KR950000870A - 탁솔의 고수율 세포배양 제조방법 - Google Patents

탁솔의 고수율 세포배양 제조방법 Download PDF

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Publication number
KR950000870A
KR950000870A KR1019930010693A KR930010693A KR950000870A KR 950000870 A KR950000870 A KR 950000870A KR 1019930010693 A KR1019930010693 A KR 1019930010693A KR 930010693 A KR930010693 A KR 930010693A KR 950000870 A KR950000870 A KR 950000870A
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South Korea
Prior art keywords
taxol
cell culture
taxus
high yield
taxus media
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KR1019930010693A
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English (en)
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KR970009157B1 (en
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변상요
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김영길
주식회사 녹십자
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Priority to KR93010693A priority Critical patent/KR970009157B1/ko
Publication of KR950000870A publication Critical patent/KR950000870A/ko
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Publication of KR970009157B1 publication Critical patent/KR970009157B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

본 발명은 주목나무에서 유리된 식물세포의 세포배양에 의한 항암물질인 탁솔 및 그 유도체들을 제조하는 방법에 관한 것이다.
본 발명의 목적은 새로운 종류의 주목나무를 이용하여 높은 생산성으로 탁솔을 제조하는 방법을 제공하기 위한 것이다.
본 발명은 주목나무의 살아있는 조직을 캘러스 유동용 SH고체배지에서 배양하여 캘러스를 유도하고 현탁배양할때, 일리시터를 첨가하여 세포내 쟈스몬산을 증가시켜 고수율로 세포배양함을 특징으로 한다.
얻어진 탁솔은 항암제로 유용하게 사용된다.

Description

탁솔의 고수율 세포배양 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 주목나무의 살아있는 조직을 캘러스 유도용 SH고체배지에서 배양하여 캘러스를 유도하고 현택배양할때, 일리시터를 첨가하여 세포내 쟈스몬산을 증가시켜 고수율로 세포배양함을 특징으로 하는 탁솔의 고수율 세포배양 제조방법.
  2. 제 1 항에 있어서, 주목나무가Taxus caespitosaNAKAI,Taxus mediaHICKSII,Taxus mediaANDERSONII,taxus mediaHUNNEWELLANA,Taxus mediaVERMEULEN,Taxus mediaROBUSTA,Taxus mediaTRRANDIDOLIA,Taxus mediaKELSEYI 및Taxus baccataPENDULA임을 특징으로 하는 탁솔의 고수율 세포배양 제조방법.
  3. 제 1 항에 있어서, 일리시터는 효모 또는 곰팡이로 부터 추출한 것임을 특징으로 하는 탁솔의 고수율 세포배양 제조방법.
  4. 제 3 항에 있어서, 곰팡이로 부터 추출한 일리시터는 Phytophtora megasperma의 세포벽 추출 일리시터임을 특징으로 하는 탁솔의 고수율 세포배양 제조방법.
  5. 제 1 항에 있어서, 쟈스몬산을 배양세포에 직접 첨가함을 특징으로 하는 탁솔의 고수율 세포배양 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR93010693A 1993-06-12 1993-06-12 Process for the high yield production of taxol by cell culture KR970009157B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR93010693A KR970009157B1 (en) 1993-06-12 1993-06-12 Process for the high yield production of taxol by cell culture

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR93010693A KR970009157B1 (en) 1993-06-12 1993-06-12 Process for the high yield production of taxol by cell culture

Publications (2)

Publication Number Publication Date
KR950000870A true KR950000870A (ko) 1995-01-03
KR970009157B1 KR970009157B1 (en) 1997-06-07

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KR93010693A KR970009157B1 (en) 1993-06-12 1993-06-12 Process for the high yield production of taxol by cell culture

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100763858B1 (ko) * 1995-06-07 2008-11-07 디에프비 바이오테크 인코포레이티드 식물세포의동결보존방법및회복방법

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8053238B2 (en) 2005-10-31 2011-11-08 Unhwa Corporation Isolated population of plant single cells and method of preparing the same
KR101064518B1 (ko) 2007-09-21 2011-09-19 주식회사 운화 저장근을 가지는 초본식물의 형성층 유래 식물줄기세포주 및 이의 분리방법

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100763858B1 (ko) * 1995-06-07 2008-11-07 디에프비 바이오테크 인코포레이티드 식물세포의동결보존방법및회복방법

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