KR910012233A - 칠면조의 재조합 포진바이러스와 그것에서 유도한 생존상태의 벡터 백신류 - Google Patents
칠면조의 재조합 포진바이러스와 그것에서 유도한 생존상태의 벡터 백신류 Download PDFInfo
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Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 HNT 게놈의 Us 부위에 거의 상응하는 DNA 단편의 제한 효소지도이다.
Claims (19)
- 이종의 핵산 서열을 포함하며, 제1도에 거의 제시된 제한 효소 지도를 갖는 HVT 게놈의 DNA 단편내에 위치한 ORF-1의 말단으로 부터 ORF-5를 포함하는 게놈부와 일치하는 HVT게놈의 삽입부위로 상기 핵산 서열을 유입하는 것을 특징으로 하는 재조합 HVT.
- 이종의 핵산 서열을 포함하며, SEQ ID NO : 1 에 거의 제시된 DNA 서열의 뉴클레오티드 82와 4504 사이의 DNA 서열과 일치하는 HVT- 게놈의 삽입부위로 상기의 핵산서열을 유입하는 것을 특징으로 하는 재조합 HVT.
- 제1항 또는 제2항에 있어서, ORF-2, ORF-3, ORF-4 또는 ORF-5 와 일치하는 삽입부위를 특징으로 하는 재조합 HVT.
- 제3항에 있어서, 상기의 이종 핵산 서열을 ORF-2 나 ORF-3에 존재하는 BglⅡ 제한 효소부위에 결합시키는 것을 특징으로 하는 재조합 HVT.
- 제1항 내지 제4항중 어느 한항에 있어서, 상기 삽입부위에 HVT 핵산 서열의 적어도 일부가 누락된 것을 특징으로 하는 재조합 HVT.
- 제1항 내지 제5항중 어느 한항에 있어서, 상기의 이종 핵산 서열이 폴리펩타이드를 코오드하여 재조합 HVT로 감염된 세포내에서 상기 핵산서열의 형질발현을 조절하는 프르모터의 조절하에 있는 것을 특징으로 하는 재조합 HVT.
- 제1항 내지 제6항중 어느 한항에 있어서, 상기의 이종 핵산 서열이 조류 병원체의 항원을 코오드하는 것을 특징으로 하는 재조합 HVT.
- 제7항에 있어서, 상기의 항원 머레크 병 바이러스, 기관지염 감염 바이러스, 뉴우캣슬병 바이러스 또는 감염성 점액낭 병 바이러스로 구성된 그룹에서 유도된 것을 특징으로 하는 재조합 HVT.
- ORF-1 의 말단으로부터 ORF-5를 포함하는 HVT 게놈 부위와 일치하는 HVT 게놈의 삽입부위로 부터 유도된 DNA 서열에 의해 플랭크 되었으며 프로모터의 조절하에서 HVT 에 이종인 유전자 또는 그것의 일부를 적어도 포함하는 핵산서열.
- 제9항에 의한 핵산 서열을 포함하는 재조합 DNA 분자.
- 제9항에 의한 핵산 서열이나 제10항에 의한 재조합 DNA 분자로 형질 전환된 숙주세포.
- 적당한 세포 배양물을 HVT DNA 및 제10항에 의한 재조합 DNA 분자와 함께 트랜스펙트 시키는 것을 특징으로 하는 제1항 내지 제8항중 어느 한 항의 재조합 HVT의 제조방법.
- 제1항 내지 제8항중 어느 한항에 의한 재조합 HVT로 감염된 세포 배양물.
- 제1항 내지 제8항중 어느 한항에 의한 재조합 HVT를 포함하는 백신.
- 제1항 내지 제8항중 어느 한항에 의한 재조합 HVT에 의한 형질 발현된 폴리펩타이드를 포함한 백신, 약제 조성물 또는 진단용 조성물.
- HVT 함유물질이 제13항에 의한 세포배양물로 부터 회수되며 백신으로 가공되는 것을 특징으로 하는 백신의 제조방법.
- 제1항 내지 제8항중 어느 한항에 의한 재조합 HVT에 의해 형질발현되는 폴리펩타이드가 면역용, 치료용 또는 진단용 활성을 지닌 제제로 가공되는 것을 특징으로 하는 백신.
- 제1항 내지 제8항중 어느 한항에 의한 재조합 HVT에 대응하는 항체를 포함한 항혈청.
