KR930011151B1 - 세포 분화의 유발에 유효한 화합물 - Google Patents

세포 분화의 유발에 유효한 화합물 Download PDF

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Publication number
KR930011151B1
KR930011151B1 KR1019890702481A KR890702481A KR930011151B1 KR 930011151 B1 KR930011151 B1 KR 930011151B1 KR 1019890702481 A KR1019890702481 A KR 1019890702481A KR 890702481 A KR890702481 A KR 890702481A KR 930011151 B1 KR930011151 B1 KR 930011151B1
Authority
KR
South Korea
Prior art keywords
compound
hydroxy
group
dihydroxyvitamin
compounds
Prior art date
Application number
KR1019890702481A
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English (en)
Korean (ko)
Other versions
KR900700449A (ko
Inventor
헥터 에프. 드루카
하인리히 케이. 쉬노에스
캐토 엘. 펄먼
안드르예즈 쿠트너
Original Assignee
위스콘신 알럼나이 리써취 파운데이션
존 알. 파이크
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 위스콘신 알럼나이 리써취 파운데이션, 존 알. 파이크 filed Critical 위스콘신 알럼나이 리써취 파운데이션
Publication of KR900700449A publication Critical patent/KR900700449A/ko
Application granted granted Critical
Publication of KR930011151B1 publication Critical patent/KR930011151B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019890702481A 1988-04-29 1989-04-18 세포 분화의 유발에 유효한 화합물 KR930011151B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US187,680 1988-04-29
US07/187,680 US4927815A (en) 1988-04-29 1988-04-29 Compounds effective in inducing cell differentiation and process for preparing same
PCT/US1989/001633 WO1989010353A1 (en) 1988-04-29 1989-04-18 Compounds effective in inducing cell differentiation

Publications (2)

Publication Number Publication Date
KR900700449A KR900700449A (ko) 1990-08-13
KR930011151B1 true KR930011151B1 (ko) 1993-11-24

Family

ID=22690003

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890702481A KR930011151B1 (ko) 1988-04-29 1989-04-18 세포 분화의 유발에 유효한 화합물

Country Status (15)

