HRP20181259T1 - Biokonjugati načinjeni iz rekombinantnih n-glikoziliranih proteina iz prokariotskih stanica - Google Patents

Biokonjugati načinjeni iz rekombinantnih n-glikoziliranih proteina iz prokariotskih stanica

Info

Publication number
HRP20181259T1
HRP20181259T1 HRP20181259TT HRP20181259T HRP20181259T1 HR P20181259 T1 HRP20181259 T1 HR P20181259T1 HR P20181259T T HRP20181259T T HR P20181259TT HR P20181259 T HRP20181259 T HR P20181259T HR P20181259 T1 HRP20181259 T1 HR P20181259T1
Authority
HR
Croatia
Prior art keywords
recombinant
glycosylated proteins
procaryotic cells
bioconjugates
bioconjugates made
Prior art date
Application number
HRP20181259TT
Other languages
English (en)
Inventor
Fabiana Fernandez
Michael Wetter
Michael Kowarik
Michael Wacker
Original Assignee
Glaxosmithkline Biologicals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals S.A. filed Critical Glaxosmithkline Biologicals S.A.
Publication of HRP20181259T1 publication Critical patent/HRP20181259T1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0283—Shigella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/104—Pseudomonadales, e.g. Pseudomonas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
HRP20181259TT 2008-02-20 2018-08-02 Biokonjugati načinjeni iz rekombinantnih n-glikoziliranih proteina iz prokariotskih stanica HRP20181259T1 (hr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US6416308P 2008-02-20 2008-02-20
US7154508P 2008-05-05 2008-05-05
US12948008P 2008-06-30 2008-06-30
US12985208P 2008-07-24 2008-07-24
US13668708P 2008-09-25 2008-09-25
PCT/IB2009/000287 WO2009104074A2 (en) 2008-02-20 2009-02-19 Bioconjugates made from recombinant n-glycosylated proteins from procaryotic cells
EP09712440.8A EP2257307B1 (en) 2008-02-20 2009-02-19 Bioconjugates made from recombinant n-glycosylated proteins from procaryotic cells

Publications (1)

Publication Number Publication Date
HRP20181259T1 true HRP20181259T1 (hr) 2018-10-05

Family

ID=40888413

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20181259TT HRP20181259T1 (hr) 2008-02-20 2018-08-02 Biokonjugati načinjeni iz rekombinantnih n-glikoziliranih proteina iz prokariotskih stanica

Country Status (20)

