KR910011841A - 2-아미노피리미딘-4-카르복사미드 유도체, 그 제조방법 및 그것의 치료에의 이용 - Google Patents

2-아미노피리미딘-4-카르복사미드 유도체, 그 제조방법 및 그것의 치료에의 이용 Download PDF

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KR910011841A
KR910011841A KR1019900021093A KR900021093A KR910011841A KR 910011841 A KR910011841 A KR 910011841A KR 1019900021093 A KR1019900021093 A KR 1019900021093A KR 900021093 A KR900021093 A KR 900021093A KR 910011841 A KR910011841 A KR 910011841A
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compound
group
formula
general formula
temperature
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KR1019900021093A
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조르쥬 파스칼
마누리 필립
프루와썽 쟈끄
메를리 쟝-피에르
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에. 뚜레 레메뜨르
신떼라보 소시에떼 아노님
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Publication of KR910011841A publication Critical patent/KR910011841A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음

Description

2-아미노피리미딘-4-카르복사미드 유도체, 그 제조방법 및 그것의 치료에의 이용
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 유리 염기 또는 산부가염 형채의 다음 일반식(Ⅰ)의 화합물.
    상기식에서, n은 수2,3,4 또는 5를 표시하고, p는 수 0 또는 1을 표시하고, R1은 수소원자 또는 메틸기를 표시하고, Xm은 수소, 플루오르, 염소, 메톡시, 이소프로필, 시클로프로필 중에서 선택된 하나 또는 둘 이상의 원자 또는 기를 표시한다.
  2. 다음 일반식(Ⅱ)의 화합물을
    (여기서 Xm 및 P는 제1항에서의정의와 같음) 다음 일반식(Ⅲ)의 할로겐화 반응물과
    (여기서 Y는 할로겐 원자를 나타내고, n은 제1항에서의 정의와 같고, R1은 제1항에서의 정의와 같고, R은 아민보호기 예컨대 트리페닐메틸기를 나타내거나, 또는 R1과 R이 함께 프탈이미드기와 같은 보호기를 형성함) 40 내지 80℃의 온도에서 유기 또는 무기염기의 존재하에 비양성자성 용매 중에서 반응시키고, 그래서 그의 말단 알킬아민이 탈보호된 일반식(Ⅳ)의화합물을 얻고;
    R이 트리페닐메틸기인 경우 지방족 알코올중의 기체염산으로 0 내지 40℃의 온도에서 처리를 하고, R과 R1이 함께 프탈이미드기를 형성하는 경우에는 히드라진으로 처리하며, 그리하여 일반식(Ⅴ)의 화합물을 얻고,
    이 화합물을 20 내지 80℃온도에서 염기의 존재하에 비양성자성 용매중에서 일반식(Ⅵ)의 화합물과
    반응시키는 것을 특징으로 하는 제1항에 의한 화합물을 제조하는 방법.
  3. 제 1 항에 의한 화합물을 함유하는 것을 특징으로 하는 의약.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900021093A 1989-12-28 1990-12-19 2-아미노피리미딘-4-카르복사미드 유도체, 그 제조방법 및 그것의 치료에의 이용 KR910011841A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR89.17304 1989-12-28
FR8917304A FR2656609B1 (fr) 1989-12-28 1989-12-28 Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.

Publications (1)

Publication Number Publication Date
KR910011841A true KR910011841A (ko) 1991-08-07

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ID=9389050

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900021093A KR910011841A (ko) 1989-12-28 1990-12-19 2-아미노피리미딘-4-카르복사미드 유도체, 그 제조방법 및 그것의 치료에의 이용

Country Status (22)

