LT2875003T - Naujos 5-aminotetrahidrochinolin-2-karboksirūgštys ir jų panaudojimas - Google Patents

Naujos 5-aminotetrahidrochinolin-2-karboksirūgštys ir jų panaudojimas

Info

Publication number
LT2875003T
LT2875003T LTEP13744464.2T LT13744464T LT2875003T LT 2875003 T LT2875003 T LT 2875003T LT 13744464 T LT13744464 T LT 13744464T LT 2875003 T LT2875003 T LT 2875003T
Authority
LT
Lithuania
Prior art keywords
aminotetrahydroquinoline
new
carboxylic acids
acids und
und
Prior art date
Application number
LTEP13744464.2T
Other languages
English (en)
Inventor
Michael Hahn
Markus Follmann
Walter Hübsch
Eva-Maria Becker-Pelster
Johannes-Peter Stasch
Joerg Keldenich
Martina Delbeck
Hanna Tinel
Frank Wunder
Joachim Mittendorf
Ildiko Terebesi
Dieter Lang
René Martin
Original Assignee
Bayer Pharma Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma Aktiengesellschaft filed Critical Bayer Pharma Aktiengesellschaft
Publication of LT2875003T publication Critical patent/LT2875003T/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47064-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
LTEP13744464.2T 2012-07-20 2013-07-16 Naujos 5-aminotetrahidrochinolin-2-karboksirūgštys ir jų panaudojimas LT2875003T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12177284 2012-07-20
EP13167967 2013-05-16
PCT/EP2013/065017 WO2014012934A1 (de) 2012-07-20 2013-07-16 Neue 5-aminotetrahydrochinolin-2-carbonsäuren und ihre verwendung

Publications (1)

Publication Number Publication Date
LT2875003T true LT2875003T (lt) 2017-02-27

Family

ID=48914233

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP13744464.2T LT2875003T (lt) 2012-07-20 2013-07-16 Naujos 5-aminotetrahidrochinolin-2-karboksirūgštys ir jų panaudojimas

Country Status (41)

Country Link
US (3) US8981104B2 (lt)
EP (1) EP2875003B1 (lt)
JP (1) JP6251259B2 (lt)
KR (1) KR102137517B1 (lt)
CN (1) CN104822661B (lt)
AR (1) AR091838A1 (lt)
AU (1) AU2013292046C1 (lt)
BR (1) BR112015001211B1 (lt)
CA (1) CA2879369C (lt)
CL (1) CL2015000120A1 (lt)
CO (1) CO7240369A2 (lt)
CR (1) CR20150020A (lt)
CY (1) CY1118588T1 (lt)
DK (1) DK2875003T3 (lt)
DO (1) DOP2015000012A (lt)
EA (1) EA028918B9 (lt)
EC (1) ECSP15001882A (lt)
ES (1) ES2616036T3 (lt)
GT (1) GT201500011A (lt)
HK (1) HK1209413A1 (lt)
HR (1) HRP20170185T1 (lt)
HU (1) HUE030540T2 (lt)
IL (1) IL236616B (lt)
JO (1) JO3343B1 (lt)
LT (1) LT2875003T (lt)
ME (1) ME02603B (lt)
MX (1) MX360863B (lt)
MY (1) MY172994A (lt)
NZ (1) NZ702977A (lt)
PE (1) PE20150350A1 (lt)
PH (1) PH12015500106A1 (lt)
PL (1) PL2875003T3 (lt)
PT (1) PT2875003T (lt)
RS (1) RS55651B1 (lt)
SG (2) SG10201700454PA (lt)
SI (1) SI2875003T1 (lt)
TN (1) TN2015000026A1 (lt)
TW (1) TWI598338B (lt)
UY (1) UY34918A (lt)
WO (1) WO2014012934A1 (lt)
ZA (1) ZA201409394B (lt)

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Also Published As

Publication number Publication date
UY34918A (es) 2014-02-28
US8981104B2 (en) 2015-03-17
SI2875003T1 (sl) 2017-03-31
PH12015500106B1 (en) 2015-03-02
CY1118588T1 (el) 2017-07-12
PT2875003T (pt) 2017-02-16
KR20150036084A (ko) 2015-04-07
KR102137517B1 (ko) 2020-07-24
DK2875003T3 (en) 2017-02-20
JP2015522597A (ja) 2015-08-06
NZ702977A (en) 2017-10-27
PL2875003T3 (pl) 2017-05-31
EA028918B1 (ru) 2018-01-31
SG10201700454PA (en) 2017-03-30
ECSP15001882A (es) 2015-09-30
DOP2015000012A (es) 2015-03-15
HUE030540T2 (en) 2017-05-29
RS55651B1 (sr) 2017-06-30
MY172994A (en) 2019-12-18
JO3343B1 (ar) 2019-03-13
US20170260139A1 (en) 2017-09-14
AU2013292046B2 (en) 2017-12-14
CL2015000120A1 (es) 2015-06-26
AR091838A1 (es) 2015-03-04
MX2015000739A (es) 2015-08-10
TN2015000026A1 (en) 2016-06-29
CA2879369C (en) 2020-09-22
US9688636B2 (en) 2017-06-27
TWI598338B (zh) 2017-09-11
HRP20170185T1 (hr) 2017-03-24
IL236616B (en) 2018-05-31
ME02603B (me) 2017-06-20
SG11201408421TA (en) 2015-02-27
EP2875003B1 (de) 2016-11-16
BR112015001211A2 (pt) 2017-07-04
EP2875003A1 (de) 2015-05-27
CO7240369A2 (es) 2015-04-17
ZA201409394B (en) 2016-07-27
HK1209413A1 (en) 2016-04-01
BR112015001211B1 (pt) 2020-12-15
AU2013292046C1 (en) 2018-03-15
TW201408643A (zh) 2014-03-01
CN104822661A (zh) 2015-08-05
ES2616036T3 (es) 2017-06-09
CA2879369A1 (en) 2014-01-23
US20150148376A1 (en) 2015-05-28
JP6251259B2 (ja) 2017-12-20
IL236616A0 (en) 2015-02-26
EA028918B9 (ru) 2018-07-31
CN104822661B (zh) 2017-05-31
WO2014012934A1 (de) 2014-01-23
GT201500011A (es) 2017-10-09
US10053428B2 (en) 2018-08-21
AU2013292046A1 (en) 2015-02-19
CR20150020A (es) 2015-03-06
MX360863B (es) 2018-11-09
EA201590251A1 (ru) 2015-07-30
US20140031391A1 (en) 2014-01-30
PH12015500106A1 (en) 2015-03-02
PE20150350A1 (es) 2015-02-28

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