Country Link
US (3) US8895014B2 (hr)
EP (2) EP2257307B1 (hr)
JP (2) JP5782258B2 (hr)
KR (1) KR20100123730A (hr)
CN (1) CN101983070B (hr)
AU (1) AU2009215341B2 (hr)
CA (1) CA2716187C (hr)
CY (1) CY1120512T1 (hr)
DK (1) DK2257307T3 (hr)
ES (1) ES2684129T3 (hr)
HK (1) HK1155938A1 (hr)
HR (1) HRP20181259T1 (hr)
HU (1) HUE039413T2 (hr)
IL (1) IL207350A (hr)
LT (1) LT2257307T (hr)
PL (1) PL2257307T3 (hr)
PT (1) PT2257307T (hr)
SG (1) SG10201400320TA (hr)
SI (1) SI2257307T1 (hr)
WO (1) WO2009104074A2 (hr)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60303591T2 (de) 2002-03-07 2007-03-01 Eidgenössische Technische Hochschule Zürich System und methode zur herstellung von rekombinanten, glykosylierten protein in prokaryontischen wirtszellen
US9211248B2 (en) 2004-03-03 2015-12-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
KR101284710B1 (ko) * 2004-03-03 2013-07-23 레반스 테라퓨틱스, 아이엔씨. 국소 진단제 및 치료제의 수송을 위한 조성물 및 방법
US10105448B2 (en) 2005-01-11 2018-10-23 The United States Of America As Represented By The Secretary Of The Navy Combined enteropathogen recombinant construct
BRPI0608249A2 (pt) * 2005-03-03 2009-12-08 Revance Therapeutics Inc formulação, método para aplicação tópica e kit para distribuição transdérmica de toxina botulìnica
DK2257307T3 (en) 2008-02-20 2018-08-20 Glaxosmithkline Biologicals Sa BIOCONJUGATES MANUFACTURED FROM RECOMBINANT N-Glycosylated PROTEINS FROM PROCARYOTIC CELLS
GB0915403D0 (en) * 2009-09-04 2009-10-07 London School Hygiene & Tropical Medicine Protein glycosylation
PL2501406T3 (pl) * 2009-11-19 2018-05-30 Glaxosmithkline Biologicals S.A. Biosyntetyczny układ wytwarzający immunogenne polisacharydy w komórkach prokariotycznych
JP5925699B2 (ja) 2010-02-11 2016-05-25 ザ・ガバナーズ・オブ・ザ・ユニバーシティー・オブ・アルバータ Ｎ結合型グリカン化合物
JP6339366B2 (ja) * 2010-05-06 2018-06-06 グリコヴァキシン アーゲー 莢膜グラム陽性菌のバイオコンジュゲートワクチン
CA2809890A1 (en) * 2010-09-03 2012-03-08 The Governors Of The University Of Alberta Peptide containing multiple n-linked glycosylation sequons
KR20120062457A (ko) 2010-12-06 2012-06-14 삼성전자주식회사 솔더 접합 신뢰도를 높이는 반도체 패키지용 인쇄회로기판 및 이를 포함하는 반도체 패키지
EP2742355B1 (en) * 2011-08-12 2018-12-19 The Governors of the University of Alberta Method of diagnosing bacterial infections using bacterial glycoproteins
EP2753353A1 (en) 2011-09-06 2014-07-16 Glycovaxyn AG Bioconjugate vaccines made in prokaryotic cells
WO2013159234A1 (en) 2012-04-27 2013-10-31 The Governors Of The University Of Alberta Glycoengineered outer membrane vesicles and use thereof as vaccines
WO2014018858A2 (en) 2012-07-26 2014-01-30 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Multimeric fusion protein vaccine and immunotherapeutic
US20150238596A1 (en) * 2012-09-10 2015-08-27 Glycovaxyn Ag Bioconjugates comprising modified antigens and uses thereof
CA2887133C (en) * 2012-10-12 2022-05-03 Glycovaxyn Ag Methods of host cell modification
EP2724730A1 (en) * 2012-10-29 2014-04-30 Institut Pasteur Glycoconjugates and their use as potential vaccines against infection by Shigella Flexneri
KR20150079964A (ko) 2012-11-07 2015-07-08 글리코박신 아게 효소적 컨쥬게이션에 의한 ｅ．콜라이에서 재조합 백신의 생성
CN105120896B (zh) 2013-01-17 2019-11-12 阿尔萨尼斯生物科学有限责任公司 多重抗药性大肠杆菌特异性抗体
EP2946010B1 (en) 2013-01-18 2018-08-29 London School of Hygiene and Tropical Medicine Glycosylation method
GB201301085D0 (en) 2013-01-22 2013-03-06 London School Hygiene & Tropical Medicine Glycoconjugate Vaccine
EA201690529A1 (ru) * 2013-10-11 2016-11-30 Гликоваксин Аг Способы модификации клетки-хозяина
FI3110441T3 (fi) * 2014-02-24 2024-05-06 Glaxosmithkline Biologicals Sa Uusi polysakkaridi ja sen käyttöjä
WO2015158403A1 (en) * 2014-04-17 2015-10-22 Glycovaxyn Ag Modified host cells and uses thereof
AU2015321698B2 (en) * 2014-09-24 2018-06-28 The United States Of America As Represented By The Secretary Of The Navy Combined enterotoxigenic Escherichia coli and Campylobacter jejuni recombinant construct
CA2966754A1 (en) 2014-11-05 2016-05-12 The United States Of America As Represented By The Secretary Of The Navy Synthetic antigen constructs against campylobacter jejuni
