KR920703577A - 치환된 이환식 화합물의 이미다졸-2-일 유도체 및 이의 제조방법 - Google Patents
치환된 이환식 화합물의 이미다졸-2-일 유도체 및 이의 제조방법Info
- Publication number
- KR920703577A KR920703577A KR1019920701778A KR920701778A KR920703577A KR 920703577 A KR920703577 A KR 920703577A KR 1019920701778 A KR1019920701778 A KR 1019920701778A KR 920701778 A KR920701778 A KR 920701778A KR 920703577 A KR920703577 A KR 920703577A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- methyl
- imidazol
- benzopyran
- oxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 125000002619 bicyclic group Chemical group 0.000 title description 2
- 125000003037 imidazol-2-yl group Chemical group [H]N1C([*])=NC([H])=C1[H] 0.000 title description 2
- 238000002360 preparation method Methods 0.000 title description 2
- -1 1-methyl-1H-imidazol-2-yl Chemical group 0.000 claims 28
- 150000001875 compounds Chemical class 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical group 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 201000001320 Atherosclerosis Diseases 0.000 claims 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 230000023597 hemostasis Effects 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- RYSYAHFZFHLMRV-UHFFFAOYSA-N 1-cyclohexyl-3,3-dimethyl-6-[[3-(1-methylimidazol-2-yl)-2-(2-phenylethyl)-2h-chromen-6-yl]oxy]hexan-2-one Chemical compound CN1C=CN=C1C1=CC2=CC(OCCCC(C)(C)C(=O)CC3CCCCC3)=CC=C2OC1CCC1=CC=CC=C1 RYSYAHFZFHLMRV-UHFFFAOYSA-N 0.000 claims 1
- YNMXAVUSHLGCTC-UHFFFAOYSA-N 5,5-dimethyl-8-[[3-(1-methylimidazol-2-yl)-2-(2-phenylethyl)-2h-chromen-6-yl]oxy]octan-4-one Chemical compound N=1C=CN(C)C=1C1=CC2=CC(OCCCC(C)(C)C(=O)CCC)=CC=C2OC1CCC1=CC=CC=C1 YNMXAVUSHLGCTC-UHFFFAOYSA-N 0.000 claims 1
- UAOVYSQTXJCCFO-UHFFFAOYSA-N 5,5-dimethyl-8-[[3-(1-methylimidazol-2-yl)-2-propyl-2h-chromen-6-yl]oxy]octan-4-one Chemical compound CCCC1OC2=CC=C(OCCCC(C)(C)C(=O)CCC)C=C2C=C1C1=NC=CN1C UAOVYSQTXJCCFO-UHFFFAOYSA-N 0.000 claims 1
- SWGXDLRCJNEEGZ-UHFFFAOYSA-N N-cyclohexylformamide Chemical compound O=CNC1CCCCC1 SWGXDLRCJNEEGZ-UHFFFAOYSA-N 0.000 claims 1
- 102000001494 Sterol O-Acyltransferase Human genes 0.000 claims 1
- 108010054082 Sterol O-acyltransferase Proteins 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 229940030225 antihemorrhagics Drugs 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 150000003857 carboxamides Chemical class 0.000 claims 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- JBDSSBMEKXHSJF-UHFFFAOYSA-N cyclopentanecarboxylic acid Chemical compound OC(=O)C1CCCC1 JBDSSBMEKXHSJF-UHFFFAOYSA-N 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 claims 1
- 239000002874 hemostatic agent Substances 0.000 claims 1
- 230000002439 hemostatic effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Detergent Compositions (AREA)
- Lubricants (AREA)
- Photoreceptors In Electrophotography (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909025848A GB9025848D0 (en) | 1990-11-28 | 1990-11-28 | Imidazol-2-yl derivatives of substituted bicyclic compounds and process for their preparation |
| GB9025848.4 | 1990-11-28 | ||
| PCT/EP1991/002228 WO1992009582A1 (en) | 1990-11-28 | 1991-11-26 | Imidazol-2-yl derivatives of substituted bicyclic compounds and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR920703577A true KR920703577A (ko) | 1992-12-18 |
Family
ID=10686107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019920701778A Abandoned KR920703577A (ko) | 1990-11-28 | 1991-11-26 | 치환된 이환식 화합물의 이미다졸-2-일 유도체 및 이의 제조방법 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5356920A (enExample) |
| EP (1) | EP0513285B1 (enExample) |
| JP (1) | JPH05503716A (enExample) |
| KR (1) | KR920703577A (enExample) |
| AT (1) | ATE133411T1 (enExample) |
| AU (1) | AU646708B2 (enExample) |
| CA (1) | CA2074729A1 (enExample) |
| DE (1) | DE69116680T2 (enExample) |
| DK (1) | DK0513285T3 (enExample) |
| ES (1) | ES2085493T3 (enExample) |
| FI (1) | FI923391A7 (enExample) |
| GB (1) | GB9025848D0 (enExample) |
| GR (1) | GR3019349T3 (enExample) |
| HU (1) | HUT62885A (enExample) |
| IE (1) | IE914126A1 (enExample) |
