KR930703346A - 보호기, 이기로 보호된 화합물 및 보호된 화합물상에 보호기를 그라프트 하기 위한 장치 - Google Patents

보호기, 이기로 보호된 화합물 및 보호된 화합물상에 보호기를 그라프트 하기 위한 장치

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KR930703346A
KR930703346A KR1019930701991A KR930701991A KR930703346A KR 930703346 A KR930703346 A KR 930703346A KR 1019930701991 A KR1019930701991 A KR 1019930701991A KR 930701991 A KR930701991 A KR 930701991A KR 930703346 A KR930703346 A KR 930703346A
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라피 길리
라마지 로베르뜨
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프랑소와 리깔렁
롱-쁠랑 쉬미
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/34—Monohydroxylic alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/96—Esters of carbonic or haloformic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/54—Ortho- or ortho- and peri-condensed systems containing more than five condensed rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Liquid Developers In Electrophotography (AREA)
  • Coupling Device And Connection With Printed Circuit (AREA)
  • Saccharide Compounds (AREA)
  • Inorganic Insulating Materials (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Container Filling Or Packaging Operations (AREA)
  • Packages (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

Abstract

보호기
하기식(I)의 보호기 : Ar-L- [식중, Ar은 실질적으로 평면인 4이상의 방향족 고리를 함유하는 융합 고리계를 나타내고, L은 보호될 기에 결합할 수 있는 하나 이상의 탄소원자를 함유하는 기를 나타낸다.]

Description

보호기, 이기로 보호된 화합물 및 보호된 화합물상에 보호기를 그라프트 하기 위한 장치
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도 및 제2도는 알콜(31)의 결정 구조를 나타낸다.

Claims (23)

  1. 하기식(I)의 보호기 : Ar-L- [식중, Ar은 실질적으로 평면인 4이상의 방향족 고리를 함유하는 융합고리계를 나타내고, L은 보호될 기에 결합할 수 있는 1 이상의 탄소원자를 함유하는 기를 나타낸다.]
  2. 제1항에 있어서, Ar기가 6이상dml 방향족 고리를 함유하는 기.
  3. 제1항 또는 제2항에 있어서, 방향족 고리가 육각 구조(hexagonal)인 기.
  4. 제1항 내지 제3항중의 어느 한 항에 있어서, Ar이 헤테로 원자를 함유하지 않는 기.
  5. 제1항 내지 제4항중의 어느 한 항에 있어서, 하기식(Ⅱ)의 기.
  7. [식중, n은 0또는 1이며, 0은 n이 1일때 주위의 고리가 방향족이고 n이 0일때 비 방향족인 것을 의미하고, 한편으로는 R1및 R2와 다른 한편으로는 R3및 R4는 각기 그들에 부착된 탄소원자와 함께 융합 방향족 고리계를 형성할 수 있도록 선택되며, R′는 알킬기 또는 수소이고, L′는 직접 결합을 나타내거나 또는 보호될 기에 결합할 수 있는 기를 나타낸다.]
  8. 제1항 또는 제4항중의 어느 한 항에 있어서, 하기식(Ⅲ)의 기.
  10. [식중 : 0, n, R1, R2, R3, R4, R′및 L′는 제5항 또는 제6항에서 정의한 바와 같고, R5는 그것이 부착되는 원자와 함께 하나 이상의 보충고리를 형성한다.]
  11. 제5항 또는 제6항에 있어서, L′는 -CO-, -O-, -CO-, -S-, -O-, -(CH2)m, -O- (식중 m은 1∼6이거나 또는 직접 결합이다.)인 기.
  12. L또는 L′기를 통해서 이탈기에 부착된 제1항 내지 제7항중의 어느 한 항에서 정의된 기를 함유하는 보호 화합물.
  13. 제8항에 있어서, 이탈기가 질소, 산소, 황, 셀렌, 텔루르, 규소 또는 할로겐 원자를 함유하는 화합물.
  14. 제9항에 있어서, 이탈기가 할로겐원자, -OH, -COOH, -NH2, -CONH2, -SO2C6H4-pCH2, -SH, -CN 또는 Si(CH3)3기인 화합물.
  15. 보호될 화합물의 기에 부착된 제1항 내지 제6항중의 어느 한 항에서 정의된 기를 함유하는 보호 화합물.
  16. 제11항에 있어서, 보호될 화합물의 기가 알콜, 티올, 산, 아민 또는 아미드기인 화합물.
  17. 제12항에 있어서, 보호될 화합물이 천연 또는 합성 펩티드 또는 아미노산인 화합물.
  18. a)흑연화 물질로 채원진 챔버 및 b)분자상에 제1항 내지 제6항중의 어느 한 항에서 정의된 보호기를 그라프트 하기 위한 키트(kit)를 함유하는 연속 또는 동시용으로 사용되는 장치.
  19. 제14항에 있어서, 흑연물질이 흑연 또는 활성탄인 장치.
  20. 제14항 또는 제15항에 있어서, c)자외(UV), 가시 분광, 또는 형광 분광 검출기가 부착된 분획-수집계도 또한 함유하는 장치.
  21. -분리될 화합물의 혼합물중 하나이상의 화합물에 있는 하나 이상의 기를 제1항 내지 제6항중의 어느 한 항에서 정의된 기로 보호하고, -흑연화 물질로 채워진 챔버를 통해 화합물의 화합물을 통과시키는 단계를 함유하는 화합물의 혼합물을 합성 또는 분리하는 방법.
  22. 분자의 하나이상의 관능기를 보호하기 위해 사용되는 제1항 내지 제6항중의 어느 한 항에서 정의된 기.
  23. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930701991A 1990-12-31 1991-12-31 보호기, 이 기로 보호된 화합물 및 보호된 화합물상에 보호기를 그라프트하기 위한 장치 KR100232396B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9028208A GB2251242B (en) 1990-12-31 1990-12-31 Protecting compound
GB9028208.8 1990-12-31
PCT/FR1991/001083 WO1992012167A1 (fr) 1990-12-31 1991-12-31 Groupe protecteur, compose protege par ce groupe et dispositif pour greffer le groupe protecteur sur le compose a proteger

