KR920008001A - (3-플루오로피리딘-2-일옥시)페녹시프로피온산의 제조방법 - Google Patents

(3-플루오로피리딘-2-일옥시)페녹시프로피온산의 제조방법 Download PDF

Info

Publication number
KR920008001A
KR920008001A KR1019910017336A KR910017336A KR920008001A KR 920008001 A KR920008001 A KR 920008001A KR 1019910017336 A KR1019910017336 A KR 1019910017336A KR 910017336 A KR910017336 A KR 910017336A KR 920008001 A KR920008001 A KR 920008001A
Authority
KR
South Korea
Prior art keywords
mixture
hydrogen fluoride
anhydrous medium
yloxy
compound
Prior art date
Application number
KR1019910017336A
Other languages
English (en)
Other versions
KR100212690B1 (ko
Inventor
홰지크 로베르트
지그리스트 우르스
Original Assignee
베르너 발데크
시바-가이기 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 베르너 발데크, 시바-가이기 아게 filed Critical 베르너 발데크
Publication of KR920008001A publication Critical patent/KR920008001A/ko
Application granted granted Critical
Publication of KR100212690B1 publication Critical patent/KR100212690B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C07D213/643—2-Phenoxypyridines; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • C07D213/67—2-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals

Abstract

내용 없음

Description

(3-플루오로피리딘-2-일옥시)페녹시프로피온산의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (19)

  1. 무수 매질중에서 하기 일반식(Ⅱ)의 화합물을 플루오르화수소 및 디아조화제와 반응시키고 이렇게 생성된 플루오르화디아조늄을 열분해에 의해 하기 일반식(I)의 (3-플루오로피리딘-2-일옥시)페녹시프로피온산 또는 그의 나트륨 또는 칼륨염으로 전환시키는 것을 특징으로 하는, 하기 일반식(I)의 (3-플루오로피리딘-2-일옥시)페녹시프로피온산의 제조방법.
    상기식에서, X는 수소, 플루오로, 클로로, 브로모 또는 트리플루오로메틸이고, Y는 수소, 나트륨 또는 칼륨이다.
  2. 제1항에 있어서, 열분해가 30 내지 60℃에서 실시되는 방법.
  3. 제1항에 있어서, 열분해가 45 내지 60℃에서 실시되는 방법.
  4. 제1항에 있어서, 무수 매질이 플루오로화수소와 불활성의 극성 비양성자성 용매의 혼합물인 방법.
  5. 제4항에 있어서, 무수 매질이 디메틸 술폭사이드, 술폴란, N, N-디메틸포름아미드, N-메틸-2-피롤리딘은, 디메틸 아닐린, 디이소프로필 에테르, 테트라히드로푸란 및 1,4-디옥산으로부터 선정된 용매와 플루오르화 수소의 혼합물인 방법.
  6. 제5항에 있어서, 무수 매질이 플루오르화수소와 디메틸 술폭사이드의 혼합물인 방법.
  7. 제5항에 있어서, 디아조화제가 아질산나트륨, 아질산칼륨, N2O3, NOF, NOCl, 이소아밀 니트라이트 및 3차부틸 니트라이트로부터 선정되는 방법.
  8. 제1항에 있어서, 디아조화제가 아질산트륨인 방법.
  9. 무수 매질에서 플루오르화수소와 일반식(Ⅱ)의 화합물의 혼합물에 디아조화제를 첨가하는 것을 포함하는 방법.
  10. 제9항에 있어서, 무수 매질이 디메틸 술폭사이드, 술폴란, N,N-디메틸포름아미드, N-메틸-2-피롤리딘은, 디메틸 아닐린, 디이소프로필 에테르, 테트라히드로푸란 또는 1,4-디옥산과 플루오르화수소의 혼합물인 방법.
  11. 제10항에 있어서, 무수 매질이 플루오르화수소와 디메틸 술폭사이드의 혼합물인 방법.
  12. 제9항에 있어서, 반응이 45 내지 60℃에서 실시되는 방법.
  13. 제9항에 있어서, 디아조화제가 아질산나트륨인 방법.
  14. 제1항에 있어서, 45 내지 60℃에서 디메틸 술폭사이드의 존재하에 플루오르화수소와 4-(5-클로로-3-아미노피리딘-2-일옥시)페녹시프로피온산의 혼합물을 아질산나트륨과 반응시키는 단계를 포함하는 방법.
  15. 제1항에 있어서, 1 내지 5MPa의 압력하에 플루오르화수소와 일반식(Ⅱ)의 화합물의 혼합물을 반응기에 넣고 이어서 디아조화제와 플루오르화수소의 혼합물을 첨가하는 단계를 포함하는 방법.
  16. 제15항에 있어서, 반응이 2 내지 4MPa의 압력하에 실시되는 방법.
  17. 제1항에 있어서, 45 내지 60℃에서 2 내지 4MPa의 압력하에 4-(5-클로로-3-아미노피리딘-2-일옥시)페녹시프로피온산과 플루오르화수소의 혼합물을 아질산나트륨과 플루오르화수소의 혼합물과 반응시키는 단계를 포함하는 방법.
  18. 하기 일반식(Ⅱ)의 화합물.
    상기식에서, X 및 Y는 제1항에서 정의한 바와 같다.
  19. 하기 일반식(Ⅲ)의 화합물.
    상기식에서, X 및 Y는 제1항에서 정의한 바와 같다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
KR1019910017336A 1990-10-23 1991-10-02 (3-플루오로피리딘-2-일옥시)페녹시프로피온산의 제조방법 KR100212690B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH337990 1990-10-23
CH3379/90-7 1990-10-23