US10500261B2 (en) 2014-11-05 2019-12-10 The United States Of America As Represented By The Secretary Of The Navy Synthetic antigen constructs against campylobacter jejuni
CN105734001B (zh) 2014-12-08 2020-04-07 中国人民解放军军事医学科学院生物工程研究所 一种o抗原糖链延长的甲型副伤寒沙门氏菌及其应用
JP6850724B2 (ja) 2014-12-30 2021-03-31 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム タンパク質グリコシル化のための組成物および方法
EP3050973A1 (en) * 2015-01-30 2016-08-03 Jennewein Biotechnologie GmbH Fermentation process for producing monosaccharides in free form from nucleotide-activated sugars
TWI715617B (zh) 2015-08-24 2021-01-11 比利時商葛蘭素史密斯克藍生物品公司 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物
GB201518668D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Immunogenic Comosition
EP3423587B1 (en) 2016-04-05 2020-06-24 Council of Scientific & Industrial Research A multifunctional recombinant nucleotide dependent glycosyltransferase protein and its method of glycosylation thereof
GB201610599D0 (en) 2016-06-17 2016-08-03 Glaxosmithkline Biologicals Sa Immunogenic Composition
GB201615427D0 (en) * 2016-09-12 2016-10-26 London School Of Hygeine & Tropical Medicine Francisella glycoconjugate vaccines
AR109621A1 (es) 2016-10-24 2018-12-26 Janssen Pharmaceuticals Inc Formulaciones de vacunas contra glucoconjugados de expec
CN106801029B (zh) * 2017-01-22 2020-05-01 山东大学 一株重组大肠杆菌及其在制备抗志贺氏菌的糖疫苗中的应用
GB201704117D0 (en) 2017-03-15 2017-04-26 London School Hygiene & Tropical Medicine Oligosaccharyl Transferase polypeptide
JP7220502B2 (ja) 2017-03-15 2023-02-10 ロンドン スクール オブ ハイジーン アンド トロピカル メディシン 全細胞ワクチン
GB201712678D0 (en) 2017-08-07 2017-09-20 Glaxosmithkline Biologicals Sa Process for the manipulation of nucleic acids
GB201721582D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa S aureus antigens and immunogenic compositions
GB201721576D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa Hla antigens and glycoconjugates thereof
TW201946650A (zh) 2018-03-12 2019-12-16 美商詹森藥物公司 針對腹內感染之疫苗
US11530432B2 (en) * 2018-03-19 2022-12-20 Northwestern University Compositions and methods for rapid in vitro synthesis of bioconjugate vaccines in vitro via production and N-glycosylation of protein carriers in detoxified prokaryotic cell lysates
GB201807303D0 (en) 2018-05-03 2018-06-20 London School Of Hygeine & Tropical Medicine Glyconjugate vaccines
JP2022513458A (ja) 2018-12-12 2022-02-08 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Ｏ－結合型グリコシル化のための修飾キャリアタンパク質
CA3134216A1 (en) 2019-03-18 2020-09-24 Janssen Pharmaceuticals, Inc. Bioconjugates of e. coli o-antigen polysaccharides, methods of production thereof, and methods of use thereof
EP4253554A3 (en) 2019-03-18 2024-01-17 Janssen Pharmaceuticals, Inc. Methods of producing bioconjugates of e. coli o-antigen polysaccharides, compositions thereof, and methods of use thereof
EP3757217A1 (en) 2019-06-27 2020-12-30 GlaxoSmithKline Biologicals S.A. Methods for protein purification
EP3770269A1 (en) 2019-07-23 2021-01-27 GlaxoSmithKline Biologicals S.A. Quantification of bioconjugate glycosylation
US20220403347A1 (en) * 2019-08-09 2022-12-22 Glaxosmithkline Biologicals S.A. Mutated pglb oligosaccharyltransferase enzymes
EP3777884A1 (en) 2019-08-15 2021-02-17 GlaxoSmithKline Biologicals S.A. Immunogenic composition
JP7485771B2 (ja) 2020-01-16 2024-05-16 ヤンセン ファーマシューティカルズ，インコーポレーテッド ＦｉｍＨ変異体、その組成物、及びその使用
MX2022016587A (es) 2020-06-18 2023-02-01 Glaxosmithkline Biologicals Sa Bioconjugado tetravalente de shigella (shigella4v).
WO2021259743A2 (en) 2020-06-25 2021-12-30 Glaxosmithkline Biologicals Sa Vaccine
IL308201A (en) 2020-09-17 2024-01-01 Janssen Pharmaceuticals Inc Multivalent vaccine compositions and uses thereof
CA3203450A1 (en) 2020-11-30 2022-06-02 Janssen Pharmaceuticals, Inc. Analytical method for glycoconjugates using a capillary-based immunoassay system
KR20230125842A (ko) 2021-01-12 2023-08-29 얀센 파마슈티칼즈, 인코포레이티드 FimH 돌연변이체, 이를 포함하는 조성물 및 이의 용도
KR20230164108A (ko) 2021-04-01 2023-12-01 얀센 파마슈티칼즈, 인코포레이티드 E. coli O18 생물접합체의 생산
JP2024513914A (ja) 2021-04-08 2024-03-27 ヤンセン ファーマシューティカルズ，インコーポレーテッド バイオコンジュゲート生産のためのプロセス
WO2023118033A1 (en) 2021-12-22 2023-06-29 Glaxosmithkline Biologicals Sa Vaccine

