LT2257307T - Biokonjugatai, gauti iš rekombinantinių n-glikozilintų baltymų iš prokariotinių ląstelių - Google Patents
Biokonjugatai, gauti iš rekombinantinių n-glikozilintų baltymų iš prokariotinių ląsteliųInfo
- Publication number
- LT2257307T LT2257307T LTEP09712440.8T LT09712440T LT2257307T LT 2257307 T LT2257307 T LT 2257307T LT 09712440 T LT09712440 T LT 09712440T LT 2257307 T LT2257307 T LT 2257307T
- Authority
- LT
- Lithuania
- Prior art keywords
- recombinant
- glycosylated proteins
- procaryotic cells
- bioconjugates
- bioconjugates made
- Prior art date
Links
- 108091006036 N-glycosylated proteins Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0283—Shigella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/104—Pseudomonadales, e.g. Pseudomonas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6416308P | 2008-02-20 | 2008-02-20 | |
| US7154508P | 2008-05-05 | 2008-05-05 | |
| US12948008P | 2008-06-30 | 2008-06-30 | |
| US12985208P | 2008-07-24 | 2008-07-24 | |
| US13668708P | 2008-09-25 | 2008-09-25 | |
| PCT/IB2009/000287 WO2009104074A2 (en) | 2008-02-20 | 2009-02-19 | Bioconjugates made from recombinant n-glycosylated proteins from procaryotic cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT2257307T true LT2257307T (lt) | 2018-08-10 |
Family
ID=40888413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP09712440.8T LT2257307T (lt) | 2008-02-20 | 2009-02-19 | Biokonjugatai, gauti iš rekombinantinių n-glikozilintų baltymų iš prokariotinių ląstelių |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US8895014B2 (lt) |
| EP (2) | EP3427749A1 (lt) |
| JP (2) | JP5782258B2 (lt) |
| KR (1) | KR20100123730A (lt) |
| CN (1) | CN101983070B (lt) |
| AU (1) | AU2009215341B2 (lt) |
| CA (1) | CA2716187C (lt) |
| CY (1) | CY1120512T1 (lt) |
| DK (1) | DK2257307T3 (lt) |
| ES (1) | ES2684129T3 (lt) |
| HR (1) | HRP20181259T1 (lt) |
| HU (1) | HUE039413T2 (lt) |
| IL (1) | IL207350A (lt) |
| LT (1) | LT2257307T (lt) |
| PL (1) | PL2257307T3 (lt) |
| PT (1) | PT2257307T (lt) |
| SG (1) | SG10201400320TA (lt) |
| SI (1) | SI2257307T1 (lt) |
| WO (1) | WO2009104074A2 (lt) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1481057E (pt) | 2002-03-07 | 2006-05-31 | Eidgenoess Tech Hochschule | Sistema e metodo para a producao de proteinas glicosiladas recombinantes num hospedeiro procariota |
| US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| US8092788B2 (en) | 2004-03-03 | 2012-01-10 | Revance Therapeutics, Inc. | Compositions and methods for topical diagnostic and therapeutic transport |
| US10105448B2 (en) | 2005-01-11 | 2018-10-23 | The United States Of America As Represented By The Secretary Of The Navy | Combined enteropathogen recombinant construct |
| ZA200707352B (en) * | 2005-03-03 | 2009-04-29 | Revance Therapeutics Inc | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| LT2257307T (lt) * | 2008-02-20 | 2018-08-10 | Glaxosmithkline Biologicals S.A. | Biokonjugatai, gauti iš rekombinantinių n-glikozilintų baltymų iš prokariotinių ląstelių |
| GB0915403D0 (en) * | 2009-09-04 | 2009-10-07 | London School Hygiene & Tropical Medicine | Protein glycosylation |
| CN102724997B (zh) * | 2009-11-19 | 2016-09-21 | 格林考瓦因有限公司 | 在原核细胞中产生免疫原性多糖的生物合成系统 |
| EP2545081B1 (en) | 2010-02-11 | 2015-01-28 | The Governors of the University of Alberta | N-Linked Glycan Compounds |
| JP6339366B2 (ja) * | 2010-05-06 | 2018-06-06 | グリコヴァキシン アーゲー | 莢膜グラム陽性菌のバイオコンジュゲートワクチン |
| WO2012027850A1 (en) * | 2010-09-03 | 2012-03-08 | Christine Szymanski | Peptide containing multiple n-linked glycosylation sequons |
| KR20120062457A (ko) | 2010-12-06 | 2012-06-14 | 삼성전자주식회사 | 솔더 접합 신뢰도를 높이는 반도체 패키지용 인쇄회로기판 및 이를 포함하는 반도체 패키지 |
| US20150316549A2 (en) | 2011-08-12 | 2015-11-05 | Mario Feldman | Method of diagnosing bacterial infections using bacterial glycoproteins |