| IL (1) | IL99819A (enExample) |
| MX (1) | MX9102232A (enExample) |
| MY (1) | MY106773A (enExample) |
| NZ (1) | NZ240398A (enExample) |
| PT (1) | PT99625A (enExample) |
| TW (1) | TW207997B (enExample) |
| WO (1) | WO1992009582A1 (enExample) |
| ZA (1) | ZA919325B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100388345B1 (ko) | 1995-10-05 | 2004-03-30 | 교토 야쿠힝 고교 가부시키가이샤 | 신규헤테로시클릭유도체및이것의의약용도 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2122997B (en) * | 1982-07-05 | 1985-08-14 | Erba Farmitalia | Imidazoles |
| ES523609A0 (es) * | 1982-07-05 | 1985-03-01 | Erba Farmitalia | Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos. |
| GB8805628D0 (en) * | 1988-03-09 | 1988-04-07 | Erba Farmitalia | Hypolipidaemic imidazol-2-yl-derivatives of bicyclic compounds & process for their preparation |
| IL91542A0 (en) * | 1988-10-06 | 1990-04-29 | Erba Carlo Spa | N-imidazolyl-and n-imidazolyl-methyl derivatives of substituted bicyclic compounds,their preparation and pharmaceutical compositions containing them |
-
1990
- 1990-11-28 GB GB909025848A patent/GB9025848D0/en active Pending
-
1991
- 1991-10-22 IL IL9981991A patent/IL99819A/en not_active IP Right Cessation
- 1991-10-30 NZ NZ240398A patent/NZ240398A/xx unknown
- 1991-11-21 TW TW080109145A patent/TW207997B/zh active
- 1991-11-26 MY MYPI91002185A patent/MY106773A/en unknown
- 1991-11-26 CA CA002074729A patent/CA2074729A1/en not_active Abandoned
- 1991-11-26 ZA ZA919325A patent/ZA919325B/xx unknown
- 1991-11-26 EP EP91920452A patent/EP0513285B1/en not_active Expired - Lifetime
- 1991-11-26 WO PCT/EP1991/002228 patent/WO1992009582A1/en not_active Ceased
- 1991-11-26 AU AU89388/91A patent/AU646708B2/en not_active Ceased
- 1991-11-26 US US07/915,835 patent/US5356920A/en not_active Expired - Fee Related
- 1991-11-26 JP JP4500321A patent/JPH05503716A/ja not_active Expired - Lifetime
- 1991-11-26 AT AT91920452T patent/ATE133411T1/de not_active IP Right Cessation
- 1991-11-26 HU HU922462A patent/HUT62885A/hu unknown
- 1991-11-26 DK DK91920452.9T patent/DK0513285T3/da active
- 1991-11-26 ES ES91920452T patent/ES2085493T3/es not_active Expired - Lifetime
- 1991-11-26 KR KR1019920701778A patent/KR920703577A/ko not_active Abandoned
- 1991-11-26 DE DE69116680T patent/DE69116680T2/de not_active Expired - Fee Related
- 1991-11-27 MX MX9102232A patent/MX9102232A/es not_active Application Discontinuation
- 1991-11-27 IE IE412691A patent/IE914126A1/en unknown
- 1991-11-27 PT PT99625A patent/PT99625A/pt not_active Application Discontinuation
-
1992
- 1992-07-27 FI FI923391A patent/FI923391A7/fi not_active Application Discontinuation
-
1996
- 1996-03-19 GR GR960400744T patent/GR3019349T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU8938891A (en) | 1992-06-25 |
| TW207997B (enExample) | 1993-06-21 |
| PT99625A (pt) | 1992-12-31 |
| DK0513285T3 (da) | 1996-02-12 |
| ES2085493T3 (es) | 1996-06-01 |
| IL99819A0 (en) | 1992-08-18 |
| US5356920A (en) | 1994-10-18 |
| EP0513285B1 (en) | 1996-01-24 |
| CA2074729A1 (en) | 1992-05-29 |
| DE69116680D1 (de) | 1996-03-07 |
| WO1992009582A1 (en) | 1992-06-11 |
| MY106773A (en) | 1995-07-31 |
| FI923391A0 (fi) | 1992-07-27 |
| JPH05503716A (ja) | 1993-06-17 |
| IL99819A (en) | 1995-11-27 |
| ATE133411T1 (de) | 1996-02-15 |
| DE69116680T2 (de) | 1996-06-20 |
| ZA919325B (en) | 1992-09-30 |
| IE914126A1 (en) | 1992-06-03 |
| GR3019349T3 (en) | 1996-06-30 |
| HUT62885A (en) | 1993-06-28 |
| NZ240398A (en) | 1993-12-23 |
| MX9102232A (es) | 1992-07-08 |
| GB9025848D0 (en) | 1991-01-09 |
| AU646708B2 (en) | 1994-03-03 |
| EP0513285A1 (en) | 1992-11-19 |
| HU9202462D0 (en) | 1992-10-28 |
| FI923391A7 (fi) | 1992-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19920728 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19961126 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19920728 Comment text: Patent Application |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 19981121 |
|
| NORF | Unpaid initial registration fee | ||
| PC1904 | Unpaid initial registration fee |