KR930002834B1 - 항유로키나제 모노클론 항체 함유 면역흡착제 및 이를 사용하는 유로키나제 정제방법 - Google Patents

항유로키나제 모노클론 항체 함유 면역흡착제 및 이를 사용하는 유로키나제 정제방법 Download PDF

Info

Publication number
KR930002834B1
KR930002834B1 KR1019860700225A KR860700225A KR930002834B1 KR 930002834 B1 KR930002834 B1 KR 930002834B1 KR 1019860700225 A KR1019860700225 A KR 1019860700225A KR 860700225 A KR860700225 A KR 860700225A KR 930002834 B1 KR930002834 B1 KR 930002834B1
Authority
KR
South Korea
Prior art keywords
urokinase
antibody
molecular weight
immunosorbent
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR1019860700225A
Other languages
English (en)
Korean (ko)
Other versions
KR870700022A (ko
Inventor
마리아 루이사 놀리
안 겔로 코르티
아돌포 소피엔티니
기오바니 카싸니
프란체스코 파렌티
Original Assignee
그루포 레페티트 에스.피.에이
레나토 스가르비
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848422007A external-priority patent/GB8422007D0/en
Priority claimed from GB858508244A external-priority patent/GB8508244D0/en
Priority claimed from GB858510716A external-priority patent/GB8510716D0/en
Application filed by 그루포 레페티트 에스.피.에이, 레나토 스가르비 filed Critical 그루포 레페티트 에스.피.에이
Publication of KR870700022A publication Critical patent/KR870700022A/ko
Application granted granted Critical
Publication of KR930002834B1 publication Critical patent/KR930002834B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/972—Plasminogen activators
    • G01N2333/9723—Urokinase

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1019860700225A 1984-08-24 1985-08-21 항유로키나제 모노클론 항체 함유 면역흡착제 및 이를 사용하는 유로키나제 정제방법 Expired - Lifetime KR930002834B1 (ko)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
GB84-22007 1984-08-24
GB848422007A GB8422007D0 (en) 1984-08-31 1984-08-31 Anti-urokinase monoclonal antibody
GB8422007 1984-08-31
GB8508244 1985-03-29
GB858508244A GB8508244D0 (en) 1985-03-29 1985-03-29 Anti-urokinase monoclonal antibody
GB85-8244 1985-03-29
GB85-10716 1985-04-26
GB858510716A GB8510716D0 (en) 1985-04-26 1985-04-26 Anti-urokinase monoclonal antibody
GB8510716 1985-04-26
PCT/EP1985/000428 WO1986001411A1 (en) 1984-08-31 1985-08-21 Anti-urokinase monoclonal antibody; its production and use

Publications (2)

Publication Number Publication Date
KR870700022A KR870700022A (ko) 1987-02-28
KR930002834B1 true KR930002834B1 (ko) 1993-04-10

Family

ID=27262453

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860700225A Expired - Lifetime KR930002834B1 (ko) 1984-08-24 1985-08-21 항유로키나제 모노클론 항체 함유 면역흡착제 및 이를 사용하는 유로키나제 정제방법

Country Status (16)

Country Link
EP (1) EP0192675B1 (https=)
KR (1) KR930002834B1 (https=)
AT (1) ATE56617T1 (https=)
AU (1) AU590216B2 (https=)
CA (1) CA1297818C (https=)
DE (1) DE3579808D1 (https=)
DK (1) DK176986D0 (https=)
ES (3) ES8704351A1 (https=)
FI (1) FI86255C (https=)
GR (1) GR852008B (https=)
HU (1) HU203257B (https=)
IL (1) IL76187A0 (https=)
NO (1) NO172549C (https=)
NZ (1) NZ213125A (https=)
PT (1) PT81050B (https=)
WO (1) WO1986001411A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8604851D0 (en) * 1986-02-27 1986-04-03 Lepetit Spa Immunosorbent-amidolytic method
EP0241907A3 (en) * 1986-04-14 1989-09-13 The General Hospital Corporation Heterobifunctional antibodies and method of use
AT388618B (de) * 1987-05-05 1989-08-10 Binder Bernd Dr Verfahren zur quantitativen bestimmung von funktion und antigener konzentration einer in einer biologischen fluessigkeit enthaltenen substanz
US5609869A (en) * 1988-08-19 1997-03-11 The General Hospital Corporation Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use
US5811265A (en) * 1988-08-19 1998-09-22 The General Hospital Corporation Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3790663A (en) * 1970-07-07 1974-02-05 Us Health Preparation of dry antiserum coated solid-phase for radioimmunoassay of antigens
EP0084344A3 (en) * 1982-01-14 1983-08-03 Asahi Kasei Kogyo Kabushiki Kaisha Anti-urokinase monoclonal antibodies and process for preparing the same
BE896253A (fr) * 1983-03-24 1983-07-18 Wallone Region Anticorps monoclonaux diriges contre l'urokinase humaine
WO1985000663A1 (en) * 1983-07-25 1985-02-14 Beckman Instruments, Inc. Immunometric assay using polyclonal and monoclonal antibodies and a kit for use therein

