LT3072B - Renin inhibiting n-(2-amino-2-oxoethyl)butanediamide derivatives - Google Patents

Renin inhibiting n-(2-amino-2-oxoethyl)butanediamide derivatives Download PDF

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Publication number
LT3072B
LT3072B LTIP1092A LTIP1092A LT3072B LT 3072 B LT3072 B LT 3072B LT IP1092 A LTIP1092 A LT IP1092A LT IP1092 A LTIP1092 A LT IP1092A LT 3072 B LT3072 B LT 3072B
Authority
LT
Lithuania
Prior art keywords
methyl
cyclohexylmethyl
dihydroxy
oxoethyl
amino
Prior art date
Application number
LTIP1092A
Other languages
English (en)
Lithuanian (lt)
Inventor
Pierre Lavallee
Bruno Simoneau
Original Assignee
Bio Mega Boehringer Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Mega Boehringer Ingelheim filed Critical Bio Mega Boehringer Ingelheim
Publication of LTIP1092A publication Critical patent/LTIP1092A/xx
Publication of LT3072B publication Critical patent/LT3072B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
LTIP1092A 1992-09-25 1993-09-23 Renin inhibiting n-(2-amino-2-oxoethyl)butanediamide derivatives LT3072B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95147892A 1992-09-25 1992-09-25

Publications (2)

Publication Number Publication Date
LTIP1092A LTIP1092A (en) 1994-05-15
LT3072B true LT3072B (en) 1994-11-25

Family

ID=25491725

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1092A LT3072B (en) 1992-09-25 1993-09-23 Renin inhibiting n-(2-amino-2-oxoethyl)butanediamide derivatives

Country Status (29)

Country Link
US (2) US5541163A (pt)
EP (1) EP0589445B1 (pt)
JP (1) JP3490442B2 (pt)
KR (1) KR950703520A (pt)
CN (1) CN1090278A (pt)
AT (1) ATE147720T1 (pt)
AU (1) AU680829B2 (pt)
BG (1) BG99542A (pt)
BR (1) BR9307110A (pt)
CA (1) CA2143300C (pt)
CO (1) CO4560549A1 (pt)
CZ (1) CZ74895A3 (pt)
DE (1) DE69307446T2 (pt)
EE (1) EE03083B1 (pt)
FI (1) FI951398A0 (pt)
HU (2) HUT70432A (pt)
IL (1) IL107092A (pt)
LT (1) LT3072B (pt)
LV (1) LV10945B (pt)
MX (1) MX9305918A (pt)
NO (1) NO951133L (pt)
NZ (1) NZ255301A (pt)
PH (1) PH30881A (pt)
PL (1) PL174454B1 (pt)
RU (1) RU95113586A (pt)
SK (1) SK37695A3 (pt)
TW (1) TW239117B (pt)
WO (1) WO1994007846A1 (pt)
ZA (1) ZA937079B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9307111A (pt) * 1992-09-25 1999-06-15 Boehringer Ingelheim Ca Ltd Derivados de n-(hidroxietil) butanodiamida como inibidores de renina
CA2165996C (en) * 1995-12-22 2002-01-29 Murray Douglas Bailey Stereoselective preparation of 2-substituted succinic derivatives
US6096759A (en) 1997-09-19 2000-08-01 Georgetown University Method for treating essential hypertension
WO2005037317A2 (en) * 2003-10-17 2005-04-28 Cornell Research Foundation, Inc. Mast cell-derived renin
US10517839B2 (en) * 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0278158A2 (en) 1986-11-12 1988-08-17 Merck & Co. Inc. Renin inhibitors containing phenylalanyl-histidine replacements
US4839357A (en) 1987-10-02 1989-06-13 Merck & Co., Inc. Renin inhibitors containing phenylalanyl-histidine replacements
EP0402646A1 (en) 1989-05-23 1990-12-19 Abbott Laboratories Retroviral protease inhibiting compounds
CA2025093A1 (en) 1989-09-12 1991-03-13 Holger Heitsch Amino acid derivatives with renin-inhibiting properties, a process for the preparation thereof, agents containing these, and the use thereof
US5001113A (en) 1987-10-14 1991-03-19 Merck & Co., Inc. Di- or tripeptide renin inhibitors containing lactam conformational restriction in ACHPA