| CA2847621A1 (en) | 2011-09-06 | 2013-03-14 | Glycovaxyn Ag | Bioconjugate vaccines made in prokaryotic cells |
| WO2013159234A1 (en) | 2012-04-27 | 2013-10-31 | The Governors Of The University Of Alberta | Glycoengineered outer membrane vesicles and use thereof as vaccines |
| EP2877205A4 (en) | 2012-07-26 | 2016-04-06 | Jackson H M Found Military Med | VACCINE WITH A MULTIMED FUSION PROTEIN AND IMMUNOTHERAPY |
| BR112015004817A2 (pt) * | 2012-09-10 | 2017-07-04 | Glycovaxyn Ag | bioconjugados compreendendo antígenos modificados e seus usos |
| ES2720040T3 (es) * | 2012-10-12 | 2019-07-17 | Glaxosmithkline Biologicals Sa | Procedimientos de modificación de células hospedadoras |
| EP2724730A1 (en) | 2012-10-29 | 2014-04-30 | Institut Pasteur | Glycoconjugates and their use as potential vaccines against infection by Shigella Flexneri |
| US20150273043A1 (en) | 2012-11-07 | 2015-10-01 | Glycovaxyn Ag | Production of recombinant vaccine in e.coli by enzymatic conjugation |
| TR201807924T4 (tr) | 2013-01-17 | 2018-06-21 | Arsanis Biosciences Gmbh | MDR e. koli spesifik antikor. |
| CA2923957C (en) | 2013-01-18 | 2021-08-31 | London School Of Hygiene And Tropical Medicine | Glycosylation method |
| GB201301085D0 (en) | 2013-01-22 | 2013-03-06 | London School Hygiene & Tropical Medicine | Glycoconjugate Vaccine |
| CA2926523C (en) * | 2013-10-11 | 2023-09-26 | Glycovaxyn Ag | Methods of host cell modification |
| JP6276427B2 (ja) * | 2014-02-24 | 2018-02-07 | グリコヴァキシン アーゲー | 新規の多糖及びその使用 |
| HUE049806T2 (hu) | 2014-04-17 | 2020-10-28 | Glaxosmithkline Biologicals Sa | Módosított gazdasejtek és alkalmazásaik |
| EP4183408A1 (en) * | 2014-09-24 | 2023-05-24 | The United States of America as Represented by The Secretary of the Navy | Combined enterotoxigenic escherichia coli and shigella recombinant |
| US10500261B2 (en) | 2014-11-05 | 2019-12-10 | The United States Of America As Represented By The Secretary Of The Navy | Synthetic antigen constructs against campylobacter jejuni |
| AU2015342943B2 (en) | 2014-11-05 | 2018-06-28 | The United States Of America As Represented By The Secretary Of The Navy | Synthetic antigen constructs against Campylobacter jejuni |
| CN105734001B (zh) * | 2014-12-08 | 2020-04-07 | 中国人民解放军军事医学科学院生物工程研究所 | 一种o抗原糖链延长的甲型副伤寒沙门氏菌及其应用 |
| DK3240895T3 (da) * | 2014-12-30 | 2022-04-11 | Glaxosmithkline Biologicals Sa | Sammensætninger og fremgangsmåder til proteinglykosylering |
| EP3050973A1 (en) * | 2015-01-30 | 2016-08-03 | Jennewein Biotechnologie GmbH | Fermentation process for producing monosaccharides in free form from nucleotide-activated sugars |
| TWI715617B (zh) | 2015-08-24 | 2021-01-11 | 比利時商葛蘭素史密斯克藍生物品公司 | 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物 |
| GB201518668D0 (en) * | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Immunogenic Comosition |
| WO2017175239A1 (en) | 2016-04-05 | 2017-10-12 | Council Of Scientific & Industrial Research | A multifunctional recombinant nucleotide dependent glycosyltransferase protein and its method of glycosylation thereof |
| GB201610599D0 (en) | 2016-06-17 | 2016-08-03 | Glaxosmithkline Biologicals Sa | Immunogenic Composition |
| GB201615427D0 (en) | 2016-09-12 | 2016-10-26 | London School Of Hygeine & Tropical Medicine | Francisella glycoconjugate vaccines |
| AR109621A1 (es) | 2016-10-24 | 2018-12-26 | Janssen Pharmaceuticals Inc | Formulaciones de vacunas contra glucoconjugados de expec |
| CN106801029B (zh) * | 2017-01-22 | 2020-05-01 | 山东大学 | 一株重组大肠杆菌及其在制备抗志贺氏菌的糖疫苗中的应用 |
| GB201704117D0 (en) | 2017-03-15 | 2017-04-26 | London School Hygiene & Tropical Medicine | Oligosaccharyl Transferase polypeptide |
