ATE147720T1 - Renin inhibierende n-(2-amino-2-oxoethyl)- butandiamid-derivate - Google Patents

Renin inhibierende n-(2-amino-2-oxoethyl)- butandiamid-derivate

Info

Publication number
ATE147720T1
ATE147720T1 AT93115326T AT93115326T ATE147720T1 AT E147720 T1 ATE147720 T1 AT E147720T1 AT 93115326 T AT93115326 T AT 93115326T AT 93115326 T AT93115326 T AT 93115326T AT E147720 T1 ATE147720 T1 AT E147720T1
Authority
AT
Austria
Prior art keywords
alkyl
amino
butadiamide
oxoethyl
derivatives
Prior art date
Application number
AT93115326T
Other languages
English (en)
Inventor
Pierre Lavallee
Bruno Simoneau
Original Assignee
Bio Mega Boehringer Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Mega Boehringer Ingelheim filed Critical Bio Mega Boehringer Ingelheim
Application granted granted Critical
Publication of ATE147720T1 publication Critical patent/ATE147720T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182Radicals derived from carboxylic acids
    • C07D295/185Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215Radicals derived from nitrogen analogues of carbonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pyridine Compounds (AREA)
AT93115326T 1992-09-25 1993-09-23 Renin inhibierende n-(2-amino-2-oxoethyl)- butandiamid-derivate ATE147720T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95147892A 1992-09-25 1992-09-25

Publications (1)

Publication Number Publication Date
ATE147720T1 true ATE147720T1 (de) 1997-02-15

Family

ID=25491725

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93115326T ATE147720T1 (de) 1992-09-25 1993-09-23 Renin inhibierende n-(2-amino-2-oxoethyl)- butandiamid-derivate

Country Status (29)

Country Link
US (2) US5541163A (de)
EP (1) EP0589445B1 (de)
JP (1) JP3490442B2 (de)
KR (1) KR950703520A (de)
CN (1) CN1090278A (de)
AT (1) ATE147720T1 (de)
AU (1) AU680829B2 (de)
BG (1) BG99542A (de)
BR (1) BR9307110A (de)
CA (1) CA2143300C (de)
CO (1) CO4560549A1 (de)
CZ (1) CZ74895A3 (de)
DE (1) DE69307446T2 (de)
EE (1) EE03083B1 (de)
FI (1) FI951398A (de)
HU (2) HUT70432A (de)
IL (1) IL107092A (de)
LT (1) LT3072B (de)
LV (1) LV10945B (de)
MX (1) MX9305918A (de)
NO (1) NO951133L (de)
NZ (1) NZ255301A (de)
PH (1) PH30881A (de)
PL (1) PL174454B1 (de)
RU (1) RU95113586A (de)
SK (1) SK37695A3 (de)
TW (1) TW239117B (de)
WO (1) WO1994007846A1 (de)
ZA (1) ZA937079B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9307111A (pt) * 1992-09-25 1999-06-15 Boehringer Ingelheim Ca Ltd Derivados de n-(hidroxietil) butanodiamida como inibidores de renina
CA2165996C (en) * 1995-12-22 2002-01-29 Murray Douglas Bailey Stereoselective preparation of 2-substituted succinic derivatives
US6096759A (en) * 1997-09-19 2000-08-01 Georgetown University Method for treating essential hypertension
WO2005037317A2 (en) * 2003-10-17 2005-04-28 Cornell Research Foundation, Inc. Mast cell-derived renin
US10517839B2 (en) * 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142056A (en) 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
US5006511A (en) * 1981-10-14 1991-04-09 Merck & Co., Inc. Di- or tripeptide renin inhibitors containing lactam conformational restriction in achpa
EP0278158A3 (de) 1986-11-12 1990-05-23 Merck & Co. Inc. Renin-Inhibitoren enthaltende Phenylalanin-Histidin-Stellvertreter
US4839357A (en) 1987-10-02 1989-06-13 Merck & Co., Inc. Renin inhibitors containing phenylalanyl-histidine replacements
EP0312283A3 (de) * 1987-10-14 1990-05-09 Merck & Co. Inc. Di- oder Tripeptid-Renin-Inhibitoren, die Lactam-Konformationsrestriktion in ACHPA enthalten
US5001113A (en) 1987-10-14 1991-03-19 Merck & Co., Inc. Di- or tripeptide renin inhibitors containing lactam conformational restriction in ACHPA
US5055466A (en) * 1987-11-23 1991-10-08 E. R. Squibb & Sons, Inc. N-morpholino derivatives and their use as anti-hypertensive agents
CA1329680C (en) * 1987-11-23 1994-05-17 Harold Norris Weller, Iii N-heterocyclic alcohol derivatives
NO892728L (no) * 1988-07-01 1990-01-02 Searle & Co Aminoalkyl-aminokarbonyl-aminodiolaminosyre derivater somanti-hypertensive midler.
IE902446A1 (en) * 1989-07-26 1991-02-13 Abbott Lab Peptidyl aminodiol renin inhibitors
US5063208A (en) * 1989-07-26 1991-11-05 Abbott Laboratories Peptidyl aminodiol renin inhibitors
ES2086341T3 (es) * 1989-09-12 1996-07-01 Hoechst Ag Derivados de aminoacidos con propiedades inhibidoras de la renina, procedimiento para su preparacion, agentes que los contienen y su utilizacion.
JPH0532602A (ja) * 1991-07-26 1993-02-09 Terumo Corp ナフチルメチルアミン誘導体及びこれを含有するレニン阻害剤

Also Published As

Publication number Publication date
BG99542A (bg) 1995-12-29
CA2143300A1 (en) 1994-04-14
WO1994007846A1 (en) 1994-04-14
RU95113586A (ru) 1997-01-10
PL174454B1 (pl) 1998-07-31
BR9307110A (pt) 1999-03-30
ZA937079B (en) 1994-06-06
LT3072B (en) 1994-11-25
NZ255301A (en) 1997-05-26
NO951133D0 (no) 1995-03-24
SK37695A3 (en) 1995-07-11
FI951398A0 (fi) 1995-03-24
JP3490442B2 (ja) 2004-01-26
EP0589445B1 (de) 1997-01-15
IL107092A (en) 1997-09-30
FI951398A (fi) 1995-03-24
US5693619A (en) 1997-12-02
EP0589445A1 (de) 1994-03-30
TW239117B (de) 1995-01-21
AU4940393A (en) 1994-04-26
MX9305918A (es) 1994-05-31
CN1090278A (zh) 1994-08-03
LTIP1092A (en) 1994-05-15
HU9500871D0 (en) 1995-05-29
JPH08501567A (ja) 1996-02-20
DE69307446T2 (de) 1997-05-15
IL107092A0 (en) 1993-12-28
CZ74895A3 (en) 1995-12-13
CA2143300C (en) 1998-04-21
NO951133L (no) 1995-05-24
KR950703520A (ko) 1995-09-20
PH30881A (en) 1997-12-23
LV10945A (lv) 1995-12-20
CO4560549A1 (es) 1998-02-10
US5541163A (en) 1996-07-30
EE03083B1 (et) 1998-04-15
PL308180A1 (en) 1995-07-24
HUT70432A (en) 1995-10-30
AU680829B2 (en) 1997-08-14
LV10945B (en) 1996-06-20
DE69307446D1 (de) 1997-02-27
HU211315A9 (en) 1995-11-28

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Legal Events

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