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3584198D1 (de) 1984-08-01 1991-10-31 Boehringer Ingelheim Int Neue genetische sequenzen, die durch sie codierten interferon-peptide vom typ i und diese sie produzierende organismen.
US5643758A (en) 1987-03-10 1997-07-01 New England Biolabs, Inc. Production and purification of a protein fused to a binding protein
CA2136724A1 (en) * 1992-06-18 1993-12-23 Ira H. Pastan Recombinant pseudomonas exotoxin with increased activity
EP0698103A1 (en) 1993-05-14 1996-02-28 PHARMACIA & UPJOHN COMPANY CLONED DNA ENCODING A UDP-GALNAc:POLYPEPTIDE,N-ACETYLGALACTOS AMINYLTRANSFERASE
US6503744B1 (en) 1999-02-01 2003-01-07 National Research Council Of Canada Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics
CA2363297C (en) 1999-03-02 2011-08-09 Michael J. Betenbaugh Engineering intracellular sialylation pathways
EP1285072A2 (en) 2000-05-12 2003-02-26 Neose Technologies, Inc. In vitro fucosylation recombinant glycopeptides
US6803225B2 (en) 2000-06-30 2004-10-12 Flanders Interuniversity Institute For Biotechnology Protein glycosylation modification in Pichia pastoris
DE60303591T2 (de) 2002-03-07 2007-03-01 Eidgenössische Technische Hochschule Zürich System und methode zur herstellung von rekombinanten, glykosylierten protein in prokaryontischen wirtszellen
KR100938026B1 (ko) 2002-03-07 2010-01-21 아이드게노쉬쉐 테흐니쉐 호흐슐레 쥬리히 원핵 숙주에서 재조합 글리코실화 단백질의 생산방법 및생산계
WO2004013151A2 (en) 2002-08-01 2004-02-12 National Research Council Of Canada Campylobacter glycans and glycopeptides
EP2314711A1 (en) * 2003-08-01 2011-04-27 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Methods for expression and purification of immunotoxins
EP2657251B1 (en) 2004-05-24 2018-03-21 The Government of The United States of America, as represented by The Secretary, Department of Health and Human Services Live, oral vaccine for protection against Shigella dysenteriae serotype 1
EP1888761B1 (en) * 2005-05-11 2010-09-29 ETH Zurich Recombinant n-glycosylated proteins from procaryotic cells
DK2257307T3 (en) 2008-02-20 2018-08-20 Glaxosmithkline Biologicals Sa BIOCONJUGATES MANUFACTURED FROM RECOMBINANT N-Glycosylated PROTEINS FROM PROCARYOTIC CELLS
JP6339366B2 (ja) 2010-05-06 2018-06-06 グリコヴァキシン アーゲー 莢膜グラム陽性菌のバイオコンジュゲートワクチン

