préparation et les intermédiaires de ce procédé, leur application comme médicaments et les compositions les contenant
EP0389368B1 (fr) 1989-03-22 1997-01-29 Roussel Uclaf Nouveaux dérivés de la 6-(1-pipérazinyl) 2,5-pyridine diamine N,N,N',N'-substituée, leur procédé de préparation et les intermédiaires de ce procédé, leur application comme médicaments et les compositions pharmaceutiques les renfermant

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2176516B1 (ko) * 1972-03-22 1975-03-14 Synthelabo
HU171663B (hu) * 1975-09-01 1978-02-28 Richter Gedeon Vegyeszet Sposob poluchenija novykh proizvodnykh 14-skobka-zamehhennogo metil-skobka zakryta-vinkana
US4547505A (en) * 1983-03-25 1985-10-15 Degussa Aktiengesellschaft N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production
US5099019A (en) * 1985-09-12 1992-03-24 Upjohn Company Amines useful in producing pharmaceutically active CNS compounds

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001706A2 (en) 1985-09-12 1987-03-26 The Upjohn Company C20 through c26 amino steroids
WO1987007895A1 (en) 1986-06-23 1987-12-30 The Upjohn Company Androstane-type and cortical aminoesters
WO1988007527A1 (en) 1987-04-03 1988-10-06 The Upjohn Company Amino-9,10-secosteroids
WO1988008424A1 (en) 1987-04-27 1988-11-03 The Upjohn Company Pharmaceutically active amines
EP0389370B1 (fr) 1989-03-22 1994-04-27 Roussel-Uclaf Nouveaux stéroides 19-Nor 3-céto comportant une chaîne en 17 aminosubstituée, leur procédé de préparation et les intermédiaires de ce procédé,leur application comme médicaments et les compositions pharmaceutiques les contenant
EP0389369B1 (fr) 1989-03-22 1994-11-09 Roussel-Uclaf Nouveaux stéroides 3-céto comportant une chaîne en 17 aminosubstituée, leur procédé de préparation et les intermédiaires de ce procédé, leur application comme médicaments et les compositions les contenant
EP0389368B1 (fr) 1989-03-22 1997-01-29 Roussel Uclaf Nouveaux dérivés de la 6-(1-pipérazinyl) 2,5-pyridine diamine N,N,N',N'-substituée, leur procédé de préparation et les intermédiaires de ce procédé, leur application comme médicaments et les compositions pharmaceutiques les renfermant
WO1991011453A2 (en) 1990-01-26 1991-08-08 The Upjohn Company 5-oxygenated-2,4,6-triaminopyrimidines

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. LUNEC IR KT.: "Celluar antioxidant defence mechanisms", pages: 143 - 159
J.FEHER A. VERECKEI: "The impportance oof free radical reactions in the medicine", pages: 99 - 104

Also Published As

Publication number Publication date
US5510345A (en) 1996-04-23
ZA934037B (en) 1994-01-06
WO1993025550A1 (en) 1993-12-23
AU4352493A (en) 1994-01-04
SI9300309A (sl) 1993-12-31
HU9201911D0 (en) 1992-09-28
NZ253308A (en) 1995-11-27
CZ307994A3 (en) 1995-07-12
CA2136547A1 (en) 1993-12-23
GR1001597B (el) 1994-06-30
KR950701924A (ko) 1995-05-17
JPH07507793A (ja) 1995-08-31
HRP930957A2 (en) 1995-02-28
FI945780A (fi) 1994-12-08
LTIP599A (en) 1994-07-15
EP0644885A1 (en) 1995-03-29
HU209678B (en) 1994-10-28
IL105942A0 (en) 1993-10-20
FI945780A0 (fi) 1994-12-08
EE9400070A (et) 1995-12-15
HUT64540A (en) 1994-01-28

Similar Documents

Publication Publication Date Title
LT3118B (en) Novel, biologically active eburnamenine derivatives and a process for preparing the same
EP0633886B1 (en) Pharmaceutically active bicyclic-heterocyclic amines
US5506354A (en) Imidazolylpiperazinyl steroids
EP0207901B1 (en) Antianaphylactic and antibronchospastic n-benzhydryldiazacycloalkylalkananilides
US5589477A (en) Pyrimidine derivatives and drugs
US5380724A (en) Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing same
JP2000516602A (ja) 置換ピリミジン誘導体および薬剤としてのそれらの使用
BR112020019939A2 (pt) Compostos de pirazol substituídos com heteroarila e seu uso farmacêutico
US5547949A (en) Steroids with pregnane skeleton, pharmaceutical compositions containing them
CS262690B2 (en) Process for preparing 1-/hydroxystyryl/-5h-2,3-benzodiazepines
FI80455B (fi) Foerfarande foer framstaellning av farmakologiskt vaerdefulla 8-alkyltio-2-piperazino-pyrimido/5,4-d/pyrimider.
US5550240A (en) Piperazinyl-bis(alkylamino)pyrimidine derivatives and process for preparing same
US5099019A (en) Amines useful in producing pharmaceutically active CNS compounds
EP0425669B1 (en) 1-amino-5-halogenouracils, process for their preparation, and central nervous system depressants containing same as active ingredient
EP0852226A1 (en) Pyrimidine derivatives
SK13762003A3 (sk) Deriváty 5-tio-beta-D-xylopyranozidov, spôsob ich prípravy, farmaceutické kompozície tieto deriváty obsahujúce a ich terapeutické použitie
EP1645556A1 (en) Arylpiperazine-benzoylamide derivatives useful as pharmaceutical agents
US5268477A (en) Triazinylpiperazinyl amine intermediates
US5322943A (en) Piperazine compounds which are substituted
DK175347B1 (da) Aminosubstitueret steroid, Delta9(11)-steroid og amin samt farmaceutisk acceptable salte, hydrater og solvater deraf
JP2852538B2 (ja) 〔１，２，４〕トリアゾロ〔１，５―ａ〕ピリミジン誘導体
US6346620B1 (en) Methods for preparation of 2-(4-(4-(4,5-dichloro-2-methylimidazol-1-yl)butyl)-1-piperazinyl)-5-fluoropyrimidine and salts thereof
LT3071B (en) Novel steroids with pregnane skeleton,pharmaceutical compositions containing them and process for preparing thereof
EP0806422A2 (en) Anti-cataract agent
USRE35053E (en) Amines useful in producing pharmaceutically active CNS compounds

Legal Events

Date Code Title Description
MM9A Lapsed patents

Effective date: 19960602