PL4010467T3 - Zmutowane enzymy oligosacharylotransferazy pglb - Google Patents

Zmutowane enzymy oligosacharylotransferazy pglb

Info

Publication number
PL4010467T3
PL4010467T3 PL20753722.6T PL20753722T PL4010467T3 PL 4010467 T3 PL4010467 T3 PL 4010467T3 PL 20753722 T PL20753722 T PL 20753722T PL 4010467 T3 PL4010467 T3 PL 4010467T3
Authority
PL
Poland
Prior art keywords
mutated
oligosaccharyl transferase
transferase enzymes
pglb oligosaccharyl
pglb
Prior art date
Application number
PL20753722.6T
Other languages
English (en)
Inventor
Leigh Anne IHNKEN
Joel KARPIAK
Stefan Jochen KEMMLER
Michael Thomas KOWARIK
Joel Melby
Anne OLLIS
Julien Laurent QUEBATTE
Original Assignee
Glaxosmithkline Biologicals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals Sa filed Critical Glaxosmithkline Biologicals Sa
Publication of PL4010467T3 publication Critical patent/PL4010467T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/99Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99019Undecaprenyl-diphosphooligosaccharide—protein glycotransferase (2.4.99.19)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
PL20753722.6T 2019-08-09 2020-08-06 Zmutowane enzymy oligosacharylotransferazy pglb PL4010467T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962884791P 2019-08-09 2019-08-09
US201962931265P 2019-11-06 2019-11-06
PCT/EP2020/072102 WO2021028303A1 (en) 2019-08-09 2020-08-06 Mutated pglb oligosaccharyltransferase enzymes

Publications (1)

Publication Number Publication Date
PL4010467T3 true PL4010467T3 (pl) 2024-08-05

Family

ID=71995990

Family Applications (1)

Application Number Title Priority Date Filing Date
PL20753722.6T PL4010467T3 (pl) 2019-08-09 2020-08-06 Zmutowane enzymy oligosacharylotransferazy pglb

Country Status (12)

Country Link
US (1) US12559731B2 (pl)
EP (2) EP4010467B1 (pl)
JP (1) JP7591037B2 (pl)
CN (1) CN114207122A (pl)
BR (1) BR112022000969A2 (pl)
CA (1) CA3149430A1 (pl)
ES (1) ES2984862T3 (pl)
HR (1) HRP20240776T1 (pl)
HU (1) HUE066794T2 (pl)
MX (1) MX2022001606A (pl)
PL (1) PL4010467T3 (pl)
WO (1) WO2021028303A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023118033A1 (en) 2021-12-22 2023-06-29 Glaxosmithkline Biologicals Sa Vaccine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2257307T (lt) 2008-02-20 2018-08-10 Glaxosmithkline Biologicals S.A. Biokonjugatai, gauti iš rekombinantinių n-glikozilintų baltymų iš prokariotinių ląstelių
BR112012020882A2 (pt) * 2010-02-24 2015-11-03 Merck Sharp & Dohme métodos para produzir uma glicoproteína heteróloga e para produzir uma composição de glicoproteína, célula hospedeira, composição de glicoproteína, e, uso da pichia pastoris recombinante.
JP6339366B2 (ja) 2010-05-06 2018-06-06 グリコヴァキシン アーゲー 莢膜グラム陽性菌のバイオコンジュゲートワクチン
EP2705155B1 (en) 2011-05-04 2016-04-27 ETH Zurich Rational design of components of the oligo-saccharyltransferase-catalysed asparagine-linked glycosylation
HK1202896A1 (en) 2011-11-04 2015-10-09 康奈尔大学 A prokaryote-based cell-free system for the synthesis of glycoproteins
ES2720040T3 (es) 2012-10-12 2019-07-17 Glaxosmithkline Biologicals Sa Procedimientos de modificación de células hospedadoras
GB201301085D0 (en) 2013-01-22 2013-03-06 London School Hygiene & Tropical Medicine Glycoconjugate Vaccine
WO2016023018A2 (en) 2014-08-08 2016-02-11 Glycobia, Inc. Engineered oligosaccharyltransferases
DK3240895T3 (da) 2014-12-30 2022-04-11 Glaxosmithkline Biologicals Sa Sammensætninger og fremgangsmåder til proteinglykosylering

Also Published As

Publication number Publication date
JP7591037B2 (ja) 2024-11-27
EP4010467B1 (en) 2024-04-24
EP4389908A3 (en) 2024-11-27
CN114207122A (zh) 2022-03-18
ES2984862T3 (es) 2024-10-31
BR112022000969A2 (pt) 2022-06-14
CA3149430A1 (en) 2021-02-18
HUE066794T2 (hu) 2024-09-28
WO2021028303A1 (en) 2021-02-18
HRP20240776T1 (hr) 2024-09-13
EP4389908A2 (en) 2024-06-26
EP4010467A1 (en) 2022-06-15
US20220403347A1 (en) 2022-12-22
EP4010467C0 (en) 2024-04-24
US12559731B2 (en) 2026-02-24
JP2022543678A (ja) 2022-10-13
MX2022001606A (es) 2022-03-11

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