Publications (2)

Publication Number Publication Date
KR920008001A true KR920008001A (ko) 1992-05-27
KR100212690B1 KR100212690B1 (ko) 1999-08-02

Family

ID=4254687

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910017336A KR100212690B1 (ko) 1990-10-23 1991-10-02 (3-플루오로피리딘-2-일옥시)페녹시프로피온산의 제조방법

Country Status (9)

Country Link
EP (1) EP0483061B1 (ko)
JP (1) JP3069810B2 (ko)
KR (1) KR100212690B1 (ko)
BR (1) BR9104557A (ko)
CA (1) CA2053803C (ko)
DE (1) DE59105515D1 (ko)
IE (1) IE66342B1 (ko)
IL (1) IL99805A (ko)
ZA (1) ZA918408B (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115108972A (zh) * 2022-08-29 2022-09-27 北京迪泰医药科技有限公司 一种2-甲基-3-氟-5-溴吡啶的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0305593A3 (de) * 1983-12-06 1989-10-11 Ciba-Geigy Ag Neue Zwischenprodukte für 2-Pyridinyloxyphenoxypropionsäure-cyanamide

Also Published As

Publication number Publication date
DE59105515D1 (de) 1995-06-22
EP0483061A2 (de) 1992-04-29
EP0483061A3 (en) 1992-10-28
KR100212690B1 (ko) 1999-08-02
CA2053803C (en) 2002-12-17
EP0483061B1 (de) 1995-05-17
CA2053803A1 (en) 1992-04-24
JPH04264070A (ja) 1992-09-18
IL99805A0 (en) 1992-08-18
ZA918408B (en) 1992-06-24
IE913704A1 (en) 1992-05-22
JP3069810B2 (ja) 2000-07-24
IE66342B1 (en) 1995-12-27
BR9104557A (pt) 1992-06-09
IL99805A (en) 1995-12-31

Similar Documents

Publication Publication Date Title
AU1550488A (en) Glycol monoethers as intermediates in organic synthesis
KR850004483A (ko) 치환된 2-피리딜메틸-티오 및 -설피닐 벤즈이미다졸의 제조방법
KR920008001A (ko) (3-플루오로피리딘-2-일옥시)페녹시프로피온산의 제조방법
NL193373B (nl) Werkwijze voor het bereiden van 3-fenoxybenzyl-2-(4-alkoxyfenyl)-2-methylpropylethers.
JP2500229B2 (ja) ３−アミノ−２−ハロピリジン類
KR890001958A (ko) 방향족 폴리이소시아네이트, 그의 제조 방법 및 접착제 성분으로서의 용도
ATE78474T1 (de) Verfahren zur herstellung von pyrimidinderivaten.
KR920002535A (ko) 2-아릴-5-(트리플루오로메틸)피롤 화합물의 제조 방법 및 이를 위한 1,1,1-트리플루오로-2-프로펜 화합물 및 이의 제조방법
JP2936044B2 (ja) トリフルオロプロピレンカーボナート及びその製造法
GB1535894A (en) Preparation of azo dyestuffs
KR927003522A (ko) 5-클로로-2-하이드록시-4-알킬-벤젠설폰산의 제조방법
KR840000514A (ko) 벤조일- 페닐- 피페리딘 유도체의 제법
KR830006180A (ko) 뱃트물감제조용 신규중간물 α-벤즈아미도-5'(또는 8')-할로게노-1, 1'-디안트 리미드류 등의 α-벤즈아미도 -α'-할로게노-1, 1'-디안트리미드류의 제조방법
CN115650919A (zh) 一种自三氯甲基亚磺酰氯制备氟虫腈的方法
JPS55115853A (en) Preparation of aromatic amine
KR900014313A (ko) 아미노벤젠설폰산의 제조방법
CN116082271A (zh) 一步法制备2-氯-5-氯甲基噻唑的方法
KR950011440A (ko) 아졸 유도체의 제조방법
KR960034181A (ko) 방향족 헤테로고리 아민 n-옥사이드의 제조방법
SE7906416L (sv) Forfarande for framstellning av 4,5-dikloro-2-fenyl-3(2h)-pyridazinon utgaende fran 5-kloro-4-amino-2-fenyl-3(2h)-pyridazinon
JPH04279556A (ja) フルオロアルキル基含有アゾ化合物及びその製造方法
AU571079B2 (en) Preparing 3-cyano-4-amino aceto phenones
JPS56103157A (en) Sulfonyl nitrite and its preparation
JPS5686148A (en) Preparation of sulfobetaine
KR840001963A (ko) 피록시캄 및 그 중간체의 제조방법

Legal Events

Date Code Title Description
A201 Request for examination
N231 Notification of change of applicant
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20030424

Year of fee payment: 5

LAPS Lapse due to unpaid annual fee