KR930005998A - 비사이클릭 카복실산 유도체 - Google Patents
비사이클릭 카복실산 유도체 Download PDFInfo
- Publication number
- KR930005998A KR930005998A KR1019920016374A KR920016374A KR930005998A KR 930005998 A KR930005998 A KR 930005998A KR 1019920016374 A KR1019920016374 A KR 1019920016374A KR 920016374 A KR920016374 A KR 920016374A KR 930005998 A KR930005998 A KR 930005998A
- Authority
- KR
- South Korea
- Prior art keywords
- cor
- compound
- formula
- independently
- lower alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 Bicyclic Carboxylic Acid Derivatives Chemical class 0.000 title claims 4
- 150000001875 compounds Chemical class 0.000 claims abstract 26
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 21
- 125000000217 alkyl group Chemical group 0.000 claims abstract 17
- 125000001424 substituent group Chemical group 0.000 claims abstract 12
- 125000003435 aroyl group Chemical group 0.000 claims abstract 10
- 125000001589 carboacyl group Chemical group 0.000 claims abstract 10
- 229910052736 halogen Inorganic materials 0.000 claims abstract 10
- 150000002367 halogens Chemical class 0.000 claims abstract 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 7
- 239000001257 hydrogen Substances 0.000 claims abstract 7
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 6
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 3
- 150000002431 hydrogen Chemical class 0.000 claims abstract 3
- 208000014674 injury Diseases 0.000 claims abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract 3
- 201000004624 Dermatitis Diseases 0.000 claims abstract 2
- 201000005569 Gout Diseases 0.000 claims abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 claims abstract 2
- 206010061218 Inflammation Diseases 0.000 claims abstract 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims abstract 2
- 208000019693 Lung disease Diseases 0.000 claims abstract 2
- 208000020339 Spinal injury Diseases 0.000 claims abstract 2
- 230000007815 allergy Effects 0.000 claims abstract 2
- 206010003246 arthritis Diseases 0.000 claims abstract 2
- 208000006673 asthma Diseases 0.000 claims abstract 2
- 208000027866 inflammatory disease Diseases 0.000 claims abstract 2
- 230000004054 inflammatory process Effects 0.000 claims abstract 2
- 230000003287 optical effect Effects 0.000 claims abstract 2
- 230000008733 trauma Effects 0.000 claims abstract 2
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
- 239000003054 catalyst Substances 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 2
- KLENIMLYAFNVOB-UHFFFAOYSA-N 6-[2-(2-carboxyethyl)-3-[6-[(4-oxo-8-propyl-2,3-dihydrochromen-7-yl)oxy]hexyl]phenoxy]hexanoic acid Chemical compound C1=CC=2C(=O)CCOC=2C(CCC)=C1OCCCCCCC1=CC=CC(OCCCCCC(O)=O)=C1CCC(O)=O KLENIMLYAFNVOB-UHFFFAOYSA-N 0.000 claims 1
- MQJKPEGWNLWLTK-UHFFFAOYSA-N Dapsone Chemical compound C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=C1 MQJKPEGWNLWLTK-UHFFFAOYSA-N 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 206010063837 Reperfusion injury Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 239000003913 leukotriene B4 receptor antagonist Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical compound NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
- C07C57/50—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75710091A | 1991-09-10 | 1991-09-10 | |
| US07/757,100 | 1991-09-10 | ||
| US07/898,852 | 1992-06-15 | ||
| US07/898,852 US5273999A (en) | 1991-09-10 | 1992-06-15 | Carboxylic acid leukotriene B4 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR930005998A true KR930005998A (ko) | 1993-04-20 |
Family
ID=27116327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019920016374A Withdrawn KR930005998A (ko) | 1991-09-10 | 1992-09-08 | 비사이클릭 카복실산 유도체 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5273999A (https=) |
| EP (1) | EP0531823A1 (https=) |
| JP (1) | JPH05201915A (https=) |
| KR (1) | KR930005998A (https=) |
| CN (1) | CN1071423A (https=) |
| AU (1) | AU655057B2 (https=) |
| CA (1) | CA2077213A1 (https=) |
| CZ (1) | CZ265492A3 (https=) |
| FI (1) | FI924048A7 (https=) |
| HU (1) | HUT66238A (https=) |
| IL (1) | IL103058A0 (https=) |
| NO (1) | NO923508L (https=) |
| NZ (1) | NZ244218A (https=) |
| RU (1) | RU2067973C1 (https=) |
| TW (1) | TW218013B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5457124A (en) * | 1993-12-07 | 1995-10-10 | Hoffmann-La Roche Inc. | Carboxylic acid Leukotriene B4 antagonists |
| US5753702A (en) * | 1996-05-22 | 1998-05-19 | University Of Vermont | Arachidonic acid metabolite, 16-hete |
| US6004808A (en) * | 1996-06-21 | 1999-12-21 | Aurora Biosciences Corporation | Promiscuous G-protein compositions and their use |
| US6416733B1 (en) | 1996-10-07 | 2002-07-09 | Bristol-Myers Squibb Pharma Company | Radiopharmaceuticals for imaging infection and inflammation |
