LT2046382T - Scfv antikūnai, pereinantys epitelio ir (arba) endotelio sluoksnius - Google Patents

Scfv antikūnai, pereinantys epitelio ir (arba) endotelio sluoksnius

Info

Publication number
LT2046382T
LT2046382T LTEP07763939.1T LT07763939T LT2046382T LT 2046382 T LT2046382 T LT 2046382T LT 07763939 T LT07763939 T LT 07763939T LT 2046382 T LT2046382 T LT 2046382T
Authority
LT
Lithuania
Prior art keywords
scfv antibodies
endothelial layers
pass epithelial
epithelial
pass
Prior art date
Application number
LTEP07763939.1T
Other languages
English (en)
Inventor
Adrian Auf Der Maur
Alcide Barberis
David Urech
Peter Lichtlen
Original Assignee
Esbatech, An Alcon Biomedical Research Unit Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esbatech, An Alcon Biomedical Research Unit Llc filed Critical Esbatech, An Alcon Biomedical Research Unit Llc
Publication of LT2046382T publication Critical patent/LT2046382T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
LTEP07763939.1T 2006-07-10 2007-07-10 Scfv antikūnai, pereinantys epitelio ir (arba) endotelio sluoksnius LT2046382T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81937806P 2006-07-10 2006-07-10
US89990707P 2007-02-06 2007-02-06
PCT/CH2007/000334 WO2008006235A2 (en) 2006-07-10 2007-07-10 Scfv antibodies which pass epithelial and/or endothelial layers

Publications (1)

Publication Number Publication Date
LT2046382T true LT2046382T (lt) 2016-12-12

Family

ID=38792084

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP07763939.1T LT2046382T (lt) 2006-07-10 2007-07-10 Scfv antikūnai, pereinantys epitelio ir (arba) endotelio sluoksnius

Country Status (16)

Country Link
US (2) US8936785B2 (lt)
EP (2) EP2046382B1 (lt)
JP (6) JP2009542232A (lt)
CN (2) CN101505794B (lt)
AU (1) AU2007272224B2 (lt)
CA (1) CA2658241C (lt)
DK (1) DK2046382T3 (lt)
ES (2) ES2820837T3 (lt)
HU (1) HUE032654T2 (lt)
LT (1) LT2046382T (lt)
NZ (2) NZ700275A (lt)
PL (1) PL2046382T3 (lt)
PT (1) PT2046382T (lt)
RU (3) RU2438708C2 (lt)
SI (1) SI2046382T1 (lt)
WO (1) WO2008006235A2 (lt)

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ES2820837T3 (es) 2006-07-10 2021-04-22 Esbatech Alcon Biomed Res Unit Anticuerpos scFv que pasan las capas epitelial y/o endotelial
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SI2158315T1 (sl) 2007-06-25 2016-05-31 Esbatech, An Alcon Biomedical Research Unit Llc Postopki za spreminjanje protiteles in spremenjena protitelesa z izboljšanimi funkcionalnimi lastnostmi
US8323647B2 (en) 2007-09-13 2012-12-04 Delenex Therapeutics Ag Humanized antibodies against the β-amyloid peptide
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PL2307455T3 (pl) 2008-06-25 2017-09-29 Esbatech, An Alcon Biomedical Research Unit Llc Optymalizacja rozpuszczalności cząsteczek immunowiążących
EP3216803B1 (en) 2008-06-25 2020-03-11 Novartis Ag Stable and soluble antibodies inhibiting vegf
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CA2728004C (en) 2008-06-25 2022-05-24 Esbatech, An Alcon Biomedical Research Unit Llc Humanization of rabbit antibodies using a universal antibody framework
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US8637022B2 (en) 2008-06-30 2014-01-28 Esbatech, An Alcon Biomedical Research Unit Llc Functionalized polypeptides
CN102088958A (zh) * 2008-07-10 2011-06-08 艾斯巴技术,爱尔康生物医药研究装置有限责任公司 用于大分子的增强的递送的方法和组合物
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PE20120622A1 (es) * 2009-06-17 2012-05-26 Abbott Biotherapeutics Corp Anticuerpos anti-vegf y sus usos
US8399625B1 (en) 2009-06-25 2013-03-19 ESBATech, an Alcon Biomedical Research Unit, LLC Acceptor framework for CDR grafting
US9522153B2 (en) 2009-12-22 2016-12-20 Allergan, Inc. Compositions and methods for lowering intraocular pressure
AR083495A1 (es) 2010-10-22 2013-02-27 Esbatech Alcon Biomed Res Unit Anticuerpos estables y solubles
US20140154255A1 (en) 2012-11-30 2014-06-05 Abbvie Biotherapeutics Inc. Anti-vegf antibodies and their uses
US11079613B2 (en) * 2013-03-05 2021-08-03 EyeYon Medical Ltd. Contact lens drug depot
WO2015086830A1 (en) * 2013-12-13 2015-06-18 Delenex Therapeutics Ag Skin penetrating polypeptides
HUE050300T2 (hu) * 2014-07-09 2020-11-30 Lupin Ltd Kétcisztronos bakteriális expressziós rendszer
CN108025011A (zh) 2015-07-21 2018-05-11 艾维德洛公司 用光敏剂治疗眼睛的系统和方法
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Also Published As

Publication number Publication date
HUE032654T2 (en) 2017-10-30
RU2565399C2 (ru) 2015-10-20
EP3093026B1 (en) 2020-07-01
JP6226824B2 (ja) 2017-11-08
EP2046382A2 (en) 2009-04-15
JP2009542232A (ja) 2009-12-03
CN103251947A (zh) 2013-08-21
CN101505794A (zh) 2009-08-12
JP2016041758A (ja) 2016-03-31
JP2019089809A (ja) 2019-06-13
CN101505794B (zh) 2013-09-04
RU2438708C2 (ru) 2012-01-10
ES2820837T3 (es) 2021-04-22
DK2046382T3 (en) 2016-12-12
US20140234315A1 (en) 2014-08-21
RU2015130221A3 (lt) 2019-04-01
NZ574308A (en) 2012-06-29
WO2008006235A3 (en) 2008-02-28
ES2603399T3 (es) 2017-02-27
AU2007272224B2 (en) 2013-05-02
RU2015130221A (ru) 2017-01-27
JP2017209114A (ja) 2017-11-30
EP3093026A1 (en) 2016-11-16
CA2658241A1 (en) 2008-01-17
CN103251947B (zh) 2017-11-21
RU2009104318A (ru) 2010-08-20
PT2046382T (pt) 2016-11-23
WO2008006235A2 (en) 2008-01-17
JP2014176392A (ja) 2014-09-25
US20090311251A1 (en) 2009-12-17
JP6230195B2 (ja) 2017-11-15
JP2014169329A (ja) 2014-09-18
NZ700275A (en) 2016-03-31
EP2046382B1 (en) 2016-08-17
SI2046382T1 (sl) 2016-12-30
US8936785B2 (en) 2015-01-20
CA2658241C (en) 2018-01-02
AU2007272224A1 (en) 2008-01-17
PL2046382T3 (pl) 2017-07-31
RU2011126239A (ru) 2012-12-27

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