KR920000701A - 베타-하이드록시-알파-아미노산의 제조방법 - Google Patents

베타-하이드록시-알파-아미노산의 제조방법 Download PDF

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KR920000701A
KR920000701A KR1019910008978A KR910008978A KR920000701A KR 920000701 A KR920000701 A KR 920000701A KR 1019910008978 A KR1019910008978 A KR 1019910008978A KR 910008978 A KR910008978 A KR 910008978A KR 920000701 A KR920000701 A KR 920000701A
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alkyl
substituted
compound
esterified carboxy
hydroxy
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KR1019910008978A
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조셉 밀러 마빈
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원본미기재
더 유니버시티 오브 노트르 담 듀 락
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Publication of KR920000701A publication Critical patent/KR920000701A/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1014—Hydroxymethyl-, formyl-transferases (2.1.2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Catalysts (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

내용 없음

Description

베타-하이드록시-알파-아미노산의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 온도 약 30℃내지 약 55℃에서 PH약 5.5내지 약 9의 수용액중에서 일반식 RCH0(여기에서, R은 하기 정의한 바와 같다)의 알데하이드와 글리신을 피리독살 5'-포스페이트의 존재하에 세린하이드록시메틸트랜스페라제와 혼합시킴을 포함하는, 하기 일반식 (1)의 β-하이드륵시-α-아미노산의 제조방법 :
    상기식에서, R은 C2내지 C6알케닐, C2내지 C6알키닐, 에스테르화 카복시, C1내지 C4알콕시, 플루오로,클로로, 브로모, 시아노, 하이드록시. C1내지 C4알카노일옥시, 아릴 알콕시, 페닐, 푸릴 또는 벤질옥시로 치환 된 C1내지 C6알킬. 페닐 또는 푸릴이다.
  2. 제1항에 있어서, R이 C2내지 C6알케닐, C2내지 C6알키닐, 또는 에스테르화카복시, C1내지 C4알카노일 옥시로 치환된 C1내지 C6알킬 또는 아릴알콕시로 치환된 C1내지 C6알킬인 방법.
  3. 제1항에 있어서, R이 에스테르화 카복시 또는 C1내지 C4알카노일옥시로 치환된 C1내지 C4알킬인 방법
  4. 제1항에 있어서, 알데하이드 RCHO가R1 -(CH2)nCHO (여기에서, R1은 C1내지 C4알킬, 벤질, 디페닐메틸, 4-메톡시벤질 또는 4-니트로벤질이고, n은 2또는 3이다)인 방법.
  5. 제4항에 있어서, 알데하이드 RCHO가 숙신산 세미알데하이드 메틸 에스테르인 방법.
  6. 제4항에 있어서, 알데하이드 RCHO가 글루타르산 세미알데하이드 메틸 에스테르인 방법.
  7. 제1항에 있어서, R이 에스테르화 카복시, C1내지 C4알카노일옥시, 페닐, 푸릴 또는 벤질옥시로 치환된 C1내지 C6알킬인 방법.
  8. 제7항에 있어서, α-아미노-β-하이드룩시산이 L-에리트로 디아스테레오머인 방법.
  9. L-에리트로 디아스테레오머형의 하기 일반식의 화합물 및 그의 산부가염 (이때 R 및 R1'은 모두 소수이다)
    상기식에서 R1및 R1'는 독립적으로 수소 또는 C1내 C4알킬, 벤질, 4-메틸벤질, 4-니트로벤질 및 디페닐메틸 및 그의 알카리 금속, 알칼리 토금속, 암모늄 아민염이다.
  10. 제9항에 있어서 R1이 C1내지 C4알킬인 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910008978A 1990-06-04 1991-05-31 베타-하이드록시-알파-아미노산의 제조방법 KR920000701A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53284590A 1990-06-04 1990-06-04
US07/532,845 1990-06-04

Publications (1)

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KR920000701A true KR920000701A (ko) 1992-01-29

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KR1019910008978A KR920000701A (ko) 1990-06-04 1991-05-31 베타-하이드록시-알파-아미노산의 제조방법