Also Published As

Publication number Publication date
ES2684129T3 (es) 2018-10-01
AU2009215341A1 (en) 2009-08-27
US8895014B2 (en) 2014-11-25
HUE039413T2 (hu) 2018-12-28
CA2716187A1 (en) 2009-08-27
AU2009215341B2 (en) 2015-03-26
CA2716187C (en) 2020-01-07
US20210085772A1 (en) 2021-03-25
JP5782258B2 (ja) 2015-09-24
SG10201400320TA (en) 2014-05-29
HK1155938A1 (zh) 2012-06-01
CN101983070A (zh) 2011-03-02
JP2011514155A (ja) 2011-05-06
IL207350A (en) 2017-10-31
EP3427749A1 (en) 2019-01-16
WO2009104074A3 (en) 2009-11-05
CY1120512T1 (el) 2019-07-10
CN101983070B (zh) 2016-03-30
US11944675B2 (en) 2024-04-02
JP6122071B2 (ja) 2017-04-26
IL207350A0 (en) 2010-12-30
PL2257307T3 (pl) 2018-11-30
US20150044254A1 (en) 2015-02-12
DK2257307T3 (en) 2018-08-20
US10835592B2 (en) 2020-11-17
SI2257307T1 (sl) 2018-09-28
EP2257307B1 (en) 2018-06-06
JP2015187174A (ja) 2015-10-29
LT2257307T (lt) 2018-08-10
EP2257307A2 (en) 2010-12-08
PT2257307T (pt) 2018-10-22
WO2009104074A2 (en) 2009-08-27
KR20100123730A (ko) 2010-11-24
US20110097357A1 (en) 2011-04-28

Similar Documents

Publication Publication Date Title
HRP20181259T1 (hr) Biokonjugati načinjeni iz rekombinantnih n-glikoziliranih proteina iz prokariotskih stanica
SG10201608059VA (en) Recombinant vwf formulations
HRP20130414T1 (en) Lyophilized recombinant vwf formulations
HK1223946A1 (zh) 生物活性肽
IL202213A0 (en) Recombinant protein production in avian ebxr cells
IL193721A0 (en) Polypeptide producing cells
ZA201101166B (en) Modified bovine g-csf polypeptides and their uses
HK1244426A1 (zh) 治療性蛋白質製劑
EP2403535A4 (en) COMPATIBILIZED ELECTROLYTIC FORMULATIONS
GB2462761B (en) Protein formulation
EP2557088A4 (en) PHYSIOLOGICALLY ACTIVE PEPTIDES
ZA201104670B (en) Pharmaceutical composition comprising aleglitazar
EP2102231A4 (en) IMPROVED EXPRESSION SYSTEM FOR RECOMBINANT HUMAN ARGINASE I
ZA201105784B (en) Recombinant porcine chymotrypsin
EP2254901A4 (en) THERAPEUTIC PEPTIDES
EP2314701A4 (en) RECOMBINANT EXPRESSION VECTOR FOR ANIMAL CELL
GB2462726B (en) Protein expression
EP2264057A4 (en) RECOMBINANT ANTIGEN
GB0803594D0 (en) Protein formulation
GB0807929D0 (en) Protein formulation
GB0922155D0 (en) Interferon 8 fusion proteins
GB0810567D0 (en) Protein expression
GB0811893D0 (en) Protein expression