KR910014378A - 신규한 β-락탐 항생물질의 결정성 염산염 및 그의 제조방법 - Google Patents

신규한 β-락탐 항생물질의 결정성 염산염 및 그의 제조방법 Download PDF

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Publication number
KR910014378A
KR910014378A KR1019910001115A KR910001115A KR910014378A KR 910014378 A KR910014378 A KR 910014378A KR 1019910001115 A KR1019910001115 A KR 1019910001115A KR 910001115 A KR910001115 A KR 910001115A KR 910014378 A KR910014378 A KR 910014378A
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KR
South Korea
Prior art keywords
crystalline hydrochloride
novel
preparation
lactam antibiotic
hydrochloride
Prior art date
Application number
KR1019910001115A
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English (en)
Inventor
로버트 파이퍼 랄프
Original Assignee
리로이 휘테커
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 리로이 휘테커, 일라이 릴리 앤드 캄파니 filed Critical 리로이 휘테커
Publication of KR910014378A publication Critical patent/KR910014378A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

신규한 β-락탐 항생물질의 결정성 염산염 및 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 구조식의 화합물의 결정성 염산염:
  2. 제1항에 있어서, λ=1.5405A 의 니켈-여과된 구조조사로 수득한 하기의 X-선 분말 회절 양식(여기에서, d는 평면 사이의 간격을 나타내고 I/I1은 상대 강도를 나타낸다)을 갖는 화합물:
  3. 활성 성분으로서 제1항 또는 제2항에 특허청구되 결정성 염산염을 하나 이상의 약학적으로 허용가능한 담체, 부형제 또는 희석제와 함께 포함하는 항균성 제제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910001115A 1990-01-26 1991-01-23 신규한 β-락탐 항생물질의 결정성 염산염 및 그의 제조방법 KR910014378A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47048690A 1990-01-26 1990-01-26
US470,486 1990-01-26

Publications (1)

Publication Number Publication Date
KR910014378A true KR910014378A (ko) 1991-08-31

Family

ID=23867812

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910001115A KR910014378A (ko) 1990-01-26 1991-01-23 신규한 β-락탐 항생물질의 결정성 염산염 및 그의 제조방법

Country Status (19)

Country Link
EP (1) EP0439353B1 (ko)
JP (1) JPH04234880A (ko)
KR (1) KR910014378A (ko)
CN (1) CN1053611A (ko)
AU (1) AU631960B2 (ko)
CA (1) CA2034592C (ko)
DE (1) DE69118933T2 (ko)
ES (1) ES2087240T3 (ko)
FI (1) FI910365A (ko)
HU (1) HU208972B (ko)
IE (1) IE910251A1 (ko)
IL (1) IL96979A0 (ko)
MX (1) MX24247A (ko)
NO (1) NO910267L (ko)
NZ (1) NZ236868A (ko)
PT (1) PT96531A (ko)
RU (1) RU1825365C (ko)
YU (1) YU12191A (ko)
ZA (1) ZA91428B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352782A (en) * 1993-06-04 1994-10-04 Eli Lilly And Company Process for preparing crystalline β-lactam monohydrate
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
AU1234999A (en) * 1997-11-10 1999-05-31 Gist-Brocades B.V. Crystallization of beta-lactam compounds
AU2003283624A1 (en) * 2002-11-21 2004-06-15 Ranbaxy Laboratories Limited Monohydrate solvates of loracarbef

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO155548C (no) * 1979-02-10 1987-04-15 Kyowa Hakko Kogyo Kk Fremgangsmaate til fremstilling av optisk aktive cefalosporin-analoger.
JPS5672698A (en) * 1979-11-14 1981-06-16 Kyowa Hakko Kogyo Co Ltd Preparation of optically active cephalosporin analogue
CA1334970C (en) * 1987-10-06 1995-03-28 Carol Elaine Pasini Crystalline .beta.-lactam hydrate
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic
CA2002597C (en) * 1988-11-14 1999-03-23 Thomas M. Eckrich Solvates of b-lactam antibiotic

Also Published As

Publication number Publication date
MX24247A (es) 1993-11-01
HUT57207A (en) 1991-11-28
NO910267L (no) 1991-07-29
ES2087240T3 (es) 1996-07-16
YU12191A (sh) 1994-01-20
FI910365A (fi) 1991-07-27
AU6992391A (en) 1991-08-01
IE910251A1 (en) 1991-07-31
JPH04234880A (ja) 1992-08-24
DE69118933T2 (de) 1996-10-02
CN1053611A (zh) 1991-08-07
HU208972B (en) 1994-02-28
PT96531A (pt) 1991-10-15
FI910365A0 (fi) 1991-01-24
NZ236868A (en) 1992-04-28
EP0439353A1 (en) 1991-07-31
IL96979A0 (en) 1992-03-29
EP0439353B1 (en) 1996-04-24
ZA91428B (en) 1992-09-30
RU1825365C (ru) 1993-06-30
CA2034592A1 (en) 1991-07-27
AU631960B2 (en) 1992-12-10
NO910267D0 (no) 1991-01-23
DE69118933D1 (de) 1996-05-30
HU910263D0 (en) 1991-08-28
CA2034592C (en) 2001-06-05

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