KR950703557A - 약제로서 사용되는 헤테로아릴 화합물(Heteroaryl Compounds Used as Pharmaceuticals) - Google Patents

약제로서 사용되는 헤테로아릴 화합물(Heteroaryl Compounds Used as Pharmaceuticals) Download PDF

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Publication number
KR950703557A
KR950703557A KR1019950700940A KR19950700940A KR950703557A KR 950703557 A KR950703557 A KR 950703557A KR 1019950700940 A KR1019950700940 A KR 1019950700940A KR 19950700940 A KR19950700940 A KR 19950700940A KR 950703557 A KR950703557 A KR 950703557A
Authority
KR
South Korea
Prior art keywords
compound
hydrogen
alkyl
halo
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019950700940A
Other languages
English (en)
Korean (ko)
Inventor
데이비드 킹 프란시스
라라미 메리 가스터
케이트 레이몬드 멀홀랜드
Original Assignee
데이비드 로버츠
스미스클라인 비참 피엘씨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 데이비드 로버츠, 스미스클라인 비참 피엘씨 filed Critical 데이비드 로버츠
Publication of KR950703557A publication Critical patent/KR950703557A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1019950700940A 1992-09-10 1993-09-07 약제로서 사용되는 헤테로아릴 화합물(Heteroaryl Compounds Used as Pharmaceuticals) Ceased KR950703557A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929219163A GB9219163D0 (en) 1992-09-10 1992-09-10 Pharmaceuticals
GB9219163.4 1992-09-10
PCT/GB1993/001895 WO1994005654A1 (en) 1992-09-10 1993-09-07 Heteroaryl compounds used as pharmaceuticals

Publications (1)

Publication Number Publication Date
KR950703557A true KR950703557A (ko) 1995-09-20

Family

ID=10721705

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950700940A Ceased KR950703557A (ko) 1992-09-10 1993-09-07 약제로서 사용되는 헤테로아릴 화합물(Heteroaryl Compounds Used as Pharmaceuticals)

Country Status (13)

Country Link
US (2) US5620992A (enExample)
EP (1) EP0659183A1 (enExample)
JP (1) JPH08501293A (enExample)
KR (1) KR950703557A (enExample)
CN (1) CN1040645C (enExample)
AU (1) AU682317B2 (enExample)
CA (1) CA2144423A1 (enExample)
GB (1) GB9219163D0 (enExample)
MX (1) MX9305510A (enExample)
NZ (1) NZ255535A (enExample)
TW (1) TW268006B (enExample)
WO (1) WO1994005654A1 (enExample)
ZA (1) ZA936613B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998409A (en) * 1992-03-12 1999-12-07 Smithkline Beecham Plc Condensed indole derivatives as 5HT4 -receptor antagonists
US5708174A (en) * 1992-03-12 1998-01-13 Smithkline Beecham P.L.C. Heterocyclic-esters or -amides used as 5-HT4 receptor antagonists
US5852014A (en) * 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
WO1994008965A1 (en) * 1992-10-16 1994-04-28 Smithkline Beecham Plc N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-ht4 receptor antagonists
GB9312348D0 (en) * 1993-06-16 1993-07-28 Smithkline Beecham Plc Pharmaceuticals
JP4263240B2 (ja) * 1995-11-09 2009-05-13 サノフィ−アベンティス ５−フェニル−３−（ピペリジン−４−イル）−１，３，４−オキサジアゾール−２（３ｈ）−オン誘導体、及びその５−ｈｔ４又はｈ３レセプターリガンドとしての用途
FR2741070B1 (fr) * 1995-11-09 1997-12-12 Synthelabo Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h) -one, leur preparation et leur application en therapeutique
TW445263B (en) 1996-02-29 2001-07-11 Janssen Pharmaceutica Nv Novel esters of 1,4-disubstituted piperidine derivatives
JP3366323B2 (ja) * 1998-09-10 2003-01-14 エフ．ホフマン−ラ ロシュ アーゲー ５−ｈｔ４受容体アンタゴニストとしてのジヒドロベンゾジオキシンカルボキサミド及びケトン誘導体
TW570920B (en) 1998-12-22 2004-01-11 Janssen Pharmaceutica Nv 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
GB0211230D0 (en) 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
JP4916878B2 (ja) 2003-06-19 2012-04-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ５ｈｔ４−拮抗薬としてのアミノスルホニル置換４−（アミノメチル）−ピペリジンベンズアミド
CN103420989B (zh) * 2012-05-15 2016-03-23 华中科技大学 苯并二噁烷类衍生物及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186135A (en) * 1976-08-04 1980-01-29 Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France Substituted 2,3-alkylene bis (oxy) benzamides and derivatives and method of preparation
US4268512A (en) * 1976-08-04 1981-05-19 Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France Substituted 2,3-alkylene bis (oxy) benzamides and derivatives and method of preparation
SE8503055D0 (sv) * 1985-06-19 1985-06-19 Astra Laekemedel Ab Piperonylcarboxamido derivatives
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
ATE137501T1 (de) * 1989-07-03 1996-05-15 Yoshitomi Pharmaceutical Benzazin-verbindungen und deren pharmazeutische verwendungen
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
GB9027098D0 (en) * 1990-12-13 1991-02-06 Beecham Group Plc Pharmaceuticals
ES2135414T3 (es) * 1991-09-12 1999-11-01 Smithkline Beecham Plc Antagonistas del receptor 5-ht4.
JPH05194406A (ja) * 1991-11-12 1993-08-03 Yoshitomi Pharmaceut Ind Ltd 新規アミド化合物
CA2129112A1 (en) * 1992-02-06 1993-08-19 Francis David King Benzopyran, benzothiopyran and benzofuran derivatives as 5-ht4 antagonists

Also Published As

Publication number Publication date
US5620992A (en) 1997-04-15
AU4976493A (en) 1994-03-29
CN1089946A (zh) 1994-07-27
WO1994005654A1 (en) 1994-03-17
AU682317B2 (en) 1997-10-02
EP0659183A1 (en) 1995-06-28
CA2144423A1 (en) 1994-03-17
CN1040645C (zh) 1998-11-11
GB9219163D0 (en) 1992-10-28
ZA936613B (en) 1994-05-16
MX9305510A (es) 1994-05-31
TW268006B (enExample) 1996-01-11
US5786372A (en) 1998-07-28
NZ255535A (en) 1996-10-28
JPH08501293A (ja) 1996-02-13

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PA0105 International application

Patent event date: 19950309

Patent event code: PA01051R01D

Comment text: International Patent Application

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PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19980616

Comment text: Request for Examination of Application

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Comment text: Notification of reason for refusal

Patent event date: 20000428

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20000719

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20000428

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I