Also Published As

Publication number Publication date
HU203257B (en) 1991-06-28
ES8707563A1 (es) 1987-08-01
PT81050B (pt) 1987-10-20
EP0192675B1 (en) 1990-09-19
FI86255B (fi) 1992-04-30
HUT40574A (en) 1987-01-28
FI861715A0 (fi) 1986-04-24
KR870700022A (ko) 1987-02-28
DE3579808D1 (de) 1990-10-25
ES552073A0 (es) 1987-08-01
GR852008B (https=) 1985-12-30
NO861554L (no) 1986-04-18
NO172549B (no) 1993-04-26
IL76187A0 (en) 1985-12-31
CA1297818C (en) 1992-03-24
PT81050A (en) 1985-09-01
DK176986A (da) 1986-04-17
AU590216B2 (en) 1989-11-02
AU4773085A (en) 1986-03-24
WO1986001411A1 (en) 1986-03-13
EP0192675A1 (en) 1986-09-03
ES8704351A1 (es) 1987-04-01
ES552074A0 (es) 1987-07-01
FI86255C (fi) 1992-08-10
ES8706445A1 (es) 1987-07-01
NO172549C (no) 1993-08-04
DK176986D0 (da) 1986-04-17
ATE56617T1 (de) 1990-10-15
ES546594A0 (es) 1987-04-01
NZ213125A (en) 1991-06-25
FI861715L (fi) 1986-04-24

Similar Documents

Publication Publication Date Title
Galen et al. New monoclonal antibodies directed against human renin. Powerful tools for the investigation of the renin system.
US5202253A (en) Monoclonal antibody specific for protein C and antibody purification method
CA1315716C (en) Monoclonal antibodies to the light chain region of human factor xii and methods of preparing and using the same
Birkedal-Hansen et al. Monoclonal antibodies to human fibroblast procollagenase. Inhibition of enzymatic activity, affinity purification of the enzyme, and evidence for clustering of epitopes in the amino-terminal end of the activated enzyme
US5599678A (en) Antibodies which react with fibrinogen fragments E1, E2 and E3 and methods of their use
EP0407544B1 (en) Monoclonal antibody against protein c
EP0162078B1 (en) Method for isolating a protein from a mixture containing said protein and a conformation specific antibody useful therein
US5444156A (en) Monoclonal antibodies to human plasma prekallikrein
AU598572B2 (en) Monoclonal antibody specific for human colon fibroblast- derived t-pa
CA1339027C (en) Synthetic peptides, antibodies directed against them, and the use thereof
CA1312564C (en) Monoclonal antibodies to human plasma prekallikrein and methods of preparing and using same
KR930002834B1 (ko) 항유로키나제 모노클론 항체 함유 면역흡착제 및 이를 사용하는 유로키나제 정제방법
AU664838B2 (en) Monoclonal antibodies against the plasmin-antiplasmin complex, a method for the preparation thereof and the use thereof
Nakamura et al. Immunoaffinity purification of protein C by using conformation-specific monoclonal antibodies to protein C-calcium ion complex
EP0354408A1 (en) Anti-urokinase monoclonal antibodies
US4889922A (en) Monoclonal antibody specific for human colon fibroblast-derived T-PA
US4891312A (en) Monoclonal antibody specific for human colon fibroblast-derived t-PA
CA1291424C (en) Immunosorbent-amidolytic method for detecting human urinary plasminogenactivator precursor (pro-upa) and human urinary plasminogen activator (u-pa)
JP4612922B2 (ja) 新規のモノクローナル抗体並びにｅ−Ｄモノマー、ｅ−Ｄダイマー、及びｅ−ＤＤ／Ｅ複合体の免疫学的分析方法
Crespo et al. Monoclonal antibodies against synovial collagenase: Use for immunopurification and characterization of the latent and active enzyme
CN1019132B (zh) 抗尿激酶单克隆抗体，带有它的基质，其试验方法和使用它的生化试验药盒
NZ247533A (en) Plasminogen activator inhibitor 2 (pai-2) isolation
JPS62500379A (ja) 抗ウロキナ−ゼモノクロ−ナル抗体：その製造及び使用
JPH04218368A (ja) プラスミノーゲン・アクチベーター前駆体の製造法
JPH10179159A (ja) モノクローナル抗体、免疫吸着剤としての使用およびヒトプラスミノーゲンの製造方法

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19860419

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19900821

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19860419

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19920930

Patent event code: PE09021S01D

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

Comment text: Decision on Publication of Application

Patent event code: PG16051S01I

Patent event date: 19930315

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 19930705

NORF Unpaid initial registration fee
PC1904 Unpaid initial registration fee