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KR930703346A true KR930703346A (ko) 1993-11-29
KR100232396B1 KR100232396B1 (ko) 1999-12-01

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Country Link
EP (1) EP0565607B1 (ko)
JP (1) JP3286316B2 (ko)
KR (1) KR100232396B1 (ko)
AT (1) ATE179180T1 (ko)
AU (1) AU669324B2 (ko)
BR (1) BR9107286A (ko)
CA (1) CA2099120A1 (ko)
DE (1) DE69131168T2 (ko)
DK (1) DK0565607T3 (ko)
ES (1) ES2133313T3 (ko)
GB (1) GB2251242B (ko)
GR (1) GR3030169T3 (ko)
HU (1) HU217033B (ko)
WO (1) WO1992012167A1 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9307014D0 (en) * 1993-04-02 1993-05-26 Laporte Plc Protecting group for use in oligodeoxyribonucleotide synthesis
GB2299993A (en) * 1995-04-21 1996-10-23 Rhone Poulenc Ltd Chiral polycyclic aromatic compounds and their use as a chiral stationary phase in enantiomeric separations
DE102010001983A1 (de) * 2010-02-16 2011-08-18 peptides&elephants GmbH, 14558 Verfahren zur Erzeugung eines Peptidreinigungsmaterials auf Graphitbasis und Verfahren zur Peptidaufreinigung

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB272528A (ko) * 1900-01-01
GB201786A (en) * 1922-08-24 1923-08-09 Kalle & Co Ag Process for producing vat colouring-matters
GB303389A (en) * 1927-07-01 1929-01-01 Ig Farbenindustrie Ag The manufacture of new carboxylic acids of the fatty-aromatic series
GB327526A (en) * 1929-02-27 1930-04-10 Ig Farbenindustrie Ag Manufacture of aralkyl-benzanthrones
GB469633A (en) * 1935-08-10 1937-07-29 Ig Farbenindustrie Ag The manufacture of polycyclic condensation products
GB824175A (en) * 1955-02-21 1959-11-25 Metal & Thermit Corp Reactions involving grignard reagents
DE2036171A1 (ko) * 1970-07-21 1972-01-27
US3839396A (en) * 1971-07-15 1974-10-01 Shionogi & Co 9-lower alkyl-9-fluorenyl carbonates
DE3133390A1 (de) * 1981-08-24 1983-03-10 Basf Ag, 6700 Ludwigshafen Verfahren zur flaechenmaessigen konzentrierung von licht und neue fluoreszierende verbindungen
DE3711866A1 (de) * 1987-04-08 1988-10-27 Hoechst Ag Synthese von peptidamiden mittels festphasenmethode unter verwendung von saeurelabilen ankergruppen

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ES2133313T3 (es) 1999-09-16
JP3286316B2 (ja) 2002-05-27
AU669324B2 (en) 1996-06-06
HU217033B (hu) 1999-11-29
KR100232396B1 (ko) 1999-12-01
GB2251242A (en) 1992-07-01
GB9028208D0 (en) 1991-02-13
GR3030169T3 (en) 1999-08-31
GB2251242B (en) 1995-01-11
HU9301892D0 (en) 1993-09-28
WO1992012167A1 (fr) 1992-07-23
BR9107286A (pt) 1996-01-02
HUT69324A (en) 1995-09-28
CA2099120A1 (fr) 1992-07-01
ATE179180T1 (de) 1999-05-15
EP0565607B1 (fr) 1999-04-21
DE69131168D1 (de) 1999-05-27
DK0565607T3 (da) 1999-10-25
EP0565607A1 (fr) 1993-10-20
JPH06506914A (ja) 1994-08-04
DE69131168T2 (de) 1999-11-18
AU9170791A (en) 1992-08-17

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