| CA3054765A1 (en) * | 2017-03-15 | 2018-09-20 | London School Of Hygiene And Tropical Medicine | Whole cell vaccines |
| GB201712678D0 (en) | 2017-08-07 | 2017-09-20 | Glaxosmithkline Biologicals Sa | Process for the manipulation of nucleic acids |
| GB201721582D0 (en) | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | S aureus antigens and immunogenic compositions |
| GB201721576D0 (en) | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | Hla antigens and glycoconjugates thereof |
| WO2019175145A1 (en) | 2018-03-12 | 2019-09-19 | Janssen Vaccines & Prevention B.V. | Vaccines against urinary tract infections |
| US11530432B2 (en) * | 2018-03-19 | 2022-12-20 | Northwestern University | Compositions and methods for rapid in vitro synthesis of bioconjugate vaccines in vitro via production and N-glycosylation of protein carriers in detoxified prokaryotic cell lysates |
| GB201807303D0 (en) | 2018-05-03 | 2018-06-20 | London School Of Hygeine & Tropical Medicine | Glyconjugate vaccines |
| EP3894431A2 (en) | 2018-12-12 | 2021-10-20 | GlaxoSmithKline Biologicals SA | Modified carrier proteins for o-linked glycosylation |
| EA202192392A1 (ru) | 2019-03-18 | 2022-02-09 | Янссен Фармасьютикалз, Инк. | Способы получения биоконъюгатов полисахаридных о-антигенов e.coli, их композиции и способы их применения |
| WO2020191082A1 (en) | 2019-03-18 | 2020-09-24 | Janssen Pharmaceuticals, Inc. | Bioconjugates of e. coli o-antigen polysaccharides, methods of production thereof, and methods of use thereof |
| EP3757217A1 (en) | 2019-06-27 | 2020-12-30 | GlaxoSmithKline Biologicals S.A. | Methods for protein purification |
| EP3770269A1 (en) | 2019-07-23 | 2021-01-27 | GlaxoSmithKline Biologicals S.A. | Quantification of bioconjugate glycosylation |
| PL4010467T3 (pl) | 2019-08-09 | 2024-08-05 | Glaxosmithkline Biologicals Sa | Zmutowane enzymy oligosacharylotransferazy pglb |
| EP3777884A1 (en) | 2019-08-15 | 2021-02-17 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition |
| JP7485771B2 (ja) | 2020-01-16 | 2024-05-16 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | FimH変異体、その組成物、及びその使用 |
| EP4168040A1 (en) | 2020-06-18 | 2023-04-26 | GlaxoSmithKline Biologicals S.A. | Shigella-tetravalent (shigella4v) bioconjugate |
| CN115996749A (zh) | 2020-06-25 | 2023-04-21 | 葛兰素史克生物有限公司 | 经修饰的外毒素a蛋白 |
| PH12023550020A1 (en) | 2020-09-17 | 2024-03-11 | Janssen Pharmaceuticals Inc | Multivalent vaccine compositions and uses thereof |
| PL4252003T3 (pl) * | 2020-11-30 | 2025-08-04 | Janssen Pharmaceuticals, Inc. | Sposób analityczny dla glikokoniugatów z zastosowaniem systemu oznaczania immunologicznego na bazie kapilar |
| US11725028B2 (en) | 2021-01-12 | 2023-08-15 | Janssen Pharmaceuticals, Inc. | FimH mutants, compositions therewith and use thereof |
| CN117222427A (zh) | 2021-04-01 | 2023-12-12 | 杨森制药公司 | 大肠杆菌o18生物缀合物的生产 |
| EP4281108A1 (en) | 2021-04-08 | 2023-11-29 | Janssen Pharmaceuticals, Inc. | Process for bioconjugate production |
| WO2023118033A1 (en) | 2021-12-22 | 2023-06-29 | Glaxosmithkline Biologicals Sa | Vaccine |
| GB202302579D0 (en) | 2023-02-23 | 2023-04-12 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| EP4478050A1 (en) | 2023-06-12 | 2024-12-18 | Janssen Pharmaceuticals, Inc. | Method for quantifying bound acetate in glycoconjugates |
| WO2025032534A2 (en) | 2023-08-09 | 2025-02-13 | Glaxosmithkline Biologicals Sa | Modified proteins |
| WO2025032535A2 (en) | 2023-08-09 | 2025-02-13 | Glaxosmithkline Biologicals Sa | Modified proteins |
| WO2025172892A1 (en) | 2024-02-16 | 2025-08-21 | Glaxosmithkline Biologicals Sa | Modified proteins and methods |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0170204B1 (de) | 1984-08-01 | 1991-09-25 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Neue genetische Sequenzen, die durch sie codierten Interferon-Peptide vom Typ I und diese sie produzierende Organismen |