- 제14항의 백신을 동물에 투여하여 감염성 질환으로부터 동물을 면역시키는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
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Application Number | Priority Date | Filing Date | Title |
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NL892030719 | 1989-12-04 | ||
EP89.203071.9 | 1989-12-04 | ||
EP89203071 | 1989-12-04 |
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KR910012233A true KR910012233A (ko) | 1991-08-07 |
KR0179994B1 KR0179994B1 (ko) | 1999-04-01 |
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KR1019900019817A KR0179994B1 (ko) | 1989-12-04 | 1990-12-04 | 칠면조의 재조합 포진바이러스 및 이로부터 유도된 생존상태의 벡터 백신 |
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US (2) | US5187087A (ko) |
EP (1) | EP0431668B1 (ko) |
JP (1) | JP3194751B2 (ko) |
KR (1) | KR0179994B1 (ko) |
CN (1) | CN1056878C (ko) |
AU (1) | AU633663B2 (ko) |
BR (1) | BR1100637A (ko) |
CA (1) | CA2031164C (ko) |
DE (1) | DE69016956T2 (ko) |
ES (1) | ES2070997T3 (ko) |
HU (1) | HU214904B (ko) |
NZ (1) | NZ236294A (ko) |
ZA (1) | ZA909570B (ko) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
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US5965138A (en) * | 1985-09-06 | 1999-10-12 | Syntro Corporation | Recombinant chimeric virus and uses thereof |
US5928648A (en) * | 1985-09-06 | 1999-07-27 | Syntro Corporation | Recombinant herpesvirus of turkeys and uses thereof |
US5961982A (en) * | 1985-09-06 | 1999-10-05 | Syntro Corporation | Recombinant herpesvirus of turkeys and uses thereof |
EP0748631B1 (en) * | 1988-09-13 | 2006-02-08 | Mérial | Viral vaccines |
FR2693472B1 (fr) * | 1992-06-26 | 1994-12-23 | Rhone Merieux | Mutants du virus de la rhinotrachéite infectieuse bovine, délétés dans l'un des gènes des glycoprotéines mineures, vaccins préparés à partir de ces souches, méthodes de production et méthodes d'utilisation. |
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US4859587A (en) * | 1984-06-04 | 1989-08-22 | Institut Merieux | Recombinant herpes simplex viruses, vaccines and methods |
WO1988007088A1 (en) * | 1987-03-19 | 1988-09-22 | Synergen, Inc. | Viral vector system for the introduction of foreign dna expression products into gallinaceous birds |
AU628294B2 (en) * | 1987-07-27 | 1992-09-17 | Syntro Corporation | Attenuated herpes viruses, herpes viruses which include foreign dna encoding an amino acid sequence and vaccines containing same |
JP2779447B2 (ja) * | 1988-03-20 | 1998-07-23 | 財団法人阪大微生物病研究会 | 弱毒マレック病ウイルス・ベクターを用いる組換え遺伝子作成法、及び該ウイルスの組換え体 |
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- 1990-11-21 ES ES90203076T patent/ES2070997T3/es not_active Expired - Lifetime
- 1990-11-21 EP EP90203076A patent/EP0431668B1/en not_active Expired - Lifetime
- 1990-11-21 DE DE69016956T patent/DE69016956T2/de not_active Expired - Lifetime
- 1990-11-28 ZA ZA909570A patent/ZA909570B/xx unknown
- 1990-11-29 CA CA002031164A patent/CA2031164C/en not_active Expired - Lifetime
- 1990-11-30 US US07/621,193 patent/US5187087A/en not_active Expired - Lifetime
- 1990-11-30 NZ NZ236294A patent/NZ236294A/en unknown
- 1990-12-03 HU HU908031A patent/HU214904B/hu unknown
- 1990-12-03 CN CN90110319A patent/CN1056878C/zh not_active Expired - Lifetime
- 1990-12-03 AU AU67698/90A patent/AU633663B2/en not_active Expired
- 1990-12-04 KR KR1019900019817A patent/KR0179994B1/ko not_active IP Right Cessation
- 1990-12-04 JP JP41928690A patent/JP3194751B2/ja not_active Expired - Lifetime
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DE69016956D1 (de) | 1995-03-23 |
NZ236294A (en) | 1992-05-26 |
CA2031164C (en) | 2001-10-16 |
EP0431668B1 (en) | 1995-02-15 |
CA2031164A1 (en) | 1991-06-05 |
US5187087A (en) | 1993-02-16 |
JP3194751B2 (ja) | 2001-08-06 |
AU6769890A (en) | 1991-06-06 |
BR1100637A (pt) | 2000-03-21 |
JPH05103667A (ja) | 1993-04-27 |
HU214904B (hu) | 1998-07-28 |
CN1052896A (zh) | 1991-07-10 |
ZA909570B (en) | 1991-10-30 |
HUT57264A (en) | 1991-11-28 |
US5470734A (en) | 1995-11-28 |
ES2070997T3 (es) | 1995-06-16 |
KR0179994B1 (ko) | 1999-04-01 |
EP0431668A1 (en) | 1991-06-12 |
AU633663B2 (en) | 1993-02-04 |
DE69016956T2 (de) | 1995-07-20 |
HU908031D0 (en) | 1991-06-28 |
CN1056878C (zh) | 2000-09-27 |
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