| JP2002515480A (ja) | 1998-05-15 | 2002-05-28 | ユニバーシティ オブ バーモント | １６−ヒドロキシエイコサテトラエン酸の新規アナログ |
| AU769778B2 (en) * | 1998-11-05 | 2004-02-05 | Toyama Chemical Co. Ltd. | Novel compounds and pharmaceutical use thereof |
| US6019992A (en) * | 1998-12-04 | 2000-02-01 | Chesebrough-Pond's Usa Co. | Cosmetic skin care compositions containing 4-chromanone |
| FR2791344B1 (fr) * | 1999-03-25 | 2002-02-15 | Adir | Nouveaux derives dimeriques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| RU2183126C2 (ru) * | 2000-06-26 | 2002-06-10 | Государственное унитарное предприятие "Иммунопрепарат" | Средство, нормализующее функциональную активность спинного мозга, и способ его получения |
| RU2224528C2 (ru) * | 2001-07-24 | 2004-02-27 | Брянский государственный университет им. акад. И.Г. Петровского | Способ получения биологически активных пептидов каудальной нейросекреторной системы (кнсс) позвоночных |
| RO123430B1 (ro) * | 2001-11-16 | 2012-04-30 | Toyama Chemical Co., Ltd. | Derivaţi noi de benzofenonă sau sărurile acestora |
| EP1539137B1 (en) * | 2002-07-30 | 2010-05-26 | Merck Sharp & Dohme Corp. | Ppar alpha selective compounds for the treatment of dyslipidemia and other lipid disorders |
| JP4475406B2 (ja) * | 2002-07-30 | 2010-06-09 | メルク・シャープ・エンド・ドーム・コーポレイション | 異常脂血症および他の脂質障害の治療用のＰＰＡＲα選択的化合物 |
| US8093253B2 (en) * | 2008-03-06 | 2012-01-10 | Hoffmann-La Roche Inc. | Leukotriene B4 inhibitors |
| CN102741662B (zh) * | 2010-01-13 | 2016-09-14 | Qsc公司 | 光控电动控制设备 |
| JP6422452B2 (ja) | 2013-03-14 | 2018-11-14 | ユニバーシティ オブ マカオＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍａｃａｕ | ヤクチ（益智（ａｌｐｉｎｉａｅｏｘｙｐｈｙｌｌａｅｆｒｕｃｔｕｓ））およびその全合成から単離される新規な抗神経変性天然化合物 |
| CN105418576B (zh) * | 2015-11-16 | 2018-03-13 | 北京新沿线医药科技发展有限公司 | 一种伪麻黄碱类衍生物及其抗过敏应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3776944A (en) * | 1971-09-16 | 1973-12-04 | Warner Lambert Co | Tetraloneoxy acetic acids and esters thereof |
| DE3275295D1 (en) * | 1981-11-12 | 1987-03-05 | Fisons Plc | Anti-srs-a carboxylic acid derivatives, processes for their production, and pharmaceutical formulation containing them |
| ZA844519B (en) * | 1983-06-24 | 1985-02-27 | Hoffmann La Roche | Dihydrobenzopyran derivatives |
| US4801616A (en) * | 1986-03-25 | 1989-01-31 | Eli Lilly And Company | Diphenylmethanone compounds and anti-inflammatory use thereof |
| US4992576A (en) * | 1987-01-12 | 1991-02-12 | Eli Lilly And Company | Intermediates for leukotriene antagonists |
| FR2615515B1 (fr) * | 1987-05-22 | 1989-06-30 | Adir | Nouveaux derives du spiro 4, 5 decane, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| US4889871A (en) * | 1987-05-29 | 1989-12-26 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives |
| CA2019335C (en) * | 1989-06-27 | 2000-08-01 | Mitoshi Konno | Phenylalkan (en)oic acids |
| US5124350A (en) * | 1990-06-28 | 1992-06-23 | G. D. Searle & Co. | Leukotriene b4 antagonists |
-
1992
- 1992-06-15 US US07/898,852 patent/US5273999A/en not_active Expired - Lifetime
- 1992-08-27 TW TW081106763A patent/TW218013B/zh active
- 1992-08-27 CZ CS922654A patent/CZ265492A3/cs unknown
- 1992-08-28 EP EP92114691A patent/EP0531823A1/en not_active Ceased
- 1992-08-28 RU SU925052388A patent/RU2067973C1/ru active
- 1992-08-31 CA CA002077213A patent/CA2077213A1/en not_active Abandoned
- 1992-09-02 HU HU9202817A patent/HUT66238A/hu unknown
- 1992-09-04 IL IL103058A patent/IL103058A0/xx unknown
- 1992-09-04 NZ NZ244218A patent/NZ244218A/en unknown
- 1992-09-07 AU AU22191/92A patent/AU655057B2/en not_active Ceased
- 1992-09-08 KR KR1019920016374A patent/KR930005998A/ko not_active Withdrawn
- 1992-09-09 NO NO92923508A patent/NO923508L/no unknown
- 1992-09-09 JP JP4266694A patent/JPH05201915A/ja active Pending
- 1992-09-09 CN CN92111386A patent/CN1071423A/zh active Pending
- 1992-09-10 FI FI924048A patent/FI924048A7/fi not_active Application Discontinuation
-
1993
- 1993-09-28 US US08/128,612 patent/US5434186A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5434186A (en) | 1995-07-18 |
| EP0531823A1 (en) | 1993-03-17 |
| NO923508L (no) | 1993-03-11 |
| CZ265492A3 (en) | 1993-03-17 |
| FI924048L (fi) | 1993-03-11 |
| NO923508D0 (no) | 1992-09-09 |
| HU9202817D0 (en) | 1992-11-30 |
| FI924048A0 (fi) | 1992-09-10 |
| IL103058A0 (en) | 1993-02-21 |
| JPH05201915A (ja) | 1993-08-10 |
| HUT66238A (en) | 1994-10-28 |
| CA2077213A1 (en) | 1993-03-11 |
| RU2067973C1 (ru) | 1996-10-20 |
| TW218013B (https=) | 1993-12-21 |
| AU655057B2 (en) | 1994-12-01 |
| AU2219192A (en) | 1993-03-11 |
| NZ244218A (en) | 1995-07-26 |
| US5273999A (en) | 1993-12-28 |
| FI924048A7 (fi) | 1993-03-11 |
| CN1071423A (zh) | 1993-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19920908 |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |