KR950008512A - 이미다조피리딘 유도체의 제조방법 - Google Patents

이미다조피리딘 유도체의 제조방법 Download PDF

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Publication number
KR950008512A
KR950008512A KR1019940023449A KR19940023449A KR950008512A KR 950008512 A KR950008512 A KR 950008512A KR 1019940023449 A KR1019940023449 A KR 1019940023449A KR 19940023449 A KR19940023449 A KR 19940023449A KR 950008512 A KR950008512 A KR 950008512A
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KR
South Korea
Prior art keywords
formula
aryl
alkyl
hydrogen
aminoacetonitrile
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KR1019940023449A
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English (en)
Inventor
스턱키 게르하르트
임빙켈리트 르네
Original Assignee
비트 라우버, 베르너 그라우빌러
론자 리미티드
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Application filed by 비트 라우버, 베르너 그라우빌러, 론자 리미티드 filed Critical 비트 라우버, 베르너 그라우빌러
Publication of KR950008512A publication Critical patent/KR950008512A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

본 발명은 하기 일반식(I)의 이미다조피리딘을 제조하는 신규의 방법에 관한 것이다.
(상기 식에서, 라디칼 R1내지 R4는 명세서의 정의와 같다.)
본 방법의 중요 단계는, 하기 일반식(II)의 이미데이트를 아미노아세토니트릴 및 하기 일반식(Ⅲ)의 1,3-디카르보닐 화합물과 고리화 반응시키는 것이다.
이미다조피리딘은 안지오텐신II 길항 물질의 제조에 중요한 중간 물질이다.

Description

이미다조피리딘 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 하기 일반식(II)의 이미데이트를 아미노아세토니트릴 및 하기 일반식(Ⅲ)의 1,3-디카르보닐 화합물과 고리화 반응시키어 하기 일반식(I)의 최종 생성물을 수득하는 것을 특징으로하는 하기 일반식(I)의 이미미다조피리딘 유도체의 제조방법.
    (상기 식들에서, R1은 알킬, 시클로알킬, 아릴 또는 아르알킬기이거나, 헤테로고리 라디칼이고, R2및 R4는 동일하거나 상이하고, 수소, 히드록시, 시아노, 알킬, 시클로알킬, 아릴 또는 아르알킬기이거나, 알카노일 또는 알콕시카르보닐기이고, R3는 수소, 알킬, 아릴 또는 아르알킬기이거나, 할로겐 원자이고, R5는 알킬, 아릴 또는 아르알킬이고, R6및 R7은 동일하거나 상이하고, 수소, 알킬, 아릴, 아르알킬, 알콕시 또는 알콕시카르보닐이다.)
  2. 제1항에 있어서, 아미노아세토니트릴이 염기에 의하여 아미노아세토니트릴의 염으로부터 유리되는 것을 특징으로 하는 방법.
  3. 제1항 또는 제2항에 있어서, 고리화 반응이 실온 내지 반응 혼합물의 환류 온도하에 첨가 용매의 존재 또는 부재하에서 수행되는 것을 특징으로 하는 방법.
  4. 제1항에 있어서, 상기 일반식(II)의 이미데이트가 수소 할라이드의 존재하에서, 하기 일반식(IV)의 니트릴을 하기 일반식(V)의 알콜과 반응시키어 수득되는 것을 특징으로 하는 방법.
    R1CN (IV)
    R5OH (V)
    (상기 식들에서, R1및 R5는 상기 정의와 같다.)
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940023449A 1993-09-17 1994-09-15 이미다조피리딘 유도체의 제조방법 KR950008512A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH281693 1993-09-17
CH93-2816 1993-09-17

Publications (1)

Publication Number Publication Date
KR950008512A true KR950008512A (ko) 1995-04-17

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US (1) US5446160A (ko)
EP (1) EP0645389B1 (ko)
JP (1) JP3713724B2 (ko)
KR (1) KR950008512A (ko)
AT (1) ATE148702T1 (ko)
AU (1) AU680025B2 (ko)
BR (1) BR9403594A (ko)
CA (1) CA2131680C (ko)
CZ (1) CZ285489B6 (ko)
DE (1) DE59401760D1 (ko)
DK (1) DK0645389T3 (ko)
ES (1) ES2098089T3 (ko)
GR (1) GR3022500T3 (ko)
HU (1) HU218488B (ko)
IL (1) IL110994A (ko)
PL (1) PL305067A1 (ko)
RU (1) RU94033473A (ko)
SI (1) SI0645389T1 (ko)
SK (1) SK111494A3 (ko)
TR (1) TR27788A (ko)
TW (1) TW410225B (ko)
ZA (1) ZA947189B (ko)

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MXPA06001669A (es) 2003-08-12 2006-04-28 3M Innovative Properties Co Compuestos que contienen imidazo-oxima sustituidos.
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US8871782B2 (en) 2003-10-03 2014-10-28 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
CA2545825A1 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
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EP1701955A1 (en) 2003-12-29 2006-09-20 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
CA2551399A1 (en) 2003-12-30 2005-07-21 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
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JP5313502B2 (ja) 2004-12-30 2013-10-09 スリーエム イノベイティブ プロパティズ カンパニー 置換キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
AU2005322898B2 (en) 2004-12-30 2011-11-24 3M Innovative Properties Company Chiral fused (1,2)imidazo(4,5-c) ring compounds
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JP2008530113A (ja) 2005-02-11 2008-08-07 コーリー ファーマシューティカル グループ，インコーポレイテッド オキシムおよびヒドロキシラミン置換イミダゾ［４，５−ｃ］環化合物および方法
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SK111494A3 (en) 1995-06-07
JP3713724B2 (ja) 2005-11-09
TR27788A (tr) 1995-08-29
DK0645389T3 (da) 1997-03-10
GR3022500T3 (en) 1997-05-31
AU680025B2 (en) 1997-07-17
SI0645389T1 (en) 1997-10-31
HU9402662D0 (en) 1994-11-28
HUT68250A (en) 1995-06-28
US5446160A (en) 1995-08-29
BR9403594A (pt) 1995-05-16
AU7305894A (en) 1995-03-30
CA2131680C (en) 2006-11-07
RU94033473A (ru) 1996-08-10
DE59401760D1 (de) 1997-03-20
IL110994A (en) 1998-02-08
EP0645389B1 (de) 1997-02-05
ES2098089T3 (es) 1997-04-16
HU218488B (hu) 2000-09-28
EP0645389A1 (de) 1995-03-29
JPH07179465A (ja) 1995-07-18
ZA947189B (en) 1995-05-12
CA2131680A1 (en) 1995-03-18
TW410225B (en) 2000-11-01
CZ285489B6 (cs) 1999-08-11
ATE148702T1 (de) 1997-02-15
PL305067A1 (en) 1995-03-20
CZ226694A3 (en) 1995-04-12
IL110994A0 (en) 1994-11-28

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