Country Link
US (2) US4927815A (US20100012521A1-20100121-C00001.png)
EP (1) EP0375757A1 (US20100012521A1-20100121-C00001.png)
JP (2) JPH0725730B2 (US20100012521A1-20100121-C00001.png)
KR (1) KR930011151B1 (US20100012521A1-20100121-C00001.png)
AU (1) AU630096B2 (US20100012521A1-20100121-C00001.png)
CA (1) CA1340615C (US20100012521A1-20100121-C00001.png)
DK (2) DK666589A (US20100012521A1-20100121-C00001.png)
FR (1) FR2630740A1 (US20100012521A1-20100121-C00001.png)
GB (1) GB2217715A (US20100012521A1-20100121-C00001.png)
HU (1) HU206083B (US20100012521A1-20100121-C00001.png)
IE (1) IE67868B1 (US20100012521A1-20100121-C00001.png)
IL (1) IL90066A (US20100012521A1-20100121-C00001.png)
IN (1) IN170659B (US20100012521A1-20100121-C00001.png)
NL (1) NL8920414A (US20100012521A1-20100121-C00001.png)
WO (1) WO1989010353A1 (US20100012521A1-20100121-C00001.png)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250523A (en) * 1988-04-29 1993-10-05 Wisconsin Alumni Research Foundation Side chain unsaturated 1α-hydroxyvitanim D homologs
CA1339383C (en) * 1989-03-09 1997-08-26 Hector Floyd Deluca Method for preparing intermediates for the synthesis of steroid side chains in optically active form
DE3933034A1 (de) * 1989-10-02 1991-04-11 Schering Ag 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung
GB9007236D0 (en) * 1990-03-30 1990-05-30 Leo Pharm Prod Ltd Chemical compounds
US5459136A (en) * 1990-08-24 1995-10-17 Wisconsin Alumni Research Foundation Methods using vitamin D compounds for improvement of skin conditions
US5276061A (en) * 1990-08-24 1994-01-04 Wisconsin Alumni Research Foundation Cosmetic compositions containing 1α-hydroxyvitamin D homologs
US5756783A (en) * 1990-09-21 1998-05-26 Bone Care International, Inc. 1α-Hydroxy-24-EPI-vitamin D4
DE4221961A1 (de) * 1992-06-30 1994-01-05 Schering Ag 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel
US5380720A (en) * 1993-05-11 1995-01-10 Wisconsin Alumni Research Foundation Iodo vitamin D3 compounds and method for preparing same
PE28297A1 (es) * 1995-01-26 1997-08-20 Hoffmann La Roche Empleo dermatologico de derivados de vitamina d
US5744128A (en) * 1995-05-03 1998-04-28 Holick; Michael F. Use of emu oil for stimulating skin and hair growth
IL118156A (en) * 1995-05-09 2001-08-26 Duphar Int Res Vitamin d compounds, their preparation and pharmaceutical compositions containing them
AUPO727097A0 (en) * 1997-06-10 1997-07-03 Unisearch Limited Method of treatment of hepatoma and pharmaceutical compositions for use therein
US6521608B1 (en) 1998-03-27 2003-02-18 Oregon Health & Science University Vitamin D and its analogs in the treatment of tumors and other hyperproliferative disorders
PT1180035E (pt) * 1999-04-01 2007-02-28 Univ Johns Hopkins Análogos não calcémicos, antiproliferativos, transcricionalmente activos de 1-alfa, 25-di-hidroxivitamina d3 contendo enxofre
WO2001040177A2 (en) 1999-12-02 2001-06-07 Women And Infants Hospital Esters of vitamin d3 and uses thereof
US7166585B2 (en) * 2001-08-22 2007-01-23 Cytochroma Inc. 24-Sulfur-substituted analogs of 1α,25-dihydroxy vitamin D3
AU2003262179A1 (en) * 2002-04-11 2003-10-27 Instytut Farmaceutyczny Preparation of 24 alkyl analogs of cholecalciferol and non-racemic compounds
BRPI0508333A (pt) * 2004-03-01 2007-07-17 Bioxell Spa uso de um composto de vitamina d, método de prevenir e/ou tratar cistite intersticial, formulação farmacêutica, composto de vitamina d, e, kit
EP1812011A1 (en) 2004-11-12 2007-08-01 Bioxell S.p.a. Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
WO2008131267A2 (en) * 2007-04-18 2008-10-30 Johns Hopkins University Low calcemic, highly antiproliferative, analogs of calcitriol
EA201691980A1 (ru) 2009-01-27 2017-07-31 БЕРГ ЭлЭлСи Способы уменьшения побочных эффектов, связанных с химиотерапией
SG178382A1 (en) 2009-08-14 2012-04-27 Berg Biosystems Llc Vitamin d3 and analogs thereof for treating alopecia
WO2012065050A1 (en) 2010-11-12 2012-05-18 Wisconsin Alumni Research Foundation 22-haloacetoxy-homopregnacalciferol analogs and their uses
WO2014194133A1 (en) 2013-05-29 2014-12-04 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
CN110981765A (zh) * 2019-11-07 2020-04-10 肇庆巨元生化有限公司 一种25-羟基维生素d3中间体的制备方法
CN112920096A (zh) * 2019-12-05 2021-06-08 四川大学 一种制备2-甲基-4-(苯磺酰基)-2-丁醇的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8520265A (nl) * 1984-10-04 1986-09-01 Wisconsin Alumni Res Found Derivaten van vitamine d en werkwijzen voor het bereiden daarvan.
US4717721A (en) * 1985-05-30 1988-01-05 Howard W. Bremer Sidechain homo-vitamin D compounds with preferential anti-cancer activity
DE3687377T2 (de) * 1985-01-17 1993-04-29 Wisconsin Alumni Res Found Vitamin-d-abkoemmlinge und deren herstellungsverfahren.
IL77668A (en) * 1986-01-21 1989-03-31 Teva Pharma Production of cholecalciferol derivatives and novel intermediates used therefor
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
DE68907483T2 (de) * 1988-04-21 1993-10-21 Leo Pharm Prod Ltd Vitamin d analoge.
RU2057117C1 (ru) * 1988-04-29 1996-03-27 Висконсин Алюмни Рисерч Фаундейшн ГОМОЛОГИ 1α - ГИДРОКСИВИТАМИНА D3 С НЕНАСЫЩЕННОЙ БОКОВОЙ ЦЕПЬЮ, КОМПОЗИЦИЯ, СПОСОБСТВУЮЩАЯ СТИМУЛЯЦИИ И УСИЛЕНИЮ ДИФФЕРЕНЦИАЦИИ ЗЛОКАЧЕСТВЕННЫХ КЛЕТОК ЛЕЙКЕМИИ ЧЕЛОВЕКА, СПОСОБ СТИМУЛЯЦИИ И УСИЛЕНИЯ ДИФФЕРЕНЦИАЦИИ ЗЛОКАЧЕСТВЕННЫХ КЛЕТОК ЛЕЙКЕМИИ ЧЕЛОВЕКА

Also Published As

Publication number Publication date
HUT52475A (en) 1990-07-28
IE67868B1 (en) 1996-05-01
JPH02504154A (ja) 1990-11-29
KR900700449A (ko) 1990-08-13
IL90066A0 (en) 1989-12-15
NL8920414A (nl) 1990-04-02
DK89091D0 (da) 1991-05-13
HU206083B (en) 1992-08-28
WO1989010353A1 (en) 1989-11-02
HU892989D0 (en) 1990-06-28
AU3573089A (en) 1989-11-24
IN170659B (US20100012521A1-20100121-C00001.png) 1992-05-02
JPH0725730B2 (ja) 1995-03-22
DK666589D0 (da) 1989-12-22
DK89091A (da) 1991-05-13
FR2630740A1 (fr) 1989-11-03
IL90066A (en) 1995-12-08
US4927815A (en) 1990-05-22
JPH0748343A (ja) 1995-02-21
US5061699A (en) 1991-10-29
GB8909570D0 (en) 1989-06-14
EP0375757A1 (en) 1990-07-04
AU630096B2 (en) 1992-10-22
DK666589A (da) 1990-02-28
GB2217715A (en) 1989-11-01
JP2505713B2 (ja) 1996-06-12
CA1340615C (en) 1999-06-29
IE891406L (en) 1989-10-29

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