NO178192C - Analogifremgangsmåte ved fremstilling av terapeutisk aktive 3-arylindol- og 3-arylindazolderivater - Google Patents

Analogifremgangsmåte ved fremstilling av terapeutisk aktive 3-arylindol- og 3-arylindazolderivater

Info

Publication number
NO178192C
NO178192C NO912739A NO912739A NO178192C NO 178192 C NO178192 C NO 178192C NO 912739 A NO912739 A NO 912739A NO 912739 A NO912739 A NO 912739A NO 178192 C NO178192 C NO 178192C
Authority
NO
Norway
Prior art keywords
alkyl
hydrogen
arylindole
group
trifluoromethyl
Prior art date
Application number
NO912739A
Other languages
English (en)
Other versions
NO912739L (no
NO912739D0 (no
NO178192B (no
Inventor
Jens Kristian Perregaard
Kim Andersen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of NO912739D0 publication Critical patent/NO912739D0/no
Publication of NO912739L publication Critical patent/NO912739L/no
Publication of NO178192B publication Critical patent/NO178192B/no
Publication of NO178192C publication Critical patent/NO178192C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
NO912739A 1990-07-30 1991-07-12 Analogifremgangsmåte ved fremstilling av terapeutisk aktive 3-arylindol- og 3-arylindazolderivater NO178192C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK181190A DK181190D0 (da) 1990-07-30 1990-07-30 3-aryl-indol- eller 3-aryl-indazolderivater
SG19995A SG19995G (en) 1990-07-30 1995-02-07 Novel 3-arylindole and 3-arylindazole derivatives

Publications (4)

Publication Number Publication Date
NO912739D0 NO912739D0 (no) 1991-07-12
NO912739L NO912739L (no) 1992-01-31
NO178192B NO178192B (no) 1995-10-30
NO178192C true NO178192C (no) 1996-02-07

Family

ID=26066139

Family Applications (1)

Application Number Title Priority Date Filing Date
NO912739A NO178192C (no) 1990-07-30 1991-07-12 Analogifremgangsmåte ved fremstilling av terapeutisk aktive 3-arylindol- og 3-arylindazolderivater

Country Status (20)

Country Link
US (1) US5393761A (no)
EP (1) EP0470039B1 (no)
JP (1) JP3165181B2 (no)
KR (1) KR100233955B1 (no)
AT (1) ATE115128T1 (no)
AU (1) AU646679B2 (no)
CA (1) CA2048027C (no)
DE (1) DE69105659T2 (no)
DK (2) DK181190D0 (no)
ES (1) ES2064974T3 (no)
FI (1) FI99111C (no)
GR (1) GR3015274T3 (no)
HK (1) HK51495A (no)
IE (1) IE65673B1 (no)
IL (1) IL98829A (no)
NO (1) NO178192C (no)
NZ (1) NZ238956A (no)
PT (1) PT98483B (no)
SG (1) SG19995G (no)
ZA (1) ZA915805B (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643784A (en) * 1990-12-04 1997-07-01 H, Lundbeck A/S Indan derivatives
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
DK8492D0 (da) * 1992-01-23 1992-01-23 Lundbeck & Co As H Behandling af psykoser
US5264576A (en) * 1992-10-22 1993-11-23 Hoechst-Roussel Pharmaceuticals Incorporated Pyrazolo[4,3-c]pyridines which are intermediates
TW421649B (en) * 1995-01-31 2001-02-11 Janssen Pharmaceutica Nv 4-(1H-indol-1yl)-1-piperidinyl derivatives
GB9523462D0 (en) * 1995-11-16 1996-01-17 Merck Sharp & Dohme Therapeutic agents
FR2744452B1 (fr) * 1996-02-06 1998-03-06 Cird Galderma Composes biaryles heterocycliques, compositions pharmaceutiques et cosmetiques les contenant et utilisations
DE19642255A1 (de) * 1996-10-14 1998-04-16 Bayer Ag Verwendung von 1-Benzyl-3-(substituierten-hetaryl) -kondensierten Pyrazol-Derivaten
TWI242011B (en) 1997-03-31 2005-10-21 Eisai Co Ltd 1,4-substituted cyclic amine derivatives
FR2788772B1 (fr) * 1999-01-26 2001-03-02 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2001274049A1 (en) * 2000-05-26 2001-12-11 Ciba Specialty Chemicals Holding Inc. Process for the preparation of indole derivatives and intermediates of the process
ES2275853T3 (es) * 2001-02-16 2007-06-16 Aventis Pharmaceuticals Inc. Derivados heterociclicos de urea y su uso como ligandos de receptores de dopamina d3.
GB0117950D0 (en) * 2001-02-16 2001-09-19 Aventis Pharma Inc Novel heterocyclic urea derivatives andd their use as dopamine D3 receptor ligands
CN100497334C (zh) 2002-06-24 2009-06-10 先灵公司 用作组胺h3拮抗剂的吲哚衍生物
TW200409759A (en) 2002-09-25 2004-06-16 Wyeth Corp Substituted 4-(indazol-3-yl)phenols
GB0306604D0 (en) * 2003-03-21 2003-04-30 Curidium Ltd Second medical use
CA2546493A1 (en) 2003-11-19 2005-06-09 Signal Pharmaceuticals, Llc Indazole compounds and methods of use thereof as protein kinase inhibitors
DE102006043443A1 (de) * 2006-09-15 2008-03-27 Bayer Healthcare Ag Neue aza-bicyclische Verbindungen und ihre Verwendung
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
WO2014102588A2 (en) * 2012-12-27 2014-07-03 Purdue Pharma L.P. Indole and indoline-type piperidine compounds and uses thereof
KR20150119871A (ko) 2013-02-21 2015-10-26 아드베리오 파마 게엠베하 메틸 ｛4,6-디아미노-2-[1-(2-플루오로벤질)-1H-피라졸로[3,4-b]피리디노-3-일]피리미디노-5-일｝메틸 카르바메이트의 형태

