KR930010015A - 단백질 분해효소 억제제인 2-치환된 사카린 유도체 - Google Patents

단백질 분해효소 억제제인 2-치환된 사카린 유도체 Download PDF

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Publication number
KR930010015A
KR930010015A KR1019920021437A KR920021437A KR930010015A KR 930010015 A KR930010015 A KR 930010015A KR 1019920021437 A KR1019920021437 A KR 1019920021437A KR 920021437 A KR920021437 A KR 920021437A KR 930010015 A KR930010015 A KR 930010015A
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KR
South Korea
Prior art keywords
phenyl
alkyl
oxadiazol
alkoxy
substituted
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Ceased
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KR1019920021437A
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English (en)
Korean (ko)
Inventor
폴 던랩 리챠드
와렌 보즈 네일
조셉 뮤라 알버트
존 홀라스타 데니스
치만랄 데자이 란지트
수브라마니암 챠크라파니
해밀톤 라티머 리
피아트 로지 에릭
Original Assignee
폴 이. 듀퐁
스터링 윈드롭 인코포레이티드
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Publication of KR930010015A publication Critical patent/KR930010015A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1019920021437A 1991-11-15 1992-11-14 단백질 분해효소 억제제인 2-치환된 사카린 유도체 Ceased KR930010015A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/793,033 US5236917A (en) 1989-05-04 1991-11-15 Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US793,033 1991-11-15

Publications (1)

Publication Number Publication Date
KR930010015A true KR930010015A (ko) 1993-06-21

Family

ID=25158880

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920021437A Ceased KR930010015A (ko) 1991-11-15 1992-11-14 단백질 분해효소 억제제인 2-치환된 사카린 유도체

Country Status (17)

Country Link
US (5) US5236917A (https=)
EP (1) EP0542372A1 (https=)
JP (1) JPH05194444A (https=)
KR (1) KR930010015A (https=)
AU (1) AU654581B2 (https=)
CA (1) CA2079822A1 (https=)
CZ (1) CZ339092A3 (https=)
FI (1) FI925167L (https=)
HU (2) HUT66873A (https=)
IL (1) IL103748A (https=)
MX (1) MX9206008A (https=)
MY (1) MY107740A (https=)
NO (1) NO303119B1 (https=)
NZ (1) NZ244446A (https=)
RU (1) RU2101281C1 (https=)
SG (1) SG55181A1 (https=)
TW (1) TW221433B (https=)

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* Cited by examiner, † Cited by third party
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IL103748A (en) 1997-02-18
NO303119B1 (no) 1998-06-02
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US5236917A (en) 1993-08-17
US5371074A (en) 1994-12-06
CA2079822A1 (en) 1993-05-16
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US5874432A (en) 1999-02-23
MX9206008A (es) 1993-11-01
HUT66873A (en) 1995-01-30
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IL103748A0 (en) 1993-04-04
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