KR860002453A - 3-아미노-2-벤조일아크릴산 유도체의 제조방법 - Google Patents

3-아미노-2-벤조일아크릴산 유도체의 제조방법 Download PDF

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KR860002453A
KR860002453A KR1019850007204A KR850007204A KR860002453A KR 860002453 A KR860002453 A KR 860002453A KR 1019850007204 A KR1019850007204 A KR 1019850007204A KR 850007204 A KR850007204 A KR 850007204A KR 860002453 A KR860002453 A KR 860002453A
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halogen
group
methyl
hydrogen
alkyl
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KR1019850007204A
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KR870001999B1 (ko
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그로에 클라우스
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클라우스 데너, 게르하르트 뷔네만
바이엘 악티엔 게젤샤프트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Abstract

내용 없음

Description

3-아미노-2-벤조일아크릴산 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 하기일반식(Ⅰ)으로 표시되는 3-아미노-2-벤조일 아크릴산 유도체.
    상기 식중, R1는 니트릴기, 에스테르기-COOR4(여기에서, R4는 C1-C6-알킬기임)또는 카르복스아미드기(여기에서, R5및 R6는 수소, C1-C3-알킬 또는 페닐기임)이고, R2및 R3는 서로 동일하거나 또는 상이한 것으로서, C1-C6-알킬기이고, 또한 이들과 결합된 질소 원자와 함께 5 또는 6원 헤테로시클릭 고리(이 고리는 고리 부재로서 -O-, -S-, -SO- 또는 -SO2-와 같은 원자 또는 기를 부차적으로 함유할수 있음)을 형성할 수도 있고, X는 할로겐이고,X1는 수소, 메틸, 니트로 또는 할로겐이고, X2는 할로겐 또는 메틸기이고, X3는 수소 또는 할로겐이다.
  2. 메틸 3-디메틸아미노-2-(2,4-디클로로-5-플루오로벤조일)아크릴레이트.
  3. 에틸 3-디메틸아미노-2-(2,4-디클로로-5-플루오로벤조일)아크릴레이트.
  4. 3-디메틸아미노-2-(2,3,4,5-테트라플루오로벤조일)아크릴로니트릴.
  5. 3-디메틸아미노-2-(2,4-디클로로-5-플루오로벤조일)아크릴로니트릴.
  6. 하기 일반식(Ⅱ)의 벤조일 할라이드를 필요에 따라서 산 수용체 존재 하에, 일반식(Ⅲ)의 3-아미노 아크릴산 유도체와 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)으로 표시되는 3-아미노-2-벤조일아크릴산 유도체의 제조방법.
    상기 식중, R1는 니트릴기, 에스테르기 -COOR4(여기에서, R4는 C1-C6-알킬임) 또는 카르복스아미드기(여기에서, R5및 R6는 수소, C1-C3-알킬 또는 페닐기임)이고, R2및 R3는 서로 동일 하거나, 또는 상이한 것으로서, C1-C6-알킬기이고, 또한 이들과 결합된 질소 원자와 함께 5 또는 6원 헤테로시클릭 고리(이 고리는 고리 부재로서 -O-. -S-. -SO- 또는 -SO2-와 같은 원자 또는 기를 부차적으로 함유할 수 있음)를 형성할 수도 있고, X는 할로겐이고, X1는 수소, 메틸, 니트로 또는 할로겐이고,X2는 할로겐 또는 메틸기이고, X3는 수소 또는 할로겐이고, Hal는 할로겐이다.
  7. 제6항에 있어서, 2,4-디클로로-5-플루오로벤조일 클로라이드 메틸 3-디메틸아미노아크릴레이트와 반응시킴을 특징으로 하는 방법.
  8. 제6항에 있어서, 2,4-디클로로-5-플루오로벤조일 클로라이드 메틸 3-디메틸아미노아크릴레이트와 반응시킴을 특징으로 하는 방법.
  9. 제6항에 있어서, 2,4-디클로로-5-플루오로벤조일 클로라이드를 3-디메틸아미노아크릴로니트릴과 반응시킴을 특징으로 하는 방법.
  10. 제6항에 있어서, 산 수용체로서 유기 염기 또는 수소화 나트륨을 사용함을 특징으로 하는 방법.
  11. 제1항에 의한 일반식(Ⅰ)의 3-아미노-2-벤조일아크릴산 유도체의 항세균제 중간체로서의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850007204A 1984-09-29 1985-09-28 3-아미노-2-벤조일아크릴산 유도체의 제조 방법 KR870001999B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE3435930,3 1984-09-29
DE3435930 1984-09-29
DEP3435930.3 1984-09-29
DE19853502935 DE3502935A1 (de) 1984-09-29 1985-01-30 3-amino-2-benzoyl-acrylsaeurederivate und ein verfahren zu ihrer herstellung
DEP3502935.8 1985-01-30
DE3502935.8 1985-01-30

Publications (2)

Publication Number Publication Date
KR860002453A true KR860002453A (ko) 1986-04-26
KR870001999B1 KR870001999B1 (ko) 1987-11-30

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KR1019850007204A KR870001999B1 (ko) 1984-09-29 1985-09-28 3-아미노-2-벤조일아크릴산 유도체의 제조 방법

Country Status (16)

Country Link
US (1) US4699992A (ko)
EP (1) EP0176846B1 (ko)
KR (1) KR870001999B1 (ko)
AT (1) ATE45565T1 (ko)
CA (1) CA1255678A (ko)
DE (2) DE3502935A1 (ko)
DK (1) DK170638B1 (ko)
ES (1) ES8705098A1 (ko)
FI (1) FI87765C (ko)
GR (1) GR852344B (ko)
HU (1) HU193346B (ko)
IL (1) IL76521A (ko)
NO (1) NO170150C (ko)
PT (1) PT81214B (ko)
SU (1) SU1590039A3 (ko)
UA (1) UA8023A1 (ko)

