KR920021550A - 신규의 항균 화합물 - Google Patents

신규의 항균 화합물 Download PDF

Info

Publication number
KR920021550A
KR920021550A KR1019920007740A KR920007740A KR920021550A KR 920021550 A KR920021550 A KR 920021550A KR 1019920007740 A KR1019920007740 A KR 1019920007740A KR 920007740 A KR920007740 A KR 920007740A KR 920021550 A KR920021550 A KR 920021550A
Authority
KR
South Korea
Prior art keywords
methanol
spectrum
compound
lava
nmr spectrum
Prior art date
Application number
KR1019920007740A
Other languages
English (en)
Other versions
KR0139515B1 (ko
Inventor
슈지 다까하시
히데유끼 시오자와
히데유끼 하루야마
다께시 가와사끼
겐따로 고다마
아끼라 이시이
Original Assignee
가와무라 요시부미
상꼬 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 가와무라 요시부미, 상꼬 가부시끼가이샤 filed Critical 가와무라 요시부미
Publication of KR920021550A publication Critical patent/KR920021550A/ko
Application granted granted Critical
Publication of KR0139515B1 publication Critical patent/KR0139515B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
    • C12P17/187—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system containing two or more directly linked sulfur atoms, e.g. epithiopiperazines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Tires In General (AREA)
  • Detergent Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

신규의 항균 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 하기식(I)의 화합물:
  2. 하기 특성을 갖는 화합물:성질 및 외관:황색 분말; 융점:84~89℃; 분자식:C30H44N2O9S2; 분자량:FAB-MS법에 의해 측정시, 640, ("FAB-MS"은 고속원자 충격 질량 분광법(Fast Atom Bombardment Mass Spectrometry)의 약자임); 고분해능 질량 스펙트럼; C30H45N2O9S2[FAB-MS방법에 의한 (M+H)*]:계산치:641,2567 실측치:641,2585. 원소분석치:계산치:C, 56.23%; H, 6.92%; N, 4.37%: S, 10.01%; 실측치; C, 55.95%; H, 6.82%; N, 4.23%; S, 9.90% IR흡수 스펙트럼:IR스펙트럼은 하기 흡수 최대값을 보여준다(KBr 디스크법, νmaxcm-1):3394, 2930, 1649, 1598, 1526, 1288, 1216, 1154, 1102, 1052, UV흡수 스펙트럼:메탄올 또는 메탄올+HCl내에서, 티오마리놀은 하기와 같은 UV흡수 스펙트럼을 보여준다:(λmaxnm(ε)], 387(12,000), 300(3,500), 214(26,000) 그리고 메탄올 +NaOH내에서, 하기와 같은 UV스펙트럼을 갖는다:[λmaxnm(ε)], 386(9,6000), 306(3,200), 206(25,000); 고유 광회전도:[α]D 25=+4.3°(C=1.0, 멘탄올) HPLC:분리컬럼:Senshu-Pak ODS H-2151(컬럼크기, 6×150mm, Senshu Scientific Co., Ltd제품)용매:40% v/v수성 아세토니트릴 유속:1.5ml/분 파장:220~350nm(광다이오드 배열에 의한 측정) 체류시간:5.9분1H-NMR스펙트럼:(δppm) 내부표준으로서 테트라메틸실란을 사용하는 d6-DMSO내의 NMR스펙트럼(270MHz)은 하기와 같다:0.91(3H, d, J=6.8Hz); 0.95(3H,d,J=5.9Hz); 1.30(6H,br,m); 1.55(5H,br,m); 2.03(3H,s); 2.09(3H,m); 2.34(2H,t,J=7.3Hz); 3.33(1H,d,J=10.7Hz); 3.52(2H,m); 3.64(2H,m); 3.73(1H,d of d); 4.02(2H,t,J=6.6Hz); 4.18(1H,br,d,J=7.3Hz); 4.30(1H,d,J=4.4Hz); 4.44(1H,d,J=7.8Hz); 4.63(1H,d,J=3.4Hz); 4.89(1H,d,J=7.3Hz); 5.37(2H,m); 5.97(1H,br.s); 7.04(1H,s); 9.80(1H,br,s); 10.68(1H,br,s).13C-NMR스펙트럼:(δppm):내부 표준으로서 테트라메틸실란을 사용하는 d4-메탄올내의 NMR스펙트럼(68MHz)은 하기와 같다:
    174.3(s), 170.4(s), 468.6(s), 161.1(s), 137.9(s), 135.7(d), 135.1(s), 129.8(d), 116.3(d), 115.8(s), 113.7(d), 77.6(d), 74.4(d), 72.1(d), 71.8(d), 66.0(t), 65.7(d), 64.9 (t), 45.3(d), 43.9(d), 36.6(t), 33.4(t), 30.1(t), 30.0(t), 29.7(t), 27.0(t), 26.7(t), 20.3(q), 16.6(q), 16.3(q). 용해도:메탄올, 에탄올, 프로판올 및 부탄올과 같은 알코올중에서 가용성; 디메틸술폭시드, 디메틸포름아미드, 클로로포름, 에틸아세테이트, 아세톤 및 에틸에테르내에서 가용성; 헥산 및 물내에서 불용성, 색 반응; 황산, 요오드 및 과망간산 칼륨에 대하여 양성; TLC:Rf값:0.57 흡착제:실리카겔(Merck & Co. Inc., Art. 5715) 전개용매:메틸렌 클로라이드:메탄올=85:15 부피비.
  3. 알테로모나스 라바의 생물학적 순수 배양물.
  4. 알테로모나스 라바 균주 SANK 73390 (수탁번호 RERM BP-3381)의 생물학적 순수 배양물.
  5. 제1항 또는 2항에 따른 화합물 및 약제학적으로 허용 가능한 담체를 함유하는 조성물.
  6. 제5항에 있어서, 피부 투여에 적합한 조성물.
  7. 제1항 또는 2항에 따른 화합물의 유효량을 세균 감염을 앓고 있거나 이에 감수성 있는 포유동물에 투여함을 특징으로 하는 세균 감염의 치료 또는 예방방법.
  8. 제7항에 있어서, 상기 포유동물이 사람인 방법.
  9. 제1항 또는 2항에 따른 화합물을 생성할 수 있는 알테로모나스속의 미생물을 배양하고, 이 배양물로 부터 상기 화합물을 단리함을 특징으로 하는, 제1항 또는 2항에 따른 화합물의 제조방법.
  10. 제9항에 있어서, 상기 미생물이 알테로모나스 라바인 방법.
  11. 제9항에 있어서, 상기 미생물이 알테로모나스 라바 균주 SANK 73390(수탁번호 FERM BP-3381)인 방법.
    ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019920007740A 1991-05-07 1992-05-07 신규의 항균 화합물 KR0139515B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP91-101575 1991-05-07
JP10157591 1991-05-07

