KR920009385A - 서방성 안구삽입용 약제 - Google Patents

서방성 안구삽입용 약제 Download PDF

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Publication number
KR920009385A
KR920009385A KR1019910020940A KR910020940A KR920009385A KR 920009385 A KR920009385 A KR 920009385A KR 1019910020940 A KR1019910020940 A KR 1019910020940A KR 910020940 A KR910020940 A KR 910020940A KR 920009385 A KR920009385 A KR 920009385A
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average molecular
molecular weight
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polylactic acid
biodegradable polymer
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KR1019910020940A
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KR0185215B1 (ko
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아끼라 오오또리
마사꼬 안도오
야쓰시 모리다
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요시다 쇼오지
센쥬 세이야꾸 가부시끼가이샤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/902—Method of implanting
    • Y10S623/905—Eye

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음

Description

서방성 안구삽입용 약제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 적어도 하나의 항염제 또는 하나의 세포증식길항제를 생분해성 고분자에 균일하게 분산시키고 이것을 일정한 형태로 형성함으로써 제조되는 것을 특징으로 ㅎ하는, 망막 초자체 환자의 수술 또는 녹내장 수술후 안구의 내부에 적용되는 안구내 삽입용 서방성 약제.
  2. 제1항에 있어서, 상기 항염제 또는 상기 세포증식길항제는 덱사메타손 m-술포벤조에이트 나트륨염, 히드로코르티손 아세테이트 및 플루오로메톨론 등의 스테로이드 그리고 5-플루오로우라실 등의 피리미딘 대사 길항제로 구성되는 군으로부터 선택되는 것을 특징으로 하는 안구내 삽입용 서방성 약제.
  3. 제1항 또는 제2항에 있어서, 상기 생분해성 고분자는 약 2000내지 4000의 수평균 분자량을 가지는 포리락트산과 약 5000내지 7000의 수평균 분자량을 가지는 폴리락트산의 또는 이들의 혼합물인 것을 특징으로 하는 안내구 삽입용 서방성 약제.
  4. 제1항 또는 제2항에 있어서, 상기 생분해성 고분자는 약 2000내지 4000의 수평균 분자량을 가지는 폴리락트산과 약 5000 내지 7000의 수평균 분자량을 가지는 폴리락트산의 중량비 10부/90부 내지 90부/10부 범위의 혼합물인 것을 특징으로 하는 안구내 삽입용 서방성 약제.
  5. 제1항 내지 제4항중의 어는 한항에 있어서, 상기 제제는 짧은 막대형, 바늘형 또는 필름형인 것을 특징으로 하는 안구내 삽입용 서방성 약제.
  6. 적어도 하나의 항염제 또는 하나의 세포증식길항제를 생분해성 고분자에 균일하게 분산시키고 이것을 특정 형상으로 형성함으로써 제조된 서방성 약제를 수술한 안구내에 위치시키는 것으로 이루어지는 수술후 증식성 초자체망막증 또는 녹내장의 재발을 방지하는 방법.
  7. 제6항에 있어서, 상기 항염제 또는 상기 세포증식길항제는 덱사메타손 m-술포벤조에이트 나트륨염 및 히드로코르티손 등의 스테로이드 그리고 5-플루오로우라실 등의 피라미딘 대사 길항제로 구성되는 군으로부터 선택되는 것을 특징으로 하는 방법.
  8. 제6항 또는 제7항에 있어서, 상기 생분해성 고분자는 약 2000 내지 4000의 수평균 분자량을 가지는 폴리락트산 또는 약 5000 내지 7000의 수평균 분자량을 가지는 폴리락트산 또는 이들의 혼합물인 것을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910020940A 1990-11-30 1991-11-22 서방성 안구삽입용 약제 KR0185215B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP90-338853 1990-11-30
JP33885390 1990-11-30

Publications (2)

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KR920009385A true KR920009385A (ko) 1992-06-25
KR0185215B1 KR0185215B1 (ko) 1999-05-01

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US (1) US5501856A (ko)
EP (1) EP0488401A1 (ko)
JP (1) JP3116489B2 (ko)
KR (1) KR0185215B1 (ko)
CA (1) CA2056513A1 (ko)

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