KR930701412A - 벤즈이미다졸 유도체와 이의 제조 방법 및 이의 용도 - Google Patents

벤즈이미다졸 유도체와 이의 제조 방법 및 이의 용도

Info

Publication number
KR930701412A
KR930701412A KR1019930700436A KR930700436A KR930701412A KR 930701412 A KR930701412 A KR 930701412A KR 1019930700436 A KR1019930700436 A KR 1019930700436A KR 930700436 A KR930700436 A KR 930700436A KR 930701412 A KR930701412 A KR 930701412A
Authority
KR
South Korea
Prior art keywords
alkyl
benzenesulfonamide
pyridylmethyl
methylimidazo
isobutyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019930700436A
Other languages
English (en)
Korean (ko)
Inventor
마아크 위타커
앤드류 밀러
Original Assignee
폴 리틀우드
브리티쉬 바이오-테크놀로지 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909017878A external-priority patent/GB9017878D0/en
Priority claimed from GB909018040A external-priority patent/GB9018040D0/en
Priority claimed from GB919112857A external-priority patent/GB9112857D0/en
Application filed by 폴 리틀우드, 브리티쉬 바이오-테크놀로지 리미티드 filed Critical 폴 리틀우드
Publication of KR930701412A publication Critical patent/KR930701412A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
KR1019930700436A 1990-08-15 1991-08-15 벤즈이미다졸 유도체와 이의 제조 방법 및 이의 용도 Ceased KR930701412A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB909017878A GB9017878D0 (en) 1990-08-15 1990-08-15 Compounds
GB9017878.1 1990-08-15
GB909018040A GB9018040D0 (en) 1990-08-16 1990-08-16 Compounds
GB9018040.7 1990-08-16
GB9112857.9 1991-06-14
GB919112857A GB9112857D0 (en) 1991-06-14 1991-06-14 Compounds
PCT/GB1991/001391 WO1992003422A1 (en) 1990-08-15 1991-08-15 Benzimidazole derivatives, process for their preparation and their application

Publications (1)

Publication Number Publication Date
KR930701412A true KR930701412A (ko) 1993-06-11

Family

ID=27265234

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930700436A Ceased KR930701412A (ko) 1990-08-15 1991-08-15 벤즈이미다졸 유도체와 이의 제조 방법 및 이의 용도

Country Status (17)