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5006511A (en) * 1981-10-14 1991-04-09 Merck & Co., Inc. Di- or tripeptide renin inhibitors containing lactam conformational restriction in achpa
EP0312283A3 (en) * 1987-10-14 1990-05-09 Merck & Co. Inc. Di-or tripeptide renin inhibitors containing lactam conformational restrictions in achpa
US5055466A (en) * 1987-11-23 1991-10-08 E. R. Squibb & Sons, Inc. N-morpholino derivatives and their use as anti-hypertensive agents
CA1329680C (en) * 1987-11-23 1994-05-17 Harold Norris Weller, Iii N-heterocyclic alcohol derivatives
EP0349922A3 (en) * 1988-07-01 1991-08-21 G.D. Searle & Co. Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents
IE902446A1 (en) * 1989-07-26 1991-02-13 Abbott Lab Peptidyl aminodiol renin inhibitors
US5063208A (en) * 1989-07-26 1991-11-05 Abbott Laboratories Peptidyl aminodiol renin inhibitors
JPH0532602A (ja) * 1991-07-26 1993-02-09 Terumo Corp ナフチルメチルアミン誘導体及びこれを含有するレニン阻害剤

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0278158A2 (en) 1986-11-12 1988-08-17 Merck & Co. Inc. Renin inhibitors containing phenylalanyl-histidine replacements
US4839357A (en) 1987-10-02 1989-06-13 Merck & Co., Inc. Renin inhibitors containing phenylalanyl-histidine replacements
US5001113A (en) 1987-10-14 1991-03-19 Merck & Co., Inc. Di- or tripeptide renin inhibitors containing lactam conformational restriction in ACHPA
EP0402646A1 (en) 1989-05-23 1990-12-19 Abbott Laboratories Retroviral protease inhibiting compounds
CA2025093A1 (en) 1989-09-12 1991-03-13 Holger Heitsch Amino acid derivatives with renin-inhibiting properties, a process for the preparation thereof, agents containing these, and the use thereof

Also Published As

Publication number Publication date
NO951133L (no) 1995-05-24
IL107092A (en) 1997-09-30
HU211315A9 (en) 1995-11-28
FI951398A7 (fi) 1995-03-24
IL107092A0 (en) 1993-12-28
FI951398L (fi) 1995-03-24
NZ255301A (en) 1997-05-26
CN1090278A (zh) 1994-08-03
LV10945B (en) 1996-06-20
US5541163A (en) 1996-07-30
BG99542A (bg) 1995-12-29
DE69307446T2 (de) 1997-05-15
PL308180A1 (en) 1995-07-24
US5693619A (en) 1997-12-02
CO4560549A1 (es) 1998-02-10
RU95113586A (ru) 1997-01-10
TW239117B (pt) 1995-01-21
LTIP1092A (en) 1994-05-15
DE69307446D1 (de) 1997-02-27
KR950703520A (ko) 1995-09-20
ATE147720T1 (de) 1997-02-15
BR9307110A (pt) 1999-03-30
PH30881A (en) 1997-12-23
HUT70432A (en) 1995-10-30
CA2143300C (en) 1998-04-21
JP3490442B2 (ja) 2004-01-26
FI951398A0 (fi) 1995-03-24
ZA937079B (en) 1994-06-06
AU680829B2 (en) 1997-08-14
MX9305918A (es) 1994-05-31
EE03083B1 (et) 1998-04-15
WO1994007846A1 (en) 1994-04-14
PL174454B1 (pl) 1998-07-31
JPH08501567A (ja) 1996-02-20
EP0589445A1 (en) 1994-03-30
HU9500871D0 (en) 1995-05-29
NO951133D0 (no) 1995-03-24
AU4940393A (en) 1994-04-26
CZ74895A3 (en) 1995-12-13
SK37695A3 (en) 1995-07-11
EP0589445B1 (en) 1997-01-15
LV10945A (lv) 1995-12-20
CA2143300A1 (en) 1994-04-14

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Legal Events

Date Code Title Description
PD9A Change of patent owner

Free format text: BOEHRINGER INGELHEIM (CANADA) LTD.,2100, RUE CUNARD, LAVAL (QUEBEC), H7S 2G5,CA,19971215

MM9A Lapsed patents

Effective date: 19930923