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2354766A1 (fr) * 1976-06-17 1978-01-13 Labaz Derives n-aminoalkyles d'indole et procedes pour les preparer
FR2421900A1 (fr) * 1977-03-17 1979-11-02 Sauba Lab Piperazino-3-indoles, leur procede de preparation et leurs applications therapeutiques
HU198036B (en) * 1983-08-22 1989-07-28 Hoechst Roussel Pharma Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them
DK704488D0 (da) * 1988-12-19 1988-12-19 Novo Industri As Nye n-substituerede azaheterocykliske carboxylsyrer
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives

Also Published As

Publication number Publication date
HK51495A (en) 1995-04-13
KR100233955B1 (ko) 2000-02-01
ZA915805B (en) 1992-04-29
GR3015274T3 (en) 1995-06-30
IL98829A0 (en) 1992-07-15
NO912739L (no) 1992-01-31
KR920002588A (ko) 1992-02-28
AU8141191A (en) 1992-02-06
CA2048027C (en) 2001-10-30
IE65673B1 (en) 1995-11-15
NO912739D0 (no) 1991-07-12
EP0470039A3 (en) 1992-05-27
FI99111C (fi) 1997-10-10
DE69105659T2 (de) 1995-04-27
FI99111B (fi) 1997-06-30
PT98483B (pt) 1997-09-30
AU646679B2 (en) 1994-03-03
CA2048027A1 (en) 1992-01-31
NZ238956A (en) 1993-12-23
DK181190D0 (da) 1990-07-30
SG19995G (en) 1995-08-18
IE912403A1 (en) 1992-02-12
FI913613A (fi) 1992-01-31
ES2064974T3 (es) 1995-02-01
FI913613A0 (fi) 1991-07-29
JP3165181B2 (ja) 2001-05-14
EP0470039B1 (en) 1994-12-07
DK0470039T3 (da) 1995-05-15
PT98483A (pt) 1992-05-29
US5393761A (en) 1995-02-28
ATE115128T1 (de) 1994-12-15
NO178192B (no) 1995-10-30
DE69105659D1 (de) 1995-01-19
JPH04368367A (ja) 1992-12-21
IL98829A (en) 1996-06-18
EP0470039A2 (en) 1992-02-05

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