KR960004865B1 - 인돌, 벤조푸란, 벤조티오펜-함유 리폭시게나제 억제 화합물 - Google Patents

인돌, 벤조푸란, 벤조티오펜-함유 리폭시게나제 억제 화합물 Download PDF

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Publication number
KR960004865B1
KR960004865B1 KR1019880001201A KR880001201A KR960004865B1 KR 960004865 B1 KR960004865 B1 KR 960004865B1 KR 1019880001201 A KR1019880001201 A KR 1019880001201A KR 880001201 A KR880001201 A KR 880001201A KR 960004865 B1 KR960004865 B1 KR 960004865B1
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KR
South Korea
Prior art keywords
hydroxy
benzo
urea
thien
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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KR1019880001201A
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English (en)
Korean (ko)
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KR890012994A (ko
Inventor
비. 섬머즈 제이알 제임스
피. 건 브루스
더블유. 브룩스 디이
Original Assignee
애보트 래보러토리즈
죠셉 엠. 베르니크
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Priority claimed from US07/138,073 external-priority patent/US4873259A/en
Application filed by 애보트 래보러토리즈, 죠셉 엠. 베르니크 filed Critical 애보트 래보러토리즈
Publication of KR890012994A publication Critical patent/KR890012994A/ko
Application granted granted Critical
Publication of KR960004865B1 publication Critical patent/KR960004865B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1019880001201A 1987-02-10 1988-02-09 인돌, 벤조푸란, 벤조티오펜-함유 리폭시게나제 억제 화합물 Expired - Lifetime KR960004865B1 (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US1297087A 1987-02-10 1987-02-10
US?012.970? 1987-02-10
US012,970 1987-02-10
US6078487A 1987-06-10 1987-06-10
US060,784 1987-06-10
US?060.784? 1987-06-10
US07/138,073 US4873259A (en) 1987-06-10 1988-01-11 Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
US138,073 1988-01-11
US?138.073? 1988-01-11

Publications (2)

Publication Number Publication Date
KR890012994A KR890012994A (ko) 1989-09-20
KR960004865B1 true KR960004865B1 (ko) 1996-04-16

Family

ID=27359744

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880001201A Expired - Lifetime KR960004865B1 (ko) 1987-02-10 1988-02-09 인돌, 벤조푸란, 벤조티오펜-함유 리폭시게나제 억제 화합물

Country Status (8)

Country Link
EP (1) EP0279263B1 (enExample)
JP (1) JPS63264456A (enExample)
KR (1) KR960004865B1 (enExample)
AU (1) AU608804B2 (enExample)
CA (2) CA1306744C (enExample)
DE (1) DE3882732T2 (enExample)
ES (1) ES2059408T3 (enExample)
MX (2) MX9202874A (enExample)

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US5175183A (en) * 1989-02-01 1992-12-29 Abbott Laboratories Lipoxygenase inhibiting compounds
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US5075330A (en) * 1989-05-26 1991-12-24 Warner-Lambert Co. N-hydroxyamide, N-hydroxythioamide, N-hydroxyurea, and N-hydroxythiourea derivatives of selected NSAIDS as antiinflammatory agents
US4981865A (en) * 1989-05-26 1991-01-01 Warner-Lambert Co. N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents
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US5120752A (en) * 1989-12-28 1992-06-09 Abbott Laboratories Cyclopropyl derivative lipoxygenase inhibitors
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US5128364A (en) * 1991-03-28 1992-07-07 Merck Frosst Canada, Inc. Pyrrolo[1,2-a]indole hydroxylamine derivatives as inhibitors of leukotriene biosynthesis
US5132319A (en) * 1991-03-28 1992-07-21 Merck Frosst Canada, Inc. 1-(hydroxylaminoalkyl) indole derivatives as inhibitors of leukotriene biosynthesis
US5130485A (en) * 1991-04-23 1992-07-14 Eli Lilly And Company N-hydroxy-N-(3-(2-substituted phenyl)prop-2-enyl)ureas and thioureas useful as 5-lipoxygenase inhibiting agents
US5283361A (en) * 1991-04-23 1994-02-01 Eli Lilly And Company N-hydroxy-N-[3-[2-(halophenylthio)phenyl]prop-2-enyl]ureas as lipoxygenase inhibitors
US5143927A (en) * 1991-05-09 1992-09-01 Warner-Lambert Company 3-(thiazolidone, oxazolidinone, imidazolidinone)-indoles as antiinflammatory agents
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US5442111A (en) * 1991-05-24 1995-08-15 Warner-Lambert Company 3,5-di-tetriary-4-butyl-4-hydroxyphenyloxy- or tioalkylene N-hydroxyamides, N-hydroxythioamides, N-hydroxyureas, and N-hydroxythioureas as 5-lipoxygenase inhibitors
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US5124347A (en) * 1991-07-31 1992-06-23 Warner-Lambert Co. 3-5-ditertiarybutylphenyl-4-hydroxymethylidene derivatives of 1,3-dihydro-2H-indole-2-ones as antiinflammatory agents
US5308850A (en) * 1991-09-30 1994-05-03 Merck Frosst Canada, Inc. (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5389650A (en) * 1991-09-30 1995-02-14 Merck Frosst Canada, Inc. (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5290798A (en) * 1991-09-30 1994-03-01 Merck Frosst Canada, Inc. (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
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GB1229580A (enExample) * 1967-12-15 1971-04-28

Also Published As

Publication number Publication date
AU608804B2 (en) 1991-04-18
EP0279263B1 (en) 1993-08-04
EP0279263A3 (en) 1989-12-27
MX9202874A (es) 1992-06-30
CA1327204C (en) 1994-02-22
ES2059408T3 (es) 1994-11-16
DE3882732T2 (de) 1993-12-02
DE3882732D1 (de) 1993-09-09
CA1306744C (en) 1992-08-25
JPS63264456A (ja) 1988-11-01
JPH0569822B2 (enExample) 1993-10-01
KR890012994A (ko) 1989-09-20
AU1143388A (en) 1988-08-11
MX9203187A (es) 1992-07-01
EP0279263A2 (en) 1988-08-24

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