Country Link
US (2) US5200412A (enExample)
EP (1) EP0543861B1 (enExample)
JP (1) JP3218243B2 (enExample)
KR (1) KR930701412A (enExample)
AT (1) ATE172195T1 (enExample)
AU (1) AU657920B2 (enExample)
CA (1) CA2088742C (enExample)
DE (1) DE69130362T2 (enExample)
ES (1) ES2123511T3 (enExample)
FI (1) FI930633A7 (enExample)
HU (2) HUT65983A (enExample)
IE (1) IE912874A1 (enExample)
NO (2) NO301229B1 (enExample)
NZ (1) NZ239408A (enExample)
PT (1) PT98674B (enExample)
TW (1) TW199860B (enExample)
WO (1) WO1992003422A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE70217B1 (en) * 1990-08-15 1996-10-30 British Bio Technology Benzimidazole derivatives process for their preparation and application
US5466704A (en) * 1991-02-26 1995-11-14 E. R. Squibb & Sons, Inc. N-substituted imidazole and benzimidazole derivatives useful as angiotenson II antagonists
GB9122308D0 (en) * 1991-10-21 1991-12-04 British Bio Technology Compounds
GB9200245D0 (en) * 1992-01-07 1992-02-26 British Bio Technology Compounds
GB9200209D0 (en) * 1992-01-07 1992-02-26 British Bio Technology Compounds
GB9201755D0 (en) * 1992-01-28 1992-03-11 British Bio Technology Compounds
GB9202791D0 (en) * 1992-02-11 1992-03-25 British Bio Technology Compounds
IL111785A0 (en) * 1993-12-03 1995-01-24 Ferring Bv Dp-iv inhibitors and pharmaceutical compositions containing them
AU704972B2 (en) 1994-08-04 1999-05-13 H. Lundbeck A/S Novel benzimidazole derivatives
GB9508748D0 (en) * 1995-04-28 1995-06-14 British Biotech Pharm Benzimidazole derivatives
US6495583B1 (en) 1997-03-25 2002-12-17 Synaptic Pharmaceutical Corporation Benzimidazole derivatives
TW453999B (en) * 1997-06-27 2001-09-11 Fujisawa Pharmaceutical Co Benzimidazole derivatives
FR2776925B3 (fr) * 1998-04-07 2000-05-26 Sanofi Sa Utilisation de derives d'aminothiazole pour la preparation de medicaments pour le traitement des maladies entrainant une demyelinisation
EP1490335B1 (en) * 2002-03-25 2007-09-19 Merck & Co., Inc. Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
GB201321735D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
CN113292873B (zh) * 2021-05-11 2022-03-08 重庆工程职业技术学院 一种煤矿矿井巷道喷涂材料及其制备方法
MX2024009216A (es) * 2022-01-28 2024-08-06 Insilico Medicine Ip Ltd Inhibidores de ectonucleotido pirofosfatasa-fosfodiesterasa 1 (enpp1) y usos de los mismos.
CN121969621A (zh) * 2023-08-02 2026-05-01 英矽智能科技知识产权有限公司 外核苷酸焦磷酸酶-磷酸二酯酶1 (enpp1)抑制剂的结晶形式及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6715600A (enExample) * 1966-12-02 1968-06-04
US4006151A (en) 1973-09-21 1977-02-01 Polaroid Corporation Precursors of β-aza-disubstituted amino styryl dyes
US4612323A (en) * 1983-06-27 1986-09-16 Sumitomo Chemical Company, Limited Insecticidal and acaricidal derivatives of 1-benzylbenzimidazole
US4539332A (en) * 1983-11-14 1985-09-03 Merck & Co., Inc. 2,5-Diaryl tetrahydrofurans and analogs thereof as PAF-antagonists
JP2556849B2 (ja) * 1986-02-13 1996-11-27 三共株式会社 グリセリン誘導体
US4804658A (en) * 1986-09-15 1989-02-14 G. D. Searle & Co. Imidazopyridine derivatives and pharmaceutical compositions
US4914108A (en) * 1988-03-14 1990-04-03 G. D. Searle & Co. 5-substituted(4,5-c)imidazopyridine compounds which have useful platelet activating factor antagonistic activity
EP0404797B1 (en) * 1988-03-15 1995-02-01 G.D. Searle & Co. 1H/3H-[4-(N,N-CYCLOALKYL AND/OR BRANCHED-ALKYLCARBOXAMIDO) -BENZYL]IMIDAZO[4,5-c]PYRIDINES AS PAF ANTAGONISTS
GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
US5157026A (en) * 1989-05-30 1992-10-20 Merck & Co., Inc. Oxo-purines as angiotensin II antagonists
IE70217B1 (en) * 1990-08-15 1996-10-30 British Bio Technology Benzimidazole derivatives process for their preparation and application

Also Published As

Publication number Publication date
PT98674B (pt) 1999-01-29
ES2123511T3 (es) 1999-01-16
CA2088742A1 (en) 1992-02-16
US5276153A (en) 1994-01-04
AU657920B2 (en) 1995-03-30
NZ239408A (en) 1993-12-23
HU210218A9 (en) 1995-02-28
AU8421691A (en) 1992-03-17
FI930633L (fi) 1993-04-07
JP3218243B2 (ja) 2001-10-15
HUT65983A (en) 1994-08-29
WO1992003422A1 (en) 1992-03-05
NO301229B1 (no) 1997-09-29
EP0543861B1 (en) 1998-10-14
PT98674A (pt) 1992-07-31
CA2088742C (en) 2002-02-12
EP0543861A1 (en) 1993-06-02
FI930633A0 (fi) 1993-02-12
US5200412A (en) 1993-04-06
NO930499D0 (no) 1993-02-12
FI930633A7 (fi) 1993-04-07
DE69130362D1 (de) 1998-11-19
DE69130362T2 (de) 1999-04-01
HU9300390D0 (en) 1993-04-28
ATE172195T1 (de) 1998-10-15
NO973981L (no) 1993-04-14
TW199860B (enExample) 1993-02-11
IE912874A1 (en) 1992-02-26
NO930499L (no) 1993-04-14
NO973981D0 (no) 1997-08-29
JPH06500085A (ja) 1994-01-06

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Legal Events

Date Code Title Description
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Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19930215

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PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19960625

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19930215

Comment text: Patent Application

E902 Notification of reason for refusal
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Comment text: Notification of reason for refusal

Patent event date: 19981022

Patent event code: PE09021S01D

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Patent event date: 19981230

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Patent event date: 19981022

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I