ES8706445A1 - Un metodo en emparedado de doble anticuerpo para detectar o ensayar un antigeno seleccionado de urocinasa humana y un precursor de la misma - Google Patents
Un metodo en emparedado de doble anticuerpo para detectar o ensayar un antigeno seleccionado de urocinasa humana y un precursor de la mismaInfo
- Publication number
- ES8706445A1 ES8706445A1 ES552074A ES552074A ES8706445A1 ES 8706445 A1 ES8706445 A1 ES 8706445A1 ES 552074 A ES552074 A ES 552074A ES 552074 A ES552074 A ES 552074A ES 8706445 A1 ES8706445 A1 ES 8706445A1
- Authority
- ES
- Spain
- Prior art keywords
- urokinase
- immono
- immunoassays
- epitope
- impair
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/972—Plasminogen activators
- G01N2333/9723—Urokinase
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
METODO PARA DETECTAR O ENSAYAR UN ANTIGENO SELECCIONADO DE UROCINASA HUMANA Y UN PRECURSOR DE LA MISMA. COMPRENDE: A) HACER QUE UNA SOLUCION DE ENSAYO QUE CONTIENE AL ANTIGENO REACCIONE CON UN PRIMER ANTICUERPO ANTI-UROCINADA INMOVILIZADO SOBRE UN SOPORTE EN FASE SOLIDA; PARA LIGAR EL ANTIGENO A LA FASE SOLIDA; B) PONER EN CONTACTO CON EL ACTIGENO LIGADO UNA SOLUCION QUE CONTIENE UN SEGUNDO ANTICUERPO ANTI-UROCINASA QUE TIENE UNIDO A SI UN MARCADOR DETERMINABLE, SIENDO UNO DE LOS PRIMERO Y SEGUNDOS ANTICUERPOS UN ANTICUERPO MONOCLONAL; Y C) DETECTAR O ENSAYAR EL ANTIGENO SEGUN EL GRADO EN QUE EL MARCADOR DETERMINABLE SE HA LIGADO AL SOPORTE EN FASE SOLIDA. TIENE APLICACION EN TECNICAS DE ANALISIS EN LABORATORIOS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848422007A GB8422007D0 (en) | 1984-08-31 | 1984-08-31 | Anti-urokinase monoclonal antibody |
GB858508244A GB8508244D0 (en) | 1985-03-29 | 1985-03-29 | Anti-urokinase monoclonal antibody |
GB858510716A GB8510716D0 (en) | 1985-04-26 | 1985-04-26 | Anti-urokinase monoclonal antibody |
Publications (2)
Publication Number | Publication Date |
---|---|
ES552074A0 ES552074A0 (es) | 1987-07-01 |
ES8706445A1 true ES8706445A1 (es) | 1987-07-01 |
Family
ID=27262453
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES546594A Expired ES8704351A1 (es) | 1984-08-31 | 1985-08-30 | Un procedimiento para preparar un anticuerpo monocional anti-urocinasa. |
ES552073A Expired ES8707563A1 (es) | 1984-08-31 | 1986-02-17 | Un procedimiento para purificar urocinasa |
ES552074A Expired ES8706445A1 (es) | 1984-08-31 | 1986-02-17 | Un metodo en emparedado de doble anticuerpo para detectar o ensayar un antigeno seleccionado de urocinasa humana y un precursor de la misma |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES546594A Expired ES8704351A1 (es) | 1984-08-31 | 1985-08-30 | Un procedimiento para preparar un anticuerpo monocional anti-urocinasa. |
ES552073A Expired ES8707563A1 (es) | 1984-08-31 | 1986-02-17 | Un procedimiento para purificar urocinasa |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0192675B1 (es) |
KR (1) | KR930002834B1 (es) |
AT (1) | ATE56617T1 (es) |
AU (1) | AU590216B2 (es) |
CA (1) | CA1297818C (es) |
DE (1) | DE3579808D1 (es) |
DK (1) | DK176986A (es) |
ES (3) | ES8704351A1 (es) |
FI (1) | FI86255C (es) |
GR (1) | GR852008B (es) |
HU (1) | HU203257B (es) |
IL (1) | IL76187A0 (es) |
NO (1) | NO172549C (es) |
NZ (1) | NZ213125A (es) |
PT (1) | PT81050B (es) |
WO (1) | WO1986001411A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8604851D0 (en) * | 1986-02-27 | 1986-04-03 | Lepetit Spa | Immunosorbent-amidolytic method |