| US5643758A (en) | 1987-03-10 | 1997-07-01 | New England Biolabs, Inc. | Production and purification of a protein fused to a binding protein |
| EP0646175B1 (en) * | 1992-06-18 | 2005-12-28 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Recombinant pseudomonas exotoxin with increased activity |
| AU6663294A (en) | 1993-05-14 | 1994-12-12 | Upjohn Company, The | Cloned dna encoding a udp-galnac:polypeptide,n-acetylgalactos aminyltransferase |
| US6503744B1 (en) | 1999-02-01 | 2003-01-07 | National Research Council Of Canada | Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics |
| AU3508300A (en) | 1999-03-02 | 2000-09-21 | Human Genome Sciences, Inc. | Engineering intracellular sialylation pathways |
| EP1285072A2 (en) | 2000-05-12 | 2003-02-26 | Neose Technologies, Inc. | In vitro fucosylation recombinant glycopeptides |
| WO2002000856A2 (en) | 2000-06-30 | 2002-01-03 | Flanders Interuniversity Institute For Biotechnology (Vib) | Protein glycosylation modification in pichia pastoris |
| KR20100119905A (ko) | 2002-03-07 | 2010-11-11 | 아이드게노쉬쉐 테흐니쉐 호흐슐레 쥬리히 | 원핵 숙주에서의 재조합 글리코실화 단백질 생산 방법 및 생산계 |
| PT1481057E (pt) | 2002-03-07 | 2006-05-31 | Eidgenoess Tech Hochschule | Sistema e metodo para a producao de proteinas glicosiladas recombinantes num hospedeiro procariota |
| US7598354B2 (en) | 2002-08-01 | 2009-10-06 | National Research Council Of Canada | Campylobacter glycans and glycopeptides |
| ATE550437T1 (de) * | 2003-08-01 | 2012-04-15 | Us Gov Health & Human Serv | Verfahren zur expression und reinigung von immunotoxinen |
| EP1756149B1 (en) * | 2004-05-24 | 2013-09-04 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Live, oral vaccine for protection against shigella dysenteriae serotype 1 |
| DK1888761T3 (da) * | 2005-05-11 | 2010-11-01 | Eth Zuerich | Rekombinante N-glycosylerede proteiner fra prokaryote celler |
| LT2257307T (lt) | 2008-02-20 | 2018-08-10 | Glaxosmithkline Biologicals S.A. | Biokonjugatai, gauti iš rekombinantinių n-glikozilintų baltymų iš prokariotinių ląstelių |
| JP6339366B2 (ja) | 2010-05-06 | 2018-06-06 | グリコヴァキシン アーゲー | 莢膜グラム陽性菌のバイオコンジュゲートワクチン |
-
2009
- 2009-02-19 LT LTEP09712440.8T patent/LT2257307T/lt unknown
- 2009-02-19 CN CN200980110137.XA patent/CN101983070B/zh active Active
- 2009-02-19 PL PL09712440T patent/PL2257307T3/pl unknown
- 2009-02-19 HU HUE09712440A patent/HUE039413T2/hu unknown
- 2009-02-19 PT PT09712440T patent/PT2257307T/pt unknown
- 2009-02-19 KR KR1020107020946A patent/KR20100123730A/ko not_active Ceased
- 2009-02-19 AU AU2009215341A patent/AU2009215341B2/en active Active
- 2009-02-19 ES ES09712440.8T patent/ES2684129T3/es active Active
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- 2009-02-19 HR HRP20181259TT patent/HRP20181259T1/hr unknown
- 2009-02-19 WO PCT/IB2009/000287 patent/WO2009104074A2/en not_active Ceased
- 2009-02-19 EP EP18176145.3A patent/EP3427749A1/en not_active Withdrawn
- 2009-02-19 JP JP2010547265A patent/JP5782258B2/ja active Active
- 2009-02-19 CA CA2716187A patent/CA2716187C/en active Active
- 2009-02-19 EP EP09712440.8A patent/EP2257307B1/en active Active
- 2009-02-19 SI SI200931870T patent/SI2257307T1/sl unknown
- 2009-02-19 SG SG10201400320TA patent/SG10201400320TA/en unknown
- 2009-02-19 DK DK09712440.8T patent/DK2257307T3/en active
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2010
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2014
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2015
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2018
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2020
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2024
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