KR910012233A - 칠면조의 재조합 포진바이러스와 그것에서 유도한 생존상태의 벡터 백신류 - Google Patents

칠면조의 재조합 포진바이러스와 그것에서 유도한 생존상태의 벡터 백신류 Download PDF

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KR910012233A
KR910012233A KR1019900019817A KR900019817A KR910012233A KR 910012233 A KR910012233 A KR 910012233A KR 1019900019817 A KR1019900019817 A KR 1019900019817A KR 900019817 A KR900019817 A KR 900019817A KR 910012233 A KR910012233 A KR 910012233A
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야코버스 안토니우스 서더메이저 파울러스
안토니우스 요세프 클래슨즈 요하네스
필립 아드리안 모케트 알버트
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에프.쥐.엠. 헤르만스, 피.씨.샬크비크
악조 엔.브이
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Abstract

내용 없음

Description

칠면조의 재조합 포진바이러스와 그것에서 유도한 생존상태의 벡터 백신류
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 HNT 게놈의 Us 부위에 거의 상응하는 DNA 단편의 제한 효소지도이다.

Claims (19)

  1. 이종의 핵산 서열을 포함하며, 제1도에 거의 제시된 제한 효소 지도를 갖는 HVT 게놈의 DNA 단편내에 위치한 ORF-1의 말단으로 부터 ORF-5를 포함하는 게놈부와 일치하는 HVT게놈의 삽입부위로 상기 핵산 서열을 유입하는 것을 특징으로 하는 재조합 HVT.
  2. 이종의 핵산 서열을 포함하며, SEQ ID NO : 1 에 거의 제시된 DNA 서열의 뉴클레오티드 82와 4504 사이의 DNA 서열과 일치하는 HVT- 게놈의 삽입부위로 상기의 핵산서열을 유입하는 것을 특징으로 하는 재조합 HVT.
  3. 제1항 또는 제2항에 있어서, ORF-2, ORF-3, ORF-4 또는 ORF-5 와 일치하는 삽입부위를 특징으로 하는 재조합 HVT.
  4. 제3항에 있어서, 상기의 이종 핵산 서열을 ORF-2 나 ORF-3에 존재하는 BglⅡ 제한 효소부위에 결합시키는 것을 특징으로 하는 재조합 HVT.
  5. 제1항 내지 제4항중 어느 한항에 있어서, 상기 삽입부위에 HVT 핵산 서열의 적어도 일부가 누락된 것을 특징으로 하는 재조합 HVT.
  6. 제1항 내지 제5항중 어느 한항에 있어서, 상기의 이종 핵산 서열이 폴리펩타이드를 코오드하여 재조합 HVT로 감염된 세포내에서 상기 핵산서열의 형질발현을 조절하는 프르모터의 조절하에 있는 것을 특징으로 하는 재조합 HVT.
  7. 제1항 내지 제6항중 어느 한항에 있어서, 상기의 이종 핵산 서열이 조류 병원체의 항원을 코오드하는 것을 특징으로 하는 재조합 HVT.
  8. 제7항에 있어서, 상기의 항원 머레크 병 바이러스, 기관지염 감염 바이러스, 뉴우캣슬병 바이러스 또는 감염성 점액낭 병 바이러스로 구성된 그룹에서 유도된 것을 특징으로 하는 재조합 HVT.
  9. ORF-1 의 말단으로부터 ORF-5를 포함하는 HVT 게놈 부위와 일치하는 HVT 게놈의 삽입부위로 부터 유도된 DNA 서열에 의해 플랭크 되었으며 프로모터의 조절하에서 HVT 에 이종인 유전자 또는 그것의 일부를 적어도 포함하는 핵산서열.
  10. 제9항에 의한 핵산 서열을 포함하는 재조합 DNA 분자.
  11. 제9항에 의한 핵산 서열이나 제10항에 의한 재조합 DNA 분자로 형질 전환된 숙주세포.
  12. 적당한 세포 배양물을 HVT DNA 및 제10항에 의한 재조합 DNA 분자와 함께 트랜스펙트 시키는 것을 특징으로 하는 제1항 내지 제8항중 어느 한 항의 재조합 HVT의 제조방법.
  13. 제1항 내지 제8항중 어느 한항에 의한 재조합 HVT로 감염된 세포 배양물.
  14. 제1항 내지 제8항중 어느 한항에 의한 재조합 HVT를 포함하는 백신.
  15. 제1항 내지 제8항중 어느 한항에 의한 재조합 HVT에 의한 형질 발현된 폴리펩타이드를 포함한 백신, 약제 조성물 또는 진단용 조성물.
  16. HVT 함유물질이 제13항에 의한 세포배양물로 부터 회수되며 백신으로 가공되는 것을 특징으로 하는 백신의 제조방법.
  17. 제1항 내지 제8항중 어느 한항에 의한 재조합 HVT에 의해 형질발현되는 폴리펩타이드가 면역용, 치료용 또는 진단용 활성을 지닌 제제로 가공되는 것을 특징으로 하는 백신.
  18. 제1항 내지 제8항중 어느 한항에 의한 재조합 HVT에 대응하는 항체를 포함한 항혈청.
  19. 제14항의 백신을 동물에 투여하여 감염성 질환으로부터 동물을 면역시키는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900019817A 1989-12-04 1990-12-04 칠면조의 재조합 포진바이러스 및 이로부터 유도된 생존상태의 벡터 백신 KR0179994B1 (ko)

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NL892030719 1989-12-04
EP89.203071.9 1989-12-04
EP89203071 1989-12-04

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