Publications (2)

Publication Number Publication Date
KR920021550A true KR920021550A (ko) 1992-12-18
KR0139515B1 KR0139515B1 (ko) 1998-06-01

Family

ID=14304198

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920007740A KR0139515B1 (ko) 1991-05-07 1992-05-07 신규의 항균 화합물

Country Status (23)

Country Link
EP (1) EP0512824B1 (ko)
JP (1) JP2766421B2 (ko)
KR (1) KR0139515B1 (ko)
CN (1) CN1043786C (ko)
AT (1) ATE127805T1 (ko)
AU (1) AU646615B2 (ko)
CA (1) CA2068083C (ko)
CZ (1) CZ279780B6 (ko)
DE (1) DE69204734T2 (ko)
DK (1) DK0512824T3 (ko)
ES (1) ES2079797T3 (ko)
FI (1) FI100112B (ko)
GR (1) GR3018161T3 (ko)
HK (1) HK3896A (ko)
HU (2) HU214738B (ko)
IE (1) IE70452B1 (ko)
IL (1) IL101786A (ko)
IS (1) IS1606B (ko)
NO (1) NO300736B1 (ko)
NZ (1) NZ242648A (ko)
RU (1) RU2077534C1 (ko)
TW (1) TW224488B (ko)
ZA (1) ZA923242B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3038064B2 (ja) * 1991-10-07 2000-05-08 日清製粉株式会社 インドール誘導体およびこれを有効成分とする抗潰瘍薬
IL107017A (en) * 1992-09-18 1998-01-04 Sankyo Co History of thiomarinol, processes for their preparation, and pharmaceutical preparations containing them
EP0698027A1 (en) * 1993-05-13 1996-02-28 Smithkline Beecham Plc Deoxythiomarinol derivatives, process and intermediates for their preparation and their use as microbicides and herbicides
GB9310485D0 (en) * 1993-05-21 1993-07-07 Smithkline Beecham Plc Novel compounds
WO1995005384A1 (en) * 1993-08-13 1995-02-23 Smithkline Beecham Plc Derivatives of monic acids a and c having antibacterial, antimycoplasmatical, antifungal and herbicidal activity
AU4496996A (en) * 1995-01-31 1996-08-21 Sankyo Company Limited Pseudomonic acid derivatives
US6245921B1 (en) * 1999-02-03 2001-06-12 Biogal Gyogyszergyar Rt. Process for the isolation of pseudomonic acid A from pseudomonic acid complex-containing culture broth

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2173499A (en) * 1985-02-04 1986-10-15 Ici Plc Fungicidal dithiolopyrrolones