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EP (1) EP0460883B1 (ko)
JP (1) JPH0787989A (ko)
KR (1) KR920000701A (ko)
CN (1) CN1058046A (ko)
AT (1) ATE147785T1 (ko)
AU (1) AU637705B2 (ko)
CA (1) CA2043761A1 (ko)
CS (1) CS164591A3 (ko)
DE (1) DE69124143T2 (ko)
DK (1) DK0460883T3 (ko)
ES (1) ES2099135T3 (ko)
FI (1) FI912626A (ko)
GR (1) GR3022558T3 (ko)
HU (1) HU212925B (ko)
IE (1) IE911879A1 (ko)
IL (1) IL98312A0 (ko)
NO (1) NO912120L (ko)
NZ (1) NZ238342A (ko)
YU (1) YU97891A (ko)
ZA (1) ZA914201B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8283268B2 (en) 2007-04-24 2012-10-09 Schott Ag Metal colloid-colored glass ceramic and colorless glass convertible into same

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EP0628638A3 (en) * 1993-05-25 1995-09-06 Lilly Co Eli Process for the preparation of 2-amino-3-hydroxy-carboxylic acids.
JP4032441B2 (ja) * 1995-08-30 2008-01-16 味の素株式会社 Ｌ−アミノ酸の製造方法
CN1062603C (zh) * 1996-01-31 2001-02-28 中国科学院大连化学物理研究所 酶法生产d－对羟基苯甘氨酸的膜反应方法
CA2234412C (en) * 1997-06-09 2008-09-02 Kyowa Hakko Kogyo Co., Ltd. Method for producing optically active compound
KR100939503B1 (ko) 2002-04-26 2010-01-29 차이나 페트로리움 앤드 케미컬 코포레이션 하향류 접촉분해 반응기 및 이의 용도
WO2015103583A1 (en) * 2014-01-06 2015-07-09 President And Fellows Of Harvard College Monobactams and methods of their synthesis and use
JP7402157B2 (ja) 2017-05-27 2023-12-20 エンズィマスター（ニンボー）バイオ－エンジニアリング カンパニー リミテッド 操作されたポリペプチドおよびβ－ヒドロキシ－α－アミノ酸合成におけるそれらの用途
CN114657221A (zh) * 2020-12-22 2022-06-24 安徽华恒生物科技股份有限公司 一种d-泛酸的制备方法

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US3871958A (en) * 1972-03-04 1975-03-18 Ajinomoto Kk Biological method of producing serine and serinol derivatives
GR79037B (ko) * 1982-11-19 1984-10-02 Genex Corp

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8283268B2 (en) 2007-04-24 2012-10-09 Schott Ag Metal colloid-colored glass ceramic and colorless glass convertible into same

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EP0460883A3 (en) 1992-11-19
NZ238342A (en) 1993-10-26
CA2043761A1 (en) 1991-12-05
EP0460883A2 (en) 1991-12-11
CS164591A3 (en) 1992-01-15
FI912626A0 (fi) 1991-05-31
HUT61597A (en) 1993-01-28
AU7814691A (en) 1991-12-05
JPH0787989A (ja) 1995-04-04
HU212925B (en) 1996-12-30
DK0460883T3 (da) 1997-07-14
EP0460883B1 (en) 1997-01-15
FI912626A (fi) 1991-12-05
AU637705B2 (en) 1993-06-03
NO912120D0 (no) 1991-06-03
ZA914201B (en) 1993-02-24
ES2099135T3 (es) 1997-05-16
DE69124143D1 (de) 1997-02-27
YU97891A (sh) 1994-01-20
NO912120L (no) 1991-12-05
HU911854D0 (en) 1991-12-30
ATE147785T1 (de) 1997-02-15
CN1058046A (zh) 1992-01-22
IE911879A1 (en) 1991-12-04
DE69124143T2 (de) 1997-05-22
IL98312A0 (en) 1992-06-21
GR3022558T3 (en) 1997-05-31

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