Country Link
US (1) US5164397A (ko)
EP (1) EP0435749B1 (ko)
JP (1) JP2515434B2 (ko)
KR (1) KR910011841A (ko)
AT (1) ATE132859T1 (ko)
AU (1) AU630777B2 (ko)
CA (1) CA2033303A1 (ko)
CS (1) CS405291A3 (ko)
DE (1) DE69024778T2 (ko)
DK (1) DK0435749T3 (ko)
ES (1) ES2084015T3 (ko)
FI (1) FI94953C (ko)
FR (1) FR2656609B1 (ko)
GR (1) GR3019508T3 (ko)
HU (1) HU207515B (ko)
IE (1) IE72954B1 (ko)
IL (1) IL96815A (ko)
MX (1) MX172953B (ko)
NO (1) NO178968C (ko)
NZ (1) NZ236605A (ko)
PT (1) PT96381B (ko)
ZA (1) ZA9010412B (ko)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2667317B1 (fr) * 1990-10-02 1992-12-04 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
FR2678271B1 (fr) * 1991-06-27 1995-01-13 Synthelabo Derives de pyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
FR2678272B1 (fr) * 1991-06-27 1994-01-14 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
CZ279305B6 (cs) * 1992-01-24 1995-04-12 Lonza A.G. Kyseliny 2-halogen pyrimidin-4-karboxylové, způsob jejich přípravy a jejich použití pro přípravu derivátů substituovaných pyrimidinů-4-karboxylový ch kyselin
IT1254469B (it) * 1992-02-25 1995-09-25 Recordati Chem Pharm Derivati benzopiranici e benzotiopiranici
US5474994A (en) * 1992-05-26 1995-12-12 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A
FR2699171B1 (fr) * 1992-12-14 1995-02-03 Synthelabo Dérivés de 2-amino-N[[[4-aminocarbonyl) pyrimidin-2-yl]amino]alkyl]pyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique.
ATE123025T1 (de) * 1992-07-03 1995-06-15 Synthelabo 2-amino-n-(((4-(aminocarbonyl)pyrimidin-2- yl>amino>alkyl>-pyrimidin-4- carbonsäureamidderivate, ihre herstellung und ihre anwendung in der therapeutica.
FR2693195B1 (fr) * 1992-07-03 1994-09-23 Synthelabo Dérivés de 2-amino-N-[[[(4-aminocarbonyl)pyrimidin-2-yl]amino]alkyl] pyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique.
FR2703355B1 (fr) * 1993-03-29 1995-05-05 Synthelabo Dérivés de 2-aminopyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique.
FR2705344B1 (fr) * 1993-05-17 1995-06-30 Synthelabo Dérivés de 2-aminopyrazine-5-carboxamide, leur préparation et leur application en thérapeutique.
FR2724383B1 (fr) * 1994-09-13 1996-10-18 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique
US5688795A (en) * 1994-11-08 1997-11-18 Syntex (U.S.A.) Inc. 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists
FR2744722B1 (fr) * 1996-02-14 1998-03-13 Synthelabo Devires de 2-((3-(piperazin-1-yl)propyl)amino)pyrimidine-4- carboxamide et leur application en therapeutique
TW593290B (en) * 1996-05-10 2004-06-21 Janssen Pharmaceutica Nv Alkylaminobenzothiazole and -benzoxazole derivatives
ITMI20010164A1 (it) * 2001-01-30 2002-07-30 Recordati Chem Pharm Alfa 1 antagonisti selettivi a + d
AR078793A1 (es) 2009-10-27 2011-12-07 Orion Corp Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros
CA2872883A1 (en) * 2012-05-09 2013-11-14 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787126A (fr) * 1971-08-04 1973-02-05 Byk Gulden Lomberg Chem Fab Pyrimidines substituees, procedes de preparation de ces composes et medicaments contenant lesdits composes
DE2143730A1 (de) * 1971-09-01 1973-03-08 Byk Gulden Lomberg Chem Fab Substituierte pyridine, verfahren zu deren herstellung und sie enthaltende arzneimittel

Also Published As

Publication number Publication date
NO178968B (no) 1996-04-01
NO905591L (no) 1991-07-01
CA2033303A1 (en) 1991-06-29
ES2084015T3 (es) 1996-05-01
DE69024778T2 (de) 1996-09-19
FR2656609A1 (fr) 1991-07-05
NO905591D0 (no) 1990-12-27
AU630777B2 (en) 1992-11-05
IL96815A (en) 1996-06-18
PT96381A (pt) 1991-10-15
ZA9010412B (en) 1991-10-30
IL96815A0 (en) 1991-09-16
HUT56092A (en) 1991-07-29
FI94953B (fi) 1995-08-15
EP0435749B1 (fr) 1996-01-10
ATE132859T1 (de) 1996-01-15
IE72954B1 (en) 1997-05-07
HU207515B (en) 1993-04-28
US5164397A (en) 1992-11-17
FI94953C (fi) 1995-11-27
FI906408A (fi) 1991-06-29
JPH04139173A (ja) 1992-05-13
FI906408A0 (fi) 1990-12-27
CS405291A3 (en) 1992-04-15
IE904719A1 (en) 1991-07-17
NZ236605A (en) 1992-08-26
AU6845190A (en) 1991-07-04
DK0435749T3 (da) 1996-05-20
MX172953B (es) 1994-01-25
EP0435749A1 (fr) 1991-07-03
FR2656609B1 (fr) 1992-03-27
DE69024778D1 (de) 1996-02-22
PT96381B (pt) 1998-06-30
JP2515434B2 (ja) 1996-07-10
NO178968C (no) 1996-07-10
GR3019508T3 (en) 1996-07-31

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