Also Published As

Publication number Publication date
CA2068083C (en) 2002-11-12
CZ279780B6 (cs) 1995-06-14
CA2068083A1 (en) 1992-11-08
IL101786A (en) 1995-05-26
IL101786A0 (en) 1992-12-30
ATE127805T1 (de) 1995-09-15
NO921783L (no) 1992-11-09
NO300736B1 (no) 1997-07-14
FI100112B (fi) 1997-09-30
ZA923242B (en) 1993-01-27
JP2766421B2 (ja) 1998-06-18
AU646615B2 (en) 1994-02-24
CN1043786C (zh) 1999-06-23
IS3855A (is) 1992-11-08
GR3018161T3 (en) 1996-02-29
FI922058A (fi) 1992-11-08
FI922058A0 (fi) 1992-05-06
JPH05132486A (ja) 1993-05-28
DE69204734D1 (de) 1995-10-19
NO921783D0 (no) 1992-05-06
AU1603392A (en) 1992-11-12
HU214738B (hu) 2000-03-28
ES2079797T3 (es) 1996-01-16
NZ242648A (en) 1994-03-25
HU9201526D0 (en) 1992-07-28
HK3896A (en) 1996-01-19
HU211594A9 (en) 1995-12-28
HUT63197A (en) 1993-07-28
CN1067921A (zh) 1993-01-13
IE921460A1 (en) 1992-11-18
CS139292A3 (en) 1992-11-18
IE70452B1 (en) 1996-11-27
KR0139515B1 (ko) 1998-06-01
IS1606B (is) 1996-10-18
RU2077534C1 (ru) 1997-04-20
EP0512824A1 (en) 1992-11-11
DE69204734T2 (de) 1996-05-09
EP0512824B1 (en) 1995-09-13
TW224488B (ko) 1994-06-01
DK0512824T3 (da) 1996-01-02

Similar Documents

Publication Publication Date Title
Sugawara et al. Lactimidomycin, a new glutarimide group antibiotic production, isolation, structure and biological activity
JPH0574595B2 (ko)
Ui et al. Nafuredin, a novel inhibitor of NADH-fumarate reductase, produced by Aspergillus niger FT-0554
Fukuda et al. Phenatic acids A and B, new potentiators of antifungal miconazole activity produced by Streptomyces sp. K03-0132
CN1332163A (zh) 具有抗肿瘤活性的半合成紫杉烷
Tabata et al. Xanthoquinodin B3, a new anticoccidial agent produced by Humicola sp. FO-888
KR920021550A (ko) 신규의 항균 화합물
EP1904505B1 (en) Biologically active compounds obtainable from sorangium cellulosum
Ishibashi et al. Studies on the macrolides from marine dinoflagellate Amphidinium sp.: structures of amphidinolides R and S and a succinate feeding experiment
TSUKAMOTO et al. BE-32030 A, B, C, D and E, new antitumor substances produced by Nocavdia sp. A32030
Fusetani et al. Topsentiasterol sulfates, antimicrobial sterol sulfates possessing novel side chains, from a marine sponge, Topsentia sp.
ISSHIKI et al. 3-O-ISOBUTYRYLKINAMYCIN C AND 4-DEACETYL-4-0-ISOBUTYRYLKINA-MYCIN C, NEW ANTIBIOTICS PRODUCED BY A SACCHAROTHRIX SPECIES
TSUNAKAWA et al. New antiviral antibiotics, cycloviracins B1 and B2 I. Production, isolation, physico-chemical properties and biological activity
KR20020092899A (ko) 항생 물질 카프라자마이신류 및 그 제조법
KR940007039A (ko) 신규 티오마리놀 유도체 및 그의 제조방법
FR2502155A1 (fr) Nouveaux antibiotiques macrolides semi-synthetiques, procede microbiologique pour leur preparation et micro-organisme s'y rapportant, nouveaux produits intermediaires pour leur preparation et compositions pharmaceutiques les contenant
US5320955A (en) 10'desmethoxystreptonigrin production by Streptomyces albus
NISHII et al. A new antitumor antibiotic, guanine 7-N-oxide produced by Streptomyces sp
KR102100431B1 (ko) 스트렙토미세스로부터 유래된 새로운 화합물 및 용도
KR970000527B1 (ko) 프라디미신 유도체
Kleinwaechter et al. New inhibitors of 3α-hydroxysteroid dehydrogenase, 0231A and 0231B from streptomyces sp. HKI 0231
Uyeda et al. A new antiherpetic agent, AH-135Y, produced by Streptomyces albovinaceus strain No. AH-135
Xu et al. Two new compounds from gorgonian-associated fungus Aspergillus sp
EP0721957B1 (en) Compound ge3
WO2018056470A1 (ja) 上皮間葉転換誘導細胞阻害剤

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20040226

Year of fee payment: 7

LAPS Lapse due to unpaid annual fee