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US4772706A (en) * 1986-01-13 1988-09-20 Warner-Lambert Company Process for quinoline-3-carboxylic acid antibacterial agents
DE3615767A1 (de) * 1986-05-10 1987-11-12 Bayer Ag Verfahren zur herstellung von 4-hydroxy-chinolin-3-carbonsaeuren
US5591744A (en) * 1987-04-16 1997-01-07 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
DE3724466A1 (de) * 1987-07-24 1989-02-02 Bayer Ag Verfahren zur herstellung von chinoloncarbonsaeuren
AT391863B (de) * 1988-06-09 1990-12-10 Chemie Linz Gmbh Verfahren zur herstellung von substituierten 3-amino-2-(benzoyl)-acrylsaeureestern, sowie ein verfahren zur herstellung von zwischenprodukten fuer antibakterielle wirkstoffe
US5138088A (en) * 1988-06-17 1992-08-11 Korea Advanced Institute Of Science And Technology Nitrobenzoyl-3-cyclopropylaminoacrylates and a process for the preparation thereof
KR910003634B1 (ko) * 1988-06-17 1991-06-07 한국과학기술원 니트로벤조일-3-시클로프로필아미노아크릴레이트 및 그 제조방법
GB8814881D0 (en) * 1988-06-22 1988-07-27 Shell Int Research Herbicidal acrylonitrile derivatives
IL91418A (en) * 1988-09-01 1997-11-20 Rhone Poulenc Agrochimie (hetero) cyclic amide derivatives, process for their preparation and fungicidal compositions containing them
FR2649699A1 (fr) * 1989-07-13 1991-01-18 Rhone Poulenc Agrochimie 4-phenyl pyrimidine fongicides
GB8920519D0 (en) * 1989-09-11 1989-10-25 Rhone Poulenc Ltd New compositions of matter
US5747424A (en) * 1989-09-11 1998-05-05 Rhone-Poulenc Agriculture Ltd. Herbicidal 4-substituted isoxazol
US5656573A (en) * 1989-09-11 1997-08-12 Rhone-Poulenc Agriculture Ltd. Herbicidal 4-substituted isoxazoles
US5650533A (en) * 1989-09-11 1997-07-22 Rhone-Poulenc Agriculture Ltd. Intermediates to herbicidal 4-substituted isoxazoles
DE4015299A1 (de) * 1990-05-12 1991-11-14 Bayer Ag Verfahren zur herstellung von 3-amino-2-(het)-aroyl-acrylsaeurederivaten
US5059709A (en) * 1990-11-13 1991-10-22 American Cyanamid Company Process for the synthesis of α-[(dialkylamino)substituted-methylene]-β-oxo-(substituted)propanentriles
DE19826050A1 (de) * 1998-06-12 1999-12-16 Bayer Ag Verfahren zur Herstellung von Chinolon- und Naphthyridoncarbonsäuren und deren Ester
EP1132375B1 (en) 1998-11-18 2003-07-16 Asahi Glass Company Ltd. Aminoacrylic acid derivatives and process for producing the same
DE10021900A1 (de) * 2000-05-08 2001-11-15 Bayer Ag Phenyl-substituierte 2-Enamino-Ketonitrile
CN104292159B (zh) * 2014-10-10 2016-12-07 浙江同丰医药化工有限公司 一种诺氟沙星、环丙沙星及恩诺沙星的制备方法
CN114436875B (zh) * 2022-03-01 2023-05-12 江苏飞宇医药科技股份有限公司 一种环丙乙酯胺化物的制备方法

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DE2808070A1 (de) * 1978-02-24 1979-08-30 Bayer Ag Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten
JPS55500866A (ko) * 1978-11-03 1980-10-30
US4243406A (en) * 1978-12-26 1981-01-06 Monsanto Company 5-Aryl-4-isoxazolecarboxylate-safening agents
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3142856A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 2,4-dichlor-5-fluor-benzoylchlorid
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Publication number Publication date
HU193346B (en) 1987-09-28
SU1590039A3 (ru) 1990-08-30
PT81214B (pt) 1988-01-22
GR852344B (ko) 1986-01-27
KR870001999B1 (ko) 1987-11-30
DK438885D0 (da) 1985-09-27
PT81214A (en) 1985-10-01
NO170150C (no) 1992-09-16
EP0176846A2 (de) 1986-04-09
DE3502935A1 (de) 1986-04-10
NO853604L (no) 1986-04-01
DK170638B1 (da) 1995-11-20
NO170150B (no) 1992-06-09
EP0176846A3 (en) 1987-06-03
DK438885A (da) 1986-03-30
ATE45565T1 (de) 1989-09-15
IL76521A (en) 1988-10-31
CA1255678A (en) 1989-06-13
EP0176846B1 (de) 1989-08-16
ES547253A0 (es) 1987-04-16
FI87765B (fi) 1992-11-13
UA8023A1 (uk) 1995-12-26
US4699992A (en) 1987-10-13
ES8705098A1 (es) 1987-04-16
FI853717L (fi) 1986-03-30
HUT39148A (en) 1986-08-28
FI853717A0 (fi) 1985-09-26
DE3572345D1 (en) 1989-09-21
FI87765C (fi) 1993-02-25
IL76521A0 (en) 1986-01-31

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