JP2635343B2 (ja) * | 1986-04-14 | 1997-07-30 | ザ・ジェネラル・ホスピタル・コーポレーション | ヘテロ二官能性抗体および利用方法 |
AT388618B (de) * | 1987-05-05 | 1989-08-10 | Binder Bernd Dr | Verfahren zur quantitativen bestimmung von funktion und antigener konzentration einer in einer biologischen fluessigkeit enthaltenen substanz |
US5811265A (en) * | 1988-08-19 | 1998-09-22 | The General Hospital Corporation | Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use |
US5609869A (en) * | 1988-08-19 | 1997-03-11 | The General Hospital Corporation | Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3790663A (en) * | 1970-07-07 | 1974-02-05 | Us Health | Preparation of dry antiserum coated solid-phase for radioimmunoassay of antigens |
EP0084344A3 (en) * | 1982-01-14 | 1983-08-03 | Asahi Kasei Kogyo Kabushiki Kaisha | Anti-urokinase monoclonal antibodies and process for preparing the same |
BE896253A (fr) * | 1983-03-24 | 1983-07-18 | Wallone Region | Anticorps monoclonaux diriges contre l'urokinase humaine |
WO1985000663A1 (en) * | 1983-07-25 | 1985-02-14 | Beckman Instruments, Inc. | Immunometric assay using polyclonal and monoclonal antibodies and a kit for use therein |
-
1985
- 1985-08-16 NZ NZ213125A patent/NZ213125A/en unknown
- 1985-08-19 GR GR852008A patent/GR852008B/el unknown
- 1985-08-21 AU AU47730/85A patent/AU590216B2/en not_active Ceased
- 1985-08-21 DE DE8585904112T patent/DE3579808D1/de not_active Expired - Fee Related
- 1985-08-21 WO PCT/EP1985/000428 patent/WO1986001411A1/en active IP Right Grant
- 1985-08-21 AT AT85904112T patent/ATE56617T1/de not_active IP Right Cessation
- 1985-08-21 HU HU853722A patent/HU203257B/hu not_active IP Right Cessation
- 1985-08-21 KR KR1019860700225A patent/KR930002834B1/ko active IP Right Grant
- 1985-08-21 EP EP19850904112 patent/EP0192675B1/en not_active Expired - Lifetime
- 1985-08-26 IL IL76187A patent/IL76187A0/xx not_active IP Right Cessation
- 1985-08-29 CA CA000489659A patent/CA1297818C/en not_active Expired - Fee Related
- 1985-08-29 PT PT81050A patent/PT81050B/pt not_active IP Right Cessation
- 1985-08-30 ES ES546594A patent/ES8704351A1/es not_active Expired
-
1986
- 1986-02-17 ES ES552073A patent/ES8707563A1/es not_active Expired
- 1986-02-17 ES ES552074A patent/ES8706445A1/es not_active Expired
- 1986-04-17 DK DK176986A patent/DK176986A/da not_active Application Discontinuation
- 1986-04-18 NO NO86861554A patent/NO172549C/no unknown
- 1986-04-24 FI FI861715A patent/FI86255C/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HU203257B (en) | 1991-06-28 |
ES552074A0 (es) | 1987-07-01 |
FI861715A0 (fi) | 1986-04-24 |
ATE56617T1 (de) | 1990-10-15 |
HUT40574A (en) | 1987-01-28 |
DE3579808D1 (de) | 1990-10-25 |
KR870700022A (ko) | 1987-02-28 |
DK176986D0 (da) | 1986-04-17 |
AU4773085A (en) | 1986-03-24 |
NO172549C (no) | 1993-08-04 |
ES546594A0 (es) | 1987-04-01 |
EP0192675B1 (en) | 1990-09-19 |
PT81050B (pt) | 1987-10-20 |
ES8704351A1 (es) | 1987-04-01 |
GR852008B (es) | 1985-12-30 |
ES8707563A1 (es) | 1987-08-01 |
NO861554L (no) | 1986-04-18 |
KR930002834B1 (ko) | 1993-04-10 |
FI861715A (fi) | 1986-04-24 |
PT81050A (en) | 1985-09-01 |
IL76187A0 (en) | 1985-12-31 |
ES552073A0 (es) | 1987-08-01 |
NZ213125A (en) | 1991-06-25 |
CA1297818C (en) | 1992-03-24 |
AU590216B2 (en) | 1989-11-02 |
FI86255C (fi) | 1992-08-10 |
DK176986A (da) | 1986-04-17 |
FI86255B (fi) | 1992-04-30 |
NO172549B (no) | 1993-04-26 |
EP0192675A1 (en) | 1986-09-03 |
WO1986001411A1 (en) | 1986-03-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970505 |